المؤلفون: Sulic, Ana-Marija, Roy, Rishi Das, Papagno, Verdiana, Lan, Qiang, Saikkonen, Riikka, Jernvall, Jukka, Thesleff, Irma, Mikkola, Marja L.

المساهمون: Institute of Biotechnology, CAN-PRO - Translational Cancer Medicine Program, Department of Geosciences and Geography, Jukka Jernvall / Principal Investigator, Marja Mikkola / Principal Investigator

مصطلحات موضوعية: Gene-expression, Sonic-hedgehog, Skin appendage, Kappa-b, Enrichment analysis, Unexpected role, Cell-migration, Stem-cells, Differentiation, Ectodysplasin, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: Sulic , A-M , Roy , R D , Papagno , V , Lan , Q , Saikkonen , R , Jernvall , J , Thesleff , I & Mikkola , M L 2023 , ' Transcriptomic landscape of early hair follicle and epidermal development ' , Cell Reports , vol. 42 , no. 6 , 112643 . https://doi.org/10.1016/j.celrep.2023.112643; ORCID: /0000-0002-3276-7279/work/139506596; ORCID: /0000-0002-6915-9146/work/155091548; ORCID: /0000-0002-7765-6767/work/155659587; http://hdl.handle.net/10138/563492; 535efd64-6283-4d4e-ba7b-b649523270a0; 001022609100001

الاتاحة: http://hdl.handle.net/10138/563492

المؤلفون: Malmgren, Barbro, Thesleff, Irma, Dahllöf, Göran, Åström, Eva, Tsilingaridis, Georgios

المساهمون: Institute of Biotechnology

مصطلحات موضوعية: Bisphosphonates, Tooth abnormalities, Enamel, Tooth morphology, Tooth agenesis, Osteogenesis imperfecta, Dentistry

وصف الملف: application/pdf

Relation: Open access funding provided by Karolinska Institute. This study was funded by grants from Stiftelsen Olle Engkvist Byggmastare (Grant Number: 191-449) to B. M., and from Stiftelsen Sunnerdahls Handikappfond (Grant Number: 35/18 and 40/19) to E.A.; Malmgren , B , Thesleff , I , Dahllöf , G , Åström , E & Tsilingaridis , G 2021 , ' Abnormalities in Tooth Formation after Early Bisphosphonate Treatment in Children with Osteogenesis Imperfecta ' , Calcified Tissue International , vol. 109 , no. 2 , pp. 121-131 . https://doi.org/10.1007/s00223-021-00835-2; http://hdl.handle.net/10138/339331; 5ee13aca-8a2b-4c65-b977-278aa84b74dd; 000630827500001

الاتاحة: http://hdl.handle.net/10138/339331

المؤلفون: Juuri, Emma, Saito, Kan, Ahtiainen, Laura, Seidel, Kerstin, Tummers, Mark, Hochedlinger, Konrad, Klein, Ophir D, Thesleff, Irma, Michon, Frederic

المصدر: Developmental Cell. 23(2)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Stem Cell Research - Nonembryonic - Human, Dental/Oral and Craniofacial Disease, Stem Cell Research, Regenerative Medicine, Stem Cell Research - Nonembryonic - Non-Human, 1.1 Normal biological development and functioning, Adaptor Proteins, Signal Transducing, Animals, Biomarkers, Cell Differentiation, Cell Lineage, Cells, Cultured, Epithelial Cells, Fibroblast Growth Factor 8, Gene Expression Regulation, Developmental, Intercellular Signaling Peptides and Proteins, Mice, MicroRNAs, Organ Culture Techniques, SOXB1 Transcription Factors, Stem Cells, Tooth, Medical and Health Sciences, Developmental Biology, Biochemistry and cell biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5pz9319d
https://escholarship.org/content/qt5pz9319d/qt5pz9319d.pdf

المؤلفون: Binder, Martin, Chmielarz, Piotr, Mckinnon, Peter J., Biggs, Leah C., Thesleff, Irma, Balic, Anamaria

