المؤلفون: Kacey J. Prentice, Stacy G. Wendell, Ying Liu, Judith A. Eversley, Sonia R. Salvatore, Haneesha Mohan, Sydney L. Brandt, Andrew C. Adams, X. Serena Wang, David Wei, Garret A. FitzGerald, Timothy B. Durham, Craig D. Hammond, Kyle W. Sloop, Carsten Skarke, Francisco J. Schopfer, Michael B. Wheeler

المصدر: EBioMedicine, Vol 27, Iss C, Pp 200-213 (2018)

مصطلحات موضوعية: Medicine, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396417305017; https://doaj.org/toc/2352-3964

URL الوصول: https://doaj.org/article/8859af43754d46f59999fc8b6184ede4

المؤلفون: Rongjun He, Jifeng Wang, Zhi-Hong Yu, Julie S. Moyers, M. Dodson Michael, Timothy B. Durham, Jeff W. Cramer, Yuewei Qian, Amy Lin, Li Wu, Nicholas Noinaj, David G. Barrett, Zhong-Yin Zhang

المصدر: J Med Chem

مصطلحات موضوعية: Molecular Weight, Mice, Catalytic Domain, Drug Discovery, Animals, Molecular Medicine, Protein Tyrosine Phosphatases, Enzyme Inhibitors, Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c61119301642263decda2d2789be67b
https://doi.org/10.1021/acs.jmedchem.2c01143

المؤلفون: Harold B. Brooks, Shuang Luo, Timothy I. Meier, Kwame Frimpong, Timothy B. Durham, Matthew Lee, Kevin Robert Fales, Kenneth Jeff Thrasher, Philip W. Iversen, Robert T. Foreman, Yu-Hua Hui, Charles D. Spencer, Sandaruwan Geeganage, Kenneth D. Roth, Alicia Torrado, Yong Wang, Chong Si, Jefferson R. Mc Cowan, Stefan Jon Thibodeaux, Zhipei Wu, Timothy Alan Shepherd, James Lee Toth, Tao Wang, Yue-Wei Qian, Robert Dean Dally, Njoroge F George, Susan A. Konicek

المصدر: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Purine, Hydroxymethyl and Formyl Transferases, Lung Neoplasms, Mice, Nude, lcsh:Medicine, Antineoplastic Agents, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Downregulation and upregulation, Multienzyme Complexes, Cell Line, Tumor, Animals, Humans, Enzyme Inhibitors, lcsh:Science, Nucleotide salvage, Hypoxanthine, Multidisciplinary, Cell growth, lcsh:R, AMPK, Ribonucleotides, Aminoimidazole Carboxamide, Xenograft Model Antitumor Assays, Neoplasm Proteins, 030104 developmental biology, chemistry, Cell culture, Nucleotide Deaminases, 030220 oncology & carcinogenesis, Cancer research, Female, lcsh:Q, Growth inhibition

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8239c8bd258656146d4e890853c7f73a
http://link.springer.com/article/10.1038/s41598-018-33453-4

المؤلفون: José Francisco Soriano, Javier Agejas, Rosario Gonzalez, Ramón Rodríguez, Timothy B. Durham, Howard Barff Broughton, Juan F. Espinosa, Paloma Vidal, Ana B. Bueno, Robert Dean Dally, Hsiu-Chiung Yang, Alicia Marcos, David E. Timm, Gema Sanz, James R. McCarthy, Patric James Hahn

المصدر: Journal of Medicinal Chemistry. 60:9807-9820

مصطلحات موضوعية: Models, Molecular, Steric effects, Magnetic Resonance Spectroscopy, Stereochemistry, Isostere, Morpholines, Peptide, Crystallography, X-Ray, 01 natural sciences, Pyrrolidine, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Ethylamines, Animals, Aspartic Acid Endopeptidases, Humans, Molecule, Protease Inhibitors, chemistry.chemical_classification, biology, 010405 organic chemistry, Chemistry, Brain, Active site, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Cyclization, Drug Design, biology.protein, Molecular Medicine, Piperidine, Amyloid Precursor Protein Secretases, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c3ae5f96ab4869e6ec456bade5b1dc
https://doi.org/10.1021/acs.jmedchem.7b01304

