المؤلفون: MacLean, Lorna, Thomas, John, Lewis, Michael D., Cotillo, Ignacio, Gray, David, De Rycker, Manu

المصدر: MacLean , L , Thomas , J , Lewis , M D , Cotillo , I , Gray , D & De Rycker , M 2018 , ' Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery ' , PLoS Neglected Tropical Diseases , vol. 12 , no. 7 , e0006612 , pp. 1-22 . https://doi.org/10.1371/journal.pntd.0006612

مصطلحات موضوعية: Biological Assay/methods, Chagas Disease/drug therapy, Drug Discovery/methods, Ergosterol/biosynthesis, Humans, Triazoles/pharmacology, Trypanocidal Agents/pharmacology, Trypanosoma cruzi/drug effects

وصف الملف: application/pdf

الاتاحة: https://discovery.dundee.ac.uk/en/publications/6e45cefd-4f00-43d6-8955-b32086bcdd4c
https://doi.org/10.1371/journal.pntd.0006612
https://discovery.dundee.ac.uk/ws/files/27822730/journal.pntd.0006612.pdf

المؤلفون: Menzies, Stefanie K., Tulloch, Lindsay B., Florence, Gordon J., Smith, Terry K.

المصدر: Menzies , S K , Tulloch , L B , Florence , G J & Smith , T K 2018 , ' The trypanosome alternative oxidase : a potential drug target? ' , Parasitology , vol. 145 , no. 2 , pp. 175-183 . https://doi.org/10.1017/S0031182016002109

مصطلحات موضوعية: Animals, Drug Discovery, Humans, Mitochondria/drug effects, Mitochondrial Proteins/chemistry, Oxidoreductases/chemistry, Plant Proteins/chemistry, Trypanocidal Agents/pharmacology, Trypanosoma brucei brucei/drug effects, Trypanosomiasis, African/drug therapy

وصف الملف: application/pdf

Relation: https://discovery.dundee.ac.uk/en/publications/91a0f394-1c7a-4de6-b914-732b7f001244

الاتاحة: https://discovery.dundee.ac.uk/en/publications/91a0f394-1c7a-4de6-b914-732b7f001244
https://doi.org/10.1017/S0031182016002109
https://discovery.dundee.ac.uk/ws/files/35608777/Smith_2016_Parasitology_Trypanosome_AAM.pdf

المؤلفون: Wall, Richard, Rico Vidal, Eva, Lukac, Iva, Zuccotto, Fabio, Elg, Sara, Gilbert, Ian, Freund, Yvonne R., Alley, Michael R. K., Field, Mark, Wyllie, Susan, Horn, David

المصدر: Wall , R , Rico Vidal , E , Lukac , I , Zuccotto , F , Elg , S , Gilbert , I , Freund , Y R , Alley , M R K , Field , M , Wyllie , S & Horn , D 2018 , ' Clinical and veterinary trypanocidal benzoxaboroles target CPSF3 ' , Proceedings of the National Academy of Sciences of the United States of America , vol. 115 , no. 38 , pp. 9616-9621 . https://doi.org/10.1073/pnas.1807915115

مصطلحات موضوعية: CPSF73, Drug discovery, Genetic screening, N-myristoyltransferase, Ysh1, Trypanosoma brucei brucei/drug effects, Trypanocidal Agents/pharmacology, Humans, Boron Compounds/pharmacology, Drug Resistance/drug effects, Gene Knockdown Techniques, Cleavage And Polyadenylation Specificity Factor/antagonists & inhibitors, Cell Nucleus/genetics, High-Throughput Screening Assays/methods, Valine/analogs & derivatives, Gene Library, Benzamides/pharmacology, RNA, Messenger/metabolism, Protozoan/metabolism, Animals, CRISPR-Cas Systems, RNA Processing, Post-Transcriptional/drug effects, Protozoan Proteins/antagonists & inhibitors, Molecular Docking Simulation, Trypanosomiasis, African/prevention & control, /dk/atira/pure/subjectarea/asjc/1000, name=General

وصف الملف: application/pdf

Relation: https://discovery.dundee.ac.uk/en/publications/0af9974b-7d43-4283-badb-4b0e0ade2fe8