المساهمون: Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE

مصطلحات موضوعية: Tooth epithelial stem cells, Stem cell niche, Cervical loop, Hedgehog, Patched, SONIC-HEDGEHOG, PERIPHERAL-NERVES, SHH, EXPRESSION, GENE, PROLIFERATION, MAINTENANCE, HOMEOSTASIS, INHIBITION, APOPTOSIS, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: We thank Prof. Jukka Jernvall for the critical reading of the manuscript and Dr. Benjamin Allen for kindly providing Ptch1-/- MEFs. We also thank Merja Makinen and Raija Savolainen for technical help, and Dr. Iris Hovatta for providing assistance with Western blot analysis. This study was supported by the Suomen Akatemia and Sigrid Juseliuksen Saatio.; Binder , M , Chmielarz , P , Mckinnon , P J , Biggs , L C , Thesleff , I & Balic , A 2019 , ' Functionally Distinctive Ptch Receptors Establish Multimodal Hedgehog Signaling in the Tooth Epithelial Stem Cell Niche ' , Stem Cells , vol. 37 , no. 9 , pp. 1238-1248 . https://doi.org/10.1002/stem.3042; ORCID: /0000-0001-6796-1197/work/66366838; ORCID: /0000-0002-4990-8664/work/75466237; http://hdl.handle.net/10138/326349; 199c2256-9f70-42ba-8ba3-e6cd9cf7c991; 000482967700012

الاتاحة: http://hdl.handle.net/10138/326349

المؤلفون: Imhof, Thomas, Balic, Anamaria, Heilig, Juliane, Chiquet-Ehrismann, Ruth, Chiquet, Matthias, Niehoff, Anja, Brachvogel, Bent, Thesleff, Irma, Koch, Manuel

المساهمون: Institute of Biotechnology

مصطلحات موضوعية: tenascin-W, tenascin-N, bone, remodeling, periodontal ligament, pain, tenascin, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: This work was supported by grants from the DFG (A2, CRC829; B2, D1, M1 FOR2722) and Koln Fortune to MK. the DFG (A2, CRC829; B2, D1, M1 FOR2722) and Koln Fortune to MK.; Imhof , T , Balic , A , Heilig , J , Chiquet-Ehrismann , R , Chiquet , M , Niehoff , A , Brachvogel , B , Thesleff , I & Koch , M 2021 , ' Pivotal Role of Tenascin-W (-N) in Postnatal Incisor Growth and Periodontal Ligament Remodeling ' , Frontiers in Immunology , vol. 11 , 608223 . https://doi.org/10.3389/fimmu.2020.608223; ORCID: /0000-0001-6796-1197/work/98919948; http://hdl.handle.net/10138/333478; a86a7ce3-0ca5-4ba2-82f2-a2ce27be4e59; 000614762900001

الاتاحة: http://hdl.handle.net/10138/333478

المؤلفون: Aonuma, Tomo, Tamamura, Nagato, Fukunaga, Tomohiro, Sakai, Yuichi, Takeshita, Nobuo, Shigemi, Shohei, Yamashiro, Takashi, Thesleff, Irma, Takano-Yamamoto, Teruko

المساهمون: Institute of Biotechnology

مصطلحات موضوعية: Dentistry, Genetics, developmental biology, physiology

وصف الملف: application/pdf

Relation: Aonuma , T , Tamamura , N , Fukunaga , T , Sakai , Y , Takeshita , N , Shigemi , S , Yamashiro , T , Thesleff , I & Takano-Yamamoto , T 2020 , ' Delayed tooth movement in Runx2+/− mice associated with mTORC2 in stretch-induced bone formation ' , Bone Reports , vol. 12 , 100285 . https://doi.org/10.1016/j.bonr.2020.100285; RIS: urn:DF63B3843AEF2CFBC44FE14899389F5C; http://hdl.handle.net/10138/328305; 50e88c6e-f8dd-4ca1-85fd-9e930ca40bba; 85085480745; 000639913300053

الاتاحة: http://hdl.handle.net/10138/328305

المؤلفون: Malmgren, Barbro, Thesleff, Irma, Dahllöf, Göran, Åström, Eva, Tsilingaridis, Georgios

المساهمون: Stiftelsen Olle Engkvist Byggmästare, Stiftelsen Sunnerdahls Handikappfond, Karolinska Institute

المصدر: Calcified Tissue International ; volume 109, issue 2, page 121-131 ; ISSN 0171-967X 1432-0827

الاتاحة: http://dx.doi.org/10.1007/s00223-021-00835-2
https://link.springer.com/content/pdf/10.1007/s00223-021-00835-2.pdf
https://link.springer.com/article/10.1007/s00223-021-00835-2/fulltext.html

المؤلفون: Kassai, Yoshiaki, Munne, Pauliina, Hotta, Yuhei, Penttilä, Enni, Kavanagh, Kathryn, Ohbayashi, Norihiko, Takada, Shinji, Thesleff, Irma, Jernvall, Jukka, Itoh, Nobuyuki

المصدر: Science, 2005 Sep . 309(5743), 2067-2070.

