المؤلفون: Tulloch, Lindsay B, Tinti, Michele, Wall, Richard J, Weidt, Stefan K, Corpas-Lopez, Victoriano, Dey, Gourav, Smith, Terry K, Fairlamb, Alan H, Barrett, Michael P, Wyllie, Susan

المصدر: Tulloch , L B , Tinti , M , Wall , R J , Weidt , S K , Corpas-Lopez , V , Dey , G , Smith , T K , Fairlamb , A H , Barrett , M P & Wyllie , S 2024 , ' Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1 ' , PLoS Pathogens , vol. 20 , no. 7 , e1012382 . https://doi.org/10.1371/journal.ppat.1012382

مصطلحات موضوعية: NADPH-ferrihemoprotein Reductase - metabolism - genetics, Drug resistance, Amphotericin B - pharmacology, Sterol 14-demethylase - metabolism - genetics, Protozoan proteins - metabolism - genetics, Antiprotozoal agents - pharmacology, Humans, Leishmania donovani - enzymology, Leishmaniasis, visceral - parasitology - drug therapy, Ergosterol - metabolism

وصف الملف: application/pdf

الاتاحة: https://research-portal.st-andrews.ac.uk/en/publications/1b379a79-1264-40df-81be-2bf15296e954
https://doi.org/10.1371/journal.ppat.1012382
https://research-repository.st-andrews.ac.uk/bitstream/10023/30270/1/Tulloch-2024-Sterol-14-alpha-PLOSPath-20-7-e1012382-CCBY.pdf

المؤلفون: Howie, Jacqueline, Tulloch, Lindsay B., Brown, Elaine, Reilly, Louise, Ashford, Fiona B., Kennedy, Jennifer, Wypijewski, Krzysztof J., Aughton, Karen L., Mak, Jason K. C., Shattock, Michael J., Fraser, Niall J., Fuller, William

المصدر: Howie , J , Tulloch , L B , Brown , E , Reilly , L , Ashford , F B , Kennedy , J , Wypijewski , K J , Aughton , K L , Mak , J K C , Shattock , M J , Fraser , N J & Fuller , W 2024 , ' Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6 ' , Cell Reports , vol. 43 , no. 2 , 113679 . https://doi.org/10.1016/j.celrep.2024.113679

مصطلحات موضوعية: CP: Cell biology, FXYD, Na/K ATPase, deacylation, glutathione, peroxiredoxin, phospholemman, sodium pump, thioesterase, /dk/atira/pure/subjectarea/asjc/1300/1300, name=General Biochemistry,Genetics and Molecular Biology

وصف الملف: application/pdf

الاتاحة: https://discovery.dundee.ac.uk/en/publications/e94fdadc-d65b-41b3-a982-b7d123dc9dc1
https://doi.org/10.1016/j.celrep.2024.113679
https://discovery.dundee.ac.uk/ws/files/117595401/1-s2.0-S221112472400007X-main.pdf

المؤلفون: Tulloch, Lindsay B., Carvalho, Sandra, Lima, Marta, Wall, Richard J., Tinti, Michele, Pinto, Erika G., MacLean, Lorna, Wyllie, Susan

المصدر: Tulloch , L B , Carvalho , S , Lima , M , Wall , R J , Tinti , M , Pinto , E G , MacLean , L & Wyllie , S 2023 , ' RES-Seq – a barcoded library of drug-resistant Leishmania donovani allowing rapid assessment of cross-resistance and relative fitness ' , MBio , vol. 14 , no. 6 , e01803-23 . https://doi.org/10.1128/mbio.01803-23

مصطلحات موضوعية: Drug resistance profiling, mechanism of action, Leishmania, visceral leishmaniasis, Illumina sequencing

وصف الملف: application/pdf

Relation: https://discovery.dundee.ac.uk/en/publications/ff277794-1a72-4f2e-a0e3-54979a7ab4a2

الاتاحة: https://discovery.dundee.ac.uk/en/publications/ff277794-1a72-4f2e-a0e3-54979a7ab4a2
https://doi.org/10.1128/mbio.01803-23
https://discovery.dundee.ac.uk/ws/files/116395487/tulloch-et-al-2023-res-seq-a-barcoded-library-of-drug-resistant-leishmania-donovani-allowing-rapid-assessment-of-cross_1_.pdf

المؤلفون: Tulloch, Lindsay B.

