المساهمون: Jun Ho Choi, Ju Yeong Kim, Myung-Hee Yi, Myungjun Kim, Tai-Soon Yong, Kim, Ju Young

مصطلحات موضوعية: Airway Remodeling* / drug effects, Animals, Anisakis / physiology, Antibody Specificity / immunology, Biomarkers / metabolism, Bronchial Hyperreactivity / blood, Bronchial Hyperreactivity / complications, Bronchial Hyperreactivity / physiopathology, Cytokines / metabolism, Disease Models, Animal, Inflammation Mediators / metabolism, Lung / drug effects, Lung / physiopathology, Methacholine Chloride / pharmacology, Mice, Inbred BALB C, Pneumonia / blood, Pneumonia / complications, Pneumonia / parasitology, Pneumonia / physiopathology, Th2 Cells / metabolism

Relation: BIOMED RESEARCH INTERNATIONAL; J00315; OAK-2022-04384; OAK-2022-04385; OAK-2022-04386; https://ir.ymlib.yonsei.ac.kr/handle/22282913/190531; T202126148; BIOMED RESEARCH INTERNATIONAL, Vol.2021 : 2522305, 2021-09

الاتاحة: https://ir.ymlib.yonsei.ac.kr/handle/22282913/190531
https://doi.org/10.1155/2021/2522305

المؤلفون: Bohner, P., Chevalier, M.F., Cesson, V., Rodrigues-Dias, S.C., Dartiguenave, F., Burruni, R., Tawadros, T., Valerio, M., Lucca, I., Nardelli-Haefliger, D., Jichlinski, P., Derré, L.

المصدر: Frontiers in immunology, vol. 10, pp. 622

مصطلحات موضوعية: Aged, 80 and over, CD4 Antigens/blood, CD4 Antigens/immunology, CD8 Antigens/blood, CD8 Antigens/immunology, Female, Flow Cytometry, Humans, Kidney Neoplasms/blood, Kidney Neoplasms/immunology, Kidney Neoplasms/pathology, Male, Middle Aged, Prostatic Neoplasms/blood, Prostatic Neoplasms/immunology, Prostatic Neoplasms/pathology, Th2 Cells/immunology, Th2 Cells/metabolism, Th2 Cells/pathology, Urinary Bladder Neoplasms/blood, Urinary Bladder Neoplasms/immunology, Urinary Bladder Neoplasms/pathology, CD4+CD8+ T cells, Th1, Th2, bladder cancer, double positive T cells, kidney cancer, prostate cancer

وصف الملف: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/30984190; info:eu-repo/semantics/altIdentifier/eissn/1664-3224; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_4BC4F69D11588; https://serval.unil.ch/notice/serval:BIB_4BC4F69D1158; https://serval.unil.ch/resource/serval:BIB_4BC4F69D1158.P001/REF.pdf

الاتاحة: https://serval.unil.ch/notice/serval:BIB_4BC4F69D1158
https://doi.org/10.3389/fimmu.2019.00622
https://serval.unil.ch/resource/serval:BIB_4BC4F69D1158.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4BC4F69D11588

المؤلفون: Giang, Nicolas, Mars, Marion, Moreau, Marc, Mejia, Jose, Bouchaud, Grégory, Magnan, Antoine, Michelet, Marine, Ronsin, Brice, Murphy, Geoffrey, Striessnig, Joerg, Guéry, Jean‐charles, Pelletier, Lucette, Savignac, Magali

المساهمون: Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Biologie Intégrative (CBI), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA), ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Service Pneumologie et allergologie pédiatrique CHU Toulouse, Pôle Enfants CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre d'investigation clinique de Toulouse (CIC 1436), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique CHU Toulouse, University of Michigan Ann Arbor, University of Michigan System, Universität Innsbruck Innsbruck, Austrian Science Fund (FWF) : P27809, Foundation for Medical Research : DEQ20180339187, French Society of Allergology : A11013BS.

المصدر: ISSN: 0105-4538.

مصطلحات موضوعية: asthma, calcium channels, Ca(v)1, cytokines, signaling, Th2 lymphocytes, MESH: Animals, MESH: Asthma* / metabolism, MESH: Calcium / metabolism, MESH: Calcium Channels* / metabolism, MESH: Cytokines / metabolism, MESH: Humans, MESH: Inflammation / metabolism, MESH: Mice, MESH: Receptors, Antigen, T-Cell / metabolism, MESH: Th2 Cells / metabolism, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, [SDV]Life Sciences [q-bio], [SDV.IMM]Life Sciences [q-bio]/Immunology

Relation: info:eu-repo/semantics/altIdentifier/pmid/34181765; PUBMED: 34181765; WOS: 000672042900001

الاتاحة: https://hal.inrae.fr/hal-03344050
https://doi.org/10.1111/all.14993

المؤلفون: Yan, D., Wang, H.W., Bowman, R.L., Joyce, J.A.

