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1
المؤلفون: Angela C. Doran, John T. Lazzaro, Ivan Viktorovich Efremov, Allen J. Duplantier, Kenneth G. Kraus, Sheryl A. McCarthy, Douglas K. Spracklin, Lei Zhang, Jiemin Lu, Theresa J. O’Sullivan, Judith A. Siuciak, Ashley N. Hanks, Alan H. Ganong, Bruce N. Rogers, Jessica A. Haas, John Candler, Noha Maklad
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2524-2529
مصطلحات موضوعية: Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Allosteric regulation, Biphenyl derivatives, Administration, Oral, Pharmaceutical Science, Ligands, Receptors, Metabotropic Glutamate, Biochemistry, Inhibitory Concentration 50, Allosteric Regulation, Microsomes, parasitic diseases, Drug Discovery, Humans, Inhibitory concentration 50, Molecular Biology, Oxazolidinones, Molecular Structure, Chemistry, Organic Chemistry, Hit to lead, Models, Chemical, Drug Design, Benzene derivatives, Schizophrenia, Molecular Medicine, Carbamates, Metabotropic glutamate receptor 2, Allosteric Site
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2
المؤلفون: Heinrich J. Schostarez, F. Craig Stevens, John E. Bleasdale, Theresa J. O’Sullivan, Scott D. Larsen, Charlotta Liljebris, Derek Ogg, Barbara J. Palazuk, Tjeerd Barf, Paul D. May
المصدر: Journal of Medicinal Chemistry. 45:598-622
مصطلحات موضوعية: Models, Molecular, Peptidomimetic, Protein tyrosine phosphatase, Deoxyglucose, Crystallography, X-Ray, Receptor tyrosine kinase, Cell Line, Structure-Activity Relationship, Drug Discovery, Insulin, Enzyme Inhibitors, Tyrosine, Protein Tyrosine Phosphatase, Non-Receptor Type 1, biology, Chemistry, GRB10, Molecular Mimicry, Hydrogen Bonding, Dipeptides, IRS2, Molecular Weight, Insulin receptor, Biochemistry, ROR1, biology.protein, Molecular Medicine, Protein Tyrosine Phosphatases, Peptides
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3
المؤلفون: Loretta A. Cipkus-Dubray, Vincent E. Groppi, Heinrich J. Schostarez, Theresa J. O’Sullivan
المصدر: Bioorganic & Medicinal Chemistry Letters. 6:2187-2192
مصطلحات موضوعية: Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Potassium channel, chemistry.chemical_compound, chemistry, Group (periodic table), Drug Discovery, Pinacidil, Molecular Medicine, Moiety, Potassium channel opener, Molecular Biology, Structural class
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4
المؤلفون: Jason K. Dutra, Jayvardhan Pandit, Hong Wang, Mahmoud N. Mansour, Christine E. Oborski, Binqing Wei, Alexander S. McColl, Theresa J. O’Sullivan, Steven W. Goldstein, Steven Capetta, Stephen Noell, Jane M. Withka, Dorff Peter H, Hou Chen, Thomas N. O'Connell, Felix Vajdos, Ivan Viktorovich Efremov, Kris A. Borzilleri
المصدر: Journal of medicinal chemistry. 55(21)
مصطلحات موضوعية: Drug, Models, Molecular, Indoles, Pyrrolidines, Stereochemistry, media_common.quotation_subject, Stereoisomerism, Crystallography, X-Ray, chemistry.chemical_compound, Structure-Activity Relationship, Fragment (logic), Drug Discovery, Structure–activity relationship, Aspartic Acid Endopeptidases, Humans, Spiro Compounds, media_common, chemistry.chemical_classification, Ligand efficiency, Molecular Structure, Chemistry, Enzyme, Biochemistry, Drug Design, β secretase, Molecular Medicine, Amyloid Precursor Protein Secretases, Lead compound
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5
المؤلفون: Karki Kapil Kumar, Theresa J. O’Sullivan, Kenneth J. DiRico, Jason K. Dutra, Evelyn Sibley, Charles E. Nolan, Leslie R. Pustilnik, Chakrapani Subramanyam, Stacey L. Becker, Christine E. Oborski, Andrew J. Hallgren, Christopher J. O’Donnell, Yasong Lu, Bethany L. Kormos, W. Scott McDonald, Kevin Atchison, Michael Eric Green, Dorff Peter H, Steven Capetta, Annie Won, Liming Zhang, Ivan Viktorovich Efremov, Blossom Sneed, Ashley Robshaw, Antonia F. Stepan, Gregory W. Kauffman, David Riddell
المصدر: Journal of medicinal chemistry. 55(7)
مصطلحات موضوعية: Stereochemistry, Administration, Oral, Biological Availability, Stereoisomerism, Cell Line, chemistry.chemical_compound, Bridged Bicyclo Compounds, Mice, Structure-Activity Relationship, Dogs, Pentanes, Drug Discovery, Structure–activity relationship, Phenyl group, Moiety, Animals, Humans, Tissue Distribution, Oxadiazoles, Sulfonamides, biology, Bicyclic molecule, Brain, Rats, Pentane, chemistry, Enzyme inhibitor, biology.protein, Microsomes, Liver, Molecular Medicine, Female, Bioisostere, Amyloid Precursor Protein Secretases
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6
المؤلفون: Stacey L. Becker, Chakrapani Subramanyam, Hao Sun, Blossom Sneed, Ivan Viktorovich Efremov, Karki Kapil Kumar, Antonia F. Stepan, Emily Miller, Kenneth J. DiRico, R. Scott Obach, Kevin Atchison, David Riddell, W. Scott McDonald, Anthony Wood, Charles E. Nolan, Dorff Peter H, Ashley Robshaw, Evelyn Sibley, Theresa J. O’Sullivan, Leslie R. Pustilnik, Christopher J. O’Donnell, Yasong Lu, Andrew J. Hallgren, Steven Capetta, Annie Won, Jason K. Dutra