الاتاحة: https://discovery.dundee.ac.uk/en/publications/0af9974b-7d43-4283-badb-4b0e0ade2fe8
https://doi.org/10.1073/pnas.1807915115
https://discovery.dundee.ac.uk/ws/files/28308102/439108_2_other_pcp44c.pdf
https://discovery.dundee.ac.uk/ws/files/28636727/9616.full.pdf
http://www.scopus.com/inward/record.url?scp=85053440486&partnerID=8YFLogxK

المؤلفون: Loureiro, I, Thoo-Lin, P, Ramos, I, Roura, M, Pruvost, A, Pemberton, I, Loukil, H, MacDougall, J, Tavares, J, Cordeiro-da-Silva, A, Graça, NA, Gaspar, L, Costa, DM

المساهمون: Instituto de Investigação e Inovação em Saúde

مصطلحات موضوعية: Neurons/cytology, Neurons/drug effects, Neurons/metabolism, Parasite Load, Pentamidine/pharmacology, Primary Cell Culture, Structure-Activity Relationship, Survival Analysis, Trypanocidal Agents/chemical synthesis, Trypanosoma brucei brucei/drug effects, Trypanosoma brucei brucei/growth & development, Trypanosoma brucei brucei/metabolism, Trypanosomiasis, African/drug therapy, African/mortality, African/parasitology, African/pathology, Trypanocidal Agents/pharmacology, Animals, Cell Line, Drug Stability, Female, Hepatocytes/cytology, Hepatocytes/drug effects, Hepatocytes/metabolism, Humans, Inhibitory Concentration 50, Liver/drug effects, Liver/metabolism, Macrophages/cytology

وصف الملف: application/pdf

Relation: info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F81604%2F2011/PT; Antimicrobial Agents and Chemotherapy, vol.60(4), p. 2532-2536; https://aac.asm.org/content/60/4/2532.long; https://repositorio-aberto.up.pt/handle/10216/118203

الاتاحة: https://repositorio-aberto.up.pt/handle/10216/118203
https://doi.org/10.1128/AAC.02490-15

المؤلفون: Stijlemans, Benoît, Caljon, Guy, Natesan, Senthil Kumar A, Saerens, Dirk, Conrath, Katja, Perez-Morga, David, Skepper, Jeremy N, Nikolaou, Alexandros, Brys, Lea, Pays, Etienne, Magez, Stefan, Field, Mark C, De Baetselier, Patrick, Muyldermans, Serge

المصدر: P L o S Pathogens, 7 (6

مصطلحات موضوعية: Sciences exactes et naturelles, Sciences bio-médicales et agricoles, Amino Acid Sequence, Animals, Antibodies, Protozoan -- immunology -- pharmacology -- therapeutic use, Antibody Affinity, Cells, Cultured, Down-Regulation -- drug effects, Endocytosis -- drug effects, Humans, Mice, Inbred C57BL, Models, Biological, Molecular, Molecular Sequence Data, Nanoparticles, Trypanocidal Agents -- pharmacology -- therapeutic use, Trypanosoma brucei brucei -- immunology -- metabolism -- physiology -- ultrastructure, Trypanosomiasis, African -- immunology -- metabolism -- therapy, Variant Surface Glycoproteins, Trypanosoma -- immunology

وصف الملف: 1 full-text file(s): application/pdf

Relation: uri/info:doi/10.1371/journal.ppat.1002072; uri/info:pii/10-PLPA-RA-4101; uri/info:pmid/21698216; uri/info:scp/79959851947; uri/info:pmcid/PMC3116811; uri/info:ulb-repo/set/1; https://dipot.ulb.ac.be/dspace/bitstream/2013/160716/4/doi_146170.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/160716

الاتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/160716
https://dipot.ulb.ac.be/dspace/bitstream/2013/160716/4/doi_146170.pdf

المؤلفون: Lepesheva, Galina I, Park, Hee-Won, Hargrove, Tatiana Y, Vanhollebeke, Benoît, Wawrzak, Zdzislaw, Harp, Joel M, Sundaramoorthy, Munirathinam, Nes, W David, Pays, Etienne, Chaudhuri, Minu, Villalta, Fernando, Waterman, Michael R