مصطلحات موضوعية: 615

الاتاحة: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.663088

المؤلفون: Lima, Marta L, Tulloch, Lindsay B, Corpas-Lopez, Victoriano, Carvalho, Sandra, Wall, Richard J, Milne, Rachel, Rico, Eva, Patterson, Stephen, Gilbert, Ian H, Moniz, Sonia, MacLean, Lorna, Torrie, Leah S, Morgillo, Carmine, Horn, David, Zuccotto, Fabio, Wyllie, Susan

وصف الملف: text

Relation: https://researchonline.lshtm.ac.uk/id/eprint/4668042/1/Lima_etal_2021_Identification-of-a-proteasome-targeting.pdf; Lima, Marta L; Tulloch, Lindsay B; Corpas-Lopez, Victoriano; Carvalho, Sandra; Wall, Richard J ; Milne, Rachel; Rico, Eva; Patterson, Stephen; Gilbert, Ian H; Moniz, Sonia; +6 more. MacLean, Lorna; Torrie, Leah S; Morgillo, Carmine; Horn, David; Zuccotto, Fabio; Wyllie, Susan; (2022) Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease. Antimicrobial agents and chemotherapy, 66 (1). e0153521-. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.01535-21

الاتاحة: https://researchonline.lshtm.ac.uk/id/eprint/4668042/
https://researchonline.lshtm.ac.uk/id/eprint/4668042/1/Lima_etal_2021_Identification-of-a-proteasome-targeting.pdf
https://doi.org/10.1128/aac.01535-21

المؤلفون: Tulloch, Lindsay B., Tinti, Michele, Wall, Richard J., Weidt, Stefan K., Corpas- Lopez, Victoriano, Dey, Gourav, Smith, Terry K., Fairlamb, Alan H., Barrett, Michael P., Wyllie, Susan

المصدر: PLoS Pathogens; 7/11/2024, Vol. 20 Issue 7, p1-23, 23p

مصطلحات موضوعية: CYTOCHROME P-450, LEISHMANIA donovani, DEMETHYLASE, VISCERAL leishmaniasis, AMPHOTERICIN B, PHYTOSTEROLS

المؤلفون: Van den Kerkhof, Magali, Leprohon, Philippe, Mabille, Dorien, Hendrickx, Sarah, Tulloch, Lindsay B., Wall, Richard J., Wyllie, Susan, Chatelain, Eric, Mowbray, Charles E., Braillard, Stéphanie, Ouellette , Marc, Maes, Louis, Calijon, Guy

المصدر: Van den Kerkhof , M , Leprohon , P , Mabille , D , Hendrickx , S , Tulloch , L B , Wall , R J , Wyllie , S , Chatelain , E , Mowbray , C E , Braillard , S , Ouellette , M , Maes , L & Calijon , G 2021 , ' Identification of resistance determinants for a promising antileishmanial oxaborole series ' , Microorganisms , vol. 9 , no. 7 , 1408 . https://doi.org/10.3390/microorganisms9071408

مصطلحات موضوعية: Leishmania, ABC transporters, oxaboroles, resistance, /dk/atira/pure/subjectarea/asjc/2700/2726, name=Microbiology (medical), /dk/atira/pure/subjectarea/asjc/2400/2406, name=Virology, /dk/atira/pure/subjectarea/asjc/2400/2404, name=Microbiology

وصف الملف: application/pdf

الاتاحة: https://discovery.dundee.ac.uk/en/publications/8e10e40d-e6e5-400b-8832-c5d16ecbc80d
https://doi.org/10.3390/microorganisms9071408
https://discovery.dundee.ac.uk/ws/files/59559706/microorganisms_09_01408_v2_1_.pdf
http://www.scopus.com/inward/record.url?scp=85108842253&partnerID=8YFLogxK

المؤلفون: Zacharova, Marija K., Tulloch, Lindsay B., Gould, Eoin R., Fraser, Andrew L., King, Elizabeth F., Menzies, Stefanie K., Smith, Terry K., Florence, Gordon J.

