المؤلفون: Izabella Góral, Tomasz Wichur, Emilia Sługocka, Justyna Godyń, Natalia Szałaj, Paula Zaręba, Monika Głuch-Lutwin, Barbara Mordyl, Dawid Panek, Anna Więckowska

المصدر: Molecules, Vol 29, Iss 11, p 2616 (2024)

مصطلحات موضوعية: GSK-3β, IKK-β, ROCK-1, anti-inflammatory activity, neuroprotective properties Alzheimer’s disease, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/11/2616; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/d794b4a155cb4c9da646e809bc8a5781

المؤلفون: Natalia Szałaj, Justyna Godyń, Jakub Jończyk, Anna Pasieka, Dawid Panek, Tomasz Wichur, Krzysztof Więckowski, Paula Zaręba, Marek Bajda, Anja Pislar, Barbara Malawska, Raimon Sabate, Anna Więckowska

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1944-1952 (2020)

مصطلحات موضوعية: multifunctional ligands, β-secretase, 5-ht6 receptor antagonists, cholinesterase inhibitors, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/8664353705ab4c3dbfa4416d81bfa9d5

المؤلفون: Michalina Hebda, Marek Bajda, Anna Więckowska, Natalia Szałaj, Anna Pasieka, Dawid Panek, Justyna Godyń, Tomasz Wichur, Damijan Knez, Stanislav Gobec, Barbara Malawska

المصدر: Molecules, Vol 21, Iss 4, p 410 (2016)

مصطلحات موضوعية: cholinesterase inhibitors, molecular modelling, β-amyloid aggregation inhibitors, Alzheimer’s disease, multi-target-directed ligands (MTDL), PAMPA-BBB assay, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/21/4/410; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/6783527ad45f4c018b3bc70940f4a966

المؤلفون: Krzysztof Więckowski, Natalia Szałaj, Beata Gryzło, Tomasz Wichur, Izabella Góral, Emilia Sługocka, Joanna Sniecikowska, Gniewomir Latacz, Agata Siwek, Justyna Godyń, Adam Bucki, Marcin Kołaczkowski, Anna Więckowska

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 9443

مصطلحات موضوعية: Alzheimer’s disease, cholinesterase inhibitors, AChE, BuChE, 5-HT 6 receptor ligands, antioxidant properties, metal-chelating properties, multifunctional ligands

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms23169443

الاتاحة: https://doi.org/10.3390/ijms23169443

المؤلفون: Krzysztof, Więckowski, Natalia, Szałaj, Beata, Gryzło, Tomasz, Wichur, Izabella, Góral, Emilia, Sługocka, Joanna, Sniecikowska, Gniewomir, Latacz, Agata, Siwek, Justyna, Godyń, Adam, Bucki, Marcin, Kołaczkowski, Anna, Więckowska

المصدر: International journal of molecular sciences. 23(16)

مصطلحات موضوعية: Serotonin, Structure-Activity Relationship, Amyloid beta-Peptides, Alzheimer Disease, Butyrylcholinesterase, Drug Design, Receptors, Serotonin, Acetylcholinesterase, Humans, Cholinesterase Inhibitors, Ligands, Antioxidants, Chelating Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::6bd4358802443ef327e1978a76a7da5a
https://pubmed.ncbi.nlm.nih.gov/36012707

المؤلفون: Tomasz, Wichur, Anna, Pasieka, Justyna, Godyń, Dawid, Panek, Izabella, Góral, Gniewomir, Latacz, Ewelina, Honkisz-Orzechowska, Adam, Bucki, Agata, Siwek, Monika, Głuch-Lutwin, Damijan, Knez, Xavier, Brazzolotto, Stanislav, Gobec, Marcin, Kołaczkowski, Raimon, Sabate, Barbara, Malawska, Anna, Więckowska

المصدر: European journal of medicinal chemistry. 225

مصطلحات موضوعية: Amyloid beta-Peptides, Indoles, Dose-Response Relationship, Drug, Molecular Structure, tau Proteins, Hep G2 Cells, Ligands, Molecular Docking Simulation, Mice, Protein Aggregates, Structure-Activity Relationship, Butyrylcholinesterase, Receptors, Serotonin, Drug Discovery, Electrophorus, Acetylcholinesterase, Microsomes, Liver, Animals, Humans, Cholinesterase Inhibitors, Horses, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::077914f6dc7def7c5c689536d69bdbf6
https://pubmed.ncbi.nlm.nih.gov/34461507

