المؤلفون: Marianne Schimpl, Xiaowei Zheng, Vladimir S Borodkin, David E Blair, Andrew T Ferenbach, Er W Schüttelkopf, Iva Navratilova, Tonia Aristotelous, Osama Albarbarawi, David A Robinson, Megan A Macnaughtan, Daan M F Van Aalten

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://davapc1.bioch.dundee.ac.uk/pdf/ogtrx.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.417.7680; http://davapc1.bioch.dundee.ac.uk/pdf/ogtrx.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.417.7680
http://davapc1.bioch.dundee.ac.uk/pdf/ogtrx.pdf

المؤلفون: Tonia Aristotelous, Andrew L. Hopkins, Iva Navratilova, Louise E Bird

المصدر: Analytical Biochemistry. 556:23-34

مصطلحات موضوعية: 0301 basic medicine, Receptors, CXCR4, 030103 biophysics, Receptors, CCR5, medicine.drug_class, Biophysics, Monoclonal antibody, Biochemistry, 03 medical and health sciences, Chemokine receptor, medicine, Humans, Surface plasmon resonance, Receptor, Molecular Biology, G protein-coupled receptor, Chemistry, Antibodies, Monoclonal, Cell Biology, Surface Plasmon Resonance, Small molecule, 030104 developmental biology, Membrane, Solubility, Membrane protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74764f75f3c67e81c8b1ea82fa093afe
https://doi.org/10.1016/j.ab.2018.06.012

المؤلفون: Daan M. F. van Aalten, Nithya Selvan, Tonia Aristotelous, Vladimir S. Borodkin, Iva Navratilova, Andrew T. Ferenbach, Karim Rafie

المصدر: ACS Chem Biol

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Fluorescence Polarization, Crystallography, X-Ray, N-Acetylglucosaminyltransferases, Proof of Concept Study, 01 natural sciences, Biochemistry, Article, Acetylglucosamine, Substrate Specificity, Serine, 03 medical and health sciences, Protein structure, Humans, Transferase, Glycoside hydrolase, Threonine, chemistry.chemical_classification, 010405 organic chemistry, General Medicine, 0104 chemical sciences, 3. Good health, Hexosaminidases, 030104 developmental biology, Enzyme, Proteostasis, chemistry, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ea27df4c64341f613fcd026d838950
https://doi.org/10.1021/acschembio.8b00183

المؤلفون: Daniel Mariappa, Andrew T. Ferenbach, Daan M. F. van Aalten, Tonia Aristotelous, Matthias Trost, Nithya Selvan, Ritchie Williamson, David G. Campbell, Robert Gourlay, Iva Hopkins-Navratilova

المصدر: Nat Chem Biol

مصطلحات موضوعية: 0301 basic medicine, Mutation, biology, ved/biology, Mutant, ved/biology.organism_classification_rank.species, Cell Biology, biology.organism_classification, medicine.disease_cause, beta-N-Acetylhexosaminidases, Article, Cell biology, 03 medical and health sciences, Drosophila melanogaster, 030104 developmental biology, Proteome, medicine, Animals, Hox gene, Homeotic gene, Model organism, Molecular Biology, Gene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a8ac9501ca7a6a6f7f659903e6ce82
https://doi.org/10.1038/nchembio.2404

المؤلفون: Tonia Aristotelous, Stefan Knapp, Apirat Chaikuad, Sarah Picaud, Iva Navratilova, Panagis Filappakopoulos, Andrew L. Hopkins

المصدر: ACS Medicinal Chemistry Letters. 7:1213-1218

مصطلحات موضوعية: 0301 basic medicine, BRD4, Chemistry, Organic Chemistry, Computational biology, Biochemistry, Small molecule, 3. Good health, Bromodomain, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, PCAF, Transcription (biology), 030220 oncology & carcinogenesis, Drug Discovery, Transferase, Surface plasmon resonance, Biosensor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0202ac2cc4645100718bed47a130aec
https://doi.org/10.1021/acsmedchemlett.6b00154

