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1
المؤلفون: Tomas Akerud, Hannah de la Motte, Eva Hurt-Camejo, Tim D. J. Perkins, Åsa Månsson, Frank Jansen, Hans-Georg Beisel, Mikael Dahlström, Gabrielle Saarinen, Fabrizio Giordanetto, Robert G. Roth, Marie Ahlqvist, Fredrik Klingegård, Birgitta Rosengren, Laurent Knerr, Kenth Hallberg, Ingemar Starke, Jenny Sandmark, Daniel Pettersen, Nidhal Selmi, Margareta Herslöf, Johan Brengdahl, Tommy Olsson, Mattias Rohman, Peter Nordberg, Johan Broddefalk
المصدر: ACS Medicinal Chemistry Letters. 9:594-599
مصطلحات موضوعية: 0301 basic medicine, Indole test, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, Phospholipase A2, Drug Discovery, biology.protein, Selectivity
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2
المؤلفون: Tim D. J. Perkins, Richard A. Ward, Jackie Stafford
المصدر: Journal of Medicinal Chemistry. 48:6991-6996
مصطلحات موضوعية: Models, Molecular, Quantitative structure–activity relationship, Databases, Factual, Molecular model, Stereochemistry, Dipeptidyl Peptidase 4, Quantitative Structure-Activity Relationship, Ligands, Dipeptidyl peptidase, Drug Discovery, Molecule, Protease Inhibitors, chemistry.chemical_classification, Virtual screening, Binding Sites, Molecular Structure, biology, Chemistry, Combinatorial chemistry, Molecular Weight, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Pharmacophore, Algorithms, Protein Binding
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3
المؤلفون: Kerstin Wieland, Tim D. J. Perkins, Henk Timmerman, Wiro M. P. B. Menge, R. Leurs, Marcel Hoffmann, James Edward John Mills, G. Romeo, P.H.J. Nederkoorn, Philip M. Dean, I.J.P. (Iwan) de Esch
المساهمون: Medicinal chemistry, Chemistry and Pharmaceutical Sciences
المصدر: De Esch, I J, Mills, J E, Perkins, T D, Romeo, G, Hoffmann, M, Wieland, K, Leurs, R, Menge, W M P B, Nederkoorn, P H J, Dean, P M & Timmerman, H 2001, ' Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE ', Journal of Medicinal Chemistry, vol. 44, no. 11, pp. 1666-74 . https://doi.org/10.1021/jm001109k
Journal of Medicinal Chemistry, 44(11), 1666-74. American Chemical Societyمصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Guinea Pigs, Histamine Antagonists, Quantitative Structure-Activity Relationship, In Vitro Techniques, Ligands, Histamine Release, Radioligand Assay, Piperidines, SDG 3 - Good Health and Well-being, Benzyl Compounds, Drug Discovery, Animals, Receptors, Histamine H3, Cerebral Cortex, Hydrogen bond, Chemistry, Imidazoles, Muscle, Smooth, Rats, Intestines, Molecular Medicine, Pharmacophore, Histamine H3 receptor, Software, Muscle Contraction
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4
المصدر: Journal of Computer-Aided Molecular Design. 15:81-96
مصطلحات موضوعية: Crystallography, Superposition principle, α2 adrenoceptor, Stack (abstract data type), Hydrogen bond, Chemistry, Thermolysin, Drug Discovery, Simulated annealing, Molecule, Physical and Theoretical Chemistry, Distance matrices in phylogeny, Computer Science Applications
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المؤلفون: Philip M. Dean, Tim D. J. Perkins, James Edward John Mills
المصدر: Journal of Computer-Aided Molecular Design. 11:229-242
مصطلحات موضوعية: Steric effects, Superposition principle, Crystallography, Hydrogen bond, Ligand, Chemistry, Drug Discovery, Atom, Intermolecular force, Molecule, Stereoisomerism, Physical and Theoretical Chemistry, Computer Science Applications
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6
المؤلفون: Tim D. J. Perkins, Philip M. Dean, James Edward John Mills
المصدر: Journal of Computer-Aided Molecular Design. 9:479-490
مصطلحات موضوعية: Models, Molecular, Surface (mathematics), Steric effects, Serine Proteinase Inhibitors, Similarity (geometry), Matching (graph theory), Crystallography, X-Ray, Ligands, Drug Discovery, Humans, Molecule, Computer Simulation, Enzyme Inhibitors, Physical and Theoretical Chemistry, Conformational isomerism, Binding Sites, Molecular Structure, Basis (linear algebra), Chemistry, Thrombin, Hydrogen Bonding, HIV Protease Inhibitors, Computer Science Applications, Enzyme binding, Crystallography, Chemical physics, Drug Design, Allosteric Site
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7
المؤلفون: Tim D. J. Perkins, Philip M. Dean
المصدر: Computer-Assisted Lead Finding and Optimization: Current Tools for Medicinal Chemistry
مصطلحات موضوعية: Surface (mathematics), Similarity (network science), Geometry, Volume (compression), Mathematics
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8
المؤلفون: Nasfim Haque, Tim D. J. Perkins, Philip M. Dean
المصدر: Molecular Modeling and Prediction of Bioactivity ISBN: 9781461368571
مصطلحات موضوعية: chemistry.chemical_classification, Enzyme, Protease, chemistry, Diversity analysis, medicine.medical_treatment, Human immunodeficiency virus (HIV), medicine, HIV Protease Inhibitor, Computational biology, medicine.disease_cause, Ligand (biochemistry), Receptor
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9
المؤلفون: Philip M. Dean, Tim D. J. Perkins
المصدر: Journal of computer-aided molecular design. 7(2)
مصطلحات موضوعية: Models, Molecular, Mathematical optimization, Molecular Structure, Chemistry, Combined use, Molecular Conformation, Angiotensin II, Consensus method, Computer Science Applications, Superposition principle, Angiotensin Receptor Antagonists, Structure-Activity Relationship, Drug Design, Drug Discovery, Simulated annealing, Data analysis, Molecule, Conformational energy, Computer Simulation, Physical and Theoretical Chemistry, Biological system, Algorithms, Software
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10
المؤلفون: Philip M. Dean, Tim D. J. Perkins
المصدر: Trends in QSAR and Molecular Modelling 92 ISBN: 9789072199133
Trends in QSAR and Molecular Modelling 92مصطلحات موضوعية: Similarity (network science), Computer science, Molecule, Computational biology