المؤلفون: Alicia Torrado, Shane Atwell, Timothy B. Durham, Njoroge F George, Timothy I. Meier, Brandon J. Margolis, Stefan Jon Thibodeaux, Yu-Hua Hui, Robert Dean Dally, Kevin Robert Fales, Kenneth Jeff Thrasher, James Lee Toth, Jing Wang, Kwame Frimpong, Susan A. Konicek, Yong Wang, Chong Si, Kenneth D. Roth, Matthew Lee, Zhipei Wu, Jefferson R. Mc Cowan, Timothy Alan Shepherd, Sandaruwan Geeganage, Harold B. Brooks

المصدر: Journal of Medicinal Chemistry. 60:9599-9616

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Purine, Ribonucleotide, Mice, Nude, Antineoplastic Agents, Triple Negative Breast Neoplasms, Thiophenes, Phosphoribosylaminoimidazolecarboxamide Formyltransferase, Mice, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Breast, Cell Proliferation, Sulfonamides, Phosphoribosylaminoimidazolecarboxamide formyltransferase, Cell growth, Cancer, medicine.disease, Oncolytic virus, 030104 developmental biology, chemistry, Biochemistry, Antifolate, Cancer research, Folic Acid Antagonists, Molecular Medicine, Female, Growth inhibition

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b243bbece7ad1a8ca057dbf632832ff1
https://doi.org/10.1021/acs.jmedchem.7b01046

المؤلفون: Kannan Thirunavukkarasu, Mark Chambers, Daniel R. Mudra, Michael Robert Wiley, Craig A. Swearingen, Lisa A. Adams, Timothy B. Durham, Jothirajah Marimuthu, C. Lin, James Lee Toth, Chin Liu

المصدر: Journal of Medicinal Chemistry. 60:5933-5939

مصطلحات موضوعية: Male, 0301 basic medicine, Hydantoin, Osteoarthritis, Pharmacology, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Aggrecans, Enzyme Inhibitors, IC50, Aggrecan, Aggrecanase, Metalloproteinase, 010405 organic chemistry, Hydantoins, Cartilage, medicine.disease, Rats, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, medicine.anatomical_structure, chemistry, Biochemistry, Rats, Inbred Lew, ADAMTS4 Protein, Molecular Medicine, ADAMTS5 Protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1aa6bde3d0801758aea530059c1a40
https://doi.org/10.1021/acs.jmedchem.7b00650

المؤلفون: Kannan Thirunavukkarasu, Mark Chambers, Daniel R. Mudra, Craig A. Swearingen, Lisa A. Adams, Jennifer M. Weller, P.G. Mitchell, Timothy B. Durham, Chin Liu, C. Lin, James Lee Toth, Michael Robert Wiley, Jothirajah Marimuthu

المصدر: Journal of Medicinal Chemistry. 59:5810-5822

مصطلحات موضوعية: Male, 0301 basic medicine, Drug, Osmosis, media_common.quotation_subject, Pharmacology, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, In vivo, Endopeptidases, Osteoarthritis, Drug Discovery, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, media_common, Aggrecanase, Dose-Response Relationship, Drug, Molecular Structure, Drug discovery, Pharmacokinetic pharmacodynamic, Chemistry, Hydantoins, Target engagement, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Rats, Inbred Lew, Pharmacodynamics, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f252c22eeb38a66a724a46f915a1a225
https://doi.org/10.1021/acs.jmedchem.6b00398

المؤلفون: Timothy B. Durham, Jeffrey T. Dixon, James Lee Toth, Angela M. Siesky, Michael E. Christe, Valentine J. Klimkowski, Nathan A. Calvert, John F. Schindler, Dana Sindelar, Kyle W. Sloop, M. Dodson Michael, Jesline T. Alexander-Chacko, Julia X.C. Cao, Ginger Y. Wu, James E. McGee, Rachel N. Cavitt, Stefan Jon Thibodeaux, Sherry Y. Guo, Yong Wang, Michael J. Coghlan, Vladislav V. Kiselyov