المصدر: The Journal of biological chemistry, 285 (3

مصطلحات موضوعية: Sciences bio-médicales et agricoles, Amino Acid Sequence, Benzamides -- chemistry, Benzamides -- metabolism, Benzamides -- pharmacology, Benzamides -- therapeutic use, Biocatalysis, Crystallography, X-Ray, Cytochrome P-450 Enzyme System -- antagonists & inhibitors, Cytochrome P-450 Enzyme System -- chemistry, Cytochrome P-450 Enzyme System -- metabolism, Drug Design, Enzyme Inhibitors -- chemistry, Enzyme Inhibitors -- metabolism, Enzyme Inhibitors -- pharmacology, Enzyme Inhibitors -- therapeutic use, Humans, Ligands, Microsomes -- enzymology, Models, Molecular, Protein Conformation, Sterols -- biosynthesis, Substrate Specificity, Trypanocidal Agents -- chemistry, Trypanocidal Agents -- metabolism, Trypanocidal Agents -- pharmacology, Trypanocidal Agents -- therapeutic use, Trypanosoma brucei brucei -- drug effects

وصف الملف: 2 full-text file(s): application/pdf | application/pdf

Relation: uri/info:doi/10.1074/jbc.M109.067470; uri/info:pii/M109.067470; uri/info:pmid/19923211; uri/info:scp/76249100348; https://dipot.ulb.ac.be/dspace/bitstream/2013/51605/5/doi_26716.pdf; https://dipot.ulb.ac.be/dspace/bitstream/2013/51605/3/doi_26716.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51605

الاتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51605
https://dipot.ulb.ac.be/dspace/bitstream/2013/51605/5/doi_26716.pdf
https://dipot.ulb.ac.be/dspace/bitstream/2013/51605/3/doi_26716.pdf

المؤلفون: Mahin Abad Dar, Franziska Maiwald, Diego Benítez, Laurent Meijer, Nadège Loaëc, Conrad Kunick, Lutz Preu, Hanna Erdmann, Marcelo A. Comini, Oliver Koch, Diego Charquero, Christoph Hölscher

المساهمون: Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Institut Pasteur de Montevideo, Réseau International des Instituts Pasteur (RIIP), Forschungszentrum Borstel - Research Center Borstel, Technische Universität Dortmund [Dortmund] (TU), ManRos Therapeutics, This project was funded by the German 'Bundesministerium für Bildung und Forschung' (KMU-innovativ 5, Förderkennzeichen 0315814, to F. M., M. A. D., O. K., C. H., and C. K.). The support of FOCEM (MERCOSUR Structural Convergence Fund, COF 03/11) and ANII (grant Innova Uruguay, agreement DCI-ALA/2007/19.040 between Uruguay and the European Commission, INI_X_2011_1_4077 and POS_NAC_2013_1_114477) is acknowledged by M. A. C., D. B. and D. C.. L. M. was supported by a grant from the ‘Agence Nationale de la Recherche’ (ANR- 11-RPIB-0016 grant, Transleish).

المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2014, 83, pp.274-283. ⟨10.1016/j.ejmech.2014.06.020⟩

مصطلحات موضوعية: MESH: Trypanocidal Agents/chemical synthesis, MESH: Benzazepines/toxicity, Nagana, Mice, Chalcones, MESH: Structure-Activity Relationship, MESH: Cell Proliferation/drug effects, Human trypanosomiasis, Drug Discovery, MESH: Animals, MESH: Benzazepines/chemistry, biology, MESH: Trypanosoma brucei brucei/physiology, Chemistry, MESH: Macrophages/drug effects, General Medicine, Trypanocidal Agents, 3. Good health, MESH: Trypanocidal Agents/pharmacology, Biochemistry, Paullones, MESH: Trypanocidal Agents/toxicity, MESH: Trypanosomiasis, African/parasitology, Trypanosoma brucei brucei, Cell Line, Structure-Activity Relationship, Heck reaction, parasitic diseases, medicine, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Trypanosoma brucei brucei/drug effects, MESH: Drug Design, MESH: Mice, Cell Proliferation, Pharmacology, MESH: Humans, MESH: Benzazepines/chemical synthesis, MESH: Trypanocidal Agents/chemistry, Macrophages, Organic Chemistry, MESH: Benzazepines/pharmacology, Benzazepines, biology.organism_classification, medicine.disease, Antiparasitic agent, Cinnamides, MESH: Cell Line, Trypanosomiasis, African, Drug Design, Trypanosoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f950885441e6cd8f086d1dfed0feca
https://doi.org/10.1016/j.ejmech.2014.06.020

