المؤلفون: Edward Perez-Reyes, Juan C. Gomora, Tiffany N. Heady, Timothy L. Macdonald

المصدر: The Japanese Journal of Pharmacology. 2001, 85(4):339

المؤلفون: Doris M. Haverstick, Tiffany N. Heady, Timothy L. Macdonald, Contact The Aacr Publications, Lloyd S. Gray

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://cancerres.aacrjournals.org/content/60/4/1002.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.329.101; http://cancerres.aacrjournals.org/content/60/4/1002.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.329.101
http://cancerres.aacrjournals.org/content/60/4/1002.full.pdf

المؤلفون: Angela M. Whetzel, David T. Bolick, Suseela Srinivasan, Timothy L. Macdonald, Margaret A. Morris, Klaus Ley, Catherine C. Hedrick

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://circres.ahajournals.org/content/circresaha/99/7/731.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1025.9792; http://circres.ahajournals.org/content/circresaha/99/7/731.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1025.9792
http://circres.ahajournals.org/content/circresaha/99/7/731.full.pdf

المؤلفون: Andrew J. Kennedy, Igor N. Olekhnovich, Catherine Gineste, Alexandra M. Bruce, Timothy L. Macdonald, T. Eric Ballard, Paul S. Hoffman

المصدر: Antimicrobial Agents and Chemotherapy. 60:3980-3987

مصطلحات موضوعية: 0301 basic medicine, Antiparasitic, medicine.drug_class, 030106 microbiology, Cofactor, Campylobacter jejuni, Bacteria, Anaerobic, 03 medical and health sciences, chemistry.chemical_compound, Oxidoreductase, Pyruvic Acid, medicine, Pharmacology (medical), Enzyme Inhibitors, Mechanisms of Action: Physiological Effects, Ferredoxin, Pharmacology, chemistry.chemical_classification, Helicobacter pylori, biology, Clostridioides difficile, Chemistry, Nitazoxanide, Anti-Bacterial Agents, Thiazoles, Infectious Diseases, Biochemistry, Docking (molecular), Benzamides, biology.protein, Ferredoxins, Epsilonproteobacteria, Anaerobic bacteria, Oxidoreductases, Thiamine pyrophosphate, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1edc0d2c440c7afc228fa968b0647f
https://doi.org/10.1128/aac.00670-16

المؤلفون: David Schiff, Timothy L. Macdonald, Lloyd S. Gray

المصدر: Expert Review of Anticancer Therapy. 13:589-595

مصطلحات موضوعية: Biology, Models, Biological, S Phase, Calcium Channels, T-Type, Neoplasms, medicine, Animals, Humans, Pharmacology (medical), Cell Proliferation, Clinical Trials as Topic, Voltage-dependent calcium channel, Cell growth, Stem Cells, Cell Cycle, G1 Phase, T-type calcium channel, Cancer, Cell cycle, medicine.disease, Potassium channel, Cell biology, Oncology, Calcium, Stem cell, Restriction point

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751ce13185d825ce534848075f5cdd00
https://doi.org/10.1586/era.13.34

المؤلفون: Andrew J. Kennedy, Joseph D. Houck, Thomas K. Dawson, Saundra D. Field, Niels D. Naimon, Kevin R. Lynch, Yugesh Kharel, Timothy L. Macdonald

مصطلحات موضوعية: 0301 basic medicine, biology, Sphingosine, Organic Chemistry, Sphingosine kinase, Oxadiazole, Biochemistry, Amidine, 03 medical and health sciences, chemistry.chemical_compound, SPHK2, 030104 developmental biology, Sphingosine kinase 1, chemistry, Docking (molecular), Drug Discovery, biology.protein, Sphingosine-1-phosphate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bfa952692ac007c2c1577103f44437
https://europepmc.org/articles/PMC4867490/

المؤلفون: Edward J. van Opstal, Cirle A. Warren, Glynis L. Kolling, Andrew J. Kennedy, Igor N. Olekhnovich, Michelle Warthan, Timothy L. Macdonald, Richard L. Guerrant, T. Eric Ballard, Paul S. Hoffman, Mary S. Riggins, Xia Wang

المصدر: Antimicrobial Agents and Chemotherapy. 56:4103-4111

مصطلحات موضوعية: Pyruvate Synthase, medicine.drug_class, Antibiotics, Microbial Sensitivity Tests, Biology, Microbiology, Mice, Vancomycin, medicine, Animals, Potency, Experimental Therapeutics, Pharmacology (medical), Fidaxomicin, Enzyme Inhibitors, Pharmacology, Clostridioides difficile, Nitazoxanide, Clostridium difficile, Nitro Compounds, Anti-Bacterial Agents, Disease Models, Animal, Thiazoles, Metronidazole, Aminoglycosides, Treatment Outcome, Infectious Diseases, Benzamides, Clostridium Infections, Anaerobic bacteria, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c889edc51316d910ed913eb52b76545d
https://doi.org/10.1128/aac.00360-12