المصدر: Cell reports, vol. 16, no. 11, pp. 2914-2927

مصطلحات موضوعية: Animals, Carcinogenesis/metabolism, Carcinogenesis/pathology, Cathepsins/genetics, Cathepsins/secretion, Cytokines/pharmacology, Endoribonucleases/metabolism, Gene Deletion, Gene Expression Regulation/drug effects, Macrophages/secretion, Mice, Neoplasm Invasiveness, Phenotype, Protein-Serine-Threonine Kinases/metabolism, STAT3 Transcription Factor/metabolism, STAT6 Transcription Factor/metabolism, Signal Transduction, Th2 Cells/drug effects, Th2 Cells/metabolism, Transcription, Genetic/drug effects, Unfolded Protein Response/drug effects

وصف الملف: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/27626662; info:eu-repo/semantics/altIdentifier/eissn/2211-1247; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_6B0AE4F9D2363; https://serval.unil.ch/notice/serval:BIB_6B0AE4F9D236; https://serval.unil.ch/resource/serval:BIB_6B0AE4F9D236.P001/REF.pdf

الاتاحة: https://serval.unil.ch/notice/serval:BIB_6B0AE4F9D236
https://doi.org/10.1016/j.celrep.2016.08.035
https://serval.unil.ch/resource/serval:BIB_6B0AE4F9D236.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_6B0AE4F9D2363

المساهمون: W. I. Heo, K. E. Lee, J. Y. Hong, M. N. Kim, M. S. Oh, Y. S. Kim, K. W. Kim, K. E. Kim, M. H. Sohn, Son, Myung Hyun, Oh, Mi Seon, Hong, Jung Yeon, Kim, Kyung Won, Kim, Kyu Earn, Kim, Mina, Kim, Yun Seon

مصطلحات موضوعية: Animals, Cytokines/metabolism, Dermatitis, Atopic/immunology, Atopic/metabolism, Atopic/pathology, Contact/immunology, Contact/metabolism, Contact/pathology, Disease Models, Animal, Ear, Interleukin-17/immunology, Mice, Inbred BALB C, Microscopy, Electron, Real-Time Polymerase Chain Reaction, Th2 Cells/metabolism, Water Loss, Insensible/physiology

وصف الملف: 665~671

Relation: CLINICAL AND EXPERIMENTAL DERMATOLOGY; J00549; OAK-2015-01769; https://ir.ymlib.yonsei.ac.kr/handle/22282913/140929; T201503074; CLINICAL AND EXPERIMENTAL DERMATOLOGY, Vol.40(6) : 665-671, 2015

الاتاحة: https://ir.ymlib.yonsei.ac.kr/handle/22282913/140929
https://doi.org/10.1111/ced.12567
http://onlinelibrary.wiley.com/doi/10.1111/ced.12567/abstract

المؤلفون: Navarro, Séverine, Lazzari, Anne, Kanda, Akira, Fleury, Sébastien, Dombrowicz, David, Glaichenhaus, Nicolas, Julia, Valérie

المساهمون: Immunologie des muqueuses et inflammation, Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UniCA), Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA), Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Institut Pasteur de Lille, Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), This work was supported by a grant from the Fondation pour la Recherche Médicale and INSERM. S.N. was supported by a fellowship from the FRM, A.L. was supported by a fellowship from Vaincre la Mucoviscidose, and A.K is supported by a grant from the Agence Nationale de la Recherche (ANR)., We thank Nicolas Guy and the animal facility staff for their excellent animal care, as well as Julie Cazareth for the cell sorting experiments.

المصدر: ISSN: 1933-0219.

مصطلحات موضوعية: Th2, T reg, specific immunotherapy, asthma, immune tolerance, airway inflammation, MESH: Allergens/administration & dosage, MESH: Allergens/immunology, MESH: Disease Models, Animal, MESH: Immunoglobulin E/immunology, MESH: Inducible T-Cell Co-Stimulator Protein/metabolism, MESH: Interleukin-2 Receptor alpha Subunit/metabolism, MESH: Lymphocyte Activation/immunology, MESH: Mice, Transgenic, MESH: Ovalbumin/administration & dosage, MESH: Ovalbumin/immunology, MESH: Protozoan Proteins/immunology, MESH: Animals, MESH: Respiratory Hypersensitivity/immunology, MESH: Respiratory Hypersensitivity/metabolism, MESH: Respiratory Hypersensitivity/therapy, MESH: T-Lymphocytes, Regulatory/immunology, Regulatory/metabolism, MESH: Th2 Cells/immunology, MESH: Th2 Cells/metabolism, MESH: Antigens, Protozoan/immunology

Relation: info:eu-repo/semantics/altIdentifier/pmid/25425267; PUBMED: 25425267; PUBMEDCENTRAL: PMC5410219

الاتاحة: https://inserm.hal.science/inserm-01116372
https://inserm.hal.science/inserm-01116372v1/document
https://inserm.hal.science/inserm-01116372v1/file/Navarro-Muc%20Immunol.pdf
https://doi.org/10.1038/mi.2014.115

المؤلفون: Pelletier, Lucette, Moreau, Marc

المساهمون: Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de biologie du développement (CBD), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 0167-4889 ; Biochimica et Biophysica Acta - Molecular Cell Research ; https://ut3-toulouseinp.hal.science/hal-03652093 ; Biochimica et Biophysica Acta - Molecular Cell Research, 2021, 1868 (6), pp.118996. ⟨10.1016/j.bbamcr.2021.118996⟩.