المصدر: Zacharova , M K , Tulloch , L B , Gould , E R , Fraser , A L , King , E F , Menzies , S K , Smith , T K & Florence , G J 2019 , ' Structure‐based design, synthesis and biological evaluation of bis‐tetrahydropyran furan acetogenin mimics targeting the trypanosomatid F1 component of ATP synthase ' , European Journal of Organic Chemistry , vol. 2019 , no. 31-32 , pp. 5434-5440 . https://doi.org/10.1002/ejoc.201900541

مصطلحات موضوعية: Biological activity, Drug design, FoF1-ATP synthase, Homogeneous catalysis, Trypanosomatid, /dk/atira/pure/subjectarea/asjc/1600/1606, name=Physical and Theoretical Chemistry, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

وصف الملف: application/pdf

Relation: https://discovery.dundee.ac.uk/en/publications/777c3053-aa2f-4aa1-8fdd-1301e4705713

الاتاحة: https://discovery.dundee.ac.uk/en/publications/777c3053-aa2f-4aa1-8fdd-1301e4705713
https://doi.org/10.1002/ejoc.201900541
https://discovery.dundee.ac.uk/ws/files/35607908/Zacharova_et_al_2019_European_Journal_of_Organic_Chemistry.pdf
http://www.scopus.com/inward/record.url?scp=85066630767&partnerID=8YFLogxK

المؤلفون: Howie, Jacqueline, Wypijewski, Krzysztof J., Plain, Fiona, Tulloch, Lindsay B., Fraser, Niall J, Fuller, William

المصدر: Howie , J , Wypijewski , K J , Plain , F , Tulloch , L B , Fraser , N J & Fuller , W 2018 , ' Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation ' , Critical Reviews in Biochemistry and Molecular Biology , vol. 53 , no. 2 , pp. 175-191 . https://doi.org/10.1080/10409238.2018.1432560

مصطلحات موضوعية: Acylation, DHHC, Palmitoyl acyl transferase, Thioesterase, Post-translational modification, P-type ATPase, Ion transport, Phospholemman

الاتاحة: https://risweb.st-andrews.ac.uk/portal/en/researchoutput/greasing-the-wheels-or-a-spanner-in-the-works(abc42ae1-f2c2-426a-8089-4ad106c5d05b).html
https://doi.org/10.1080/10409238.2018.1432560
http://eprints.gla.ac.uk/156485/

المؤلفون: Tulloch, Lindsay B., Menzies, Stefanie K., Coron, Ross P., Roberts, Matthew D., Florence, Gordon J., Smith, Terry K.

المصدر: Tulloch , L B , Menzies , S K , Coron , R P , Roberts , M D , Florence , G J & Smith , T K 2018 , ' Direct and indirect approaches to identify drug modes of action ' , IUBMB Life , vol. 70 , no. 1 , pp. 9-22 . https://doi.org/10.1002/iub.1697

مصطلحات موضوعية: Drug mode of action, Target ID, Genomics, Transcriptomics, Proteomics, Metabolomics, Affinity chromatography, Photo-affinity labelling

وصف الملف: application/pdf

الاتاحة: https://risweb.st-andrews.ac.uk/portal/en/researchoutput/direct-and-indirect-approaches-to-identify-drug-modes-of-action(bf16bbe6-c295-406f-a178-f6ac36c78ce3).html
https://doi.org/10.1002/iub.1697
https://research-repository.st-andrews.ac.uk/bitstream/10023/16633/1/Direct_and_indirect_approaches_to_identify_drug_modes_of_action_IUBMB_Life_author_accepted_version.pdf

المؤلفون: Menzies, Stefanie K., Tulloch, Lindsay B., Florence, Gordon J., Smith, Terry K.

المصدر: Menzies , S K , Tulloch , L B , Florence , G J & Smith , T K 2018 , ' The trypanosome alternative oxidase : a potential drug target? ' , Parasitology , vol. 145 , no. 2 , pp. 175-183 . https://doi.org/10.1017/S0031182016002109

مصطلحات موضوعية: Trypanosoma alternative oxidase, Drug discovery, Chemotherapy, Human African trypanosomiasis, Sleeping sickness, Trypanosoma brucei

وصف الملف: application/pdf

الاتاحة: https://risweb.st-andrews.ac.uk/portal/en/researchoutput/the-trypanosome-alternative-oxidase(d385edaa-b1ae-40bb-8351-893c8752e709).html
https://doi.org/10.1017/S0031182016002109
https://research-repository.st-andrews.ac.uk/bitstream/10023/10874/1/Smith_2016_Parasitology_Trypanosome_AAM.pdf

المؤلفون: Tulloch, Lindsay B., Menzies, Stefanie K., Fraser, Andrew L., Gould, Eoin R., King, Elizabeth F., Zacharova, Marija K., Florence, Gordon J., Smith, Terry K.

