المؤلفون: Guo-Bo Li, Gen Li, Ji Deng, Yang Lingling, Yu-Hang Yan, Xiang-Li Ning, Jun-Lin Yu, Qing-Qing Dai

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1931-1946 (2021)

مصطلحات موضوعية: Virtual screening, Indoleamine 2,3-dioxygenase, 0303 health sciences, Drug discovery, Chemistry, Metalloenzyme, Tryptophan, Metallo-β-lactamase, RM1-950, Computational biology, Tryptophan 2 3 dioxygenase, Metallo β lactamase, Tryptophan 2,3-dioxygenase, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Therapeutics. Pharmacology, General Pharmacology, Toxicology and Pharmaceutics, Pharmacophore, Anchor pharmacophore, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9019ca6965de09f847b1a307e32291e
https://doi.org/10.1016/j.apsb.2021.01.018

المؤلفون: László Vécsei, Fanni Annamária Boros

المصدر: Expert opinion on therapeutic targets. 25(10)

مصطلحات موضوعية: Kynurenine pathway, Parkinson's disease, Clinical Biochemistry, Central nervous system, Disease, Pharmacology, Tryptophan 2 3 dioxygenase, Dopamine, Drug Discovery, medicine, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Kynurenine, business.industry, Neurodegeneration, Tryptophan, 03.01. Általános orvostudomány, Parkinson Disease, medicine.disease, Tryptophan Oxygenase, medicine.anatomical_structure, Molecular Medicine, Serotonin, business, medicine.drug

وصف الملف: text

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd558cc389c6bbd8e123abb9f6d44de
https://pubmed.ncbi.nlm.nih.gov/34720020

المؤلفون: Kenji Zennami, Kosuke Fukaya, Takuhisa Nukaya, Masashi Takenaka, Makoto Sumitomo, Ryoichi Shiroki, Manabu Ichino, Kiyoshi Takahara, Hitomi Sasaki

المصدر: Journal of Urology. 206

مصطلحات موضوعية: chemistry.chemical_classification, business.industry, Urology, medicine.medical_treatment, Tryptophan, Tumor cells, Immunotherapy, Tryptophan 2 3 dioxygenase, medicine.disease, chemistry.chemical_compound, Enzyme, chemistry, Renal cell carcinoma, medicine, Cancer research, business, Kynurenine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::72c3d87fdde2e5d4f4fb45b910ec039a
https://doi.org/10.1097/ju.0000000000002071.05

المؤلفون: Arina Kozlova, Marine Deskeuvre, Vincent Stroobant, Maxime Liberelle, Léopold Thabault, Luc Pilotte, Raphaël Frédérick, Benoît Van den Eynde, Nicolas Dauguet

المصدر: European journal of medicinal chemistry. 227

مصطلحات موضوعية: chemistry.chemical_element, Tryptophan 2 3 dioxygenase, Oxygen, Chalcogen, Selenium, Structure-Activity Relationship, Heterocyclic Compounds, Drug Discovery, Humans, Enzyme Inhibitors, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Tryptophan, Stereoisomerism, General Medicine, Combinatorial chemistry, Sulfur, Tryptophan Oxygenase, chemistry, Lipophilicity, Chalcogens, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99be572a174b290c3fac0aaae25c2a80
https://pubmed.ncbi.nlm.nih.gov/34678572

المؤلفون: Mads Gyrd-Hansen, Delia Hoffmann, Nathalie Vigneron, Etienne De Plaen, Simon Klaessens, Benoît Van den Eynde, Luc Pilotte, Vincent Stroobant

المساهمون: UCL - SSS/DDUV/GECE - Génétique cellulaire

المصدر: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences, Vol. 118, no.23, p. e2022447118 (2021)
PNAS

