المؤلفون: Ramchandran, Siddharth, Tikhonov, Gleb, Lönnroth, Otto, Tiikkainen, Pekka, Lähdesmäki, Harri

مصطلحات موضوعية: Statistics - Machine Learning, Computer Science - Machine Learning

URL الوصول: http://arxiv.org/abs/2203.01218

المؤلفون: Ramchandran, Siddharth, Tikhonov, Gleb, Lönnroth, Otto, Tiikkainen, Pekka, Lahdesmaki, Harri

المساهمون: Organismal and Evolutionary Biology Research Programme

مصطلحات موضوعية: Conditional VAEs, Gaussian process, Missing value imputation, Variational autoencoders, Computer and information sciences

وصف الملف: application/pdf

Relation: We would like to acknowledge the computational resources provided by Aalto Science-IT, Finland. We would also like to thank Mine Ogretir for help with the PPMI dataset as well as Manuel Haussmann for the helpful discussions and comments. This work was supported by the Academy of Finland [328401] and Bayer Oy. The PPMI dataset used in the preparation of this article was obtained from the Parkin-son's Progression Markers Initiative (PPMI) database (https://www.ppmi-info.org/access-data-specimens/download-data). For up-to-date information on the study, visit www.ppmi-info.org. PPMI - a public-private partnership - is funded by The Michael J. Fox Foundation for Parkinson's Research and funding partners, including 4D Pharma, AbbVie Inc., AcureX Therapeutics, Allergan, Amathus Therapeutics, Aligning Science Across Parkinson's (ASAP), Avid Radiopharmaceuticals, Bial Biotech, Biogen, BioLegend, Bristol Myers Squibb, CalicoLife Sciences LLC, Celgene Corporation, DaCapo Brainscience, Denali Therapeutics, The Edmond J. Safra Foundation, Eli Lilly and Company,GE Healthcare, GlaxoSmithKline, Golub Capital, Handl Therapeutics, Insitro, Janssen Pharmaceuticals, Lundbeck, Merck & Co., Inc., MesoScale Diagnostics, LLC, Neurocrine Biosciences, Pfizer Inc., Piramal Imaging, Prevail Therapeutics, F. Hoffmann-La Roche Ltd and its affiliated company Genentech Inc., Sanofi Genzyme, Servier, Takeda Pharmaceutical Company, Teva Neuroscience, Inc., UCB, Vanqua Bio, VerilyLife Sciences, Voyager Therapeutics, Inc., Yumanity Therapeutics, Inc.; Ramchandran , S , Tikhonov , G , Lönnroth , O , Tiikkainen , P & Lahdesmaki , H 2024 , ' Learning conditional variational autoencoders with missing covariates ' , Pattern Recognition , vol. 147 , 110113 . https://doi.org/10.1016/j.patcog.2023.110113; ORCID: /0000-0003-3040-0307/work/150752080; http://hdl.handle.net/10138/569684; 2fe09774-3547-4ec7-8a3e-6400d2287d2c; 001124231300001

الاتاحة: http://hdl.handle.net/10138/569684

المؤلفون: Laine, Leena J, Mäki-Jouppila, Jenni H E, Kutvonen, Emma, Tiikkainen, Pekka, Nyholm, Thomas K M, Tien, Jerry F, Umbreit, Neil T, Härmä, Ville, Kallio, Lila, Davis, Trisha N, Asbury, Charles L, Poso, Antti, Gorbsky, Gary J, Kallio, Marko J

المصدر: Laine , L J , Mäki-Jouppila , J H E , Kutvonen , E , Tiikkainen , P , Nyholm , T K M , Tien , J F , Umbreit , N T , Härmä , V , Kallio , L , Davis , T N , Asbury , C L , Poso , A , Gorbsky , G J & Kallio , M J 2021 , ' VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro ' , Oncoscience , vol. 8 , pp. 134-153 . https://doi.org/10.18632/oncoscience.549

وصف الملف: application/pdf

الاتاحة: https://research.abo.fi/en/publications/1dad3d0a-3b55-4b11-9b23-e81560dd2e67
https://doi.org/10.18632/oncoscience.549
https://research.abo.fi/ws/files/33730218/oncoscience_v8_549.pdf
https://urn.fi/URN:NBN:fi-fe2022021819773

المؤلفون: Bucher, Elmar, Kohonen, Pekka, Fey, Vidal, Mpindi, John, Sara, Henri, Pisto, Tommi, Edgren, Henrik, Kilpinen, Sami, Ojala, Kalle, Tiikkainen, Pekka, Vainio, Paula, Iljin, Kristiina, Sahlberg, Niko, Rantala, Juha K., Mäkelä, Rami, Saviranta, Petri, Perälä, Merja, Nees, Matthias, Haapa-Paananen, Saija, Kallioniemi, Olli

المصدر: Bucher , E , Kohonen , P , Fey , V , Mpindi , J , Sara , H , Pisto , T , Edgren , H , Kilpinen , S , Ojala , K , Tiikkainen , P , Vainio , P , Iljin , K , Sahlberg , N , Rantala , J K , Mäkelä , R , Saviranta , P , Perälä , M , Nees , M , Haapa-Paananen , S & Kallioniemi , O 2008 , A link between multiple high throughput technology datasets . in The 9th International Conference on Systems Biology ....

