المؤلفون: Fallon Estaún, Inés Teresa

المساهمون: University/Department: Universitat Ramon Llull. IQS

Thesis Advisors: Méndez Camarena, Eva, Borrós Gómez, Salvador

المصدر: TDX (Tesis Doctorals en Xarxa)

مصطلحات موضوعية: Medulloblastoma, Paediatric Brain Tumours, Novel Entity Design, Hit Identification, Paediatric Cancer, Drug Discovery, Target Identification, Therapeutic Targets, Drug Repurposing, Target Validation, Ciències naturals, químiques, físiques i matemàtiques

وصف الملف: application/pdf

URL الوصول: http://hdl.handle.net/10803/691502

المؤلفون: Adil Abdelrahim Mohammed Yousif

المصدر: Journal of Biomedicine and Biochemistry, Vol 3, Iss 4 (2024)

مصطلحات موضوعية: CRISPR-Cas9, genome-editing, drug discovery, target validation, therapeutic development, Medicine

وصف الملف: electronic resource

Relation: https://biomedbiochem.nabea.pub/biomedbiochem/article/view/82; https://doaj.org/toc/2958-0528

URL الوصول: https://doaj.org/article/61f81e2e9dcc42818bcba88f4909311f

المؤلفون: Scott, Jennifer

المساهمون: Bromley, Michael, Bignell, Elaine, Amich Elias, Jorge

مصطلحات موضوعية: folates, methionine synthase, regulatable promoter, virulence, established infection, target validation, human pathogen, conditionally essentiality, primary metabolism, enzyme assay, drug discovery, sulfur, mycoses, fungi, mycology, aspergillus fumigatus, aspergillosis, fungal

URL الوصول: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.878884

المؤلفون: Eric M. Kofoed, Ignacio Aliagas, Terry Crawford, Jialin Mao, Seth F. Harris, Min Xu, Shumei Wang, Ping Wu, Fang Ma, Kevin Clark, Jessica Sims, Yiming Xu, Yutian Peng, Elizabeth Skippington, Ying Yang, Janina Reeder, Savita Ubhayakar, Matt Baumgardner, Zhengyin Yan, Jacob Chen, Summer Park, Hua Zhang, Chun-Wan Yen, Maria Lorenzo, Nicholas Skelton, Xiaorong Liang, Liuxi Chen, Bridget Hoag, Chun Sing Li, Zhiguo Liu, John Wai, Xingrong Liu, Jun Liang, Man Wah Tan

المصدر: mBio, Vol 15, Iss 10 (2024)

مصطلحات موضوعية: antibiotic target validation, structural biology, Acinetobacter baumannii, bacterial genetics, medicinal chemistry, pharmacology, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2150-7511

URL الوصول: https://doaj.org/article/92da914a1cc64fff8b2ab55b0e41acbf

المؤلفون: Jennifer Venhorst, Roeland Hanemaaijer, Remon Dulos, Martien P. M. Caspers, Karin Toet, Joline Attema, Christa de Ruiter, Gino Kalkman, Tanja Rouhani Rankouhi, Jelle C. B. C. de Jong, Lars Verschuren

المصدر: Frontiers in Pharmacology, Vol 15 (2024)

مصطلحات موضوعية: disease network, target discovery, target validation, metabolic dysfunction-associated steatohepatitis (MASH), liver fibrosis, text mining, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1442752/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/2ed7e1d7d253401ab02b8a54abdd0c8d

المؤلفون: Yang Liu, Jing Liang, Rui Zhu, Yueying Yang, Yali Wang, Wenyi Wei, Hua Li, Lixia Chen

المصدر: Acta Materia Medica, Vol 3, Iss 1, Pp 72-87 (2024)

مصطلحات موضوعية: protac, probe, target identification, target validation, Pharmacy and materia medica, RS1-441, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0010; https://doaj.org/toc/2737-7946

URL الوصول: https://doaj.org/article/49164456b0c248869c940995b8c087ec

المؤلفون: Amen, Alexandra M, Loughran, Ryan M, Huang, Chun-Hao, Lew, Rachel J, Ravi, Archna, Guan, Yuanzhe, Schatoff, Emma M, Dow, Lukas E, Emerling, Brooke M, Fellmann, Christof