المصدر: Journal of medicinal chemistry. 54(22)
مصطلحات موضوعية: Stereochemistry, Stereoisomerism, In Vitro Techniques, Oxetane, Crystallography, X-Ray, Cell Line, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Dogs, Ethers, Cyclic, Drug Discovery, Structure–activity relationship, Animals, Humans, Tissue Distribution, Sulfonamides, Amyloid beta-Peptides, CYP3A4, biology, Receptors, Notch, Chemistry, Active site, Brain, Tetrahydropyran, Metabolism, Drug Design, Lipophilicity, biology.protein, Microsomes, Liver, Molecular Medicine, Amyloid Precursor Protein Secretases, Oxidation-Reduction
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7
المؤلفون: Heinrich J. Schostarez, Loretta A. Cipkus-Dubray, Theresa J. O’Sullivan, Vincent E. Groppi
المصدر: ChemInform. 28
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Group (periodic table), Pinacidil, Moiety, Potassium channel opener, General Medicine, Structural class, Medicinal chemistry, Potassium channel
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8
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9
المؤلفون: F.Craig Stevens, Thomas J. Lindberg, John E. Bleasdale, Barbara J. Palazuk, Heinrich J. Schostarez, Theresa J. O'Sullivan, Paul M. Bodnar, Scott D. Larsen
المصدر: Bioorganicmedicinal chemistry letters. 13(5)
مصطلحات موضوعية: Stereochemistry, Peptidomimetic, Phenylalanine, Clinical Biochemistry, Pharmaceutical Science, Peptide, macromolecular substances, Protein tyrosine phosphatase, Deoxyglucose, Biochemistry, src Homology Domains, Drug Discovery, Animals, Humans, Insulin, Tyrosine, Enzyme Inhibitors, Muscle, Skeletal, Molecular Biology, Cells, Cultured, chemistry.chemical_classification, Protein Tyrosine Phosphatase, Non-Receptor Type 1, biology, Organic Chemistry, Molecular Mimicry, Biological activity, Salicylates, Amino acid, Rats, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Protein Tyrosine Phosphatases
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10
المؤلفون: W. Watt, Theresa J. O’Sullivan, Steven P. Tanis, J C Sih, J H Yu, Valerie A. Vaillancourt, M A Connell, Heinrich J. Schostarez, John A. Tucker, Thomas J. Vidmar, M D Meglasson, Michele M. Cudahy, C M Tegley, Scott D. Larsen, F C Stevens, Paul D. May, B R Evans
المصدر: Journal of medicinal chemistry. 44(8)
مصطلحات موضوعية: Blood Glucose, Carboxylic acid, Adipose tissue, Mice, Obese, Pharmacology, Acetates, In Vitro Techniques, Guanidines, Cell Line, Mice, Structure-Activity Relationship, Therapeutic index, In vivo, Drug Discovery, Structure–activity relationship, Animals, Hypoglycemic Agents, Phosphorylation, Creatine Kinase, chemistry.chemical_classification, biology, Membrane Transport Proteins, Biological activity, Muscle, Smooth, Metabolism, Creatine, chemistry, biology.protein, Molecular Medicine, Creatine kinase, Propionates, Carrier Proteins
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11
المؤلفون: E. Jon Jacobsen, Mark A. Mitchell, Susan K. Hendges, Kenneth L. Belonga, Louis L. Skaletzky, Lindsay S. Stelzer, Thomas. J. Lindberg, Edward L. Fritzen, Heinrich J. Schostarez, Theresa J. O'Sullivan, Linda L. Maggiora, Christopher W. Stuchly, Alice L. Laborde, Marc F. Kubicek, Roger A. Poorman, Joan M. Beck, Henry R. Miller, Gary L. Petzold, Pam S. Scott, Scott E. Truesdell, Tanya L. Wallace, John W. Wilks, Christopher Fisher, Linda V. Goodman, Paul S. Kaytes, Stephen R. Ledbetter, Elaine A. Powers, Gabriel Vogeli, John E. Mott, Catherine M. Trepod, Douglas J. Staples, Eric T. Baldwin, Barry C. Finzel
المصدر: Journal of medicinal chemistry. 42(9)
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Matrix metalloproteinase inhibitor, Stereochemistry, Substituent, Carboxamide, Matrix Metalloproteinase Inhibitors, Fluorescence, chemistry.chemical_compound, Structure-Activity Relationship, Thiadiazoles, Amide, Drug Discovery, medicine, Gelatinase, Structure–activity relationship, Humans, Urea, Protease Inhibitors, Binding Sites, biology, Chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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12Academic Journal
المؤلفون: Antonia F. Stepan, Kapil Karki, W. Scott McDonald, PeterH. Dorff, Jason K. Dutra, Kenneth J. DiRico, Annie Won, Chakrapani Subramanyam, Ivan V. Efremov, Christopher J. OâDonnell, Charles E. Nolan, Stacey L. Becker, Leslie R. Pustilnik, Blossom Sneed, Hao Sun, Yasong Lu, Ashley E. Robshaw, David Riddell, Theresa J. O'Sullivan, Evelyn Sibley
المصدر: Journal of Medicinal Chemistry; Nov2011, Vol. 54 Issue 22, p7772-7783, 12p