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المؤلفون: Dawei Xu, Mingkai Dai, Xiaotian Yuan
المصدر: Current Topics in Medicinal Chemistry
مصطلحات موضوعية: Telomerase, Cancer therapy, Telomere Pathway, TERT, Cell, Antineoplastic Agents, Biology, medicine.disease_cause, Malignant transformation, 03 medical and health sciences, 0302 clinical medicine, TERC, Neoplasms, Drug Discovery, medicine, Biomarkers, Tumor, Humans, TERT promoter mutation, 030304 developmental biology, 0303 health sciences, Mutation, Cancer, Telomere Homeostasis, TERRA, General Medicine, Telomere, medicine.disease, Cell biology, Chemistry, medicine.anatomical_structure, Gene transcription, 030220 oncology & carcinogenesis, Cancer cell
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المؤلفون: Jun Qin, Hui-Ju Lee, Ming-Jer Tsai, Chung-Yang Kao, Leiming Wang, Zhou Songyang, Dan Liu, Sophia Y. Tsai, Mafei Xu, Junjie Chen
المصدر: Science Advances
مصطلحات موضوعية: G2 Phase, congenital, hereditary, and neonatal diseases and abnormalities, DNA Repair, DNA damage, DNA repair, Telomere Pathway, Amino Acid Motifs, Biology, COUP Transcription Factor II, Nuclear Receptor Subfamily 2, Group C, Member 2, 03 medical and health sciences, 0302 clinical medicine, Telomere Homeostasis, hemic and lymphatic diseases, Cell Line, Tumor, Proliferating Cell Nuclear Antigen, Humans, RNA, Small Interfering, Molecular Biology, Research Articles, DNA Polymerase III, Cancer, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Fanconi Anemia Complementation Group D2 Protein, nutritional and metabolic diseases, SciAdv r-articles, DNA Repair Pathway, Telomere, Endonucleases, MUS81, Cell biology, DNA-Binding Proteins, Fanconi Anemia, 030220 oncology & carcinogenesis, Mutagenesis, Site-Directed, RNA Interference, Homologous recombination, Protein Binding, Research Article
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المؤلفون: Mykyta Artomov, Hensin Tsao, Ching-Ni Njauw, Michael Shaughnessy
المصدر: J Invest Dermatol
مصطلحات موضوعية: 0301 basic medicine, Telomerase, Skin Neoplasms, DNA Copy Number Variations, Telomere Pathway, DNA Mutational Analysis, Dermatology, Biology, medicine.disease_cause, Biochemistry, Article, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Cell Line, Tumor, Gene expression, medicine, Humans, Promoter Regions, Genetic, Molecular Biology, Melanoma, Regulation of gene expression, Sanger sequencing, Mutation, Telomere Homeostasis, Cell Biology, Prognosis, Molecular biology, Telomere, Gene Expression Regulation, Neoplastic, 030104 developmental biology, 030220 oncology & carcinogenesis, symbols, Neoplasm Recurrence, Local
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المؤلفون: Mingcui Ding, Xiaoran Duan, Wan Wei, Yongli Yang, Xiaoshan Zhou, Hui Zhang, Wei Wang, Xinling Li, Wu Yao, Qi Wang
المصدر: Environmental Toxicology and Pharmacology. 82:103541
مصطلحات موضوعية: Adult, Male, Insecticides, medicine.medical_specialty, Genotype, Health, Toxicology and Mutagenesis, Telomere Pathway, Telomere-Binding Proteins, 010501 environmental sciences, Toxicology, medicine.disease_cause, 01 natural sciences, Shelterin Complex, Restriction fragment, 03 medical and health sciences, chemistry.chemical_compound, Occupational Exposure, Internal medicine, Genetic variation, medicine, Humans, Dimethoate, Omethoate, Telomerase, Gene, 030304 developmental biology, 0105 earth and related environmental sciences, Pharmacology, 0303 health sciences, Polymorphism, Genetic, biology, Hydrogen Peroxide, General Medicine, Middle Aged, Telomere, Endocrinology, chemistry, biology.protein, Female, Oxidative stress