مصطلحات موضوعية: tumor, SCF complexes, Tryptophan 2 3 dioxygenase, tryptophanemia, liver, ubiquitination, Tryptophan 2, CUL1, Mice, Tetramer, Ubiquitin, alpha-methyl-tryptophan, Animals, Homeostasis, Humans, tryptophan, Multidisciplinary, biology, Chemistry, Catabolism, Tryptophan, Ubiquitination, Tryptophanemia, Biological Sciences, Tryptophan Oxygenase, kynurenine, degron, Mice, Inbred C57BL, 3-dioxygenase, proteasome, HEK293 Cells, Biochemistry, cullins, biology.protein, Degron

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9400f07350e89555977a4d8317c1c5a
https://pubmed.ncbi.nlm.nih.gov/34074763

المؤلفون: Abdulla A.-B. Badawy

المصدر: Immunology Letters. 225:23-24

مصطلحات موضوعية: Murine hepatitis virus, 2019-20 coronavirus outbreak, biology, Coronavirus disease 2019 (COVID-19), Chemistry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Tryptophan 2 3 dioxygenase, biology.organism_classification, Virology, Tryptophan Oxygenase, Mice, Mouse hepatitis virus, Liver metabolism, Liver, Animals, Immunology and Allergy, Coronavirus Infections

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4d47e6d7120ba23c0126317b23e4d6
https://doi.org/10.1016/j.imlet.2020.05.007

المؤلفون: Chunxiang Kuang, Menghan Cui, Shengnan Zhang, Wei Liu, Rong Wang, Qing Yang, Li Yuanyuan

المصدر: Bioorganicmedicinal chemistry letters. 30(11)

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Tryptophan 2 3 dioxygenase, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Molecular Biology, Natural product, 010405 organic chemistry, Organic Chemistry, Tryptophan, Tryptophan Oxygenase, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Inhibitory potency, Drug development, chemistry, Solubility, Drug Design, Quinazolines, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfdadb6e63402377b8c04a8115c9b3a
https://pubmed.ncbi.nlm.nih.gov/32247733

المؤلفون: Shengnan Zhang, Chunxiang Kuang, Dan Yang, Zikang Xing, Leilei Guo, Weirui Li, Qing Yang

المصدر: Bioorganic chemistry. 104

مصطلحات موضوعية: Tryptophan 2 3 dioxygenase, 01 natural sciences, Biochemistry, Enzymatic Assays, HeLa, Structure-Activity Relationship, Drug Discovery, Bioassay, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Molecular Biology, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Tryptophan, biology.organism_classification, Recombinant Proteins, Tryptophan Oxygenase, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Biological Assay, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a74863ff3519791d27aefca4a45443b
https://pubmed.ncbi.nlm.nih.gov/33142415

المؤلفون: Abdulla A.-B. Badawy

المصدر: Medical hypotheses. 132

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Tryptophan, 5 aminolevulinate synthase, General Medicine, Pharmacology, Tryptophan 2 3 dioxygenase, Heme

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ccfd66a920ccd27b487e3bf48ac28c
https://pubmed.ncbi.nlm.nih.gov/31443750

المؤلفون: Benoît Van den Eynde, Julien R. C. Prevost, Arina Kozlova, Luc Pilotte, Maxime Liberelle, Raphaël Frédérick, Simon Klaessens, Caroline Mathieu, Vincent Stroobant, Léopold Thabault

المصدر: Journal of Medicinal Chemistry. 64:13096-13096

مصطلحات موضوعية: Stereochemistry, Chemistry, Drug Discovery, Rational design, Molecular Medicine, Tryptophan 2 3 dioxygenase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::09e0853f7feb319364226d1b157d1196
https://doi.org/10.1021/acs.jmedchem.1c01455

المؤلفون: John S. Coon, Serdar E. Bulun, Ilona Neale, Anne P. Hutchinson, Ping Yin

المصدر: Fertility and Sterility. 114:e339

مصطلحات موضوعية: Uterine leiomyoma, Reproductive Medicine, Mutation (genetic algorithm), Obstetrics and Gynecology, Tryptophan 2 3 dioxygenase, Biology, Molecular biology, MED12

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7165f745b5a7d6c4df02f4ffebb08a31
https://doi.org/10.1016/j.fertnstert.2020.08.1015