المؤلفون: Timothy L. Macdonald, Olivier Peyruchaud, Marion David, Tao Huang, Perry C. Kennedy, Thomas P. Mathews, Ran Zhu, Kevin R. Lynch, Jose L. Tomsig

المصدر: Journal of Pharmacology and Experimental Therapeutics. 338:879-889

مصطلحات موضوعية: Agonist, Protein Conformation, medicine.drug_class, Sphingosine-1-phosphate receptor, Blotting, Western, CHO Cells, Pharmacology, Mass Spectrometry, Capillary Permeability, Drug Discovery and Translational Medicine, Mice, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, Sphingosine, Cricetinae, Lymphopenia, Benzene Derivatives, medicine, Animals, Prodrugs, Lymphocyte Count, Receptor, Chromatography, High Pressure Liquid, Mice, Inbred BALB C, Fingolimod Hydrochloride, Antagonist, Mammary Neoplasms, Experimental, Sphingosine Kinase 2, Prodrug, Mice, Inbred C57BL, Receptors, Lysosphingolipid, Biochemistry, chemistry, Guanosine 5'-O-(3-Thiotriphosphate), Propylene Glycols, Competitive antagonist, Molecular Medicine, Calcium, Female, Cyclobutanes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b897d6d40cc9033a134350cfbe1776d
https://doi.org/10.1124/jpet.111.181552

المؤلفون: Joseph D. Houck, Timothy L. Macdonald, Yugesh Kharel, James E. East, Saundra D. Field, Andrew J. Kennedy, Morgan L. Moyer, Kevin R. Lynch, Thomas P. Mathews

المصدر: Journal of Medicinal Chemistry. 54:3524-3548

مصطلحات موضوعية: Models, Molecular, Chemistry, Pharmaceutical, Amidines, Antineoplastic Agents, Article, Amidine, chemistry.chemical_compound, Sphingosine, Cell Line, Tumor, Drug Discovery, medicine, Humans, Sphingosine-1-phosphate, Enzyme Inhibitors, Leukemia, biology, U937 cell, Gene Expression Regulation, Leukemic, Kinase, Cancer, U937 Cells, medicine.disease, Kinetics, Phosphotransferases (Alcohol Group Acceptor), SPHK2, Models, Chemical, chemistry, Biochemistry, Sphingosine kinase 1, Drug Design, biology.protein, Molecular Medicine, Lysophospholipids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd6baf3fc66c36c987c285d398789fd
https://doi.org/10.1021/jm2001053

المؤلفون: Kevin R. Lynch, Anthony O. Awojoodu, Feilim Mac Gabhann, Timothy L. Macdonald, Shayn M. Peirce, Edward A. Botchwey, Caren E. Petrie Aronin, Brian R. Wamhoff, Soo J. Shin, Lauren S. Sefcik

المصدر: Tissue Engineering Part A. 17:617-629

مصطلحات موضوعية: Male, Biomedical Engineering, Neovascularization, Physiologic, Bioengineering, Biology, Biochemistry, Biomaterials, Mice, chemistry.chemical_compound, Tissue engineering, Sphingosine, Animals, Sphingosine-1-phosphate, Receptor, Actin, Fingolimod Hydrochloride, Activator (genetics), Muscles, Original Articles, Actins, Mice, Inbred C57BL, Receptors, Lysosphingolipid, Dorsal Skinfold Window Chamber Model, chemistry, Propylene Glycols, Delayed-Action Preparations, Microvessels, Models, Animal, Biophysics, Signal transduction, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd008e694d6df16fad9c180b906b742
https://doi.org/10.1089/ten.tea.2010.0404

المؤلفون: Andrew J. Kennedy, James E. East, Timothy L. Macdonald, Kevin R. Lynch, Jose L. Tomsig, Alexandra R. De Leon