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المؤلفون: Amanda E. Toland
المصدر: Br J Dermatol
مصطلحات موضوعية: Telomere-binding protein, Telomerase, Skin Neoplasms, Telomere Pathway, Melanoma, Telomere-Binding Proteins, Dermatology, Telomere, Biology, medicine.disease, Shelterin Complex, Article, Germline mutation, Mutation, Mutation (genetic algorithm), Cancer research, medicine, Humans, Gene, Germ-Line Mutation
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المؤلفون: Abdul M. Mondal, Xuefeng Liu, Lama Alhawas, Aleksandra Dakic, Zhixu He, Hua Zhou
المصدر: BioMed Research International
BioMed Research International, Vol 2018 (2018)مصطلحات موضوعية: 0301 basic medicine, Telomerase, Article Subject, medicine.drug_class, Carcinogenesis, Telomere Pathway, Cell, Telomere-Binding Proteins, lcsh:Medicine, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Shelterin Complex, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, Cell Line, Tumor, medicine, Humans, Telomerase reverse transcriptase, Cell Proliferation, Ovarian Neoplasms, Gene knockdown, General Immunology and Microbiology, Chemistry, Cell growth, lcsh:R, Histone deacetylase inhibitor, General Medicine, Gene Expression Regulation, Neoplastic, Histone Deacetylase Inhibitors, 030104 developmental biology, medicine.anatomical_structure, Gene Knockdown Techniques, Cancer research, Female, Signal Transduction, Research Article
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المؤلفون: Yafeng Dong, Wei Chen, Yanyan Zhou, Zhixin Wang, Chang Liu, Runchen Miao, Yong Wan, Kai Qu, Xin-Sen Xu, Ling-Qiang Zhang
المصدر: Oncotarget
مصطلحات موضوعية: Senescence, Male, Telomerase, senescence, Carcinoma, Hepatocellular, Telomere Pathway, Genetic Vectors, Mice, Nude, Biology, medicine.disease_cause, telomerase, Transfection, Proto-Oncogene Proteins c-myc, Mice, Cell Line, Tumor, medicine, Animals, Humans, Telomerase reverse transcriptase, HCC, Cellular Senescence, telomere, Forkhead Box Protein M1, Lentivirus, Liver Neoplasms, Forkhead Transcription Factors, Hep G2 Cells, Hydrogen Peroxide, Middle Aged, Prognosis, Molecular biology, Xenograft Model Antitumor Assays, Telomere, MicroRNAs, Oncology, FOXM1, Cancer research, Female, Cisplatin, Carcinogenesis, Cell aging, miR-34a, Research Paper
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المؤلفون: Beatriz Casado, Manuel Martin-Gonzalez, Matías Mayor, Cristina Gómez-Fernández, Maider Ibarrola-Villava, Maria Peña-Chilet, Marta J. Llorca-Cardeñosa, Gloria Ribas, Conrado Martinez-Cadenas, G. Carretero, Ana Lluch
المصدر: European Journal of Cancer. 50:3168-3177
مصطلحات موضوعية: Adult, Male, Cancer Research, Telomerase, Skin Neoplasms, Telomere Pathway, Population, Single-nucleotide polymorphism, Locus (genetics), TERT-CLPTM1 locus, Biology, Polymorphism, Single Nucleotide, susceptibility, cutaneous melanoma, Gene Frequency, Risk Factors, telomere length, medicine, Humans, Genetic Predisposition to Disease, Telomeric Repeat Binding Protein 1, education, Melanoma, education.field_of_study, Membrane Proteins, case–control study, Middle Aged, Telomere, medicine.disease, Molecular biology, Oncology, Case-Control Studies, Cutaneous melanoma, Female
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المؤلفون: Jonathan A. Kropski, James E. Loyd
المصدر: European Respiratory Journal. 46:312-314