المؤلفون: Abdulla Abu-Bakr Badawy

المصدر: Egyptian journal of basic and clinical pharmacology
Egyptian Journal of Basic and Clinical Pharmacology, Vol 9, Pp 1-30 (2019)

مصطلحات موضوعية: Kynurenine pathway, indoleamine 2,3-dioxygenase, lcsh:Medicine, Tryptophan 2 3 dioxygenase, Biology, tryptophan 2,3-dioxygenase, Article, 03 medical and health sciences, 0302 clinical medicine, neurological disease, Indoleamine 2,3-dioxygenase, 030304 developmental biology, 0303 health sciences, major depressive disorder, lcsh:R, lcsh:RM1-950, Tryptophan Metabolism, 3. Good health, tumoral immune escape, plasma free tryptophan, serotonin pathway, lcsh:Therapeutics. Pharmacology, inflammation, immunotherapy, Neuroscience, 030217 neurology & neurosurgery, kynurenine pathway, plasma free tryptophan, serotonin pathway

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54aec9c29bfbd906905076bafc42cfa8
http://europepmc.org/articles/PMC6520243

المؤلفون: Arina Kozlova, Raphaël Frédérick

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Expert Opinion on Therapeutic Patents, Vol. 29, no. 1, p. 11-23 (2019)

مصطلحات موضوعية: Kynurenine pathway, medicine.medical_treatment, Antineoplastic Agents, Tryptophan 2 3 dioxygenase, 01 natural sciences, Patents as Topic, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Cancer immunotherapy, Neoplasms, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, chemistry.chemical_classification, Pharmacology, Neurodegenerative Diseases, Immunotherapy, General Medicine, Tryptophan Oxygenase, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, 030220 oncology & carcinogenesis, Cancer research

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716dac0a405ebe10f5f2bf54724d1ad2
https://hdl.handle.net/2078.1/209019

المؤلفون: Fangfei Qi, Hairong Hu, Qing Yang, Xin Fang, Chunxiang Kuang, Dan Yang, Shengnan Zhang, Qiang Huang

المصدر: European journal of medicinal chemistry. 160

مصطلحات موضوعية: 0301 basic medicine, Substituent, Tryptophan 2 3 dioxygenase, Inhibitory postsynaptic potential, law.invention, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, law, Drug Discovery, Bioassay, Humans, Enzyme Inhibitors, IC50, Pharmacology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Tryptophan, General Medicine, Recombinant Proteins, Tryptophan Oxygenase, 030104 developmental biology, Enzyme, HEK293 Cells, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Recombinant DNA, Quinazolines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f5b8e3d7384d06f46eaca1996bba51
https://pubmed.ncbi.nlm.nih.gov/30321802

المؤلفون: L.L. Siu, Megan Wind-Rotolo, Jason J. Luke, Bruce S. Fischer, Yuko Ishii, Danielle Greenawalt, D. Nelson, E.H. Kandoussi, J. Santucci-Pereira

المصدر: Annals of Oncology. 30:v760-v761

مصطلحات موضوعية: 0301 basic medicine, Future studies, business.industry, Stock options, Hematology, Tryptophan 2 3 dioxygenase, Serum samples, Management, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Release date, Medicine, Nivolumab, Head and neck, business, Solid tumor, health care economics and organizations

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d8813c8c1dce0cdbf48f62b02d7d9f4c
https://doi.org/10.1093/annonc/mdz268.001

المؤلفون: Akihiro Maeta, Katsumi Shibata, Mitsue Sano, Tsutomu Fukuwatari, Hiroshi Funakoshi, Toshikazu Nakamura