مصطلحات موضوعية: Ca(2+) toolkit, Ca(V)1 channels, Gene transcription, Neural induction, Th2 function, MESH: Animals, MESH: Calcium / metabolism, MESH: Xenopus Proteins / genetics, MESH: Xenopus Proteins / metabolism, MESH: Xenopus laevis / growth & development, MESH: Xenopus laevis / metabolism, MESH: Calcium Channels, L-Type / genetics, L-Type / metabolism, MESH: Calcium Signaling, MESH: Ectoderm / growth & development, MESH: Ectoderm / metabolism, MESH: Gene Expression Regulation, Developmental, MESH: Th2 Cells / metabolism, MESH: Transcription, Genetic, [SDV]Life Sciences [q-bio], [SDV.IMM]Life Sciences [q-bio]/Immunology

Relation: info:eu-repo/semantics/altIdentifier/pmid/33675852; PUBMED: 33675852

الاتاحة: https://ut3-toulouseinp.hal.science/hal-03652093
https://doi.org/10.1016/j.bbamcr.2021.118996

المساهمون: College of Medicine, Dept. of Life Science, Paula Licona-Lim처n, Lark Kyun Kim, Noah W Palm, Richard A Flavell, Kim, Lark Kyun

مصطلحات موضوعية: Adaptive Immunity/immunology, Animals, Antigens, Helminth/immunology, Cytokines/immunology, Cytokines/metabolism, Humans, Hypersensitivity/immunology, Hypersensitivity/metabolism, Immunity, Innate/immunology, Lymphocytes/immunology, Lymphocytes/metabolism, Models, Immunological, Th2 Cells/immunology, Th2 Cells/metabolism

Relation: NATURE IMMUNOLOGY; J03205; OAK-2013-03461; https://ir.ymlib.yonsei.ac.kr/handle/22282913/158502; http://www.nature.com/articles/ni.2617; T201306253; NATURE IMMUNOLOGY, Vol.14(6) : 536-542, 2013

الاتاحة: https://ir.ymlib.yonsei.ac.kr/handle/22282913/158502
https://doi.org/10.1038/ni.2617
http://www.nature.com/articles/ni.2617

المساهمون: In Duk Jung, Hye Young Kim, Jin Wook Park, Chang-Min Lee, Kyung Tae Noh, Hyun Kyu Kang, Deok Rim Heo, Su Jung Lee, Kwang Hee Son, Hee-ju Park, Sung Jae Shin, Jong-Hwan Park, Seung-Wook Ryu, Jong Keun Seo, Yeong-Min Park, Shin, Sung Jae

المصدر: T201203104.pdf

مصطلحات موضوعية: Animals, Asthma/drug therapy, Asthma/immunology, Asthma/metabolism, Bronchoalveolar Lavage Fluid/cytology, Disease Models, Animal, Eosinophils/cytology, Eosinophils/drug effects, Female, GATA3 Transcription Factor/metabolism, Interferon-gamma/metabolism, Interleukin-4/metabolism, Lung/metabolism, Mice, Inbred BALB C, Ovalbumin/immunology, Panax/chemistry, Polysaccharides/chemistry, Polysaccharides/pharmacology, Polysaccharides/therapeutic use, Th2 Cells/drug effects, Th2 Cells/metabolism, Asthma, GATA-3, Rhamnogalacturonan II (RG-II), Thelper 2 (TH2), T-bet

Relation: BMB REPORTS; J00348; OAK-2012-01594; https://ir.ymlib.yonsei.ac.kr/handle/22282913/89767; T201203104; BMB REPORTS, Vol.45(2) : 79-84, 2012

الاتاحة: https://ir.ymlib.yonsei.ac.kr/handle/22282913/89767

المساهمون: Jin-Nyoung Ho, Eun-Ryung Kang, Ho-Geun Yoon, Hyelin Jeon, Woojin Jun, Ronal R. Watson, Jeongmin Lee, Yoon, Ho Geun

المصدر: T201103298.pdf

مصطلحات موضوعية: Animals, Cytokines/drug effects, Cytokines/immunology, Cytokines/metabolism, Disease Progression, Female, Isothiocyanates/pharmacology, Lipid Peroxidation/drug effects, Longevity/drug effects, Longevity/immunology, Mice, Inbred혻C57BL, Murine Acquired Immunodeficiency Syndrome/drug therapy, Murine Acquired Immunodeficiency Syndrome/immunology, Murine Acquired Immunodeficiency Syndrome/metabolism, Oxidative Stress/drug effects, Th1 Cells/drug effects, Th1 Cells/metabolism, Th2 Cells/drug effects, Th2 Cells/metabolism, Thiocyanates/pharmacology, Vitamin E/metabolism, isothiocyanates, murine AIDS, immune dysfunction, oxidative stress, Th1 and Th2 cytokines

وصف الملف: 1234~1239

Relation: BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY; J00328; OAK-2011-01628; https://ir.ymlib.yonsei.ac.kr/handle/22282913/94154; T201103298; BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Vol.75(7) : 1234-1239, 2011

الاتاحة: https://ir.ymlib.yonsei.ac.kr/handle/22282913/94154
https://doi.org/10.1271/bbb.100840J

المساهمون: Choong-Gu Lee, Kyu-Ho Kang, Jae-Seon So, Ho-Keun Kwon, Jun-Seock Son, Min-Kyung Song, Anupama Sahoo, Hwa-Joong Yi, Ki-Chul Hwang, Toshifumi Matsuyama, Katsuyuki Yui, Sin-Hyeog Im, Hwang, Ki Chul