مصطلحات موضوعية: Male, Pulmonary and Respiratory Medicine, Genetics, 0303 health sciences, Telomere Pathway, DNA Helicases, Genetic variants, Disease, Biology, medicine.disease, Idiopathic Pulmonary Fibrosis, 3. Good health, Telomere, 03 medical and health sciences, Idiopathic pulmonary fibrosis, 0302 clinical medicine, 030228 respiratory system, Pulmonary fibrosis, medicine, Humans, Female, Gene, Telomere Shortening, Telomere elongation, 030304 developmental biology
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المؤلفون: Alfred I. Neugut, Susan L. Teitelbaum, Mary Beth Terry, Patrick T. Bradshaw, Marilie D. Gammon, Regina M. Santella, Qiao Wang, Jing Shen
المصدر: Breast Cancer Research and Treatment. 134:393-400
مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Telomerase, Telomere Pathway, Telomere-Binding Proteins, Population, Breast Neoplasms, Cell Cycle Proteins, Single-nucleotide polymorphism, Kaplan-Meier Estimate, Biology, Bioinformatics, Polymorphism, Single Nucleotide, Article, Shelterin Complex, Breast cancer, Internal medicine, Genotype, medicine, Humans, Neoplasm Invasiveness, Telomeric Repeat Binding Protein 2, education, Genetic Association Studies, Proportional Hazards Models, Telomere-binding protein, education.field_of_study, Tumor Suppressor Proteins, Sequence Analysis, DNA, Telomere, medicine.disease, Female
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المؤلفون: Ramses Forsyth, Gitte De Boeck, Pancras C.W. Hogendoorn, Marleen Praet
المصدر: The Journal of Pathology. 217:327-344
مصطلحات موضوعية: Telomere-binding protein, Genetics, Telomerase, DNA repair, DNA damage, Telomere Pathway, Biology, Homologous recombination, Cell aging, Pathology and Forensic Medicine, Telomere
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المؤلفون: Louise A. Brinton, M Garcia-Closas, Neonilia Szeszenia-Dabrowska, Beata Peplonska, Douglas A. Richesson, Jolanta Lissowska, Witold Zatonski, Sharon A. Savage, Alicja Bardin-Mikolajczak, Stephen J. Chanock
المصدر: British Journal of Cancer
مصطلحات موضوعية: Adult, haplotype, Cancer Research, Genotype, TERT, Telomere Pathway, Telomere-Binding Proteins, Population, Breast Neoplasms, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Risk Assessment, TERF2, Shelterin Complex, breast cancer, Breast cancer, single nucleotide polymorphism, Risk Factors, Odds Ratio, medicine, Humans, Telomeric Repeat Binding Protein 2, Risk factor, education, Telomerase, Aged, Genetics, telomere, education.field_of_study, Genetic Variation, Nuclear Proteins, RNA-Binding Proteins, Genetics and Genomics, DNA, Neoplasm, Middle Aged, medicine.disease, Telomere, Oncology, Case-Control Studies, TATA Box Binding Protein-Like Proteins, Female, Poland, Carrier Proteins
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المؤلفون: Colin P.N. Dinney, Sharon A. Savage, Peter Kraft, Sarju Ralhan, Massimo Mangino, Marvin D. Peyton, Megan R. Lerner, Patrick Dib, Gurpreet Singh Wander, Narinder K. Mehra, Jennifer Prescott, Jacqueline M. Lane, Praveen Natt, Veryan Codd, Dharambir K. Sanghera, Jackie A. Cooper, Jian Gu, Daniel J. Brackett, Tim D. Spector, Lisa Mirabello, Richa Saxena, Xifeng Wu, Andrew Bjonnes, Immaculata De Vivo, Nilesh J. Samani, Yuanqing Ye, Klelia D. Salpea, Donald Stowell, Cécilia Maubaret, Ka Wah Li, Steve E. Humphries, David J. Hunter
المصدر: Circulation. Cardiovascular genetics. 7(3)