المساهمون: The Leverhulme Trust, University of St Andrews. School of Chemistry, University of St Andrews. School of Biology, University of St Andrews. Biomedical Sciences Research Complex, University of St Andrews. EaSTCHEM

مصطلحات موضوعية: QH301 Biology, RM Therapeutics. Pharmacology, NDAS, BDC, R2C, SDG 3 - Good Health and Well-being, QH301, RM

وصف الملف: application/pdf

Relation: PLoS Neglected Tropical Diseases; Tulloch , L B , Menzies , S K , Fraser , A L , Gould , E R , King , E F , Zacharova , M K , Florence , G J & Smith , T K 2017 , ' Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues ' , PLoS Neglected Tropical Diseases , vol. 11 , no. 9 , e0005886 . https://doi.org/10.1371/journal.pntd.0005886; PURE: 251026018; PURE UUID: 7f83709f-44a1-4e30-8d20-71102ce87b31; RIS: urn:C41BC9504052E3B3093055AFE6BBAFDD; Scopus: 85030718818; ORCID: /0000-0002-8987-5561/work/36874690; ORCID: /0000-0001-7223-5106/work/42522361; ORCID: /0000-0001-9921-4399/work/56638893; WOS: 000412142800033; http://hdl.handle.net/10023/11717; https://doi.org/10.1371/journal.pntd.0005886; http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005886#sec034; RL-2012-025

الاتاحة: http://hdl.handle.net/10023/11717
https://doi.org/10.1371/journal.pntd.0005886
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005886#sec034

المؤلفون: Gould, Eoin R., King, Elizabeth F. B., Menzies, Stefanie K., Fraser, Andrew L., Tulloch, Lindsay B., Zacharova, Marija K., Smith, Terry K., Florence, Gordon J.

المصدر: Gould , E R , King , E F B , Menzies , S K , Fraser , A L , Tulloch , L B , Zacharova , M K , Smith , T K & Florence , G J 2017 , ' Simplifying nature : towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins ' , Bioorganic & Medicinal Chemistry , vol. 25 , no. 22 , pp. 6126-6136 . https://doi.org/10.1016/j.bmc.2017.01.021

مصطلحات موضوعية: Tetrahydropyran, Neglected tropical diseases, Acetogenins, Natural products

وصف الملف: application/pdf

الاتاحة: https://risweb.st-andrews.ac.uk/portal/en/researchoutput/simplifying-nature(b05f98d0-3ad9-41f7-b8b8-31c9831397b4).html
https://doi.org/10.1016/j.bmc.2017.01.021
https://research-repository.st-andrews.ac.uk/bitstream/10023/12625/1/EG_GJF_TKS_BMC_2016_256_accepteddraft.pdf

المؤلفون: Menzies, Stefanie K., Tulloch, Lindsay B., Fraser, Andrew L., Gould, Eoin R., King, Elizabeth F., Zacharova, Marija K., Florence, Gordon J., Smith, Terry K.

المصدر: Menzies , S K , Tulloch , L B , Fraser , A L , Gould , E R , King , E F , Zacharova , M K , Florence , G J & Smith , T K 2017 , ' Analogs of the Natural Product Chamuvarinin Target the Trypanosomatid FoF1-ATP Synthase Mitochondrial Complex V ' , American Journal of Tropical Medicine and Hygiene , vol. 95 , no. 5 Supplement , 520 , pp. 164 . https://doi.org/10.4269/ajtmh.abstract2016

Relation: https://discovery.dundee.ac.uk/en/publications/3fa2c872-8fe5-44f8-93d0-d86d0a315a1e

الاتاحة: https://discovery.dundee.ac.uk/en/publications/3fa2c872-8fe5-44f8-93d0-d86d0a315a1e
https://doi.org/10.4269/ajtmh.abstract2016

المؤلفون: Florence, Gordon J., Fraser, Andrew L., Gould, Eoin R., King, Elizabeth F., Menzies, Stefanie K., Morris, Joanne C., Thomson, Marie I., Tulloch, Lindsay B., Zacharova, Marija K., Smith, Terry K.