مصطلحات موضوعية: Animals, Cell Line, Tumor, Cyclosporine/pharmacology, Enhancer Elements, Genetic/genetics, Humans, Interferon Regulatory Factors/genetics, Interferon Regulatory Factors/metabolism, Interleukin-10/genetics, Interleukin-10/metabolism, Mice, Inbred C57BL, Knockout, NFATC Transcription Factors/genetics, NFATC Transcription Factors/metabolism, Signal Transduction/genetics, Th1 Cells/metabolism, Th2 Cells/drug effects, Th2 Cells/immunology, Th2 Cells/metabolism, Transcriptional Activation, Th1/Th2 Cells, Cytokines, Transcription factors, Gene regulation, Molecular immunology

وصف الملف: 613~621

Relation: MOLECULAR IMMUNOLOGY; J02259; OAK-2009-01638; https://ir.ymlib.yonsei.ac.kr/handle/22282913/104978; http://www.sciencedirect.com/science/article/pii/S0161589008003313; T200903385; MOLECULAR IMMUNOLOGY, Vol.46(4) : 613-621, 2009

الاتاحة: https://ir.ymlib.yonsei.ac.kr/handle/22282913/104978
https://doi.org/10.1016/j.molimm.2008.07.037
http://www.sciencedirect.com/science/article/pii/S0161589008003313

المساهمون: Jung Won Park, Hyun Jung Min, Jung Ho Sohn, Joo Young Kim, Jeong Ho Hong, Kirsten S. Sigrist, Laurie H. Glimcher, Eun Sook Hwang, Kim, Joo Young, Park, Jung Won, Sohn, Jung Ho

مصطلحات موضوعية: Allergens/immunology, Animals, Asthma/immunology, Asthma/metabolism, Bronchoalveolar Lavage Fluid/chemistry, Bronchoalveolar Lavage Fluid/immunology, Cytokines/drug effects, Cytokines/immunology, Cytokines/metabolism, Disease Models, Animal, Doxycycline/pharmacology, Eosinophilia/immunology, Eosinophilia/metabolism, Goblet Cells/immunology, Goblet Cells/pathology, Immunoglobulin E/blood, Mice, Inbred C57BL, Knockout, Transgenic, Ovalbumin/immunology, T-Box Domain Proteins/genetics, T-Box Domain Proteins/metabolism, T-Lymphocytes/drug effects, T-Lymphocytes/immunology, T-Lymphocytes/metabolism, Th2 Cells/drug effects, Th2 Cells/immunology, Th2 Cells/metabolism

وصف الملف: 479~485

Relation: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY; J01228; OAK-2009-01580; https://ir.ymlib.yonsei.ac.kr/handle/22282913/104920; http://www.sciencedirect.com/science/article/pii/S0091674908018897; T200903336; JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol.123(2) : 479-485, 2009

الاتاحة: https://ir.ymlib.yonsei.ac.kr/handle/22282913/104920
https://doi.org/10.1016/j.jaci.2008.10.035
http://www.sciencedirect.com/science/article/pii/S0091674908018897

المؤلفون: Takamura, Kaoru, Fukuyama, Satoshi, Nagatake, Takahiro, Kim, Dong-Young, Kawamura, Aya, Kawauchi, Hideyuki, Kiyono, Hiroshi

المساهمون: 김동영

مصطلحات موضوعية: Cell Differentiation, Chemokine CCL19/genetics/*metabolism, Chemokine CCL21/genetics/*metabolism, DNA/genetics, Dendritic Cells/cytology, Hypersensitivity/metabolism/pathology, Immunoglobulin E/biosynthesis/immunology, Lymphocyte Count, Lymphoid Tissue/*metabolism, Mice, Inbred BALB C, Rhinitis/*metabolism/pathology, T-Lymphocytes, Regulatory/cytology, Th1 Cells/metabolism, Th2 Cells/metabolism

Relation: J. Immunol. 179, 5897-5906; 0022-1767 (Print); http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17947663; https://hdl.handle.net/10371/11165

الاتاحة: https://hdl.handle.net/10371/11165
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17947663

المؤلفون: Nitsche, Andreas, Zhang, Meixia, Clauss, Theresa, Siegert, Wolfgang, Brune, Kay, Pahl, Andreas

مصطلحات موضوعية: Adult, Humans, Antigens, Female, Male, Middle Aged, RNA, Surface/metabolism, Cyclosporine/pharmacology, Cytokines/biosynthesis, Cytokines/genetics, Fetal Blood/drug effects, Fetal Blood/metabolism, Gene Expression Regulation*/drug effects, Hematopoiesis/drug effects, Inhibitory Concentration 50, Kinetics, Leukocytes/drug effects, Leukocytes/metabolism, Messenger/genetics, Messenger/metabolism, Tetradecanoylphorbol Acetate/pharmacology, Th1 Cells/drug effects, Th1 Cells/metabolism, Th2 Cells/drug effects, Th2 Cells/metabolism, Transcription Factors/genetics, Transcription Factors/metabolism, 610 Medizin, ddc:610

وصف الملف: application/pdf

Relation: http://edoc.rki.de/oa/articles/re2tnbXniEJM/PDF/262rZEo7oSw8Y.pdf; http://edoc.rki.de/176904/610; urn:nbn:de:0257-1006203; http://dx.doi.org/10.25646/535

الاتاحة: http://edoc.rki.de/oa/articles/re2tnbXniEJM/PDF/262rZEo7oSw8Y.pdf
http://edoc.rki.de/176904/610
https://nbn-resolving.org/urn:nbn:de:0257-1006203
https://doi.org/10.1186/1471-2172-8-18
https://doi.org/10.25646/535