مصطلحات موضوعية: Adult, Male, Telomere Pathway, Population, India, Locus (genetics), Genome-wide association study, Disease, Biology, Polymorphism, Single Nucleotide, Article, Cohort Studies, Young Adult, Asian People, Genetics, Leukocytes, Humans, Genetic Predisposition to Disease, Phosphorylation, education, Casein Kinase II, Genotyping, Allele frequency, Genetics (clinical), Aged, education.field_of_study, Genetic Variation, Middle Aged, Telomere, Religion, Diabetes Mellitus, Type 2, Female, Cardiology and Cardiovascular Medicine, Genome-Wide Association Study
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المؤلفون: Richard J. Gibbons, Stephen Taylor, David Clynes, Matthew Mitson, Clare Jelinska, Csanád Z. Bachrati, Barbara Xella, Helena Ayyub, Douglas R. Higgs
المصدر: PLoS ONE, Vol 9, Iss 3, p e92915 (2014)
PLoS ONEمصطلحات موضوعية: DNA Replication, Chromosome Structure and Function, X-linked Nuclear Protein, Telomerase, Forms of DNA, DNA damage, Telomere Pathway, DNA repair, lcsh:Medicine, Biology, Biochemistry, Chromosomes, Chromatin remodeling, Cell Line, S Phase, Gene Knockout Techniques, Mice, Nucleic Acids, Genetics, Animals, Humans, DNA Breaks, Double-Stranded, lcsh:Science, Embryonic Stem Cells, ATRX, Multidisciplinary, Biology and life sciences, Chromosome Biology, lcsh:R, DNA Helicases, DNA replication, Nuclear Proteins, DNA, Cell Biology, Telomere, Chromatin Assembly and Disassembly, Chromatin, Cell biology, Telomeres, Multiprotein Complexes, C700 Molecular Biology, Biophysics and Biochemistry, Epigenetics, lcsh:Q, Gene Function, Homologous recombination, Research Article, DNA Damage
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المؤلفون: Zongyu Zhang, Jianming Duan, Tanjun Tong
المصدر: Journal of Biological Chemistry. 276:48325-48331
مصطلحات موضوعية: Senescence, Telomerase, DNA Repair, Tumor suppressor gene, DNA repair, Telomere Pathway, Genetic Vectors, Cell, Population, Biology, Biochemistry, medicine, Humans, education, Molecular Biology, Cells, Cultured, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, DNA Primers, education.field_of_study, Base Sequence, Cell Biology, Fibroblasts, Oligonucleotides, Antisense, beta-Galactosidase, Diploidy, Molecular biology, Cell biology, Telomere, Retroviridae, medicine.anatomical_structure, Gene Expression Regulation
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المؤلفون: Hakan Gunaydin, Xin Huang, Yan Gu
المصدر: PLoS ONE
PLoS ONE, Vol 7, Iss 3, p e33740 (2012)مصطلحات موضوعية: Models, Molecular, Drugs and Devices, Drug Research and Development, Telomere Pathway, Molecular Sequence Data, lcsh:Medicine, Biology, Crystallography, X-Ray, Biochemistry, Tankyrases, Molecular Cell Biology, Chemical Biology, Humans, Amino Acid Sequence, Binding site, Enzyme Inhibitors, lcsh:Science, Wnt Signaling Pathway, Multidisciplinary, Binding Sites, Molecular Structure, Sequence Homology, Amino Acid, lcsh:R, Wnt signaling pathway, Signaling Cascades, Recombinant Proteins, Cancer treatment, Protein Structure, Tertiary, Chemistry, Medicine, lcsh:Q, Research Article, Signal Transduction
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المؤلفون: Xifeng Wu, Joshua Chang, Colin P.N. Dinney, Jian Gu, Maosheng Huang
المصدر: PLoS ONE
PLoS ONE, Vol 7, Iss 2, p e30665 (2012)مصطلحات موضوعية: Male, Telomerase, Clinical Research Design, Epidemiology, Telomere Pathway, Urology, lcsh:Medicine, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Telomere Homeostasis, Risk Factors, Genotype, Genetic variation, Molecular Cell Biology, medicine, Genetics, Humans, Genetic Predisposition to Disease, lcsh:Science, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Bladder cancer, Chromosome Biology, Cancer Risk Factors, lcsh:R, Haplotype, Computational Biology, Genetic Variation, Epistasis, Genetic, Genomics, Middle Aged, medicine.disease, Logistic Models, Oncology, Haplotypes, Urinary Bladder Neoplasms, 030220 oncology & carcinogenesis, Medicine, lcsh:Q, Female, Population Genetics, Research Article