المؤلفون: Daan M. F. van Aalten, Iva Navratilova, Susanne Eskilsson, Wenxia Fang, Olawale G. Raimi, Iain T. Collie, Julie A. Frearson, Tonia Aristotelous, Justin R. Harrison, Michael D. Urbaniak, Michael A. J. Ferguson

المصدر: ACS Chemical Biology

مصطلحات موضوعية: Protein Conformation, Trypanosoma brucei brucei, Allosteric regulation, Trypanosoma brucei, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Allosteric Regulation, Catalytic Domain, Humans, Transferase, Enzyme kinetics, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Uridine Diphosphate N-Acetylglucosamine, biology, 010405 organic chemistry, Active site, Articles, General Medicine, biology.organism_classification, Nucleotidyltransferases, Trypanocidal Agents, Molecular biology, 0104 chemical sciences, Uridine diphosphate, Trypanosomiasis, African, Uridine diphosphate N-acetylglucosamine, Enzyme, chemistry, biology.protein, Molecular Medicine

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e40c0dbb911985ed2852d567f2e33e5
https://doi.org/10.1021/cb400411x

المؤلفون: Daan M. F. van Aalten, Megan A. Macnaughtan, David A. Robinson, Tonia Aristotelous, D.E. Blair, Xiaowei Zheng, Vladimir S. Borodkin, Andrew T. Ferenbach, Iva Navratilova, Marianne Schimpl, Alexander W. Schüttelkopf, Osama Albarbarawi

المصدر: Nature chemical biology

مصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, Stereochemistry, Lysine, Cell Biology, Plasma protein binding, 010402 general chemistry, Nucleotide sugar, 01 natural sciences, Article, 0104 chemical sciences, 03 medical and health sciences, chemistry.chemical_compound, Protein structure, chemistry, Biochemistry, Transferase, Nucleotide, Glycosyl, Uridine diphosphate galactose, Molecular Biology, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac26ad1965087441579796a026905ea
https://doi.org/10.1038/nchembio.1108

المؤلفون: Tonia, Aristotelous, Andrew L, Hopkins, Iva, Navratilova

المصدر: Methods in enzymology. 556

مصطلحات موضوعية: Models, Molecular, Allosteric Regulation, Drug Discovery, Animals, Humans, Equipment Design, Surface Plasmon Resonance, Receptors, G-Protein-Coupled

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e459f7ba904fd308212c19c559fee664
https://pubmed.ncbi.nlm.nih.gov/25857797

المؤلفون: Tonia Aristotelous, Andrew L. Hopkins, Iva Navratilova

مصطلحات موضوعية: Drug discovery, Chemistry, Allosteric regulation, Fragment-based lead discovery, Functional selectivity, Nanotechnology, Computational biology, Surface plasmon resonance, Binding site, Ligand (biochemistry), G protein-coupled receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cb69a97d2a77d47d59cd849cbdf80b45
https://doi.org/10.1016/bs.mie.2015.01.016

المؤلفون: Arun K. Shukla, Tonia Aristotelous, Robert J. Lefkowitz, Xi Ping Huang, Seungkirl Ahn, Ian H. Gilbert, Jennifer Riley, Maria F. Sassano, Prachi Tripathi-Shukla, Bryan L. Roth, Sylwia Gawron, Andrew L. Hopkins, Alem W. Kahsai, Xiao Zhu, Jérémy Besnard, Iva Navratilova, Laura M. Wingler, Kevin D. Read

المصدر: ACS Medicinal Chemistry Letters

مصطلحات موضوعية: β2 adrenoceptor, Fragment screening, Computational biology, 01 natural sciences, Biochemistry, 03 medical and health sciences, Drug Discovery, Surface plasmon resonance, Receptor, 030304 developmental biology, G protein-coupled receptor, 0303 health sciences, Reverse pharmacology, 010405 organic chemistry, Drug discovery, Chemistry, Organic Chemistry, Wild type, Combinatorial chemistry, 3. Good health, 0104 chemical sciences, G-protein coupled receptors, Membrane protein, Technology Note, Biosensor, surface plasmon resonance

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54587d1deea75c7ab2741419bf28615
https://pubmed.ncbi.nlm.nih.gov/24454993