المصدر: Cell Reports Methods. 2(7)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Genetics, Cancer, Rare Diseases, Neurosciences, Biotechnology, RNA interference, RNAi, cancer modeling, combinatorial target inhibition, gene regulation, microRNA, target discovery, target validation, viral vectors

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0cg0358f

المؤلفون: Inês C. Ferreira, Estefania Torrejón, Bernardo Abecasis, Bruno M. Alexandre, Ricardo A. Gomes, Chris Verslype, Jos van Pelt, Ana Barbas, Daniel Simão, Tiago M. Bandeiras, Alessio Bortoluzzi, Sofia P. Rebelo

المصدر: SLAS Discovery, Vol 29, Iss 3, Pp 100154- (2024)

مصطلحات موضوعية: ALDH2, Sorafenib, HCC, CETSA-MS, Target validation, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555224000169; https://doaj.org/toc/2472-5552

URL الوصول: https://doaj.org/article/f74d704ab68c4276ae4077cfc067a125

المؤلفون: Brianda A. Hernández-Morán, Gillian Taylor, Álvaro Lorente-Macías, Andrew J. Wood

المصدر: Disease Models & Mechanisms, Vol 17, Iss 4 (2024)

مصطلحات موضوعية: protein degradation, target validation, mouse models, Medicine, Pathology, RB1-214

وصف الملف: electronic resource

Relation: http://dmm.biologists.org/content/17/4/dmm050613; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

URL الوصول: https://doaj.org/article/c9b71fc688ec4bbf8268e4fcbfd974be

المؤلفون: Annika Balzulat, W. Felix Zhu, Cathrin Flauaus, Victor Hernandez‐Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko

المصدر: Advanced Science, Vol 11, Iss 15, Pp n/a-n/a (2024)

مصطلحات موضوعية: drug development, itch, kcnt1, slack, target validation, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2198-3844

URL الوصول: https://doaj.org/article/1458b733707e4809ab4a13b283445821

المؤلفون: Guidi, Mònica

المساهمون: University/Department: Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut

Thesis Advisors: Espinosa Parrilla, Yolanda, Estivill, Xavier

المصدر: TDX (Tesis Doctorals en Xarxa)

مصطلحات موضوعية: RISC complex, retinoic acid, renilla luciferase, real-time quantitative PCR, PTBP1, pri-miRNA, pre-miRNA, post-transcriptional regulation, piRNA, PicTar, pGL4.13, PCR, P-body, p75NTR, overexpression, NTRK3, NTRK2, NTRK1, non-coding RNAs, NGF, neurotrophin, neurotrophic signaling, neuronal differentiation, neurodevelopment, neuroblastoma, nervous system, mRNA, miRNA target prediction, miRNA profiling, miRNA mimic, miRNA microarray, miRNA inhibitor, miRanda, microRNA, microarray, luciferase assay, Ingenuity Pathway Analysis (IPA), heLa cells, gene silencing, gene regulation, full-length isoform (FL-NTRK3), firefly luciferase, ERK, disease, dicer, cancer development, BDNF, argonaute, alternative splicing, 3'UTR, RNAhybrid, RT-PCR, SH-SY5Y cells, siRNA, standard error, synaptic plasticity, target validation, TargetScan, transfection, translational repression, TrkA, TrkB, TrkC, truncated isoform (TR-NTRK3), tyrosine kinase (TK), western blot

وصف الملف: application/pdf

URL الوصول: http://www.tdx.cat/TDX-0209109-131109
http://hdl.handle.net/10803/7114

المؤلفون: Venugopala, Katharigatta, Chandrashekharappa, Sandeep, Deb, Pran Kishore, Al-Shar'I, Nizar, Pillay, Melendhran, Tiwari, Priya, Chopra, Deepak, Borah, Pobitra, Tamhaev, Rasoul, Mourey, Lionel, Lherbet, Christian, Aldhubiab, Bandar, Tratrat, Christophe, Attimarad, Mahesh, Nair, Anroop, Sreeharsha, Nagaraja, Mailavaram, Raghu Prasad, Venugopala, Rashmi, Mohanlall, Viresh, Morsy, Mohamed

المساهمون: King Faisal University (KFU), Inkosi Albert Luthuli Central Hospital (IALCH), Indian Institute of Science Education and Research Bhopal (IISER Bhopal), Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Institut de pharmacologie et de biologie structurale (IPBS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), University of KwaZulu-Natal Durban, Afrique du Sud (UKZN)

المصدر: ISSN: 0141-8130 ; International Journal of Biological Macromolecules ; https://hal.science/hal-04739866 ; International Journal of Biological Macromolecules, 2024, 274 (Part 2), pp.133285. ⟨10.1016/j.ijbiomac.2024.133285⟩.