المصدر: Journal of Biological Chemistry. 290:20044-20059

مصطلحات موضوعية: Models, Molecular, medicine.medical_specialty, medicine.medical_treatment, Amylin, Biology, Carbohydrate metabolism, Crystallography, X-Ray, Insulysin, Biochemistry, Glucagon, Internal medicine, Insulin receptor substrate, medicine, Insulin-degrading enzyme, Animals, Humans, Insulin, Enzyme Inhibitors, Molecular Biology, Binding Sites, Cell Biology, Insulin receptor, HEK293 Cells, Endocrinology, Proteolysis, Enzymology, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b79e6dcdb0455d21e4b543d83d06c40
https://doi.org/10.1074/jbc.m115.638205

المؤلفون: Jerome F. Baker, Kelly L. Dauer, Nicholas J. Karney, Mary C. O’Sullivan, Hannah E. Valdes, Andrew C. Forrestel, Cyrus J. Bacchi, Timothy B. Durham

المصدر: Bioorganic & Medicinal Chemistry. 23:996-1010

مصطلحات موضوعية: Clomipramine, Stereochemistry, Trypanosoma brucei brucei, Clinical Biochemistry, Trypanothione, Pharmaceutical Science, Trypanosoma brucei, Biochemistry, Mice, chemistry.chemical_compound, Drug Discovery, Polyamines, medicine, Animals, NADH, NADPH Oxidoreductases, Enzyme Inhibitors, Trypanosoma cruzi, Molecular Biology, Trypanocidal agent, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Active site, biology.organism_classification, Trypanocidal Agents, Molecular Docking Simulation, Enzyme, Docking (molecular), biology.protein, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a69750efbe3e13dc873c07606d81f7
https://doi.org/10.1016/j.bmc.2015.01.018

المؤلفون: Timothy B. Durham, Maria-Jesus Blanco

المصدر: Bioorganic & Medicinal Chemistry Letters. 25(5):998-1008

مصطلحات موضوعية: Target engagement, Receptor occupancy (RO), Clinical Biochemistry, New Drug Approvals, Pharmaceutical Science, Nanotechnology, Lead Generation, Biochemistry, Cellular thermal shift assay (CETSA), Optical imaging, Lead (geology), Drug Delivery Systems, Drug Discovery, Bioluminescent imaging (BLI), Animals, Humans, Pharmacokinetics, Molecular Biology, Pharmaceutical industry, business.industry, Chemistry, Drug discovery, Optical Imaging, Organic Chemistry, Target tissue, Biomarker, Risk analysis (engineering), Pharmaceutical Preparations, Positron emission tomography (PET), Positron-Emission Tomography, Luminescent Measurements, Spite, Molecular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4013b3197fae2a8e3fa53f19f28499

المؤلفون: C. Lin, Chin Liu, Valentine J. Klimkowski, Craig A. Swearingen, Lisa A. Adams, Stephanie L. Stout, Timothy B. Durham, Michael Robert Wiley, Kannan Thirunavukkarasu, Mark Chambers, Jim D. Durbin, Christopher John Rito, Jothirajah Marimuthu, James Lee Toth

المصدر: Journal of Medicinal Chemistry. 57:10476-10485

مصطلحات موضوعية: Male, Models, Anatomic, Models, Molecular, Hydantoin, Pharmacology, Crystallography, X-Ray, Menisci, Tibial, Structure-Activity Relationship, chemistry.chemical_compound, Microsomes, Osteoarthritis, Drug Discovery, Disintegrin, Animals, Structure–activity relationship, Protease Inhibitors, Cells, Cultured, Aggrecan, Benzofurans, Aggrecanase, Thrombospondin, Metalloproteinase, Molecular Structure, biology, Hydantoins, ADAMTS4 Protein, Rats, Tibial Meniscus Injuries, ADAM Proteins, chemistry, Biochemistry, Rats, Inbred Lew, biology.protein, Molecular Medicine, ADAMTS5 Protein, Procollagen N-Endopeptidase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f736425e180822aa9917bf1821dbef6
https://doi.org/10.1021/jm501522n

