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1Academic Journal
المساهمون: Joo-Il Kim, Jin-Sung Park, Hanna Kim, Soo-Kyung Ryu, Jina Kwak, Euna Kwon, Jun-Won Yun, Ki-Taek Nam, Han-Woong Lee, Byeong-Cheol Kang, Nam, Ki Taek
مصطلحات موضوعية: Recombination activating gene-2 (RAG-2) plays a crucial role in the development of lymphocytes by mediating recombination of T cell receptors and immunoglobulins, and loss of RAG-2 causes severe combined immunodeficiency (SCID) in humans. RAG-2 knockout mice created using homologous recombination in ES cells have served as a valuable immunodeficient platform, but concerns have persisted on the specificity of RAG-2-related phenotypes in these animals due to the limitations associated with the genome engineering method used. To precisely investigate the function of RAG-2, we recently established a new RAG-2 knockout FVB mouse line (RAG-2 -/-) manifesting lymphopenia by employing a CRISPR/Cas9 system at Center for Mouse Models of Human Disease. In this study, we further characterized their phenotypes focusing on histopathological analysis of lymphoid organs. RAG-2 -/- mice showed no abnormality in development compared to their WT littermates for 26 weeks. At necropsy, gross examination revealed significantly smaller spleens and thymuses in RAG-2 -/- mice, while histopathological investigation revealed hypoplastic white pulps with intact red pulps in the spleen, severe atrophy of the thymic cortex and disappearance of follicles in lymph nodes. However, no perceivable change was observed in the bone marrow. Moreover, our analyses showed a specific reduction of lymphocytes with a complete loss of mature T cells and B cells in the lymphoid organs, while natural killer cells and splenic megakaryocytes were increased in RAG-2 -/- mice. These findings indicate that our RAG-2 -/- mice show systemic lymphopenia with the relevant histopathological changes in the lymphoid organs, suggesting them as an improved Rag-2-related immunodeficient model
Relation: Laboratory Animal Research; J02149; OAK-2019-00154; https://ir.ymlib.yonsei.ac.kr/handle/22282913/167550; T201805644; Laboratory Animal Research, Vol.34(4) : 166-175, 2018
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2
المؤلفون: Natasa Milic, Milos D. Miljkovic, Milica Labudovic-Borovic, Ivana M. Lalić, Novica M. Milićević
المصدر: Anatomia, Histologia, Embryologia. 49:433-439
مصطلحات موضوعية: Male, Silver Staining, Cell type, Silver, Rodent, 040301 veterinary sciences, Ontogeny, Thymus Gland, Rat Thymus, 0403 veterinary science, 03 medical and health sciences, Cortex (anatomy), biology.animal, Confidence Intervals, medicine, Animals, Rats, Wistar, Postnatal day, Medulla, Analysis of Variance, 0303 health sciences, Thymic cortex, General Veterinary, biology, Macrophages, organic chemicals, fungi, 04 agricultural and veterinary sciences, General Medicine, Immunohistochemistry, Rats, Cell biology, medicine.anatomical_structure, 030301 anatomy & morphology, Regression Analysis, Female, Monte Carlo Method
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3Academic Journal
المؤلفون: Inoue, M., Fukuda, M., Miyano, K.
المصدر: Avian Diseases, 1994 Oct 01. 38(4), 839-846.