المؤلفون: Jeremy N. Skepper, Dirk Saerens, Senthil Kumar A. Natesan, Lea Brys, Mark C. Field, Alexandros Nikolaou, Serge Muyldermans, Stefan Magez, Etienne Pays, David Perez-Morga, Katja Conrath, Benoit Stijlemans, Patrick De Baetselier, Guy Caljon

المساهمون: Cellular and Molecular Immunology, Molecular and Biochemical Pharmacology

المصدر: Vrije Universiteit Brussel
PLoS Pathogens, Vol 7, Iss 6, p e1002072 (2011)
PLoS Pathogens
P L o S Pathogens, 7 (6

مصطلحات موضوعية: Models, Molecular, Trypanocidal Agents -- pharmacology -- therapeutic use, Antibody Affinity, Antibodies, Protozoan, Epitope, Mice, Trypanosome brucei, Down-Regulation -- drug effects, Molecular Cell Biology, Biology (General), Cells, Cultured, chemistry.chemical_classification, 0303 health sciences, biology, trypanosomiasis therapeutics, Trypanosoma brucei brucei -- immunology -- metabolism -- physiology -- ultrastructure, Sciences bio-médicales et agricoles, Trypanocidal Agents, nanobodies, Endocytosis, 3. Good health, Cell biology, Antibodies, Protozoan -- immunology -- pharmacology -- therapeutic use, Antibody, Endocytosis -- drug effects, Variant Surface Glycoproteins, Trypanosoma, Sciences exactes et naturelles, Research Article, Biotechnology, trypanolytic agent, Trypanosomiasis, African -- immunology -- metabolism -- therapy, QH301-705.5, Immunology, Molecular Sequence Data, Trypanosoma brucei brucei, Down-Regulation, Trypanosoma brucei, Microbiology, Models, Biological, 03 medical and health sciences, Virology, parasitic diseases, Genetics, Antigenic variation, Animals, Humans, Amino Acid Sequence, variant-specific surface glycoprotein, Molecular Biology, Biology, 030304 developmental biology, 030306 microbiology, Variant Surface Glycoproteins, Trypanosoma -- immunology, RC581-607, biology.organism_classification, Molecular biology, Complement system, Mice, Inbred C57BL, Trypanosomiasis, African, chemistry, biology.protein, Trypanosoma, Nanoparticles, Parasitology, Immunologic diseases. Allergy, Glycoprotein

وصف الملف: 1 full-text file(s): application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b0c24441acd735f0e34b460deb7685
https://doi.org/10.1371/journal.ppat.1002072

المؤلفون: Susan Wyllie, Paul G. Wyatt, Alan H. Fairlamb, Malcolm F. G. Stevens, Geoffrey Wells, Janine König

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Amide Synthases/metabolism, Time Factors, Spermidine, Thioredoxin reductase, Trypanothione, Protozoan Proteins, Amide Synthases/genetics, Biochemistry, chemistry.chemical_compound, Thioredoxins, Cysteine/metabolism, Trypanosomiasis/drug therapy, Trypanosoma brucei brucei/metabolism, Thioredoxins/genetics, biology, Glutathione/genetics, Drug Action, Thioredoxins/metabolism, Glutathione, Trypanocidal Agents, Trypanosoma brucei brucei/genetics, Tryparedoxin Peroxidase, Thiol, Drug, medicine.symptom, Thioredoxin, Antineoplastic Agents/pharmacology, Peroxidase, Protozoan Proteins/metabolism, Trypanosomiasis/genetics, Cysteine/genetics, Glutathione/analogs & derivatives, Trypanosoma brucei brucei, Trypanosomiasis/metabolism, Antineoplastic Agents, Trypanosoma brucei, Trypanosome, Dose-Response Relationship, Amide Synthases, Trypanosomiasis, medicine, Spermidine/analogs & derivatives, Animals, Benzothiazoles/pharmacology, Benzothiazoles, Cysteine, Molecular Biology, Hydroquinones/pharmacology, Dose-Response Relationship, Drug, Cell Biology, biology.organism_classification, Glutathione/metabolism, Spermidine/metabolism, Hydroquinones, Metabolism, Mechanism of action, chemistry, biology.protein, Peroxiredoxin, Trypanocidal Agents/pharmacology, Quinol

