المؤلفون: Michael R. Drumm, Wenxia Wang, Thomas K. Sears, Kirsten Bell-Burdett, Rodrigo Javier, Kristen Y. Cotton, Brynna Webb, Kayla Byrne, Dusten Unruh, Vineeth Thirunavu, Jordain Walshon, Alicia Steffens, Kathleen McCortney, Rimas V. Lukas, Joanna J. Phillips, Esraa Mohamed, John D. Finan, Lucas Santana-Santos, Amy B. Heimberger, Colin K. Franz, Jonathan Kurz, Jessica W. Templer, Geoffrey T. Swanson, Craig Horbinski

المصدر: The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)

مصطلحات موضوعية: Neuroscience, Oncology, Medicine

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1558-8238

URL الوصول: https://doaj.org/article/7fc24269c7a640d7a68744806d41d5ca

المؤلفون: Maryam Moshref, Maria Questa, Veronica Lopez-Cervantes, Thomas K. Sears, Rachel L. Greathouse, Charles K. Crawford, Amir Kol

المصدر: Frontiers in Veterinary Science, Vol 8 (2021)

مصطلحات موضوعية: canine iPSC, embryonic fibroblasts, cellular reprogramming, HDAC inhibitors, ATAC sequencing, Veterinary medicine, SF600-1100

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fvets.2021.716570/full; https://doaj.org/toc/2297-1769

URL الوصول: https://doaj.org/article/90609849fbdc4ee7875e6c86560f2744

المؤلفون: Michael Drumm, Wenxia Wang, Thomas K. Sears, Kirsten Bell-Burdett, Rodrigo Javier, Kristen Y. Cotton, Brynna T. Webb, Kayla T. Byrne, Dusten Unruh, Vineeth Thirunavu, Jordain Walshon, Alicia Steffens, Kathleen McCortney, Rimas V. Lukas, Joanna J. Phillips, Esraa Mohamed, John D. Finan, Lucas Santana-Santos, Amy B. Heimberger, Colin K. Franz, Jonathan E. Kurz, Jessica W. Templer, Geoffrey T. Swanson, Craig Horbinski

المصدر: The Journal of clinical investigation, vol 133, iss 12

مصطلحات موضوعية: Adult, Epilepsy, Brain Neoplasms, Immunology, Neurosciences, General Medicine, Glioma, Neurodegenerative, Brain cancer, Medical and Health Sciences, Isocitrate Dehydrogenase, Brain Disorders, Neoplasm Recurrence, Rare Diseases, Local, Oncology, Seizures, Mutation, Neurological, Disease Progression, Humans, Neuroscience, Cancer

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125e96da5b909fb444616a484ece9056
https://escholarship.org/uc/item/1hp8c54d

المؤلفون: Kevin D. Woolard, Thomas K. Sears, Craig Horbinski

المصدر: Journal of Neuro-Oncology

مصطلحات موضوعية: Cancer Research, Histones, chemistry.chemical_compound, Downregulation and upregulation, Panobinostat, Glioma, Histone methylation, Valproic acid, medicine, Humans, biology, Histone deacetylase (HDAC) inhibition, medicine.disease, Isocitrate Dehydrogenase, Chromatin, Histone Deacetylase Inhibitors, Isocitrate dehydrogenase (IDH) mutant glioma, Histone, Neurology, Oncology, chemistry, Acetylation, Mutation, Laboratory Investigation, Cancer research, biology.protein, Neurology (clinical), Histone deacetylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797c593f5258e50b86894d22921c0972
https://doi.org/10.1007/s11060-021-03829-0

المؤلفون: Thomas K. Sears, Kevin D. Woolard

المصدر: Journal of cancer research and clinical oncology, vol 148, iss 9

مصطلحات موضوعية: Cancer Research, Mutant isocitrate dehydrogenase 1/2, JQ1, Oncology and Carcinogenesis, Bromodomain and extraterminal, Rare Diseases, Clinical Research, Genetics, 2.1 Biological and endogenous factors, Animals, Oncology & Carcinogenesis, Aetiology, Cancer, Bromodomain inhibition, Brain Neoplasms, Neurosciences, Nuclear Proteins, General Medicine, Glioma, Isocitrate Dehydrogenase, Brain Disorders, Brain Cancer, Orphan Drug, Oncology, Mutation, Transcription Factors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce05e997342bf31e6c8b2391c5e6ddbd
https://pubmed.ncbi.nlm.nih.gov/35467128

المؤلفون: Sonia A. Allen, James M. Angelastro, Alexey Tomilov, Thomas K. Sears, Sandipan Datta, Gino A Cortopassi, Kevin D. Woolard, Jose Sandoval