URL الوصول: https://www.jstor.org/stable/1592122
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4
المؤلفون: V. Ya. Yurchinskiy
المصدر: Medicinskaâ Immunologiâ, Vol 20, Iss 4, Pp 571-576 (2018)
مصطلحات موضوعية: Functional role, Thymic cortex, Range (biology), correlation analysis, Immunology, Vertebrate Animals, Physiology, age-related changes, RC581-607, Biology, vertebrate animals, comparative morphology, thymus, Thymus Glands, Age related, Microcirculatory Bed, Correlation analysis, Immunology and Allergy, Immunologic diseases. Allergy
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5
المؤلفون: O. A. Apt, O. A. Grygorieva
المصدر: Патологія; № 3 (2017)
Pathologia; № 3 (2017)
Патология; № 3 (2017)
Patologìâ, Iss 3, Pp 358-363 (2017)مصطلحات موضوعية: lymphocytes, 0301 basic medicine, Thymic cortex, Physiology, mast cells, Biology, тимус, лимфоциты, лимфатические сосуды, тучные клетки, Edema reduction, Specific density, Local edema, lymphatic vessels, лімфоцити, лімфатичні судини, тучні клітини, Extracellular matrix, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Lymphatic system, thymus, lcsh:Pathology, European commission, lcsh:RB1-214, 030215 immunology
وصف الملف: application/pdf
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6
المؤلفون: A. V. Polevshchikov, K. A. Vasiliev
المصدر: Russian Journal of Marine Biology. 40:323-332
مصطلحات موضوعية: Thymic epithelium, Immune system, Thymic cortex, Thymic medulla, Immunology, Fish
, Aquatic Science, Biology, Oceanography, Blood–thymus barrier -
7Academic Journal
المؤلفون: Montero Herradón, Sara, García-Ceca Hernández, José Javier, Zapata González, Agustín Gregorio
مصطلحات موضوعية: 577.2, development, EphB, thymus, thymic epithelial cells, thymic cortex, thymic epithelial cell survival, thymic epithelial cell cycle, Biología molecular (Biología), 2415 Biología Molecular
وصف الملف: application/pdf
Relation: info:eu-repo/grantAgreement/MINECO//BFU2013-41112-R/ES/DESARROLLO DEL EPITELIO TIMICO: UN PROGRAMA MOLECULAR BASADO EN PROCESOS DE BRANCHING MORFOGENESIS, ESTRATIFICACION Y TRIDIMENSIONALIZACION/; info:eu-repo/grantAgreement/MINECO//RD12%2F0019%2F0007/ES/Terapia Celular/; info:eu-repo/grantAgreement/MINECO//RD16%2F0011%2F0002/ES/Terapia Celular/; https://hdl.handle.net/20.500.14352/94811; https://www.tandfonline.com/action/downloadSupplement?doi=10.1080%2F15476278.2017.1389368&file=kogg_a_1389368_sm2795.zip
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8
المؤلفون: Taku Kazamaki, Shigeo Murata, Akihiro Ishizu, Satomi Takahashi, Tomohisa Baba, Utano Tomaru, Yukiko Miyatake, Jiro Ohara, Masanori Kasahara, Sayuri Suzuki, Sari Iwasaki, Keiji Tanaka, Noriyuki Otsuka, Kazunori Fugo
المصدر: Blood. 113:5186-5191
مصطلحات موضوعية: Proteasome Endopeptidase Complex, Protein subunit, Proteolysis, Immunology, Thymus Gland, Biology, Biochemistry, Antigen, Gene expression, medicine, Humans, Tissue Distribution, chemistry.chemical_classification, Thymic cortex, medicine.diagnostic_test, Epithelial Cells, Dendritic Cells, Cell Biology, Hematology, Cell biology, Enzyme, Proteasome, chemistry, Organ Specificity, Function (biology)
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9
المؤلفون: Kristin A. Hogquist, Matthew S. Wilken, Tom M. McCaughtry
المصدر: The Journal of Experimental Medicine
مصطلحات موضوعية: CD4-Positive T-Lymphocytes, T-Lymphocytes, Immunology, Green Fluorescent Proteins, Thymus Gland, Biology, 03 medical and health sciences, Mice, 0302 clinical medicine, Antigen, Cell Movement, Genes, Reporter, Immunology and Allergy, Cytotoxic T cell, Animals, Humans, Progenitor cell, Medulla, 030304 developmental biology, 0303 health sciences, Thymic cortex, Brief Definitive Report, Natural killer T cell, Cell biology, Killer Cells, Natural, CD4 Antigens, Brief Definitive Reports, Central tolerance, Immunologic Memory, T-Cell Precursors, 030215 immunology
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10
المؤلفون: J. Slípka, Mandáková P, Virtová M, Petr Sima, Beranová M
المصدر: Folia Microbiologica. 48:394-398
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Lurcher Mice, Lurcher, Apoptosis, Enzyme-Linked Immunosorbent Assay, Thymus Gland, Biology, Microbiology, Flow cytometry, Mice, Mice, Neurologic Mutants, Necrosis, Immune system, medicine, Animals, Medulla, Mice, Inbred C3H, Thymic cortex, medicine.diagnostic_test, Neurodegeneration, General Medicine, Flow Cytometry, medicine.disease, Nerve Degeneration, Immunology, Female