URL الوصول: https://www.jstor.org/stable/3843671

المؤلفون: Wang, Xiu-Ping, Suomalainen, Marika, Felszeghy, Szabolcs, Zelarayan, Laura C, Alonso, Maria T, Plikus, Maksim V, Maas, Richard L, Chuong, Cheng-Ming, Schimmang, Thomas, Thesleff, Irma

المصدر: PLOS Biology. 5(6)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Dentistry, Medical Biotechnology, Dental/Oral and Craniofacial Disease, Regenerative Medicine, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, 1.1 Normal biological development and functioning, Generic health relevance, Activins, Animals, Bone Morphogenetic Proteins, Cell Proliferation, Fibroblast Growth Factors, Follistatin, Gene Expression Regulation, Developmental, Gene Regulatory Networks, In Situ Hybridization, Incisor, Mice, Mice, Transgenic, Models, Biological, Signal Transduction, Stem Cells, Tissue Culture Techniques, Agricultural and Veterinary Sciences, Medical and Health Sciences, Developmental Biology, Agricultural, veterinary and food sciences, Biological sciences, Biomedical and clinical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/80x5m4zg
https://escholarship.org/content/qt80x5m4zg/qt80x5m4zg.pdf

المؤلفون: Harada, Hidemitsu, Kettunen, Päivi, Jung, Han-Sung, Mustonen, Tuija, Wang, Y. Alan, Thesleff, Irma

المصدر: The Journal of Cell Biology, 1999 Oct 01. 147(1), 105-120.

URL الوصول: https://www.jstor.org/stable/1619494

المؤلفون: Srivastava, Anand K., Pispa, Johanna, Hartung, Andrew J., Du, Yangzhu, Ezer, Sini, Jenks, Ted, Shimada, Tokihiko, Pekkanen, Maija, Mikkola, Marja L., Thesleff, Irma, Kere, Juha, Schlessinger, David

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 1997 Nov . 94(24), 13069-13074.

URL الوصول: https://www.jstor.org/stable/43542

المؤلفون: Binder, Martin, Biggs, Leah C., Kronenberg, Mark S., Schneider, Pascal, Thesleff, Irma, Balic, Anamaria

المساهمون: Institute of Biotechnology, Research Programs Unit, University of Helsinki, Helsinki Institute of Life Science HiLIFE, STEMM - Stem Cells and Metabolism Research Program, Faculty of Medicine

مصطلحات موضوعية: Genetics, developmental biology, physiology

وصف الملف: application/pdf

Relation: Binder , M , Biggs , L C , Kronenberg , M S , Schneider , P , Thesleff , I & Balic , A 2020 , ' Novel strategies for expansion of tooth epithelial stem cells and ameloblast generation ' , Scientific Reports , vol. 10 , no. 1 , 4963 . https://doi.org/10.1038/s41598-020-60708-w; RIS: urn:FA8ADCCEED4DBEDF88ABC3D967843DDF; RIS: Binder2020; ORCID: /0000-0001-6796-1197/work/76332662; ORCID: /0000-0002-4990-8664/work/76332903; http://hdl.handle.net/10138/316911; 37487a9f-10fb-472f-8424-988a8fd209d2; 000563454700012

الاتاحة: http://hdl.handle.net/10138/316911

المؤلفون: Saito, Kan, Michon, Frederic, Yamada, Aya, Inuzuka, Hiroyuki, Yamaguchi, Satoko, Fukumoto, Emiko, Yoshizaki, Keigo, Nakamura, Takashi, Arakaki, Makiko, Chiba, Yuta, Ishikawa, Masaki, Okano, Hideyuki, Thesleff, Irma, Fukumoto, Satoshi

المساهمون: Biosciences, Development and Physiology of the Eye, Institute of Biotechnology

مصطلحات موضوعية: EPITHELIAL-MESENCHYMAL TRANSITION, SONIC HEDGEHOG, CELL INVASION, BETA-CATENIN, HAIR, DIFFERENTIATION, GENE, TOOTH, MUTATIONS, PROMOTES, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: Grants-in-Aid for Scientific Research (KAKENHI) from the Ministry of Education, Culture, Sports, Science and Technology of Japan: (18H03009 to K.S. and 17H01606 to S.F.); Saito , K , Michon , F , Yamada , A , Inuzuka , H , Yamaguchi , S , Fukumoto , E , Yoshizaki , K , Nakamura , T , Arakaki , M , Chiba , Y , Ishikawa , M , Okano , H , Thesleff , I & Fukumoto , S 2020 , ' Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ ' , iScience , vol. 23 , no. 7 , 101329 . https://doi.org/10.1016/j.isci.2020.101329; ORCID: /0000-0003-4305-305X/work/127002267; http://hdl.handle.net/10138/321079; 671ce20a-6929-4d9b-81b4-8684909ce70e; 000553390700003