المؤلفون: Tomasz, Wichur, Justyna, Godyń, Izabella, Góral, Gniewomir, Latacz, Adam, Bucki, Agata, Siwek, Monika, Głuch-Lutwin, Barbara, Mordyl, Joanna, Śniecikowska, Maria, Walczak, Damijan, Knez, Marko, Jukič, Kinga, Sałat, Stanislav, Gobec, Marcin, Kołaczkowski, Barbara, Malawska, Xavier, Brazzolotto, Anna, Więckowska

المصدر: European journal of medicinal chemistry. 225

مصطلحات موضوعية: Male, Models, Molecular, Amyloid beta-Peptides, Dose-Response Relationship, Drug, Molecular Structure, Cell Survival, Hep G2 Cells, Crystallography, X-Ray, Mice, Protein Aggregates, Structure-Activity Relationship, Neuroprotective Agents, Drug Development, Alzheimer Disease, Butyrylcholinesterase, Receptors, Serotonin, Electrophorus, Animals, Humans, Cholinesterase Inhibitors, Horses

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::ee45fc25145a25e10b16d6f82c3ab957
https://pubmed.ncbi.nlm.nih.gov/34530376

المؤلفون: Natalia, Szałaj, Justyna, Godyń, Jakub, Jończyk, Anna, Pasieka, Dawid, Panek, Tomasz, Wichur, Krzysztof, Więckowski, Paula, Zaręba, Marek, Bajda, Anja, Pislar, Barbara, Malawska, Raimon, Sabate, Anna, Więckowska

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record

مصطلحات موضوعية: Models, Molecular, Amyloid beta-Peptides, cholinesterase inhibitors, 5-HT6 receptor antagonists, Multifunctional ligands, tau Proteins, Ligands, Protein Aggregates, Structure-Activity Relationship, Alzheimer Disease, Drug Design, Receptors, Serotonin, Escherichia coli, Fluorescence Resonance Energy Transfer, Cholinesterases, Humans, β-secretase, Cholinesterase Inhibitors, Research Article, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::42a15e91c6c4c4598f6f76b83b7e9d77
https://pubmed.ncbi.nlm.nih.gov/33092411

المؤلفون: Xavier Brazzolotto, Izabella Góral, Anna Pasieka, Gniewomir Latacz, Anna Więckowska, Adam Bucki, Dawid Panek, Barbara Malawska, Marcin Kołaczkowski, Tomasz Wichur, Raimon Sabaté, Damijan Knez, Monika Głuch-Lutwin, Justyna Godyń, Ewelina Honkisz-Orzechowska, Stanislav Gobec, Agata Siwek

المصدر: European Journal of Medicinal Chemistry. 225:113783

مصطلحات موضوعية: Pharmacology, Indole test, cholinesterase inhibitors, biology, CYP3A4, β-amyloid, Chemistry, Amyloid beta, Organic Chemistry, General Medicine, Alzheimer's disease, In vitro, Biochemistry, Tacrine, multifunctional agents, 5-HT6 antagonists, Drug Discovery, Tau protein, medicine, 5-HT6 receptor, biology.protein, Butyrylcholinesterase, medicine.drug, Cholinesterase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e6511bad0aaf428df90277374a636a
https://doi.org/10.1016/j.ejmech.2021.113783

المؤلفون: Przemyslaw Bienkowski, Paweł Mierzejewski, Krzysztof Więckowski, Agata Siwek, Barbara Malawska, Adam Bucki, Stanislav Gobec, Tomasz Wichur, Halina Sienkiewicz-Jarosz, Damijan Knez, Monika Marcinkowska, Monika Głuch-Lutwin, Justyna Godyń, Paula Zaręba, Marcin Kołaczkowski, Anna Więckowska, Grzegorz Kazek

المصدر: European Journal of Medicinal Chemistry. 124:63-81

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Chemistry, medicine.drug_class, Organic Chemistry, General Medicine, Idalopirdine, Receptor antagonist, 01 natural sciences, Acetylcholinesterase, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Acetylcholinesterase inhibitor, Tacrine, Drug Discovery, medicine, 5-HT6 receptor, Pharmacophore, Donepezil, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7d661ec6e0a4dde12d9afb385c3ad3c7
https://doi.org/10.1016/j.ejmech.2016.08.016

المؤلفون: Tomasz Wichur, Anna Więckowska, Agata Siwek, Ondrej Soukup, Jan Korabecny, Stanislav Gobec, Monika Marcinkowska, Monika Głuch-Lutwin, Paula Zaręba, Kamil Mika, Grzegorz Kazek, Katarzyna Kieć-Kononowicz, Marketa Benkova, Krzysztof Więckowski, Marcin Kołaczkowski, Adam Bucki, Barbara Malawska, Gniewomir Latacz, Damijan Knez, Justyna Godyń