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11
المؤلفون: Barbara Plytycz, Adam J. Miodoński, Joanna Mika, Janusz Bigaj
المصدر: Developmental & Comparative Immunology. 20:129-137
مصطلحات موضوعية: Thymic cortex, Microcirculation, Rana temporaria, Immunology, Capillary network, Thymus Gland, Anatomy, Biology, Rana, Microscopy, Electron, Scanning, Animals, Blood Vessels, Repopulation, Endothelium, Vascular, Seasons, Developmental Biology
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12
المصدر: Thymic Development and Selection of T Lymphocytes ISBN: 9783642402517
مصطلحات موضوعية: Thymic cortex, Protein subunit, T-cell receptor, T-cell Antigen, Biology, Receptor, Function (biology), CD8, Cell biology
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13Academic Journal
المؤلفون: Obodo, Udochukwu
المصدر: Biology Honors Projects
مصطلحات موضوعية: Semaphorins, T-cell, thymic medulla, thymic cortex, Biology
وصف الملف: application/pdf
Relation: https://digitalcommons.macalester.edu/biology_honors/8; https://digitalcommons.macalester.edu/context/biology_honors/article/1008/viewcontent/Spring_2008_OBODO__UDOCHUKWU.pdf
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14
المؤلفون: Paul Herzmark, Ena Ladi, Ying Chen, Badrinath Roysam, Ellen A. Robey
مصطلحات موضوعية: Photon, T-Lymphocytes, Immunology, Analytical chemistry, Mice, Transgenic, Thymus Gland, Biology, Article, Mice, Software, Cell Movement, Microscopy, Image Processing, Computer-Assisted, Immunology and Allergy, Animals, Cluster analysis, Multi channel, Thymic cortex, Microscopy, Confocal, business.industry, Chimera, Cell migration, Pattern recognition, Dendritic Cells, Mice, Inbred C57BL, Thymocyte, Microscopy, Fluorescence, Multiphoton, Mice, Inbred DBA, Artificial intelligence, business, Algorithms
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15
المؤلفون: Henry S. Kaplan
المصدر: Ciba Foundation Symposium-Carcinogenesis: Mechanisms of Action
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Thymic cortex, Lymphatic leukaemia, Tumour induction, medicine, Neoplastic transformation, Biology
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16
المؤلفون: Holly L. Aaron, Tanya Schwickert, Nigel Killeen, Ellen A. Robey, Tanya Chtanova, Ena Ladi
المصدر: The FASEB Journal. 22
مصطلحات موضوعية: Thymocyte, Thymic cortex, Chemistry, Genetics, C-C chemokine receptor type 7, Dendritic cell, Molecular Biology, Biochemistry, Biotechnology, Cell biology
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17
المؤلفون: Ulrich Göbel, H. Kabisch, D. Harms, T. Niehues, G. Janka-Schaub, P. Kapaun, S Burdach
المصدر: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ISBN: 9783642719622
مصطلحات موضوعية: Pathology, medicine.medical_specialty, education.field_of_study, Thymic cortex, Population, CD1, Mediastinal mass, Childhood T-ALL, Biology, Apoptosis, Surface marker, medicine, education, Childhood Acute Lymphoblastic Leukemia
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18
المؤلفون: Toshi Horiuchi, Minoru R. Suzuki, Hiroyoshi Kuboaki, Takaharu Nakayama, Hiroo Takahashi, Kiyoko Ito, Masao Makino, Shuji Masuda
المصدر: The Journal of Toxicological Sciences. 2:141-147
مصطلحات موضوعية: medicine.medical_specialty, Adrenocortical hormone, Thymic cortex, business.industry, Toxicology, medicine.disease, Chlormadinone acetate, chemistry.chemical_compound, Atrophy, Endocrinology, chemistry, Internal medicine, Medicine, business, Serum cholesterol, Depression (differential diagnoses)
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19
المؤلفون: Roland Scollay
المصدر: Immunology Today. 4:282-286
مصطلحات موضوعية: Thymic cortex, Immunology, Biology, Medulla
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20
المؤلفون: Yoshio Hayashi, Katsuiku Hirokawa
المصدر: Pathology International. 30:23-32
مصطلحات موضوعية: medicine.medical_specialty, Pathology, chemistry.chemical_element, Thymus Gland, Lymphocyte Activation, Pathology and Forensic Medicine, Mice, Immune system, Atrophy, Internal medicine, medicine, Animals, Cytotoxic T cell, Tissue Distribution, Phytohemagglutinins, Thymic cortex, Macrophages, Normal level, Mercury, Organ Size, General Medicine, Methylmercury Compounds, medicine.disease, Mercury (element), Endocrinology, chemistry, Acute Disease, Immunology, Female, Lymph, Spleen, Antibody formation, Electron Probe Microanalysis
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