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1
المؤلفون: Swamy Yeleswaram, Jason Boer, Sharon Diamond, Nikoo Falahatpisheh, Thomas P. Maduskuie, Yu Li
المصدر: Drug Metabolism and Disposition. 38:1277-1285
مصطلحات موضوعية: Metabolite, Pharmaceutical Science, Biology, Rats, Sprague-Dawley, chemistry.chemical_compound, Cytosol, Dogs, Species Specificity, Pharmacokinetics, medicine, Animals, Humans, Xanthine oxidase, Aldehyde oxidase, Pharmacology, Kidney, Metabolism, Triazoles, Rats, Aldehyde Oxidase, Oxygen, Pyridazines, Macaca fascicularis, medicine.anatomical_structure, Liver, chemistry, Biochemistry, Toxicity, Microsomes, Liver, Microsome
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2
المؤلفون: Kim L. R. Brouwer, Lauren E. Richards, Carl P. Decicco, Frank W. Lee, C. Edwin Garner, Hao Xiong, Gang Luo, Jingwu Duan, Thomas P. Maduskuie, Hanbo Hu, Liang Shang Gan, Helen Shen
المصدر: Drug Metabolism and Disposition. 35:835-840
مصطلحات موضوعية: musculoskeletal diseases, medicine.medical_specialty, Necrosis, Anti-Inflammatory Agents, Pharmaceutical Science, ADAM17 Protein, In Vitro Techniques, Kidney, Animals, Genetically Modified, chemistry.chemical_compound, Dogs, Pharmacokinetics, Internal medicine, medicine, Animals, Bile, Humans, Drug Interactions, Rats, Wistar, Pharmacology, biology, Chemistry, Multidrug resistance-associated protein 2, Kidney metabolism, Drug interaction, Rats, ADAM Proteins, Methotrexate, Endocrinology, Liver, Enzyme inhibitor, Antirheumatic Agents, Antifolate, Quinolines, biology.protein, ATP-Binding Cassette Transporters, medicine.symptom, medicine.drug
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3
المؤلفون: Thomas P. Maduskuie, Richard G. Wilde, Jeffrey T. Billheimer, Debra A. Cromley, Sandra Germain, Peter J. Gillies, C. Anne Higley, Alex L. Johnson, Penio Pennev, Edward J. Shimshick, Ruth R. Wexler
المصدر: Journal of Medicinal Chemistry. 38:1067-1083
مصطلحات موضوعية: Sterol O-acyltransferase, Chemical synthesis, Cell Line, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Structure–activity relationship, Foam cell, chemistry.chemical_classification, biology, Cholesterol, Macrophages, Imidazoles, In vitro, Rats, Isoenzymes, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Drug Design, Microsomes, Liver, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Sterol O-Acyltransferase
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4
المؤلفون: Ruth R. Wexler, Hollis Smith Kezar, Edward S. Shimshick, Jeffrey T. Billheimer, C. Anne Higley, Richard G. Wilde, Peter J. Gillies, Sandra J. Germain, Thomas P. Maduskuie
المصدر: Bioorganic & Medicinal Chemistry Letters. 5:167-172
مصطلحات موضوعية: chemistry.chemical_classification, Quantitative structure–activity relationship, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Sterol O-acyltransferase, Pharmaceutical Science, Biochemistry, In vitro, chemistry.chemical_compound, Enzyme, chemistry, Drug Discovery, Molecular Medicine, Imidazole, Potency, Molecular Biology
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5
المؤلفون: Peter J. Gillies, C. Anne Higley, Pennio Pennev, Alexander L. Johnson, Candy S. Robinson, Richard G. Wilde, Thomas P. Maduskuie, Jeffrey T. Billheimer, Ruth R. Wexler
المصدر: Journal of Medicinal Chemistry. 37:3511-3522
مصطلحات موضوعية: Male, Stereochemistry, Sterol O-acyltransferase, Thio, Structure-Activity Relationship, In vivo, Cricetinae, Drug Discovery, Animals, Urea, Structure–activity relationship, IC50, chemistry.chemical_classification, Mesocricetus, Molecular Structure, biology, Anticholesteremic Agents, Imidazoles, In vitro, Rats, Cholesterol, Enzyme, Biochemistry, chemistry, Enzyme inhibitor, Microsomes, Liver, biology.protein, Molecular Medicine, Sterol O-Acyltransferase
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6
المؤلفون: Ruth R. Wexler, Jeffrey T. Billheimer, Peter J. Gillies, E. S. Shimshick, Sandra J. Germain, H. S. Iii Kezar, C. A. Higley, Richard G. Wilde, Thomas P. Maduskuie