مصطلحات موضوعية: high througput screening technology, database design, database management system, MySQL

Relation: https://cris.vtt.fi/en/publications/a53e97d0-ce7e-49cc-ae54-91bd9a8c0258

الاتاحة: https://cris.vtt.fi/en/publications/a53e97d0-ce7e-49cc-ae54-91bd9a8c0258
http://kdbio.inesc-id.pt/software/polarmapper/files/ICSB2008_abstract_book.pdf

المؤلفون: Kallio Marko J, Kallio Lila, Davis Trisha N, Härmä Ville, Mäki-Jouppila Jenni HE, Asbury Charles L, Kutvonen Emma, Poso Antti, Tiikkainen Pekka, Tien Jerry F, Nyholm Thomas KM, Umbreit Neil T, Gorbsky Gary J, Laine Leena J

المساهمون: Turun biotiedekeskus, Turku Bioscience Centre, biotiedekeskuksen yhteiset, Biotiedekeskuksen yhteiset, biolääketieteen laitos, yhteiset, Institute of Biomedicine, 2607100, 2609201, 2609200

Relation: Oncoscience; https://www.utupub.fi/handle/10024/167791; https://www.oncoscience.us/article/549/text/; URN:NBN:fi-fe2022021519236

الاتاحة: https://www.utupub.fi/handle/10024/167791
https://www.oncoscience.us/article/549/text/

المؤلفون: Mäki-Jouppila, Jenni, Laine, Leena, Rehnberg, Jonathan, Narvi, Elli, Tiikkainen, Pekka, Hukasova, Elvira, Halonen, Pasi, Lindqvist, Arne, Kallio, Lila, Poso, Antti, Kallio, Marko

المصدر: Mäki-Jouppila , J , Laine , L , Rehnberg , J , Narvi , E , Tiikkainen , P , Hukasova , E , Halonen , P , Lindqvist , A , Kallio , L , Poso , A & Kallio , M 2014 , ' Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na ' , Molecular Cancer Therapeutics , vol. 13 , no. 5 , pp. 1054-1066 . https://doi.org/10.1158/1535-7163.MCT-13-0685

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الاتاحة: https://cris.vtt.fi/en/publications/72c1bced-696d-412d-bc91-d4cbc81c9e08
https://doi.org/10.1158/1535-7163.MCT-13-0685

المؤلفون: Tiikkainen, Pekka, Bellis, Louisa, Light, Yvonne, Franke, Lutz

المصدر: Journal of Chemical Information and Modeling ; volume 53, issue 10, page 2499-2505 ; ISSN 1549-9596 1549-960X

الاتاحة: http://dx.doi.org/10.1021/ci400099q
https://pubs.acs.org/doi/pdf/10.1021/ci400099q

المؤلفون: Achenbach, Janosch, Tiikkainen, Pekka, Franke, Lutz, Proschak, Ewgenij

المصدر: Future Medicinal Chemistry ; volume 3, issue 8, page 961-968 ; ISSN 1756-8919 1756-8927

الاتاحة: http://dx.doi.org/10.4155/fmc.11.62
https://www.tandfonline.com/doi/pdf/10.4155/fmc.11.62

المؤلفون: Tiikkainen, Pekka, Franke, Lutz

المصدر: Journal of Chemical Information and Modeling ; volume 52, issue 2, page 319-326 ; ISSN 1549-9596 1549-960X

الاتاحة: http://dx.doi.org/10.1021/ci2003126
https://pubs.acs.org/doi/pdf/10.1021/ci2003126

المؤلفون: Tiikkainen, Pekka, Poso, Antti, Kallioniemi, Olli

المصدر: Tiikkainen , P , Poso , A & Kallioniemi , O 2009 , ' Comparison of structure fingerprint and molecular interaction file based methods in explaining biological similarity of small molecules in cell-based screens ' , Journal of Computer-Aided Molecular Design , vol. 23 , no. 4 , pp. 227-239 . https://doi.org/10.1007/s10822-008-9253-0

مصطلحات موضوعية: Ligand-based virtual screening, NCI-60, Data fusion, Chemical similarity, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الاتاحة: https://cris.vtt.fi/en/publications/e7a31bc8-fd0f-46d7-b6c3-454e7828ec28
https://doi.org/10.1007/s10822-008-9253-0

المؤلفون: Tiikkainen, Pekka, Markt, Patrick, Wolber, Gerhard, Kirchmair, Johannes, Distinto, Simona, Poso, Antti, Kallioniemi, Olli

المصدر: Tiikkainen , P , Markt , P , Wolber , G , Kirchmair , J , Distinto , S , Poso , A & Kallioniemi , O 2009 , ' Critical comparison of virtual screening methods against the MUV data set ' , Journal of Chemical Information and Modeling , vol. 49 , no. 10 , pp. 2168-2178 . https://doi.org/10.1021/ci900249b

الاتاحة: https://cris.vtt.fi/en/publications/21edd3c0-dd4b-46f6-a097-7b3b9a781aab
https://doi.org/10.1021/ci900249b

المؤلفون: Storvik, Markus, Tiikkainen, Pekka, van Iersel, Martijn, Wong, Garry

المصدر: European Neuropsychopharmacology ; volume 16, issue 3, page 211-219 ; ISSN 0924-977X

الاتاحة: http://dx.doi.org/10.1016/j.euroneuro.2005.08.007
https://api.elsevier.com/content/article/PII:S0924977X05001343?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0924977X05001343?httpAccept=text/plain

المؤلفون: Tiikkainen, Pekka, Franke, Lutz

المصدر: Journal of Chemical Information & Modeling; Feb2012, Vol. 52 Issue 2, p319-326, 8p

المؤلفون: Tiikkainen, Pekka

المساهمون: Lääketieteellinen tiedekunta, Faculty of Medicine, Institute of Biomedicine, Pharmacology

وصف الملف: fulltext

Relation: Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica; 897; http://www.utupub.fi/handle/10024/59769; URN:ISBN:978-951-29-4248-0

الاتاحة: http://www.utupub.fi/handle/10024/59769