المصدر: ACS chemical neuroscience. 9(5)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Physiology, Cognitive Neuroscience, Pharmacology, Ligands, Biochemistry, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Non-competitive inhibition, Alzheimer Disease, medicine, Structure–activity relationship, Humans, Receptor, Butyrylcholinesterase, Cholinesterase, Amyloid beta-Peptides, biology, Chemistry, Antagonist, Cell Biology, General Medicine, medicine.disease, Peptide Fragments, Molecular Docking Simulation, 030104 developmental biology, Drug Design, biology.protein, Cholinesterase Inhibitors, Alzheimer's disease, Pharmacophore, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2484771eafaffda8b91bf958816e8f5c
https://pubmed.ncbi.nlm.nih.gov/29384656

المؤلفون: Anna Pasieka, Ondrej Soukup, Jan Korabecny, Vendula Sepsova, Marek Bajda, Dawid Panek, Justyna Godyń, Anna Więckowska, Damijan Knez, Anja Pišlar, Stanislav Gobec, Jakub Jończyk, Tomasz Wichur, Janko Kos, Barbara Malawska, Raimon Sabaté

مصطلحات موضوعية: 0301 basic medicine, Physiology, Cognitive Neuroscience, Tau protein, tau Proteins, Disease, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Derivative (finance), Alzheimer Disease, Humans, Butyrylcholinesterase, Biological evaluation, Amyloid beta-Peptides, Anti alzheimer, biology, Drug discovery, Chemistry, Cell Biology, General Medicine, Peptide Fragments, Molecular Docking Simulation, 030104 developmental biology, Design synthesis, Drug Design, biology.protein, Cholinesterase Inhibitors, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56bbac15f27d1a261c124235d35b847
https://ruj.uj.edu.pl/xmlui/handle/item/118051

المؤلفون: Tomasz, Wichur, Barbara, Malawska

المصدر: Postępy Higieny i Medycyny Doświadczalnej, Vol 69, Pp 1423-1434 (2015)

مصطلحات موضوعية: Neurons, projektowanie leku, leki wielofunkcyjne, lcsh:R, lcsh:Medicine, Neurodegenerative Diseases, Neurofibrillary Tangles, Plaque, Amyloid, tau Proteins, multi-target-directed ligands, Ligands, Neuroprotective Agents, Alzheimer Disease, choroba alzheimera, Humans, ligandy wielocelowe, potencjalne leki w chorobie Alzheimera

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4c8cc27f0abd7d0f856ca2a9d24946a9
http://phmd.pl/gicid/01.3001.0009.6612

المؤلفون: Tomasz Wichur, Krzysztof Więckowski, Alvaro Del Rio Valdivieso, Justyna Godyń, Stanislav Gobec, Damijan Knez, Jakub Jończyk, Barbara Malawska, Raimon Sabaté, Dawid Panek, Anna Pasieka, Anna Więckowska

المصدر: European Journal of Medicinal Chemistry. 187:111916

مصطلحات موضوعية: Pyrrolidines, Antioxidant, Amyloid beta, medicine.medical_treatment, Tau protein, 01 natural sciences, Antioxidants, Protein Aggregates, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Alzheimer Disease, Drug Discovery, medicine, Animals, Humans, Chelation, Benzothiazoles, Horses, IC50, Butyrylcholinesterase, Chelating Agents, 030304 developmental biology, Pharmacology, 0303 health sciences, Amyloid beta-Peptides, ABTS, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Organic Chemistry, General Medicine, 0104 chemical sciences, chemistry, Biochemistry, Electrophorus, Acetylcholinesterase, biology.protein, Cholinesterase Inhibitors, Sulfonic Acids, Amyloid precursor protein secretase, Fluorescence Recovery After Photobleaching

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92803e2a635bec31f994f72c9817e69
https://doi.org/10.1016/j.ejmech.2019.111916

المؤلفون: Tomasz Wichur, Barbara Malawska, Dawid Panek, Anna Pasieka, Justyna Godyń

مصطلحات موضوعية: 0301 basic medicine, Rivastigmine, Pharmacology, Neuroprotection, 03 medical and health sciences, Inhibitory Concentration 50, Alkaloids, Piperidines, β amyloid, Alzheimer Disease, Drug Discovery, medicine, Inhibitory concentration 50, Cholinesterases, Humans, Donepezil, Cholinesterase, Amyloid beta-Peptides, biology, Chemistry, medicine.disease, 030104 developmental biology, Biochemistry, Tacrine, Indans, biology.protein, Molecular Medicine, Cholinesterase Inhibitors, Alzheimer's disease, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee0ae490644fb11ea1b25c25d362a1e
https://ruj.uj.edu.pl/xmlui/handle/item/141446