مصطلحات موضوعية: 2-substitutedindolizine, Mycobacterium tuberculosis, multidrug-resistant Mycobacterium tuberculosis, Molecular docking, molecular dynamics simulations, MTB target validation, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, [CHIM.CRIS]Chemical Sciences/Cristallography, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology

الاتاحة: https://hal.science/hal-04739866
https://hal.science/hal-04739866v1/document
https://hal.science/hal-04739866v1/file/PLAD_Manuscript_HAL.pdf
https://doi.org/10.1016/j.ijbiomac.2024.133285

المؤلفون: Sandra Johannsen, Robin M. Gierse, Arne Krüger, Rachel L. Edwards, Vittoria Nanna, Anna Fontana, Di Zhu, Tiziana Masini, Lais Pessanha de Carvalho, Mael Poizat, Bart Kieftenbelt, Dana M. Hodge, Sophie Alvarez, Daan Bunt, Antoine Lacour, Atanaz Shams, Kamila Anna Meissner, Edmarcia Elisa de Souza, Melloney Dröge, Bernard van Vliet, Jack den Hartog, Michael C. Hutter, Jana Held, Audrey R. Odom John, Carsten Wrenger, Anna K. H. Hirsch

مصطلحات موضوعية: Biochemistry, Microbiology, Pharmacology, Biotechnology, Science Policy, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, human liver cells, close structural similarities, tuberculosis prompted investigation, three different methods, high target homology, 50 , 1 , target validation, mycobacterium tuberculosis, enzyme 1, different modes, urgently needed, resistant strains, potent activity, new mode, methylerythritol 4, low toxicity, known drugs, inhibitor classes, guarantee inhibition, based activity

Relation: https://figshare.com/articles/journal_contribution/High_Target_Homology_Does_Not_Guarantee_Inhibition_Aminothiazoles_Emerge_as_Inhibitors_of_Plasmodium_falciparum/25239882

الاتاحة: https://doi.org/10.1021/acsinfecdis.3c00670.s002
https://figshare.com/articles/journal_contribution/High_Target_Homology_Does_Not_Guarantee_Inhibition_Aminothiazoles_Emerge_as_Inhibitors_of_Plasmodium_falciparum/25239882

المؤلفون: Aguado, Mirtha E., Carvalho, Sandra, Valdés-Tresanco, Mario E., Lin, De, Padilla-Mejia, Norma, Corpas-Lopez, Victoriano, Tesařová, Martina, Lukeš, Julius, Gray, David, González-Bacerio, Jorge, Wyllie, Susan, Field, Mark C.

المصدر: Aguado , M E , Carvalho , S , Valdés-Tresanco , M E , Lin , D , Padilla-Mejia , N , Corpas-Lopez , V , Tesařová , M , Lukeš , J , Gray , D , González-Bacerio , J , Wyllie , S & Field , M C 2024 , ' Identification and Validation of Compounds Targeting Leishmania major Leucyl-Aminopeptidase M17 ' , ACS Infectious Diseases , vol. 10 , no. 6 , pp. 2002-2017 . https://doi.org/10.1021/acsinfecdis.4c00009

مصطلحات موضوعية: drug discovery, Leishmania, M17 leucyl-aminopeptidase, RapidFire-MS, target validation, /dk/atira/pure/subjectarea/asjc/2700/2725, name=Infectious Diseases

وصف الملف: application/pdf

Relation: https://discovery.dundee.ac.uk/en/publications/04dfbac9-5003-4035-a3b6-2f4e586cb282

الاتاحة: https://discovery.dundee.ac.uk/en/publications/04dfbac9-5003-4035-a3b6-2f4e586cb282
https://doi.org/10.1021/acsinfecdis.4c00009
https://discovery.dundee.ac.uk/ws/files/132145459/aguado-et-al-2024-identification-and-validation-of-compounds-targeting-leishmania-major-leucyl-aminopeptidase-m17.pdf
http://www.scopus.com/inward/record.url?scp=85193566602&partnerID=8YFLogxK