المؤلفون: Denise Nardelli-Haefliger, Ilaria Lucca, Massimo Valerio, Patrice Jichlinski, Sonia-Christina Rodrigues-Dias, Laurent Derré, Rodolfo Burruni, Florence Dartiguenave, Thomas Tawadros, Valérie Cesson, Perrine Bohner, Mathieu F. Chevalier

المساهمون: Lausanne University Hospital, Lausanne university hospital

المصدر: Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2019, 10, ⟨10.3389/fimmu.2019.00622⟩
Frontiers in Immunology, Vol 10 (2019)
Frontiers in immunology, vol. 10, pp. 622

مصطلحات موضوعية: Male, lcsh:Immunologic diseases. Allergy, 0301 basic medicine, Aged, Aged, 80 and over, CD4 Antigens/blood, CD4 Antigens/immunology, CD8 Antigens/blood, CD8 Antigens/immunology, Female, Flow Cytometry, Humans, Kidney Neoplasms/blood, Kidney Neoplasms/immunology, Kidney Neoplasms/pathology, Middle Aged, Prostatic Neoplasms/blood, Prostatic Neoplasms/immunology, Prostatic Neoplasms/pathology, Th2 Cells/immunology, Th2 Cells/metabolism, Th2 Cells/pathology, Urinary Bladder Neoplasms/blood, Urinary Bladder Neoplasms/immunology, Urinary Bladder Neoplasms/pathology, CD4+CD8+ T cells, Th1, Th2, bladder cancer, double positive T cells, kidney cancer, prostate cancer, CD8 Antigens, Immunology, Double negative, Context (language use), Biology, Flow cytometry, 03 medical and health sciences, Prostate cancer, Th2 Cells, 0302 clinical medicine, Immune system, medicine, Immunology and Allergy, Cytotoxic T cell, Original Research, medicine.diagnostic_test, Prostatic Neoplasms, Cancer, medicine.disease, Kidney Neoplasms, 3. Good health, 030104 developmental biology, Urinary Bladder Neoplasms, CD4 Antigens, Cancer research, [SDV.IMM]Life Sciences [q-bio]/Immunology, CD4 + CD8 + T cells, lcsh:RC581-607, CD8, 030215 immunology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f34716cc65e1b6de45583df3a05f67e
https://hal.archives-ouvertes.fr/hal-03031633/document

المؤلفون: Micossé, C., von Meyenn, L., Steck, O., Kipfer, E., Adam, C., Simillion, C., Seyed Jafari, S.M., Olah, P., Yawlkar, N., Simon, D., Borradori, L., Kuchen, S., Yerly, D., Homey, B., Conrad, C., Snijder, B., Schmidt, M., Schlapbach, C.

المصدر: Science immunology, vol. 4, no. 31

مصطلحات موضوعية: Cytokines/immunology, Cytokines/metabolism, Dermatitis, Allergic Contact/immunology, Atopic/immunology, Humans, PPAR gamma/immunology, PPAR gamma/metabolism, Psoriasis/immunology, Th2 Cells/cytology, Th2 Cells/immunology, Th2 Cells/metabolism

Relation: info:eu-repo/semantics/altIdentifier/pmid/30658968; info:eu-repo/semantics/altIdentifier/eissn/2470-9468; https://serval.unil.ch/notice/serval:BIB_F1E6E4C16DDC

الاتاحة: https://serval.unil.ch/notice/serval:BIB_F1E6E4C16DDC
https://doi.org/10.1126/sciimmunol.aat5943

المؤلفون: Warren J. Leonard, Nima Rezaei, Kathryn Payne, Isabelle Meyts, Laurent Abel, Cindy S. Ma, Marianne Leruez-Ville, Janet Chou, Alain Hovnanian, Jian-Xin Lin, Simon J. Pelham, Danielle T. Avery, Matthieu Bouaziz, Bethany Pillay, Tanwir Habib, Anne Puel, Sevgi Keles, Juan Li, Isabelle Pellier, Jamel El-Benna, Bernhard Fleckenstein, Ahmet Ozen, Vivien Béziat, Ingrid Müller-Fleckenstein, Damien Chaussabel, Samaneh Zoghi, Yi Wang, Paul Gray, Matthias Titeux, Yoann Zerbib, Talal A. Chatila, Marie-Alexandra Alyanakian, Capucine Picard, Orli Wargon, Ayper Somer, Marie-Olivia Chandesris, Thibaut Leclercq, Ibtihal Benhsaien, Aziz Belkadi, Jean-Laurent Casanova, Romain Lévy, Peng Li, Geetha Rao, Ai Ing Lim, James P. Di Santo, Nico Marr, Sylvie Fraitag, Frédégonde About, Elissa K. Deenick, Bertrand Boisson, Jacinta Bustamante, Mélanie Migaud, Bodo Grimbacher, Aziz Bousfiha, Fatima Ailal, Safa Baris, Antoine Guérin, Stuart G. Tangye, Romain Guery, Ning Du, Vimel Rattina

