يعرض 1 - 3 نتائج من 3 نتيجة بحث عن '"Timothy G. Ingallinera"', وقت الاستعلام: 0.30s تنقيح النتائج
  1. 1
    Academic Journal
    Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton’s Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies

    المؤلفون: Daniel W. Robbins, Mark A. Noviski, Ying Siow Tan, Zef A. Konst, Aileen Kelly, Paul Auger, Nivetha Brathaban, Robert Cass, Ming Liang Chan, Ganesh Cherala, Matthew C. Clifton, Stefan Gajewski, Timothy G. Ingallinera, Dane Karr, Daisuke Kato, Jun Ma, Jenny McKinnell, Joel McIntosh, Jeff Mihalic, Brent Murphy, Jaipal Reddy Panga, Ge Peng, Janine Powers, Luz Perez, Ryan Rountree, Austin Tenn-McClellan, Arthur T. Sands, Dahlia R. Weiss, Jeffrey Wu, Jordan Ye, Cristiana Guiducci, Gwenn Hansen, Frederick Cohen

    مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Computational Biology, Chemical Sciences not elsewhere classified, transcription factors ikzf1, molecular glue interactions, human clinical trials, attractive therapeutic target, preclinical oncology models, many hematological malignancies, degradation across species, concomitant immunomodulatory activity, btk enzymatic function, orally bioavailable degrader, mediated bcr signaling, orally bioavailable, immunomodulatory activity, preclinical pharmacology, btk degrader, vivo <, tyrosine kinase

    Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Preclinical_Pharmacology_of_NX-2127_an_Orally_Bioavailable_Degrader_of_Bruton_s_Tyrosine_Kinase_with_Immunomodulatory_Activity_for_the_Treatment_of_Patients_with_B_Cell_Malignancies/25130114

    الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01007.s001
    https://figshare.com/articles/journal_contribution/Discovery_and_Preclinical_Pharmacology_of_NX-2127_an_Orally_Bioavailable_Degrader_of_Bruton_s_Tyrosine_Kinase_with_Immunomodulatory_Activity_for_the_Treatment_of_Patients_with_B_Cell_Malignancies/25130114

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  2. 2
    Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part I. Mechanistic modelling of drug product dissolution to derive a P-PSD for PBPK model input

    المؤلفون: Shveta Grover, Natalie J. Sanderson, James Mann, Timothy G. Ingallinera, Alexander Blanazs, Xavier Pepin

    المصدر: European Journal of Pharmaceutics and Biopharmaceutics. 142:421-434

    مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, Pharmaceutical Science, Capsules, 02 engineering and technology, Models, Biological, 030226 pharmacology & pharmacy, Micelle, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, In vivo, Particle Size, Solubility, Dissolution, Micelles, Chemistry, General Medicine, 021001 nanoscience & nanotechnology, Drug Liberation, Chemical engineering, Pyrazines, Benzamides, Particle size, 0210 nano-technology, Weak base, Biotechnology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dcc83255ef77b2c097cc9e9b937e2a
    https://doi.org/10.1016/j.ejpb.2019.07.014

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  3. 3
    Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part II. A mechanistic PBPK model for IR formulation comparison, proton pump inhibitor drug interactions, and administration with acidic juices

    المؤلفون: Natalie J. Sanderson, Dean S. Murphy, Marilee Andrew, Timothy G. Ingallinera, George R. Bailey, Elizabeth Meehan, Andrea Moir, Xavier Pepin, Richard Barker, Cecile M. Krejsa, Allan P. Plumb, James Mann, J. Greg Slatter

    المصدر: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 142

    مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, food.ingredient, Chemistry, Pharmaceutical, Pharmaceutical Science, Biological Availability, 02 engineering and technology, 030226 pharmacology & pharmacy, Micelle, Models, Biological, Grapefruit juice, 03 medical and health sciences, 0302 clinical medicine, IVIVC, food, Pharmacokinetics, In vivo, Humans, Drug Interactions, Dissolution, Aqueous solution, Chromatography, Chemistry, Proton Pump Inhibitors, General Medicine, 021001 nanoscience & nanotechnology, Fruit and Vegetable Juices, Solubility, Pyrazines, Benzamides, 0210 nano-technology, Biotechnology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d386f3b4419fc88cfe042b7d63da701d
    https://pubmed.ncbi.nlm.nih.gov/31306750

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