المصدر: Florence , G J , Fraser , A L , Gould , E R , King , E F , Menzies , S K , Morris , J C , Thomson , M I , Tulloch , L B , Zacharova , M K & Smith , T K 2016 , ' Development of simplified heterocyclic acetogenin analogues as potent and selective Trypanosoma brucei inhibitors ' , ChemMedChem , vol. 11 , no. 14 , pp. 1503-1506 . https://doi.org/10.1002/cmdc.201600210

مصطلحات موضوعية: [3+2] cycloaddition, Drug discovery, Natural product analogues, Trypanosomatids

وصف الملف: application/pdf

الاتاحة: https://risweb.st-andrews.ac.uk/portal/en/researchoutput/development-of-simplified-heterocyclic-acetogenin-analogues-as-potent-and-selective-trypanosoma-brucei-inhibitors(6a1ae42a-9a93-4f5e-bdd5-9144a9a82588).html
https://doi.org/10.1002/cmdc.201600210
https://research-repository.st-andrews.ac.uk/bitstream/10023/10977/1/cmdc201600210_revised_PURE.pdf

المؤلفون: Florence, Gordon J., Fraser, Andrew L., Gould, Eoin R., King, Elizabeth F. B., Menzies, Stefanie K., Morris, Joanne C., Tulloch, Lindsay B., Smith, Terry K.

المصدر: Florence , G J , Fraser , A L , Gould , E R , King , E F B , Menzies , S K , Morris , J C , Tulloch , L B & Smith , T K 2014 , ' Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors ' , ChemMedChem , vol. 9 , no. 11 , pp. 2548-2556 . https://doi.org/10.1002/cmdc.201402272

مصطلحات موضوعية: Acetogenin, Neglected diseases, HAT, T. brucei, Stereochemistry, Human African Trypanosomiasis (HAT), Natural product analogues, Trypanosoma brucei

وصف الملف: application/pdf

الاتاحة: https://risweb.st-andrews.ac.uk/portal/en/researchoutput/nonnatural-acetogenin-analogues-as-potent-trypanosoma-brucei-inhibitors(eaeca0a2-3b2b-4d0f-8350-394d34b0bdc4).html
https://doi.org/10.1002/cmdc.201402272
https://research-repository.st-andrews.ac.uk/bitstream/10023/7289/1/cmdc201402272rev_OA_PURE.pdf

المؤلفون: Wypijewski, Krzysztof J., Howie, Jacqueline, Reilly, Louise, Tulloch, Lindsay B., Aughton, Karen L., McLatchie, Linda M., Shattock, Michael J., Calaghan, Sarah C., Fuller, William

المصدر: Journal of Biological Chemistry ; volume 288, issue 19, page 13808-13820 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1074/jbc.m113.460956
https://api.elsevier.com/content/article/PII:S0021925819546099?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925819546099?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1074/jbc.M113.460956

المؤلفون: Tulloch, Lindsay B., Howie, Jacqueline, Wypijewski, Krzysztof J., Wilson, Catherine R., Bernard, William G., Shattock, Michael J., Fuller, William

المصدر: Journal of Biological Chemistry ; volume 286, issue 41, page 36020-36031 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1074/jbc.m111.282145
https://api.elsevier.com/content/article/PII:S0021925820738093?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925820738093?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1074/jbc.M111.282145

المؤلفون: Tulloch, Lindsay B., Martini, Viviane P., Iulek, Jorge, Huggan, Judith K., Lee, Jeong Hwan, Gibson, Colin L., Smith, Terry K., Suckling, Colin J., Hunter, William N.

المصدر: Journal of Medicinal Chemistry ; volume 53, issue 1, page 221-229 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/jm901059x
https://pubs.acs.org/doi/pdf/10.1021/jm901059x

المؤلفون: Mpamhanga, Chidochangu P., Spinks, Daniel, Tulloch, Lindsay B., Shanks, Emma J., Robinson, David A., Collie, Iain T., Fairlamb, Alan H., Wyatt, Paul G., Frearson, Julie A., Hunter, William N., Gilbert, Ian H., Brenk, Ruth

المصدر: Journal of Medicinal Chemistry ; volume 52, issue 14, page 4454-4465 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/jm900414x
https://pubs.acs.org/doi/pdf/10.1021/jm900414x