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644701f01b2fea36b4b7629a41fa03c3
http://europepmc.org/articles/PMC3048735

المؤلفون: Fijolek, Artur, Hofer, Anders, Thelander, Lars

المصدر: Journal of biological chemistry. 282(16):11858-11865

مصطلحات موضوعية: Animals, Carbon-Nitrogen Ligases/*biosynthesis/*chemistry, Cytidine/chemistry, Cytosine/chemistry, Dose-Response Relationship, Drug, Enzyme Inhibitors/pharmacology, Humans, Kinetics, Male, Mice, Inbred C57BL, Trypanocidal Agents/pharmacology, Trypanosoma brucei brucei/*enzymology, Trypanosoma brucei gambiense/*enzymology, Trypanosomiasis, African/*therapy

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-6341
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17331943&dopt=Citation

المؤلفون: Inês Loureiro, Jane MacDougall, Isbaal. Ramos, Paul Kong Thoo-Lin, Meritxell Roura, Anabela Cordeiro-da-Silva, Alain Pruvost, Joana Tavares, David Costa, Hadjer Loukil, Nuno A. G. Graça, Luís Gaspar, Ian K. Pemberton

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

مصطلحات موضوعية: 0301 basic medicine, Pentamidine/pharmacology, Naphthalimides/pharmacology, Neurons/metabolism, Mitochondria, Liver, Microsomes, Liver/metabolism, Pharmacology, Parasite load, Parasite Load, Neurons/cytology, Mice, 0302 clinical medicine, Macrophages/drug effects, Drug Stability, Trypanocidal Agents/chemical synthesis, Liver/drug effects, Trypanosoma brucei brucei/drug effects, Pharmacology (medical), African trypanosomiasis, Trypanosoma brucei brucei/metabolism, Hepatocytes/cytology, Neurons, Mice, Inbred BALB C, biology, Trypanosoma brucei brucei/growth & development, Trypanocidal Agents, 3. Good health, Naphthalimides, Infectious Diseases, Liver, Microsomes, Liver, Female, Trypanosomiasis, African/parasitology, Hepatocytes/drug effects, medicine.drug, Liver/metabolism, 030231 tropical medicine, Trypanosoma brucei brucei, Primary Cell Culture, Mitochondria, Liver/metabolism, Trypanosoma brucei, Cell Line, 03 medical and health sciences, Structure-Activity Relationship, Inhibitory Concentration 50, Macrophages/metabolism, medicine, Mitochondria, Liver/drug effects, Structure–activity relationship, Animals, Humans, Experimental Therapeutics, Pentamidine, Trypanocidal agent, Naphthalimides/chemical synthesis, Trypanosomiasis, African/mortality, business.industry, Macrophages, Hepatocytes/metabolism, Macrophages/cytology, medicine.disease, biology.organism_classification, Neurons/drug effects, Survival Analysis, 030104 developmental biology, Trypanosomiasis, African, Cell culture, Trypanosomiasis, African/pathology, Immunology, Hepatocytes, Trypanosomiasis, African/drug therapy, Microsomes, Liver/drug effects, business, Trypanosomiasis, Trypanocidal Agents/pharmacology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fa525ec4ee871c187c8e2ab92ea4a7
https://repositorio-aberto.up.pt/handle/10216/118203

المؤلفون: Hofer, Anders, Steverding, D, Chabes, Andrei, Brun, R, Thelander, Lars

المصدر: Proceedings of the National Academy of Sciences of the U S A. 98(11):6412-6

مصطلحات موضوعية: Adenosine Triphosphate/metabolism, Animals, Carbon-Nitrogen Ligases/*antagonists & inhibitors, Cells, Cultured, Cytidine/pharmacology, Cytidine Triphosphate/biosynthesis/metabolism, Diazooxonorleucine/*pharmacology/therapeutic use, Enzyme Inhibitors/*pharmacology/therapeutic use, Fibroblasts/cytology, Guanine/pharmacology, Guanosine Triphosphate/metabolism, Humans, Hypoxanthines/pharmacology, Intracellular Fluid, Isoxazoles/*pharmacology/therapeutic use, Mice, Inbred BALB C, Trypanocidal Agents/*pharmacology/therapeutic use, Trypanosoma brucei brucei/drug effects/*enzymology/growth & development, Trypanosomiasis, African/blood/*drug therapy/parasitology, Uridine Triphosphate/metabolism