الاتاحة: http://hdl.handle.net/10138/321079

المؤلفون: Aonuma, Tomo, Tamamura, Nagato, Fukunaga, Tomohiro, Sakai, Yuichi, Takeshita, Nobuo, Shigemi, Shohei, Yamashiro, Takashi, Thesleff, Irma, Takano-Yamamoto, Teruko

المساهمون: Ministry of Education, Culture, Sports, Science and Technology

المصدر: Bone Reports ; volume 12, page 100285 ; ISSN 2352-1872

الاتاحة: http://dx.doi.org/10.1016/j.bonr.2020.100285
https://api.elsevier.com/content/article/PII:S2352187220300450?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2352187220300450?httpAccept=text/plain

المؤلفون: Binder, Martin, Chmielarz, Piotr, Mckinnon, Peter J., Biggs, Leah C., Thesleff, Irma, Balic, Anamaria

المساهمون: Sigrid Juséliuksen Säätiö, Suomen Akatemia

المصدر: Stem Cells ; volume 37, issue 9, page 1238-1248 ; ISSN 1066-5099 1549-4918

الاتاحة: http://dx.doi.org/10.1002/stem.3042
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fstem.3042
https://onlinelibrary.wiley.com/doi/pdf/10.1002/stem.3042
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/stem.3042
https://academic.oup.com/stmcls/article-pdf/37/9/1238/42612627/stmcls_37_9_1238.pdf

المؤلفون: Ahtiainen, Laura, Uski, Isa, Thesleff, Irma, Mikkola, Marja L.

المساهمون: Institute of Biotechnology, Marja Mikkola / Principal Investigator, Visualizing Mechanisms of Development and Disease

مصطلحات موضوعية: ECTODERMAL APPENDAGE MORPHOGENESIS, HAIR FOLLICLE DEVELOPMENT, NF-KAPPA-B, MAMMALIAN TOOTH, ENAMEL KNOT, INCISOR DEVELOPMENT, DENTAL MESENCHYME, SHH EXPRESSION, TABBY MOUSE, ECTODYSPLASIN, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: This work was financially supported by the Academy of Finland, the Jane and Aatos Erkko Foundation, the Sigrid Juselius Foundation, and Biocentrum Helsinki.; Ahtiainen , L , Uski , I , Thesleff , I & Mikkola , M L 2016 , ' Early epithelial signaling center governs tooth budding morphogenesis ' , Journal of Cell Biology , vol. 214 , no. 6 , pp. 753-767 . https://doi.org/10.1083/jcb.201512074; http://hdl.handle.net/10138/174149; 8151cfd5-6c54-42a6-93aa-22031af03848; 84991250580; 000383307200013

الاتاحة: http://hdl.handle.net/10138/174149

المؤلفون: Binder, Martin, Thesleff, Irma, Balic, Anamaria

المصدر: Mechanisms of Development ; volume 145, page S161 ; ISSN 0925-4773

الاتاحة: http://dx.doi.org/10.1016/j.mod.2017.04.461
https://api.elsevier.com/content/article/PII:S0925477317305440?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0925477317305440?httpAccept=text/plain

المؤلفون: Järvinen, Elina, Salazar-Ciudad, Isaac, Birchmeier, Walter, Taketo, Makoto M., Jernvall, Jukka, Thesleff, Irma

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2006 Dec 01. 103(49), 18627-18632.

URL الوصول: https://www.jstor.org/stable/30051164

المؤلفون: Ahtiainen, Laura, Uski, Isa, Thesleff, Irma, Mikkola, Marja L.

المساهمون: Academy of Finland, Jane and Aatos Erkko Foundation, Sigrid Jusélius Foundation

المصدر: Journal of Cell Biology ; volume 214, issue 6, page 753-767 ; ISSN 0021-9525 1540-8140

الاتاحة: http://dx.doi.org/10.1083/jcb.201512074
https://rupress.org/jcb/article-pdf/214/6/753/1595758/jcb_201512074.pdf

المؤلفون: Yang, Zheqiong, Balic, Anamaria, Michon, Frederic, Juuri, Emma, Thesleff, Irma

المساهمون: Academy of Finland, Sigrid Jusélius Foundation, Biocenter Finland International Visitor Program, and National Natural Science Foundation of China

المصدر: Stem Cells ; volume 33, issue 5, page 1670-1681 ; ISSN 1066-5099 1549-4918

الاتاحة: http://dx.doi.org/10.1002/stem.1972
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fstem.1972
https://onlinelibrary.wiley.com/doi/pdf/10.1002/stem.1972
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/stem.1972
https://academic.oup.com/stmcls/article-pdf/33/5/1670/42017792/stmcls_33_5_1670.pdf