المؤلفون: Kyle W. Sloop, Craig D. Hammond, Kacey J. Prentice, Timothy B. Durham, Phillip E. Sanders, Michael B. Wheeler, Edith Nagy, Battsetseg Batchuluun, Ying Liu

المصدر: Journal of medicinal chemistry. 60(5)

مصطلحات موضوعية: 0301 basic medicine, Metabolite, Carboxylic acid, Carboxylic Acids, 030209 endocrinology & metabolism, 03 medical and health sciences, chemistry.chemical_compound, Islets of Langerhans, Mice, 0302 clinical medicine, Cytochrome P-450 Enzyme System, In vivo, Drug Discovery, Insulin Secretion, Animals, Humans, Insulin, Insulin secretion, Furans, chemistry.chemical_classification, geography, geography.geographical_feature_category, In vivo metabolism, Islet, In vitro, 3. Good health, 030104 developmental biology, Biochemistry, chemistry, Molecular Medicine, Insulin metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20415b67066e4ea713bcd5bc43a4ea4
https://pubmed.ncbi.nlm.nih.gov/28171722

المؤلفون: Michael Robert Wiley, Timothy B. Durham

المصدر: Translating Molecules into Medicines ISBN: 9783319500409

مصطلحات موضوعية: 0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Drug discovery, Human–computer interaction, Computer science, Novel protein, Target engagement, Pharmacology, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::53fad23c96cae17080d9c667b33c0de0
https://doi.org/10.1007/978-3-319-50042-3_3

المؤلفون: C. Lin, Michael Robert Wiley, Kannan Thirunavukkarasu, Mark Chambers, P.G. Mitchell, Christopher John Rito, Chin Liu, Craig A. Swearingen, Timothy B. Durham, Jothirajah Marimuthu, Dotzlaf Joe Edward, Quincy L. Carter, Srinivasan Chandrasekhar, Kevin L. Duffin

المصدر: Osteoarthritis and Cartilage. 18:1159-1166

مصطلحات موضوعية: Male, musculoskeletal diseases, Neoepitope antibody, Knee Joint, Keratan sulfate, Biomedical Engineering, Enzyme-Linked Immunosorbent Assay, Iodoacetates, Osteoarthritis, Aggrecanase inhibitor, NITEGE, Epitopes, chemistry.chemical_compound, Rheumatology, In vivo, ARGS, Endopeptidases, Synovial Fluid, medicine, Animals, Humans, Synovial fluid, Hyaluronic-acid binding region (HABR), Orthopedics and Sports Medicine, Aggrecans, Aggrecan, Aggrecanase, Cartilage, Biomarker, musculoskeletal system, medicine.disease, In vitro, Rats, medicine.anatomical_structure, Sandwich ELISA, chemistry, Biochemistry, Rats, Inbred Lew, Monosodium iodoacetate (MIA), Cattle, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0e2a169374a93b3db2078bf49cb118
https://doi.org/10.1016/j.joca.2010.02.019

المؤلفون: William R. Roush, Timothy B. Durham

المصدر: Organic Letters. 5:1871-1874

مصطلحات موضوعية: Glycosylation, animal structures, Stereochemistry, Organic Chemistry, Oligosaccharides, Galactosides, Stereoisomerism, General Medicine, Biochemistry, carbohydrates (lipids), chemistry.chemical_compound, Carbohydrate Sequence, chemistry, Carbohydrate Conformation, Indicators and Reagents, lipids (amino acids, peptides, and proteins), Glycosyl, Stereoselectivity, Physical and Theoretical Chemistry, Beta (finance), Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9868b4b8b48913896ccadd59763ab49
https://doi.org/10.1021/ol034393t