المساهمون: Imagine - Institut des maladies génétiques (IMAGINE - U1163), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Rockefeller University [New York], National Institutes of Health [Bethesda] (NIH), Garvan Institute of Medical Research [Darlinghurst, Australia], University of New South Wales [Sydney] (UNSW), CHU Ibn Rochd [Casablanca], Université Hassan II [Casablanca] (UH2MC), Service d'Immuno-Hémato-Oncologie Pédiatrique, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Shahid Beheshti University of Medical Sciences [Tehran] (SBUMS), Shahid Beheshti University, Universal Scientific Education and Research Network (USERN), Marmara University [Kadıköy - İstanbul], Necmettin Erbakan University [Konya, Turquie], Immunité Innée, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Harvard Medical School [Boston] (HMS), Boston Children's Hospital, Centre d'infectiologie Necker-Pasteur [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Sidra Medicine, Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Freiburg University Medical Center, Sydney children's hospital, Centre de Référence Déficits Immunitaires Héréditaires (CEREDIH), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Genetic skin diseases : from disease mechanism to therapies (Equipe Inserm U1163), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de pathologie [CHU Necker], Service d'immuno-hématologie pédiatrique [CHU Necker], Laboratoire de Virologie [CHU Necker], Université Paris Descartes - Paris 5 (UPD5), Centre d'étude des Déficits Immunitaires, University Hospitals Leuven [Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Istanbul University, Research Center for Immunodeficiencies [Tehran, Iran], Tehran University of Medical Sciences (TUMS), University of New South Wales [Canberra Campus] (UNSW), Howard Hughes Medical Institute [New York], New York University School of Medicine, NYU System (NYU)-NYU System (NYU)-Rockefeller University [New York]-Columbia University Irving Medical Center (CUIMC), This work was supported by grants from INSERM, Paris Descartes University, Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases (ANR-10-LABX-62-IBEID), the Jeffrey Modell Foundation Translational Research Program, the French National Research Agency (ANR, grant nos. GENCMCD-ANR-11-BSV3–005-01, HGDIFD-ANR-14-CE15-0006-01, NKIR-ANR-13-PDOC-0025-01, and EURO-CMC-ANR-14-RARE-0005-02), and grants awarded under the 'Investissement d’avenir' program (grant no. ANR-10-IAHU-01), the National Institute of Allergy and Infectious Diseases of the NIH (grant nos. U01AI109697 and R01AI127564), the Rockefeller University, the Howard Hughes Medical Institute, the St. Giles Foundation, the Institut Pasteur, and FP7, under grant agreements 305578 (PathCO) and 317057 (HOMIN). We thank the Centre de Recherche Translationnelle (Institut Pasteur) for technical assistance. V.B. is supported by the ANR (grant no. NKIR-ANR-13-PDOC-0025-01). R.L. is supported by the INSERM Ph.D. program (Poste d’Accueil INSERM), a Fulbright grant (Franco-American commission), and a Philippe Foundation scholarship. Y.Z. received the 'médaille d’or du Centre Hospitalier Universitaire d’Amiens.' Y.W. is supported by the French National Agency for Research on AIDS and Viral Hepatitis (ANRS, grant no. 13318). F. About holds a fellowship from Fondation pour la Recherche Médicale (FRM, grant no. FDM20140630671). A.G. is supported by an IFNGPHOX grant (no. ANR13-ISV3-0001-01) from ANR. B.G. was funded by BMBF (German Federal Ministry of Education and Research) grants 01E01303 and 01ZX1306F. I.M. is supported by a klinische onderzoeks-en opleidingsraad (clinical research council) grant from UZ Leuven, a klinisch onderzoeksfonds (clinical research fund) grant from KU Leuven, and an International Mobility Grant from Fonds voor Wetenschappelijk Onderzoek (fund for scientific research) Vlaanderen. C.S.M., E.K.D., and S.G.T. are supported by grants and fellowships from the National Health and Medical Research Council of Australia. C.S.M., P.G., E.K.D., and S.G.T. are members of CIRCA (Clinical Immunogenomics Research Consortia Australia), which is funded by the Office of Health and Medical Research of the NSW Government, the Jeffrey Modell Foundation, and the John Cook Brown Foundation. A.I.L. is a scholar of the Pasteur-Paris University International Ph.D. program and is supported by a Ph.D. International Training Network grant from the European Union’s Seventh Framework Program under grant agreement no. 317057 (HOMIN). T.A.C. was supported by a grant from the National Institute of Allergy and Infectious Diseases of the NIH (5R01AI065617). S.K. was supported by a grant from the Scientific and Technological Research Council of Turkey (1059B191300622). J.-X.L., P.L., N.D., and W.J.L. were supported by the Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH. A.P. was supported by an AP-HP interface contract., We thank the patients and their families for participating in this study. We thank J. E. Darnell and C. Mertens for advice and for providing reagents. We thank the members of the laboratory, especially F. Jabot-Hanin and V. Pedergnana, for their valuable input on linkage analysis, L. Amar, Y. Nemirovskaya, D. Papandrea, E. Anderson, M. Woollett, C. Desvallées, C. Patissier, and M. Corrias for administrative assistance, E. Jouanguy and Y. Itan for helpful discussions, S. Boucherit for clinical data collection, S. Jacques and the Cochin genomics platform for microarray experiments, and N. Goudin and R. Desveaux of the Necker Institute Imaging Facility., Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Garvan Institute of medical research, Immunité Innée - Innate Immunity, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sidra Medicine [Doha, Qatar], Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universitäts Klinikum Freiburg = University Medical Center Freiburg (Uniklinik), Sydney Children's hospital, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Howard Hughes Medical Institute [New York] (HHMI), Howard Hughes Medical Institute (HHMI)-New York University School of Medicine, Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP], Beziat, Vivien, Li, Juan, Lin, Jian-Xin, Ma, Cindy S., Li, Peng, Bousfiha, Aziz, Pellier, Isabelle, Zoghi, Samaneh, Baris, Safa, Keles, Sevgi, Gray, Paul, Du, Ning, Wang, Yi, Zerbib, Yoann, Levy, Romain, Leclercq, Thibaut, About, Fredegonde, Lim, Ai Ing, Rao, Geetha, Payne, Kathryn, Pelham, Simon J., Avery, Danielle T., Deenick, Elissa K., Pillay, Bethany, Chou, Janet, Guery, Romain, Belkadi, Aziz, Guerin, Antoine, Migaud, Melanie, Rattina, Vimel, Ailal, Fatima, Benhsaien, Ibtihal, Bouaziz, Matthieu, Habib, Tanwir, Chaussabel, Damien, Marr, Nico, El-Benna, Jamel, Grimbacher, Bodo, Wargon, Orli, Bustamante, Jacinta, Boisson, Bertrand, Mueller-Fleckenstein, Ingrid, Fleckenstein, Bernhard, Chandesris, Marie-Olivia, Titeux, Matthias, Fraitag, Sylvie, Alyanakian, Marie-Alexandra, Leruez-Ville, Marianne, Picard, Capucine, Meyts, Isabelle, Di Santo, James P., Hovnanian, Alain, Somer, Ayper, Ozen, Ahmet, Rezaei, Nima, Chatila, Talal A., Abel, Laurent, Leonard, Warren J., Tangye, Stuart G., Puel, Anne, Casanova, Jean-Laurent