المصدر: Mitochondrion. 50:19-24

مصطلحات موضوعية: 0301 basic medicine, Cell Survival, Antineoplastic Agents, Cetylpyridinium, Pharmacology, Cetylpyridinium chloride, Cell Line, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, AMP-activated protein kinase, medicine, Animals, Humans, Inducer, Protein kinase A, Molecular Biology, biology, Adenylate Kinase, Cancer, AMPK, Glioma, Cell Biology, medicine.disease, Metformin, 030104 developmental biology, chemistry, Mitochondrial biogenesis, Anti-Infective Agents, Local, Hepatocytes, Neoplastic Stem Cells, biology.protein, Molecular Medicine, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c856157e39769c8b3e99f57280c191ac
https://doi.org/10.1016/j.mito.2019.09.009

المؤلفون: Sandipan Datta, Gino A Cortopassi, Kevin D. Woolard, Dmytro Kovalskyy, Alexey Tomilov, Sonia A. Allen, Thomas K. Sears, James M. Angelastro, Robert T. O'Donnell, Jose Sandoval

المصدر: Pharmaceuticals
Pharmaceuticals, Vol 13, Iss 419, p 419 (2020)
Pharmaceuticals (Basel, Switzerland), vol 13, iss 12
Volume 13
Issue 12

مصطلحات موضوعية: 0301 basic medicine, Clinical Trials and Supportive Activities, meclizine, Pharmaceutical Science, lcsh:Medicine, lcsh:RS1-441, Synthetic lethality, mTORC1, Article, lcsh:Pharmacy and materia medica, 03 medical and health sciences, Rare Diseases, 0302 clinical medicine, Stem Cell Research - Nonembryonic - Human, Clinical Research, Drug Discovery, Adjuvant therapy, Medicine, Flunarizine, PI3K/AKT/mTOR pathway, Cancer, Temozolomide, business.industry, Cell growth, lcsh:R, Neurosciences, glioblastoma, Pharmacology and Pharmaceutical Sciences, Stem Cell Research, piperazine, Brain Disorders, Brain Cancer, 030104 developmental biology, 5.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Cancer research, mTOR, Molecular Medicine, Development of treatments and therapeutic interventions, Stem cell, business, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c42b00d1181c1230310114251f461c8
http://europepmc.org/articles/PMC7761300

المؤلفون: Ping K Yip, Liang-Fong Wong, Thomas A Sears, Rafael J Yáñez-Muñoz, Stephen B McMahon

المصدر: PLoS Biology, Vol 8, Iss 6, p e1000399 (2010)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20585375/?tool=EBI; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

URL الوصول: https://doaj.org/article/fbad2dc100a547e1b8b369e16fe7f3b2

المؤلفون: Maryam Moshref (11497987), Maria Questa (11497990), Veronica Lopez-Cervantes (11497993), Thomas K. Sears (11497996), Rachel L. Greathouse (11497999), Charles K. Crawford (8407698), Amir Kol (3848896)

مصطلحات موضوعية: Animal Systematics and Taxonomy, Animal Physiology - Biophysics, Animal Physiology - Cell, Animal Physiology - Systems, Animal Behaviour, Animal Cell and Molecular Biology, Animal Developmental and Reproductive Biology, Animal Immunology, Animal Neurobiology, Animal Physiological Ecology, Animal Structure and Function, Veterinary Anaesthesiology and Intensive Care, Veterinary Anatomy and Physiology, Veterinary Diagnosis and Diagnostics, Veterinary Epidemiology, Veterinary Immunology, Veterinary Medicine, Veterinary Microbiology (excl. Virology), Veterinary Parasitology, Veterinary Pathology, Veterinary Pharmacology, Veterinary Surgery, Veterinary Virology, Veterinary Sciences not elsewhere classified, canine iPSC, embryonic fibroblasts, cellular reprogramming, HDAC inhibitors, ATAC sequencing

Relation: https://figshare.com/articles/dataset/Data_Sheet_1_Panobinostat_Effectively_Increases_Histone_Acetylation_and_Alters_Chromatin_Accessibility_Landscape_in_Canine_Embryonic_Fibroblasts_but_Does_Not_Enhance_Cellular_Reprogramming_docx/16697188

الاتاحة: https://doi.org/10.3389/fvets.2021.716570.s001

المؤلفون: Thomas K. Sears, Sandipan Datta, Kevin D. Woolard, Gino A Cortopassi, James M. Angelastro

المصدر: Biomedicine & Pharmacotherapy, Vol 133, Iss, Pp 111058-(2021)
Biomed Pharmacother