المصدر: Bioscience, Biotechnology, and Biochemistry. 78:878-881

مصطلحات موضوعية: Niacinamide, Tryptophan 2 3 dioxygenase, Applied Microbiology and Biotechnology, Biochemistry, Analytical Chemistry, Eating, Mice, chemistry.chemical_compound, Biosynthesis, D tryptophan, Animals, Indoleamine-Pyrrole 2,3,-Dioxygenase, Indoleamine 2,3-dioxygenase, Molecular Biology, Mice, Knockout, Nicotinamide, Body Weight, Organic Chemistry, Tryptophan, Stereoisomerism, General Medicine, Tryptophan Oxygenase, Diet, chemistry, Knockout mouse, Female, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0dfe501f5ff730fd52b17b2a4dd9c8f
https://doi.org/10.1080/09168451.2014.905185

المؤلفون: Abdulla A.-B. Badawy

المصدر: Journal of Psychopharmacology. 28:169-172

مصطلحات موضوعية: Pharmacology, Depressive Disorder, Major, Serotonin, Chemistry, Tryptophan, Brain, Tryptophan 2 3 dioxygenase, Psychiatry and Mental health, Biochemistry, Animals, Humans, Pharmacology (medical), Serotonin biosynthesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8197cb4fd5b1472aef89d66ac8a5eda
https://doi.org/10.1177/0269881113512044

المؤلفون: Toshikazu Nakamura, Hiroshi Funakoshi, Katsumi Shibata, Tsutomu Fukuwatari, Akihiro Maeta

المصدر: International Journal of Tryptophan Research, Vol 2013, Iss Suppl. 1, Pp 55-65 (2013)
International Journal of Tryptophan Research : IJTR
International Journal of Tryptophan Research, Vol 6s1 (2013)

مصطلحات موضوعية: medicine.medical_specialty, Tryptophan 2 3 dioxygenase, Bioinformatics, Biochemistry, lcsh:Physiology, tryptophan, TDO-deficient mice, 0.06% L-Trp diet, wild-type mice, lcsh:Biochemistry, Internal medicine, Medicine, tryptophan, lcsh:QD415-436, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Molecular Biology, Original Research, chemistry.chemical_classification, 0.06% L-Trp diet, lcsh:QP1-981, business.industry, Catabolism, Tryptophan, TDO-deficient mice, Endocrinology, chemistry, Knockout mouse, Standard diet, wild-type mice, Serotonin, business, Essential nutrient, Homeostasis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6fd2533ef45038413522f2e66792ab
http://www.la-press.com/tryptophan-restriction-diets-help-to-maintain-l-tryptophan-homeostasis-article-a3778

المؤلفون: Aimin Liu, Kednerlin Dornevil, Iveta Sosova, Inchul Shin, Deborah Dewey, Fange Liu, Patrick Ferreira, Shailly Jain

المصدر: Molecular genetics and metabolism. 120(4)

مصطلحات موضوعية: 0301 basic medicine, Endocrinology, Diabetes and Metabolism, Tryptophan 2 3 dioxygenase, Compound heterozygosity, Biochemistry, Biochemical phenotype, Article, 03 medical and health sciences, Endocrinology, Catalytic Domain, Genetics, medicine, Humans, Genetic Predisposition to Disease, Molecular Biology, Gene, Amino Acid Metabolism, Inborn Errors, chemistry.chemical_classification, Tryptophan, Infant, Newborn, Hypertryptophanemia, Sequence Analysis, DNA, medicine.disease, Pathogenicity, Tryptophan Oxygenase, Protein Structure, Tertiary, 030104 developmental biology, Enzyme, chemistry, Mutation, Female, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f476e20615b1357eabb382aacbb3bb8b
https://pubmed.ncbi.nlm.nih.gov/28285122

المؤلفون: Olivier Michielin, Vincent Zoete, Ute F. Röhrig

المصدر: Topics in Medicinal Chemistry ISBN: 9783319759241

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Kynurenine pathway, Immune escape, Cancer therapy, Tryptophan, Tryptophan Metabolism, Pharmacology, Tryptophan 2 3 dioxygenase, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Enzyme, chemistry, 030220 oncology & carcinogenesis, Indoleamine 2,3-dioxygenase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e564c0a09f38f66649f1e3e6626eaf13
https://doi.org/10.1007/7355_2017_22