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7132-7136

مصطلحات موضوعية: Pyridines, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Article, Structure-Activity Relationship, chemistry.chemical_compound, Biosynthesis, Multienzyme Complexes, Drug Discovery, Lysophosphatidic acid, Humans, Structure–activity relationship, Enzyme Inhibitors, Pyrophosphatases, Tyrosine, Molecular Biology, chemistry.chemical_classification, Phosphoric Diester Hydrolases, Organic Chemistry, In vitro, Enzyme, chemistry, Phosphodiesterase I, Alkylglycerophosphoethanolamine phosphodiesterase, Molecular Medicine, lipids (amino acids, peptides, and proteins), Lysophospholipids, biological phenomena, cell phenomena, and immunity, Autotaxin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6123ca063e5d06b5723110ab866bbb5
https://doi.org/10.1016/j.bmcl.2010.09.030

المؤلفون: Liping Huang, Volker H. Haase, Hong Ye, Amandeep Bajwa, Sang Kyung Jo, Krishna R. Dondeti, Timothy L. Macdonald, Kevin R. Lynch, Mark D. Okusa, Diane L. Rosin

المصدر: Journal of the American Society of Nephrology. 21:955-965

مصطلحات موضوعية: Agonist, medicine.medical_specialty, Kidney, medicine.drug_class, Chemistry, General Medicine, medicine.disease, chemistry.chemical_compound, Basic Research, Endocrinology, medicine.anatomical_structure, Tubule, Nephrology, Internal medicine, Knockout mouse, medicine, Sphingosine-1-phosphate, Receptor, Protein kinase B, Reperfusion injury

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3b3dc76f6c9424d8fe2d78d07d416e
https://doi.org/10.1681/asn.2009060662

المؤلفون: Oana Nicoara, Andrew J. Kennedy, Kevin R. Lynch, Yugesh Kharel, Andrew J. Morris, Thomas P. Mathews, Brian R. Wamhoff, Manjula Sunkara, Timothy L. Macdonald, Perry C. Kennedy

المصدر: Journal of Medicinal Chemistry. 53:2766-2778

مصطلحات موضوعية: Vascular smooth muscle, Myocytes, Smooth Muscle, Amidines, Sphingosine kinase, Article, Substrate Specificity, Amidine, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Sphingosine, Drug Discovery, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Cell Proliferation, chemistry.chemical_classification, Oxadiazoles, Cell growth, Kinase, Protein Structure, Tertiary, Rats, Phosphotransferases (Alcohol Group Acceptor), Enzyme, chemistry, Biochemistry, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f4218487273d9411c284dc725cd6a2
https://doi.org/10.1021/jm901860h

المؤلفون: Bin Ma, Kevin Guckian, Chunhua Yang, Kevin R. Lynch, Cheryl Black, Gregg Hetu, Anthony Rossomando, Daniel Scott, Yi Luo, Sowmya Chollate, Timothy L. Macdonald, Gnanasambandam Kumaravel, Edward Yin-Shiang Lin, Kyungmin Hahm, Joy Wang, Ping Jin, Wen-Cherng Lee, Ellen Rohde, Robert H. Scannevin

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2264-2269

مصطلحات موضوعية: Models, Molecular, Agonist, Multiple Sclerosis, Tetrahydronaphthalenes, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Article, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Lymphopenia, Drug Discovery, medicine, Animals, Structure–activity relationship, Prodrugs, Tetralin, Phosphorylation, Molecular Biology, S1p1 receptor, Organic Chemistry, Substrate (chemistry), Prodrug, Bioavailability, Phosphotransferases (Alcohol Group Acceptor), Receptors, Lysosphingolipid, Orally active, chemistry, Molecular Medicine, Immunosuppressive Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0bd28d957e3d66454e8b25926b1272
https://doi.org/10.1016/j.bmcl.2010.02.006

المؤلفون: Kevin R. Lynch, Nasser Samadi, Jose L. Tomsig, David N. Brindley, Cristoforo G. Gaetano, Timothy L. Macdonald

المصدر: Molecular Carcinogenesis. 48:801-809

مصطلحات موضوعية: Cancer Research, Pyridines, Blotting, Western, Organophosphonates, Breast Neoplasms, Biology, Transfection, Article, Catalysis, Cell Line, Metastasis, chemistry.chemical_compound, Cell Movement, Multienzyme Complexes, Cell Line, Tumor, medicine, Humans, Anilides, Enzyme Inhibitors, Pyrophosphatases, RNA, Small Interfering, Receptors, Lysophosphatidic Acid, Cell adhesion, Melanoma, Molecular Biology, Phosphoric Diester Hydrolases, Reverse Transcriptase Polymerase Chain Reaction, Cell growth, Lysophosphatidylcholines, Cancer, Cell migration, medicine.disease, Organophosphates, Kinetics, Lysophosphatidylcholine, chemistry, Phosphodiesterase I, Cancer cell, Cancer research, RNA Interference, lipids (amino acids, peptides, and proteins), Lysophospholipids, Autotaxin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16691d27347da44eb33608c896c3b259
https://doi.org/10.1002/mc.20524