مصطلحات موضوعية: 0301 basic medicine, Oligomycin A, Drug repurposing, Antimycin A, Apoptosis, Mitochondrion, 0302 clinical medicine, Stem Cell Research - Nonembryonic - Human, Tumor Cells, Cultured, Cytotoxicity, Cancer, education.field_of_study, Cultured, Brain Neoplasms, Cancer stem cells, Chemistry, Glioma, Pharmacology and Pharmaceutical Sciences, General Medicine, Trifluoperazine, Tumor Cells, Mitochondria, Gene Expression Regulation, Neoplastic, 5.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, Drug, Development of treatments and therapeutic interventions, Stem cell, Signal Transduction, medicine.drug, endocrine system, Population, Antineoplastic Agents, Therapeutics, RM1-950, Glioblastoma multiforme, Article, Dose-Response Relationship, Pyrvinium pamoate, 03 medical and health sciences, Rare Diseases, Cancer stem cell, Rotenone, Autophagy, medicine, Humans, Chemotherapy, Oncology & Carcinogenesis, education, Pharmacology, Neoplastic, Temozolomide, Dose-Response Relationship, Drug, fungi, Drug Repositioning, Neurosciences, Stem Cell Research, medicine.disease, Brain Disorders, Brain Cancer, Orphan Drug, 030104 developmental biology, Gene Expression Regulation, Cancer research, Therapeutics. Pharmacology, Mitoxantrone

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a414ec034542ddc9f9cf70247c94f0
https://doi.org/10.1016/j.biopha.2020.111058

المؤلفون: Kevin D. Woolard, Thomas K. Sears

المصدر: Cancer Research. 80:1917-1917

مصطلحات موضوعية: Cancer Research, chemistry.chemical_compound, Isocitrate dehydrogenase, Oncology, Chemistry, Cell growth, Panobinostat, Cancer research, Wild type, Cytotoxic T cell, Histone deacetylase, Viability assay, Histone H3 acetylation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::99103657e29cb81beb9e9778c2792dc8
https://doi.org/10.1158/1538-7445.am2020-1917

المؤلفون: James M. Angelastro, Thomas K. Sears

المصدر: Oncotarget, vol 8, iss 48
Oncotarget

مصطلحات موضوعية: 0301 basic medicine, Cellular adaptation, Cellular differentiation, Oncology and Carcinogenesis, Activating transcription factor, Context (language use), Review, Biology, Bioinformatics, 03 medical and health sciences, medicine, ATF5, Transcription factor, protein homeostasis, CP-d/n-ATF5 (cell penetrating peptide dominant negative ATF5), Cancer, medicine.disease, 3. Good health, 030104 developmental biology, Oncology, CP, Cancer research, Unfolded protein response, CP-d/n-ATF5, Tumor growth inhibition, CP (cell penetrating peptide), ER stress

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5a5bccc91c45ae611716fa4709b2f0
https://escholarship.org/uc/item/8pv8h52k

المؤلفون: Kevin D. Woolard, Gino A Cortopassi, Thomas K. Sears, James M. Angelastro, Sandipan Datta

المصدر: Cancer Research. 79:3846-3846

مصطلحات موضوعية: Cancer Research, biology, medicine.disease_cause, chemistry.chemical_compound, Isocitrate dehydrogenase, Histone phosphorylation, Histone, Oncology, chemistry, Panobinostat, medicine, Transcriptional regulation, biology.protein, Cancer research, Epigenetics, Histone deacetylase, Carcinogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7b4a056203d5ab333585cc2cd867c4e7
https://doi.org/10.1158/1538-7445.am2019-3846

المؤلفون: Eike D. Schomburg, Thomas A. Sears, Payam Dibaj, Heinz Steffens

المصدر: Neuroscience Research. 72:155-162

مصطلحات موضوعية: medicine.medical_specialty, Withdrawal reflex, Inflammation, Carrageenan, 03 medical and health sciences, Muscle tone, 0302 clinical medicine, Internal medicine, medicine, Animals, Neurons, Afferent, Muscle, Skeletal, 030304 developmental biology, 0303 health sciences, CATS, Myositis, Reflex, Monosynaptic, business.industry, General Neuroscience, General Medicine, musculoskeletal system, Spinal cord, Nociception, medicine.anatomical_structure, Endocrinology, Spinal Cord, Anesthesia, Cats, Irritants, Excitatory postsynaptic potential, Reflex, medicine.symptom, business, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f981072329f8ac4e3cdcf813bc6ff4
https://doi.org/10.1016/j.neures.2011.10.006

المؤلفون: Patrick Huang, Kevin D. Woolard, Thomas K. Sears, Matthew Settles

المصدر: Cancer Research. 78:202-202

مصطلحات موضوعية: Cancer Research, Glioblastoma cell, Cell signaling, Oncology, Cancer research, Biology, Tumor recurrence

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::16fb96d2c25815e3beb88491a352de3d
https://doi.org/10.1158/1538-7445.am2018-202

المؤلفون: W. Brück, Vladimir A. Maisky, Thomas A. Sears, Payam Dibaj, Heinz Steffens, Eike D. Schomburg, A. I. Pilyavskii