المؤلفون: Kossatz de Mello, Elk, 1977-, Diez Alarcia, Rebeca, Gaitonde, Supriya A., Ramon Duaso, Carla, 1987-, Stepniewski, Tomasz Maciej, 1988-, Aranda García, David, Muneta Arrate, Itziar, Tepaz, Elodie, Saen-Oon, Suwipa, Soliva, Robert, Shahraki, Aida, Moreira, David, Brea, José, Loza, María I., Torre Fornell, Rafael de la, Kolb, Peter, Bouvier, Michel, Meana, J. Javier, Robledo, Patricia, 1958-, Selent, Jana

مصطلحات موضوعية: Computational biophysics, G protein-coupled receptors, Schizophrenia, Target validation

وصف الملف: application/pdf

Relation: Nat Commun. 2024 May 29;15(1):4307; info:eu-repo/grantAgreement/EC/H2020/823830; info:eu-repo/grantAgreement/ES/2PE/PID2020-119428RB-I00; info:eu-repo/grantAgreement/ES/2PE/SAF2017-88126-R; http://hdl.handle.net/10230/60760

الاتاحة: http://hdl.handle.net/10230/60760
https://doi.org/10.1038/s41467-024-48196-2

المؤلفون: Hukerikar, Nikita, Hingorani, Aroon D, Asselbergs, Folkert W, Finan, Chris, Schmidt, Amand F

المصدر: Atherosclerosis , 390 , Article 117462. (2024)

مصطلحات موضوعية: Human genetics, Mendelian randomization, Drug development, Bioinformatics, NAFLD, Drug target validation, Colocalization, Loss-of-function

وصف الملف: text

Relation: https://discovery.ucl.ac.uk/id/eprint/10186263/1/1-s2.0-S0021915024000224-main.pdf; https://discovery.ucl.ac.uk/id/eprint/10186263/

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10186263/1/1-s2.0-S0021915024000224-main.pdf
https://discovery.ucl.ac.uk/id/eprint/10186263/

المؤلفون: Das, Shibsankar

المصدر: PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY; Vol. 25 No. 9-10 (2024): 2024 - Volume 25 [Issue 9-10]; 26-34 ; 0972-2025

مصطلحات موضوعية: miRNA target interaction, target prediction algorithm, target validation, complementarity score

وصف الملف: application/pdf

Relation: https://ikprress.org/index.php/PCBMB/article/view/8783/8126; https://ikprress.org/index.php/PCBMB/article/view/8783/8127; https://ikprress.org/index.php/PCBMB/article/view/8783/8128; https://ikprress.org/index.php/PCBMB/article/view/8783

الاتاحة: https://ikprress.org/index.php/PCBMB/article/view/8783
https://doi.org/10.56557/pcbmb/2024/v25i9-108783

المؤلفون: Aziz, Umer Bin Abdul, Saoud, Ali, Bermudez, Marcel, Atef, Amira, Rudolf, Thomas, Arkona, Christoph, Böttcher, Christoph, Ludwig, Kai, Wolber, Gerhard, Rademann, Jörg

مصطلحات موضوعية: Cryoelectron tomography, Drug discovery and development, Target validation, Virtual drug screening, ddc:540

وصف الملف: 13 Seiten; application/pdf

Relation: https://refubium.fu-berlin.de/handle/fub188/43473; http://dx.doi.org/10.17169/refubium-43190

الاتاحة: https://refubium.fu-berlin.de/handle/fub188/43473
https://doi.org/10.17169/refubium-43190
https://doi.org/10.1038/s41467-024-47741-3

المؤلفون: Oldberg, Nick Alexander

مصطلحات موضوعية: Pharmacology, Oncology, Cellular biology, CBFB, Osteosarcoma, Protein Translation, RUNX2, Target Validation

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/74x7q1hf
https://escholarship.org/content/qt74x7q1hf/qt74x7q1hf.pdf

المؤلفون: Gomes, Bruno Filipe Andrade

المساهمون: Guedes, Rita Alexandra do Nascimento Cardoso, Aniceto, Natália, Repositório da Universidade de Lisboa

مصطلحات موضوعية: Target validation, Computational methods, Cavity similarity, LAT1, Teses de mestrado - 2022, Ciências da Saúde

وصف الملف: application/pdf

الاتاحة: http://hdl.handle.net/10451/63258