المؤلفون: van Breda, Simone G.J., Claessen, Sandra M.H., van Herwijnen, Marcel, Theunissen, Daniël H.J., Jennen, Danyel G.J., de Kok, Theo M.C.M., Kleinjans, Jos C.S.

المساهمون: FP7 project DETECTIVE

المصدر: Toxicology ; volume 393, page 160-170 ; ISSN 0300-483X

الاتاحة: http://dx.doi.org/10.1016/j.tox.2017.11.013
https://api.elsevier.com/content/article/PII:S0300483X17303438?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0300483X17303438?httpAccept=text/plain

المؤلفون: Hebels, Dennie G. A., Jetten, Marlon J. A., Aerts, Hugo J. W., Herwig, Ralf, Theunissen, Daniël H.J., Gaj, Stan, van Delft, Joost H., Kleinjans, Jos C. S.

المصدر: Hebels , D G A , Jetten , M J A , Aerts , H J W , Herwig , R , Theunissen , D H J , Gaj , S , van Delft , J H & Kleinjans , J C S 2014 , ' Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicity ' , Biomarkers in Medicine , vol. 8 , no. 2 , pp. 185-200 . https://doi.org/10.2217/bmm.13.154

مصطلحات موضوعية: "omics databases, biomarker, DILI, diXa, drug-induced liver injury, hepatotoxicity, over-representation analysis, pathway development, text-mining databases, toxicogenomics

وصف الملف: application/pdf

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/891eede8-d3f1-446d-8309-ce7a82afb66e
https://doi.org/10.2217/bmm.13.154
https://cris.maastrichtuniversity.nl/ws/files/65822098/hebels_2014_evaluation_of_database_derived.pdf

المؤلفون: Rieswijk, Linda, Claessen, Sandra M. H., Bekers, Otto, van Herwijnen, Marcel, Theunissen, Daniël H.J., Jennen, Danyel G. J., de Kok, Theodorus, Kleinjans, Jos C. S., van Breda, Simone G. J.

المصدر: Rieswijk , L , Claessen , S M H , Bekers , O , van Herwijnen , M , Theunissen , D H J , Jennen , D G J , de Kok , T , Kleinjans , J C S & van Breda , S G J 2016 , ' Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma ' , Toxicology , vol. 350 , pp. 31-39 . https://doi.org/10.1016/j.tox.2016.05.002

مصطلحات موضوعية: Aflatoxin B1, Epigenomics, Hepatocellular carcinoma, Persistence, Wash-out, PROMOTER HYPERMETHYLATION, DIFFERENTIAL EXPRESSION, CANCER, CYCLIN K, P53 MUTATION, EPIGENETICS, MUTATIONAL HOTSPOT, GENE, CELL-CYCLE, RAB GTPASES

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/dad7a920-5762-4c6b-891f-1b575bf542cf
https://doi.org/10.1016/j.tox.2016.05.002

المؤلفون: van Breda, Simone G. J., Claessen, Sandra M. H., Lo, Ken, van Herwijnen, Marcel, Brauers, Karen J. J., Lisanti, Sofia, Theunissen, Daniël H.J., Jennen, Danyel G. J., Gaj, Stan, de Kok, Theodorus, Kleinjans, Jos C. S.

المصدر: van Breda , S G J , Claessen , S M H , Lo , K , van Herwijnen , M , Brauers , K J J , Lisanti , S , Theunissen , D H J , Jennen , D G J , Gaj , S , de Kok , T & Kleinjans , J C S 2015 , ' Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis ' , Archives of Toxicology , vol. 89 , no. 11 , pp. 1959-1969 . https://doi.org/10.1007/s00204-014-1351-2

مصطلحات موضوعية: Epigenomics, Transcriptomics, Arsenic, Lung cancer, Genetic pathways, Data integration

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/7e0f72c3-5468-4232-85d9-96c23c71eff9
https://doi.org/10.1007/s00204-014-1351-2