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-9176
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=11353848&dopt=Citation

المؤلفون: König, Janine, Wyllie, Susan, Wells, Geoffrey, Stevens, Malcolm F, Wyatt, Paul G, Fairlamb, Alan H

مصطلحات موضوعية: Trypanosomiasis/drug therapy, Trypanosoma brucei brucei/metabolism, Trypanosoma brucei brucei/genetics, Time Factors, Trypanocidal Agents/pharmacology, Amide Synthases/metabolism, Thioredoxins/metabolism, Amide Synthases/genetics, Animals, Antineoplastic Agents/pharmacology, Benzothiazoles/pharmacology, Cysteine/genetics, Cysteine/metabolism, Dose-Response Relationship, Drug, Glutathione/analogs & derivatives, Glutathione/genetics, Glutathione/metabolism, Hydroquinones/pharmacology, Protozoan Proteins/metabolism, Spermidine/analogs & derivatives, Thioredoxins/genetics, Spermidine/metabolism, Trypanosomiasis/genetics, Trypanosomiasis/metabolism

Relation: info:eu-repo/semantics/altIdentifier/issn/0021-9258; info:eu-repo/semantics/altIdentifier/issn/1083-351X; info:eu-repo/semantics/altIdentifier/wos/000288013300079; info:eu-repo/semantics/altIdentifier/pmid/21212280; https://pub.uni-bielefeld.de/record/2476559

الاتاحة: https://pub.uni-bielefeld.de/record/2476559

المؤلفون: Vanhamme, Luc

المصدر: Current drug targets, 9 (11

مصطلحات موضوعية: Sciences bio-médicales et agricoles, Animals, DNA-Directed RNA Polymerases -- antagonists & inhibitors, DNA-Directed RNA Polymerases -- genetics, DNA-Directed RNA Polymerases -- metabolism, Gene Expression Regulation -- drug effects, Humans, Models, Biological, Protozoan Infections -- drug therapy, Protozoan Infections -- parasitology, Transcription Factors -- antagonists & inhibitors, Transcription Factors -- genetics, Transcription Factors -- metabolism, Trypanocidal Agents -- pharmacology, Trypanocidal Agents -- therapeutic use, Trypanosoma -- enzymology, Trypanosoma -- genetics, Trypanosoma -- metabolism

وصف الملف: 1 full-text file(s): application/pdf

Relation: uri/info:pmid/18991610; uri/info:scp/59049103178; https://dipot.ulb.ac.be/dspace/bitstream/2013/51914/3/Vanhammecurdrugtargets2008.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51914

الاتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51914
https://dipot.ulb.ac.be/dspace/bitstream/2013/51914/3/Vanhammecurdrugtargets2008.pdf

المؤلفون: Munirathinam Sundaramoorthy, Etienne Pays, Michael R. Waterman, W. David Nes, Benoit Vanhollebeke, Joel M. Harp, Hee Won Park, Minu Chaudhuri, Tatiana Y. Hargrove, Fernando Villalta, Zdzislaw Wawrzak, Galina I. Lepesheva

المصدر: The Journal of biological chemistry, 285 (3

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Trypanocidal Agents -- therapeutic use, Enzyme Inhibitors -- metabolism, Crystallography, X-Ray, Ligands, Biochemistry, Substrate Specificity, Sterol 14-Demethylase, Protein structure, Cytochrome P-450 Enzyme System, Enzyme Inhibitors -- pharmacology, Cytochrome P-450 Enzyme Inhibitors, Benzamides -- pharmacology, Enzyme Inhibitors -- therapeutic use, Trypanocidal Agents -- chemistry, Trypanosoma brucei brucei -- drug effects, Trypanosoma brucei brucei -- enzymology, Enzyme Inhibitors, Benzamides -- metabolism, Cytochrome P-450 Enzyme System -- metabolism, biology, Sciences bio-médicales et agricoles, Trypanosomiasis, African -- drug therapy, Trypanocidal Agents, Sterols, Protein Structure and Folding, Benzamides, Trypanocidal Agents -- metabolism, Antiparasitic, medicine.drug_class, Trypanosoma brucei brucei, Trypanosoma brucei, Benzamides -- therapeutic use, Trypanocidal Agents -- pharmacology, Enzyme activator, Enzyme Inhibitors -- chemistry, Microsomes, medicine, Humans, Amino Acid Sequence, Molecular Biology, Benzamides -- chemistry, Active site, Cell Biology, biology.organism_classification, Sterol, Microsomes -- enzymology, Trypanosomiasis, African, Cytochrome P-450 Enzyme System -- chemistry, Drug Design, Sterols -- biosynthesis, biology.protein, Biocatalysis, Cytochrome P-450 Enzyme System -- antagonists & inhibitors