المؤلفون: Timothy B. Durham, Marvin J. Miller

المصدر: The Journal of Organic Chemistry. 68:35-42

مصطلحات موضوعية: Antifungal, chemistry.chemical_classification, Antifungal Agents, Magnetic Resonance Spectroscopy, Molecular Structure, medicine.drug_class, Stereochemistry, Organic Chemistry, Rhodopeptin B5, Enantioselective synthesis, Diastereomer, Stereoisomerism, General Medicine, beta-Lactams, Peptides, Cyclic, Chemical synthesis, Cyclic peptide, chemistry.chemical_compound, chemistry, Diamine, medicine, Lactam, Combinatorial Chemistry Techniques, Azide, Amino Acids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c4f16b87d27cc030697b4ba332e6e0
https://doi.org/10.1021/jo016276m

المؤلفون: Timothy B. Durham, Marvin J. Miller

المصدر: Organic Letters. 4:135-138

مصطلحات موضوعية: chemistry.chemical_classification, Bicyclic molecule, Stereochemistry, Organic Chemistry, Glycoside, Allylic alcohol, beta-Lactams, Glucuronic acid, Key features, Ring (chemistry), Biochemistry, chemistry.chemical_compound, Glucuronic Acid, chemistry, β lactams, polycyclic compounds, Combinatorial Chemistry Techniques, Indicators and Reagents, Glycosides, Physical and Theoretical Chemistry, Glucal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85471ba8e834b03316741be85fd843be
https://doi.org/10.1021/ol017026v

المؤلفون: Robert W. Siegel, Dotzlaf Joe Edward, John W. Carpenter, Dawn P. G. Brown, Chin Liu, P.G. Mitchell, Michael Robert Wiley, Kannan Thirunavukkarasu, D. A. Laska, Jothirajah Marimuthu, Quincy L. Carter, I.J. Brittain, Craig A. Swearingen, James Lee Toth, Timothy B. Durham, Kevin L. Duffin

المصدر: Osteoarthritis and cartilage. 18(9)

مصطلحات موضوعية: Cartilage, Articular, Neoepitope antibody, medicine.drug_class, Biomedical Engineering, Enzyme-Linked Immunosorbent Assay, Monoclonal antibody, Rheumatology, ARGS, Synovial Fluid, medicine, Synovial fluid, Humans, Hyaluronic-acid binding region (HABR), Orthopedics and Sports Medicine, Aggrecans, Aggrecan, Aggrecanase, biology, Chemistry, Cartilage, Antibodies, Monoclonal, Biomarker, ADAMTS4 Protein, Osteoarthritis, Knee, Molecular biology, In vitro, Peptide Fragments, ADAM Proteins, medicine.anatomical_structure, Biochemistry, Sandwich ELISA, Creatinine, biology.protein, Antibody, Procollagen N-Endopeptidase, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be00dbc5ba2736c176a0cdbe5d9ad4f
https://pubmed.ncbi.nlm.nih.gov/20633682

المؤلفون: Timothy B, Durham, Timothy A, Shepherd

المصدر: Current opinion in drug discoverydevelopment. 9(6)

مصطلحات موضوعية: Patents as Topic, Amyloid beta-Peptides, Molecular Structure, Alzheimer Disease, Pharmacology, Clinical, Ethylamines, Aspartic Acid Endopeptidases, Humans, Amyloid Precursor Protein Secretases, Enzyme Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::8700c9b666f341f533b169e27169fcb3
https://pubmed.ncbi.nlm.nih.gov/17117686

المؤلفون: Robert Dean Dally, Timothy Alan Shepherd, Patric James Hahn, Hsiu-Chiung Yang, Gema Sanz, Rosario Gonzalez, Juan F. Espinosa, Jon A. Erickson, Debra K. Laigle, Howard Barff Broughton, Ana B. Bueno, Mccarthy James R, Patrick C. May, Javier Agejas, Paloma Vidal, Timothy B. Durham, Todd J. Kohn, David E. Timm, David M. Bender, Juan R. Rodriguez

المصدر: Alzheimer's & Dementia. 2

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a44181e968b6b15bed5288a7236341c9
https://doi.org/10.1016/j.jalz.2006.05.062