المؤلفون: Michael D. Davis, Perry C. Kennedy, Ashley H. Snyder, Timothy L. Macdonald, Thomas P. Mathews, Yugesh Kharel, Kevin R. Lynch, Frank W. Foss

المصدر: Bioorganic & Medicinal Chemistry. 17:6123-6136

مصطلحات موضوعية: Propanols, Stereochemistry, Sphingosine-1-phosphate receptor, Clinical Biochemistry, Sphingosine kinase, Pharmaceutical Science, Biochemistry, Article, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Sphingosine, Lymphopenia, Fingolimod Hydrochloride, Drug Discovery, Animals, Humans, Prodrugs, Sphingosine-1-phosphate, Molecular Biology, Oxazole, Chemistry, Kinase, Organic Chemistry, Receptors, Lysosphingolipid, SPHK2, Propylene Glycols, Molecular Medicine, Immunosuppressive Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c38b9557284658321b8f28f1e01a7a
https://doi.org/10.1016/j.bmc.2009.04.015

المؤلفون: Laura J. Sim-Selley, Paulette B. Goforth, Mba U. Mba, Timothy L. Macdonald, Kevin R. Lynch, Sheldon Milstien, Sarah Spiegel, Leslie S. Satin, Sandra P. Welch, Dana E. Selley

المصدر: Journal of Neurochemistry. 110:1191-1202

مصطلحات موضوعية: Agonist, Cannabinoid receptor, medicine.drug_class, Sphingosine-1-phosphate receptor, Pharmacology, Biology, Neurotransmission, Biochemistry, Cellular and Molecular Neuroscience, chemistry.chemical_compound, chemistry, medicine, lipids (amino acids, peptides, and proteins), Signal transduction, Receptor, Neurotransmitter, G protein-coupled receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::69b17f277d5399d32394c77090bb55bd
https://doi.org/10.1111/j.1471-4159.2009.06202.x

المؤلفون: Timothy L. Macdonald, Elizabeth M. Joshi, Brian H. Heasley

المصدر: Xenobiotica. 39:197-204

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Health, Toxicology and Mutagenesis, Thiophenes, Urine, Pharmacology, Toxicology, Biochemistry, Mass Spectrometry, chemistry.chemical_compound, Detoxification, Toxicity Tests, medicine, Hydroxyurea, Glutathione Transferase, Leukotriene, Molecular Structure, biology, General Medicine, Glutathione, Zileuton, In vitro, Isoenzymes, Kinetics, Glutathione S-transferase, Liver, chemistry, Inactivation, Metabolic, Toxicity, biology.protein, Chromatography, Liquid, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a41f3029497385e4fae1e23481ad4d
https://doi.org/10.1080/00498250802651976

المؤلفون: Timothy L. Macdonald, Kevin R. Lynch

المصدر: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1781:508-512

مصطلحات موضوعية: Biochemical Phenomena, Sphingosine-1-phosphate receptor, Sphingosine kinase, Chemical biology, Biology, Pharmacology, Biochemistry, Article, chemistry.chemical_compound, Sphingosine, Fingolimod Hydrochloride, medicine, Animals, Humans, Lipid molecule, Sphingosine-1-phosphate, Enzyme Inhibitors, Molecular Biology, organic chemicals, Cell Biology, Fingolimod, Receptors, Lysosphingolipid, chemistry, Propylene Glycols, lipids (amino acids, peptides, and proteins), Lysophospholipids, Neuroscience, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c920ce56c4ceb14715878d22cadd67ef
https://doi.org/10.1016/j.bbalip.2008.06.006

المؤلفون: Gary K. Owens, Timothy L. Macdonald, Kevin R. Lynch, Brian R. Wamhoff

المصدر: Arteriosclerosis, Thrombosis, and Vascular Biology. 28:1454-1461

مصطلحات موضوعية: Male, medicine.medical_specialty, RHOA, Sphingosine-1-phosphate receptor, Receptor expression, Myocytes, Smooth Muscle, Cell, Article, chemistry.chemical_compound, Sphingosine, In vivo, Internal medicine, medicine, Animals, Receptor, Neointimal hyperplasia, biology, medicine.disease, Rats, Cell biology, Receptors, Lysosphingolipid, Phenotype, Endocrinology, medicine.anatomical_structure, chemistry, biology.protein, Lysophospholipids, Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf29e3a8aeed4e7ab172f851904b2e3
https://doi.org/10.1161/atvbaha.107.159392