وصف الملف: 2 full-text file(s): application/pdf; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10f25cf6d7a799ccbb98ab7ab7cd026
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51605

المؤلفون: Vanhollebeke, Benoît, Nielsen, Marianne J, Watanabe, Yoshihisa, Truc, Philippe, Vanhamme, Luc, Nakajima, Kazunori, Moestrup, Soren K, Pays, Etienne

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 104 (10

مصطلحات موضوعية: Sciences bio-médicales et agricoles, Animals, Antigens, Neoplasm -- blood, Neoplasm -- physiology, Apolipoproteins -- blood, Apolipoproteins -- physiology, Blood Proteins -- physiology, Blotting, Western, Chromatography, Affinity, Haptoglobins -- physiology, Humans, Immune System, Kinetics, Lipoproteins, HDL -- blood, HDL -- physiology, Mice, Recombinant Proteins -- chemistry, Trypanocidal Agents -- pharmacology, Trypanosoma brucei brucei -- metabolism, Trypanosomiasis, African -- drug therapy, Haptoglobin receptor, Innate immunity, Sleeping sickness, Trypanolytic factor, Trypanosoma brucei

وصف الملف: 1 full-text file(s): application/pdf

Relation: uri/info:doi/10.1073/pnas.0609902104; uri/info:pii/0609902104; uri/info:pmid/17360487; uri/info:scp/34247255334; uri/info:pmcid/PMC1820718; https://dipot.ulb.ac.be/dspace/bitstream/2013/51584/4/PMC1820718.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51584

الاتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51584
https://dipot.ulb.ac.be/dspace/bitstream/2013/51584/4/PMC1820718.pdf

المؤلفون: Chan, KL, New, D., Ghandhi, S., Wong, F., Lam, CMC, Wong, JTY

مصطلحات موضوعية: Animals, Blotting, Northern, Southern, Cell Division: drug effects, Dinoflagellida: drug effects, Dinoflagellida: genetics, Dinoflagellida: growth & development, Dinoflagellida: metabolism, Eflornithine: pharmacology, Enzyme Inhibitors: pharmacology, Eukaryotic Cells, Eukaryotic Initiation Factor-5, G1 Phase: genetics, Guanine: analogs & derivatives, Guanine: pharmacology, Molecular Sequence Data, Peptide Initiation Factors: classification, Peptide Initiation Factors: genetics, Peptide Initiation Factors: metabolism, Phylogeny, Polyamines: pharmacology, Putrescine: pharmacology, RNA, Messenger: metabolism, Toxins, Biological: metabolism, Trypanocidal Agents: pharmacology

Relation: http://repository.ust.hk/ir/Record/1783.1-1221; Applied and environmental microbiology, v. 68, (5), 2002, MAY, p. 2278-2284; https://doi.org/10.1128/AEM.68.5.2278-2284.2002; http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=0099-2240&rft.volume=68&rft.issue=5&rft.date=2002&rft.spage=2278&rft.epage=2284&rft.aulast=Chan&rft.aufirst=KL&rft.atitle=Transcript+levels+of+the+eukaryotic+translation+initiation+factor+5A+gene+peak+at+early+G(1)+phase+of+the+cell+cycle+in+the+dinoflagellate+Crypthecodinium+cohnii; http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000175407300023; http://www.scopus.com/record/display.url?eid=2-s2.0-0036254738&origin=inward; http://repository.ust.hk/ir/bitstream/1783.1-1221/1/2278.pdf