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المصدر: Expert opinion on therapeutic targets. 15(5)
مصطلحات موضوعية: Pharmacology, Genetics, Telomerase, Telomere Pathway, Clinical Biochemistry, Translation (biology), Computational biology, Biology, Telomere, G-quadruplex, G-Quadruplexes, Telomeric dna, Neoplasms, Drug Discovery, Cancer cell, Molecular Medicine, Animals, Humans, Telomeric Repeat Binding Protein 2, Human cancer
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المؤلفون: Anna Malkova, Zhu Zhu, Alma Papusha, Woo-Hyun Chung, Grzegorz Ira
المصدر: PLoS Genetics, Vol 6, Iss 5, p e1000948 (2010)
PLoS Geneticsمصطلحات موضوعية: Cancer Research, DNA Repair, lcsh:QH426-470, DNA repair, Telomere Pathway, genetic processes, DNA, Single-Stranded, 03 medical and health sciences, 0302 clinical medicine, Genetics, Gene conversion, Molecular Biology, Replication protein A, Genetics (clinical), Ecology, Evolution, Behavior and Systematics, Alleles, 030304 developmental biology, Molecular Biology/Recombination, Recombination, Genetic, 0303 health sciences, Molecular Biology/DNA Repair, biology, Genetics and Genomics/Gene Therapy, Helicase, Telomere, Molecular biology, Electrophoresis, Gel, Pulsed-Field, enzymes and coenzymes (carbohydrates), lcsh:Genetics, Gene Targeting, biology.protein, Homologous recombination, 030217 neurology & neurosurgery, Sgs1, Research Article, DNA Damage
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المؤلفون: Michel Charbonneau, Nathalie Grandin
المساهمون: Laboratoire d'Innovation pour les Technologies des Energies Nouvelles et les nanomatériaux (LITEN), Institut National de L'Energie Solaire (INES), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] (GICC UMR 6239 CNRS), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours-Centre National de la Recherche Scientifique (CNRS)
المصدر: Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2009, 29 (4), pp.965-985. ⟨10.1128/MCB.00817-08⟩
Molecular and Cellular Biology, 2009, 29 (4), pp.965-985. ⟨10.1128/MCB.00817-08⟩مصطلحات موضوعية: Telomerase, Saccharomyces cerevisiae Proteins, Time Factors, Telomere Pathway, [SDV]Life Sciences [q-bio], RAD51, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Biology, MESH: Rad52 DNA Repair and Recombination Protein, 03 medical and health sciences, Telomerase RNA component, 0302 clinical medicine, Replication factor C, MESH: Saccharomyces cerevisiae Proteins, MESH: Cell Proliferation, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Saccharomycetales, Molecular Biology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, MESH: Microbial Viability, Cell Proliferation, Repetitive Sequences, Nucleic Acid, Recombination, Genetic, 0303 health sciences, MESH: Repetitive Sequences, Nucleic Acid, Microbial Viability, MESH: Kinetics, MESH: Time Factors, MESH: Telomerase, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Cell Biology, Articles, Telomere, Subtelomere, Molecular biology, Rad52 DNA Repair and Recombination Protein, enzymes and coenzymes (carbohydrates), Kinetics, 030220 oncology & carcinogenesis, Saccharomycetales, MESH: Recombination, Genetic, Homologous recombination, MESH: Telomere