المصدر: Science Immunology
Science Immunology, American Association for the Advancement of Science, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩
Science Immunology, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩

مصطلحات موضوعية: 0301 basic medicine, INBORN-ERRORS, Immunoglobulin E, MESH: STAT3 Transcription Factor/immunology, Loss of heterozygosity, PRECISION MEDICINE, Transcription (biology), OF-FUNCTION MUTATIONS, STAT3, MESH: Transcription Factors/metabolism, CELL-DIFFERENTIATION, MESH: Th2 Cells/metabolism, MESH: Immunoglobulin E/immunology, MESH: Middle Aged, MESH: Gene Expression Regulation/immunology, Cell Differentiation, General Medicine, MESH: RNA, Messenger/metabolism, MESH: Immunoglobulin E/blood, MESH: Zinc Fingers/genetics, READ ALIGNMENT, MESH: Transcription, Genetic/immunology, MESH: Cell Nucleus/metabolism, MESH: Young Adult, [SDV.IMM]Life Sciences [q-bio]/Immunology, SIGNAL TRANSDUCER, Job Syndrome, MESH: Homozygote, STAT3 Transcription Factor, Cell type, MESH: Lymphocyte Count, MESH: Pedigree, MESH: STAT3 Transcription Factor/genetics, Immunology, Biology, Article, MESH: Job Syndrome/immunology, MESH: Genes, Recessive/genetics, DIFFERENTIAL EXPRESSION, MESH: Genes, Recessive/immunology, MESH: Job Syndrome/blood, MESH: Transcription Factors/genetics, 03 medical and health sciences, MESH: Whole Exome Sequencing, MESH: Exons/genetics, Humans, Transcription factor, Gene, MESH: Adolescent, MESH: Consanguinity, MESH: Humans, CLINICAL-FEATURES, MESH: Th17 Cells/metabolism, MESH: Th17 Cells/immunology, MESH: Cytokines/immunology, MESH: Adult, MESH: Loss of Function Mutation, MESH: Job Syndrome/genetics, MESH: Cell Differentiation/genetics, Molecular biology, MESH: Male, MESH: Th2 Cells/immunology, IL-21 RECEPTOR, 030104 developmental biology, Gene Expression Regulation, MESH: STAT3 Transcription Factor/metabolism, MESH: Promoter Regions, Genetic/genetics, MESH: Cell Differentiation/immunology, T-CELLS, STAT protein, biology.protein, Th17 Cells, MESH: Transcription Factors/immunology, MESH: Cytokines/metabolism, MESH: Female

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a014e03bf19bbdfb4eb205a53e190a3a
https://doi.org/10.1126/sciimmunol.aat4956

المؤلفون: Isabelle Angers, Stephen J. Galli, Adam Flaczyk, Salman T. Qureshi, Lothar Vogel, Ingo Spreitzer, Nicolas Gaudenzio, Sonja Wolfheimer, Stefan Schülke, B. Löschner, Mindy Tsai, Stephan Scheurer, Stefan Vieths

المساهمون: Paul-Ehrlich-Institute - Federal Institute for Vaccines and Biomedicines (EPI), Stanford University, McGill University Health Center [Montreal] (MUHC), German Research Foundation (DFG SCHU2951/1-1, SCHE637/3)