المصدر: Neuroscience Research

مصطلحات موضوعية: Freund's Adjuvant, Withdrawal reflex, Stimulation, Carrageenan, Medicine, Premovement neuronal activity, Animals, Muscle, Skeletal, Myositis, Motor Neurons, Reflex, Abnormal, business.industry, Reflex, Monosynaptic, General Neuroscience, Nociceptors, General Medicine, Myalgia, musculoskeletal system, medicine.disease, Spinal cord, Electric Stimulation, medicine.anatomical_structure, Nociception, Spinal Cord, Freund's adjuvant, Anesthesia, Reflex, Cats, business, Proto-Oncogene Proteins c-fos

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4287a1eaf7b711d5f79734b5d0134ba9
https://pubmed.ncbi.nlm.nih.gov/25615850

المؤلفون: Scott Shurmur, Ralph W. Rayner, Ubeydullah Deligonul, Thomas W. Sears, Thomas R. Porter

المصدر: Catheterization and Cardiovascular Diagnosis. 32:174-177

مصطلحات موضوعية: Atherectomy, Coronary, Male, medicine.medical_specialty, medicine.diagnostic_test, Vascular disease, business.industry, Lumen (anatomy), Coronary Disease, Directional coronary atherectomy, Middle Aged, Coronary Angiography, medicine.disease, Internal medicine, Intravascular ultrasound, Angiography, Occlusion, medicine, Cardiology, Humans, Intracoronary ultrasound, Radiology, Cardiology and Cardiovascular Medicine, business, Ultrasonography, Interventional, Coronary dissection

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d75b4a54fe5a9d3026cac09f70471d0
https://doi.org/10.1002/ccd.1810320214

المؤلفون: Thomas Delbert Sears, Anna S. Dembinski, Rodney R. Miles, John R. Dobson, Bruce M. McManus, Janet E. Wilson, Stanley J. Radio

المصدر: Cardiovascular Pathology. 3:33-41

مصطلحات موضوعية: Pathology, medicine.medical_specialty, medicine.diagnostic_test, Cardiomyopathy, Adipose tissue, Autopsy, General Medicine, Biology, medicine.disease, Pathology and Forensic Medicine, Arrhythmogenic right ventricular dysplasia, Fibrosis, Biopsy, medicine, Distribution (pharmacology), Cardiology and Cardiovascular Medicine, Body mass index

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776cdde73c4d64cf4c41642ae0ac9008
https://doi.org/10.1016/1054-8807(94)90005-1

المؤلفون: Thomas A. Sears, Stephen B. McMahon, Rafael J. Yáñez-Muñoz, Ping K. Yip, Liang-Fong Wong

المصدر: PLoS Biology
PLoS Biology, 8 (6)
PLoS Biology, Vol 8, Iss 6, p e1000399 (2010)

مصطلحات موضوعية: Male, Neurite, QH301-705.5, Central nervous system, Blotting, Western, Genetic Vectors, Neuronal Calcium-Sensor Proteins, Biology, Neuroprotection, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Neuroplasticity, medicine, Animals, Biology (General), Rats, Wistar, Cells, Cultured, Spinal Cord Injuries, 030304 developmental biology, DNA Primers, Neurons, 0303 health sciences, Pyramidal tracts, Neuronal Plasticity, General Immunology and Microbiology, Base Sequence, General Neuroscience, fungi, Lentivirus, Neuropeptides, food and beverages, Anatomy, Faculty of Science\Biological Science, Spinal cord, Immunohistochemistry, Rats, Enzyme Activation, medicine.anatomical_structure, Neuronal calcium sensor-1, nervous system, Corticospinal tract, biology.protein, General Agricultural and Biological Sciences, Neuroscience, Protein Kinases, 030217 neurology & neurosurgery, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6692df8f7ad99ad9a526111d3b5d0329
http://europepmc.org/articles/PMC2889931

المؤلفون: Ernest D, Prentice, Dean L, Antonson, Lyal G, Leibrock, Vikram C, Prabhu, Timothy K, Kelso, Thomas D, Sears

المصدر: IRB. 16(1-2)

مصطلحات موضوعية: Emergency Medical Services, Research Subjects, Critical Illness, Federal Government, Guidelines as Topic, Random Allocation, Humans, Multicenter Studies as Topic, Family, Mental Competency, Third-Party Consent, Brain Diseases, Ethics Committees, United States Food and Drug Administration, Research, Drugs, Investigational, Therapeutic Human Experimentation, Hospitals, United States, Social Control, Formal, Human Experimentation, Brain Injuries, Government, Government Regulation, Wounds and Injuries, United States Dept. of Health and Human Services, Presumed Consent, Ethics Committees, Research

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::fd091a9ef6b4d96486aa569a3a3b23bc
https://pubmed.ncbi.nlm.nih.gov/11652322