المصدر: ChemInform. 26
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Enzyme, Biochemistry, Chemistry, Stereochemistry, Sterol O-acyltransferase, Imidazole, General Medicine
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7
المؤلفون: Frank W. Lee, Chii-Ming Lai, C. Edwin Garner, Carl P. Decicco, Jianrong Lin, Kevin Jones, Shimoga R. Prakash, Huey-Shin Shen, Mingxin Qian, Eric Solon, Stephen E. Mercer, Gang Luo, Lian-Shen Gan, Thomas P. Maduskuie, Jingwu Duan
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 36(6)
مصطلحات موضوعية: Male, medicine.medical_specialty, Pharmaceutical Science, Biology, Transfection, Cell Line, Excretion, Rats, Sprague-Dawley, Mice, Dogs, In vivo, Internal medicine, medicine, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Intestinal Mucosa, P-glycoprotein, Pharmacology, chemistry.chemical_classification, Mice, Inbred BALB C, In vitro, Small intestine, Rats, Endocrinology, medicine.anatomical_structure, Enzyme, chemistry, Caco-2, Cell culture, embryonic structures, biology.protein, Quinolines, Female, Caco-2 Cells
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8
المؤلفون: Howard S. Shapiro, Victor Giulio Matassa, David Aharony, David W. Snyder, Barrie Hesp, Thomas P. Maduskuie, Richard A. Keith, Robert D. Krell
المصدر: Journal of Medicinal Chemistry. 33:1781-1790
مصطلحات موضوعية: Indole test, Indazoles, Indoles, Bicyclic molecule, Stereochemistry, medicine.drug_class, Guinea Pigs, Substituent, Carboxamide, In Vitro Techniques, Dissociation constant, Guinea pig, Structure-Activity Relationship, chemistry.chemical_compound, Dyspnea, chemistry, Amide, Drug Discovery, medicine, Animals, Pyrazoles, Molecular Medicine, SRS-A, Muscle Contraction, Methyl group
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9
المؤلفون: Yuzhong Deng, Thomas P. Maduskuie, Jingwu Duan, Maryanne B. Covington, Bernice Brogdon, Mingxin Qian, Michael J Fossler, Kris Vaddi, C. Edwin Garner, James M. Trzaskos, Jing-Tao Wu, Richard Q. Liu, Stephen A. Bai, Robert Newton, David D. Christ, Carl P. Decicco
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 35(10)
مصطلحات موضوعية: Adult, Lipopolysaccharides, Male, Pan troglodytes, Anti-Inflammatory Agents, Pharmaceutical Science, Arthritis, Phases of clinical research, Pharmacology, Biology, ADAM17 Protein, Mice, Dogs, Pharmacokinetics, Double-Blind Method, Synovial Fluid, medicine, Animals, Humans, chemistry.chemical_classification, Mice, Inbred BALB C, Tumor Necrosis Factor-alpha, Rats, Inbred Strains, medicine.disease, Arthritis, Experimental, Endotoxemia, Bioavailability, Rats, ADAM Proteins, Enzyme, chemistry, Pharmacodynamics, Quinolines, Tumor necrosis factor alpha, Female, Ex vivo
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10
المؤلفون: Qian Wang, Kris Vaddi, Wenqing Yao, Song Mei, Chu-Biao Xue, Kamna Katiyar, Yun-Long Li, Maryanne B. Covington, Peggy Scherle, Brent Douty, Niu Shin, Holly Koblish, Sybil O'Connor, Sharon Diamond-Fosbenner, Yu Li, Andrew P. Combs, Eddy W. Yue, Reid Huber, Xin He, Leslie Hall, Kathy Wang, Patricia Feldman, Robert C. Newton, Yanlong Li, Swamy Yeleswaram, Thomas P. Maduskuie
المصدر: Cancer Research. 75:2671-2671
مصطلحات موضوعية: Cancer Research, Chemistry, Kinase, breakpoint cluster region, medicine.anatomical_structure, Oncology, Second messenger system, medicine, Cancer research, Signal transduction, Idelalisib, Protein kinase A, PI3K/AKT/mTOR pathway, B cell
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11
المؤلفون: Jingwu Duan, Stephen E. Mercer, Krishna Vaddi, Carl P. Decicco, Mingxin Qian, Cathy Harris, Maria D. Ribadeneria, Bryan W. King, Thomas P. Maduskuie, Rui-Qin Liu, James M. Trzaskos, Maryanne B. Covington, John L. Gilmore, Robert C. Newton
المصدر: Bioorganicmedicinal chemistry letters. 16(10)