المصدر: Allergy
Allergy, Wiley, 2015, 70 (10), pp.1259-1268. ⟨10.1111/all.12675⟩

مصطلحات موضوعية: Lipopolysaccharides, Lipopolysaccharide, medicine.medical_treatment, Monophosphoryl Lipid A, MESH: Lipopolysaccharides / pharmacology, MESH: Mast Cells / metabolism, MESH: Monocytes / immunology, MESH: Dendritic Cells / drug effects, MESH: Mice, Knockout, Monocytes, MESH: Th2 Cells / immunology, chemistry.chemical_compound, Mice, Immunology and Allergy, MESH: Animals, Mast Cells, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, MESH: Dendritic Cells / metabolism, MESH: Lipid A / analogs & derivatives, Mice, Knockout, B-Lymphocytes, lipopolysaccharide, MESH: Mast Cells / drug effects, MESH: Inflammation Mediators / metabolism, Shock, Septic, MESH: Mast Cells / immunology, 3. Good health, MESH: B-Lymphocytes / immunology, MESH: B-Lymphocytes / metabolism, medicine.anatomical_structure, Lipid A, MESH: Epithelial Cells / metabolism, MESH: Adaptor Proteins, Vesicular Transport / genetics, MESH: Lipopolysaccharides / immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, Cytokines, MESH: Dendritic Cells / immunology, Inflammation Mediators, MESH: Shock, Septic / immunology, MESH: Antigens / immunology, Immunology, monophosphoryl lipid A, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, MESH: Monocytes / drug effects, Immune system, Th2 Cells, adjuvant, MESH: Monocytes / metabolism, MESH: Adaptor Proteins, Vesicular Transport / metabolism, medicine, Animals, Humans, Secretion, MESH: Shock, Septic / metabolism, Antigens, MESH: Mice, MESH: Lipid A / immunology, MESH: Humans, MESH: Th2 Cells / metabolism, Monocyte, Epithelial Cells, Immunotherapy, Dendritic Cells, allergy, MESH: Lipid A / pharmacology, Adaptor Proteins, Vesicular Transport, Disease Models, Animal, chemistry, TLR4, MESH: Cytokines / biosynthesis, Cytokine secretion, MESH: Disease Models, Animal, MESH: Shock, Septic / genetics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead28381c905416c0cb2ec75c2a88011
https://pubmed.ncbi.nlm.nih.gov/26081583

المؤلفون: Schülke, S., Flaczyk, A., Vogel, L., Gaudenzio, N., Angers, I., Löschner, B., Wolfheimer, S., Spreitzer, I., Qureshi, S., Tsai, M., Galli, S., Vieths, S., Scheurer, S.

المساهمون: Paul-Ehrlich-Institute - Federal Institute for Vaccines and Biomedicines (EPI), Stanford University, McGill University Health Center Montreal (MUHC), German Research Foundation (DFG SCHU2951/1-1, SCHE637/3)

المصدر: ISSN: 0105-4538.

مصطلحات موضوعية: adjuvant, allergy, lipopolysaccharide, mast cells, monophosphoryl lipid A, MESH: Adaptor Proteins, Vesicular Transport / genetics, Vesicular Transport / metabolism, MESH: Monocytes / immunology, MESH: Monocytes / metabolism, MESH: Disease Models, Animal, MESH: Shock, Septic / genetics, Septic / immunology, Septic / metabolism, MESH: Antigens / immunology, MESH: Th2 Cells / immunology, MESH: Th2 Cells / metabolism, MESH: B-Lymphocytes / immunology, MESH: Lipopolysaccharides / pharmacology, MESH: B-Lymphocytes / metabolism, MESH: Cytokines / biosynthesis, MESH: Dendritic Cells / drug effects, MESH: Epithelial Cells / metabolism, MESH: Dendritic Cells / immunology, MESH: Dendritic Cells / metabolism, MESH: Humans, MESH: Inflammation Mediators / metabolism, MESH: Lipid A / analogs & derivatives

Relation: info:eu-repo/semantics/altIdentifier/pmid/26081583; hal-03479685; https://ut3-toulouseinp.hal.science/hal-03479685; PUBMED: 26081583

الاتاحة: https://ut3-toulouseinp.hal.science/hal-03479685
https://doi.org/10.1111/all.12675

المؤلفون: Übel, Caroline, Graser, Anna, Koch, Sonja, Rieker, Ralf J., Lehr, Hans A., Müller, Mathias, Finotto, Susetta

المصدر: Scientific Reports
Scientific reports, vol. 4, pp. 5865

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Animals, Asthma/immunology, Asthma/metabolism, Asthma/pathology, CD4-Positive T-Lymphocytes/cytology, CD4-Positive T-Lymphocytes/immunology, Cell Differentiation, Cell Proliferation, Cytokines/metabolism, Disease Models, Animal, Interleukin-17/genetics, Interleukin-17/metabolism, Interleukin-17/pharmacology, Lung/metabolism, Mice, Mice, Inbred BALB C, Mice, Knockout, Ovalbumin/immunology, Phenotype, Recombinant Proteins/biosynthesis, Recombinant Proteins/genetics, Recombinant Proteins/pharmacology, Suppressor of Cytokine Signaling 3 Protein, Suppressor of Cytokine Signaling Proteins/metabolism, T-Lymphocytes, Helper-Inducer/drug effects, T-Lymphocytes, Helper-Inducer/immunology, T-Lymphocytes, Helper-Inducer/metabolism, TYK2 Kinase/genetics, TYK2 Kinase/metabolism, Th17 Cells/cytology, Th17 Cells/immunology, Th17 Cells/metabolism, Th2 Cells/cytology, Th2 Cells/immunology, Th2 Cells/metabolism, Ovalbumin, Suppressor of Cytokine Signaling Proteins, Article, Th2 Cells, Medizinische Fakultät, ddc:610, Lung, TYK2 Kinase, Interleukin-17, T-Lymphocytes, Helper-Inducer, Asthma, Recombinant Proteins, Cytokines, Th17 Cells

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::449d9a72dc831f2aea32846f2e8118b9
https://pubmed.ncbi.nlm.nih.gov/25109392