المؤلفون: Dawid Panek, Justyna Godyń, Tomasz Wichur, Jana Janockova, Marek Bajda, Jan Korabecny, Kamil Mika, Jakub Jończyk, Damijan Knez, Ondrej Soukup, Barbara Malawska, Stanislav Gobec, Anna Więckowska

مصطلحات موضوعية: 0301 basic medicine, Amyloid beta, Stereochemistry, Phthalimides, 01 natural sciences, Protein Aggregation, Pathological, Phthalimide, 03 medical and health sciences, chemistry.chemical_compound, Alicyclic compound, Inhibitory Concentration 50, Drug Delivery Systems, Saccharin, Drug Discovery, Moiety, Cholinesterases, Humans, Amines, Enzyme Inhibitors, IC50, Pharmacology, chemistry.chemical_classification, Amyloid beta-Peptides, Binding Sites, biology, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Active site, General Medicine, Acetylcholinesterase, Peptide Fragments, 0104 chemical sciences, Piperazine, 030104 developmental biology, chemistry, Blood-Brain Barrier, Drug Design, biology.protein, Amyloid Precursor Protein Secretases, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71c891403da3fc0510e69334b85fa94
https://ruj.uj.edu.pl/xmlui/handle/item/101655

المؤلفون: Anna, Więckowska, Marcin, Kołaczkowski, Adam, Bucki, Justyna, Godyń, Monika, Marcinkowska, Krzysztof, Więckowski, Paula, Zaręba, Agata, Siwek, Grzegorz, Kazek, Monika, Głuch-Lutwin, Paweł, Mierzejewski, Przemysław, Bienkowski, Halina, Sienkiewicz-Jarosz, Damijan, Knez, Tomasz, Wichur, Stanislav, Gobec, Barbara, Malawska

المصدر: European journal of medicinal chemistry. 124

مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, Chemistry Techniques, Synthetic, Ligands, Rats, Kinetics, Alzheimer Disease, Blood-Brain Barrier, Butyrylcholinesterase, Catalytic Domain, Drug Design, Receptors, Serotonin, Acetylcholinesterase, Animals, Humans, Cholinesterase Inhibitors, Molecular Targeted Therapy, Rats, Wistar

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::6ed5f468761c271804a3e1cec163e2a7
https://pubmed.ncbi.nlm.nih.gov/27560283

المؤلفون: Marek Bajda, Justyna Godyń, Michalina Hebda, Barbara Malawska, Natalia Szałaj, Anna Pasieka, Damijan Knez, Anna Więckowska, Stanislav Gobec, Dawid Panek, Tomasz Wichur

المصدر: Molecules, Vol 21, Iss 4, p 410 (2016)
Molecules; Volume 21; Issue 4; Pages: 410
Molecules
Molecules, vol. 21, no. 4, 410, 2016.

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, cholinesterase inhibitors, Pharmaceutical Science, zaviralci acetilholinesteraze, Isoindoles, Ligands, 01 natural sciences, Analytical Chemistry, chemistry.chemical_compound, Drug Discovery, udc:615.2:616.894, Butyrylcholinesterase, biology, Chemistry, Alzheimerjeva bolezen, Acetylcholinesterase, molecular modelling, Acetylcholinesterase inhibitor, Biochemistry, Chemistry (miscellaneous), Blood-Brain Barrier, tarčna zdravila, Molecular Medicine, Alzheimer’s disease, PAMPA-BBB assay, Amyloid beta, medicine.drug_class, β-amyloid aggregation inhibitors, multi-target-directed ligands (MTDL), Protein Aggregation, Pathological, Article, lcsh:QD241-441, 03 medical and health sciences, Structure-Activity Relationship, lcsh:Organic chemistry, Alzheimer Disease, medicine, Humans, Physical and Theoretical Chemistry, Binding site, IC50, Cholinesterase, Amyloid beta-Peptides, Binding Sites, 010405 organic chemistry, Organic Chemistry, In vitro, molekularno modeliranje, 0104 chemical sciences, 030104 developmental biology, biology.protein, razvoj zdravil

وصف الملف: application/pdf; text/url

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a798a9999a34171838112f3e795b0c2
http://www.mdpi.com/1420-3049/21/4/410