الاتاحة: http://repository.ust.hk/ir/Record/1783.1-1221
https://doi.org/10.1128/AEM.68.5.2278-2284.2002
http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=0099-2240&rft.volume=68&rft.issue=5&rft.date=2002&rft.spage=2278&rft.epage=2284&rft.aulast=Chan&rft.aufirst=KL&rft.atitle=Transcript+levels+of+the+eukaryotic+translation+initiation+factor+5A+gene+peak+at+early+G(1)+phase+of+the+cell+cycle+in+the+dinoflagellate+Crypthecodinium+cohnii
http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000175407300023
http://www.scopus.com/record/display.url?eid=2-s2.0-0036254738&origin=inward
http://repository.ust.hk/ir/bitstream/1783.1-1221/1/2278.pdf

المؤلفون: Allaoui, Abdelmounaaim, Francois, Christine, Zemzoumi, K, Guilvard, E, Ouaissi, A

المصدر: Molecular microbiology, 32 (6

مصطلحات موضوعية: Sciences bio-médicales et agricoles, Alleles, Amino Acid Sequence, Animals, Antimony -- pharmacology, Base Sequence, DNA, Protozoan, Gene Deletion, Macrophages, Metals, Heavy, Molecular Sequence Data, Nifurtimox -- pharmacology, Nitroimidazoles -- pharmacology, Oligonucleotides, Antisense, Phenotype, Protozoan Proteins -- biosynthesis, Protozoan Proteins -- genetics, Protozoan Proteins -- physiology, Transcription, Genetic, Trypanocidal Agents -- pharmacology, Trypanosoma cruzi -- drug effects, Trypanosoma cruzi -- genetics, Trypanosoma cruzi -- growth & development, Trypanosoma cruzi -- physiology

وصف الملف: 1 full-text file(s): application/pdf

Relation: uri/info:doi/10.1046/j.1365-2958.1999.01440.x; uri/info:pii/mmi1440; uri/info:pmid/10383767; uri/info:scp/0032991708; https://dipot.ulb.ac.be/dspace/bitstream/2013/50126/3/50126.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50126

الاتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50126
https://dipot.ulb.ac.be/dspace/bitstream/2013/50126/3/50126.pdf

المؤلفون: Gamage, S.A., Figgitt, D.P., Wojcik, S.J., Ralph, R.K., Ransijn, A., Mauel, J., Yardley, V., Snowdon, D., Croft, S.L., Denny, W.A.

المصدر: Journal of Medicinal Chemistry, vol. 40, no. 16, pp. 2634-2642

مصطلحات موضوعية: Amsacrine/analogs &, derivatives, Amsacrine/chemistry, Animals, Antiprotozoal Agents/chemistry, Antiprotozoal Agents/pharmacology, Humans, Leishmania donovani/drug effects, Leishmania major/drug effects, Macrophages/parasitology, Mice, Inbred CBA, Models, Chemical, Structure-Activity Relationship, Trypanocidal Agents/chemistry, Trypanocidal Agents/pharmacology, Trypanosoma brucei brucei/drug effects, Trypanosoma cruzi/drug effects, Tumor Cells, Cultured

Relation: info:eu-repo/semantics/altIdentifier/pmid/9258370; info:eu-repo/semantics/altIdentifier/pissn/0022-2623; https://serval.unil.ch/notice/serval:BIB_1178

الاتاحة: https://serval.unil.ch/notice/serval:BIB_1178
https://doi.org/10.1021/jm970232h

المؤلفون: 1261551, Rojas de Arias, Gladys Antonieta, Billo, M., Fournet, Alain, Cabalion, P., Waikedre, J., Bories, C., Loiseau, C., Prina, E., Yaluff, Gloria, Fourneau, A., Hocquemiller, R.

المصدر: Journal of Ethnopharmacology; 3; 569 - 575; 96

مصطلحات الفهرس: New Caledonia, Vanuatu, Leishmanicidal activity, Trypanocidal activity, Animals, Drug Evaluation, Preclinical, Leishmania donovani/drug effects, Mice, Microbial Sensitivity Tests, Plant Extracts/chemistry, Plant Extracts/pharmacology, Plants, Medicinal/chemistry, Trypanocidal Agents/chemistry, Trypanocidal Agents/pharmacology, Trypanosoma cruzi/drug effects, Artículo

URL: http://dspace.conacyt.gov.py/xmlui/handle/123456789/42275
http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42275/1/2004screeningofnewcaledonianandvanuatumedicinalplantsforantiprotozoalactivity.pdf
http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42275/1/2004 screening of new caledonian and vanuatu medicinal plants for antiprotozoal activity.pdf