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, ADAM17 Protein, Biochemistry, Chemical synthesis, Cell Line, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Protease Inhibitors, Molecular Biology, Whole blood, chemistry.chemical_classification, Hydroxamic acid, biology, Organic Chemistry, Stereoisomerism, In vitro, ADAM Proteins, Enzyme, chemistry, Enzyme inhibitor, Cyclization, biology.protein, Molecular Medicine
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12
المؤلفون: Mercy Ramanjulu, Ann Y. Liauw, Thomas P. Maduskuie, Jere E. Meredith, Jeffrey N. Higaki, Robert Zaczek, Barbara Cordell, Arthur H. Roach, Dietmar A. Seiffert, David Robertson, Padmaja Kasireddy-Polam, Lorin A. Thompson, Marcie A. Glicksman, Stephen E. Mercer, Andrew P. Combs, Richard E. Olson, Rui-Qin Liu
المصدر: Bioorganicmedicinal chemistry letters. 16(9)
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Cell Line, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, In vivo, Alzheimer Disease, Drug Discovery, Endopeptidases, medicine, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Caprolactam, Humans, Enzyme Inhibitors, Molecular Biology, biology, Organic Chemistry, Stereoisomerism, Succinates, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Lactam, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase
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13
المؤلفون: Pancras C. Wong, Pieter F. W. Stouten, Matthew R. Wright, Karen A. Rossi, Richard S. Alexander, Robert A. Galemmo, Robert M. Knabb, Thomas P. Maduskuie, Bruce J. Aungst, Ruth R. Wexler, Brian L. Wells, Celia Dominguez
المصدر: Bioorganicmedicinal chemistry letters. 10(3)
مصطلحات موضوعية: Models, Molecular, Serine Proteinase Inhibitors, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Ligands, Biochemistry, Chemical synthesis, Amidine, chemistry.chemical_compound, Thrombin, In vivo, Drug Discovery, medicine, Animals, Urea, Molecular Biology, biology, Chemistry, Organic Chemistry, Ligand (biochemistry), Enzyme inhibitor, biology.protein, Molecular Medicine, Rabbits, medicine.drug, Factor Xa Inhibitors
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14
المصدر: Journal of medicinal chemistry. 41(1)
مصطلحات موضوعية: Models, Molecular, Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Molecular model, Stereochemistry, Protein Conformation, Factor Xa Inhibitor, Amidines, Carboxylic Acids, Crystallography, X-Ray, Chemical synthesis, Mass Spectrometry, Thrombin, Drug Discovery, medicine, Nuclear Magnetic Resonance, Biomolecular, Binding Sites, biology, Molecular Structure, Chemistry, Rational design, Anticoagulants, Small molecule, Kinetics, Coagulation, Enzyme inhibitor, Drug Design, Factor Xa, biology.protein, Molecular Medicine, Dimerization, medicine.drug, Factor Xa Inhibitors
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15
المؤلفون: Edward Vacek, R D Krell, Peter R. Bernstein, Laura A. Cronk, Thomas P. Maduskuie, V. G. Matassa, Ying K. Yee, Howard S. Shapiro, Frederick J. Brown, David W. Snyder
المصدر: Journal of medicinal chemistry. 33(9)
مصطلحات موضوعية: Indoles, Chemical Phenomena, medicine.drug_class, Stereochemistry, Guinea Pigs, Phenylcarbamates, Carboxamide, Thiophenes, Ring (chemistry), Tosyl Compounds, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Receptors, Immunologic, Imide, Receptors, Leukotriene, Sulfonamides, Bicyclic molecule, Chemistry, Hydrogen bond, Muscle, Smooth, Dissociation constant, Intramolecular force, Indoline, Molecular Medicine, Benzimidazoles, SRS-A
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16
المؤلفون: Willard Ak, Frederick J. Brown, Peter R. Bernstein, Howard S. Shapiro, Thomas P. Maduskuie, Dosset Dl, K. C. Hebbel, Edward Vacek, Ying K. Yee, Laura A. Cronk
المصدر: Journal of Medicinal Chemistry. 32:807-826
مصطلحات موضوعية: Leukotriene D4, Chemical Phenomena, Nitrogen, Stereochemistry, Guinea Pigs, Hydroxylation, Benzoates, Methylation, Structure-Activity Relationship, chemistry.chemical_compound, Phenols, In vivo, Drug Discovery, Animals, Moiety, Leukotriene Antagonists, Chemistry, Antagonist, Acetophenones, Ketones, Trachea, Chromones, Molecular Medicine, Biological Assay, SRS-A, Muscle Contraction