المؤلفون: Scognamiglio, Antonia, Cerqua, Ida, Citi, Valentina, Martelli, Alma, Spezzini, Jacopo, Calderone, Vincenzo, Rimoli, Maria Grazia, Sodano, Federica, Caliendo, Giuseppe, Santagada, Vincenzo, Fiorino, Ferdinando, Frecentese, Francesco, Perissutti, Elisa, Magli, Elisa, Simonelli, Martina, Corvino, Angela, Roviezzo, Fiorentina, Severino, Beatrice

المساهمون: Scognamiglio, Antonia, Cerqua, Ida, Citi, Valentina, Martelli, Alma, Spezzini, Jacopo, Calderone, Vincenzo, Rimoli, Maria Grazia, Sodano, Federica, Caliendo, Giuseppe, Santagada, Vincenzo, Fiorino, Ferdinando, Frecentese, Francesco, Perissutti, Elisa, Magli, Elisa, Simonelli, Martina, Corvino, Angela, Roviezzo, Fiorentina, Severino, Beatrice

مصطلحات موضوعية: Asthma, Hybrid, Multi-target molecule, Steroidal anti-inflammatory drug, hydrogen sulfide, isothiocyanates

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:001284235000001; volume:275; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; https://hdl.handle.net/11588/974085

الاتاحة: https://hdl.handle.net/11588/974085
https://doi.org/10.1016/j.ejmech.2024.116636

المؤلفون: Jiaxin Liu, Mingdi Pan, Jiuzeng Jin, Yunshu Lu, Zhongmin Feng, Ting Sun

مصطلحات موضوعية: Biochemistry, Medicine, Biotechnology, Ecology, Chemical Sciences not elsewhere classified, target molecule could, increasing milk production, farm wastewater samples, could avoid oxidation, active sterol estrogen, 95 × 10, 5 × 10, 15 – 108, 09 – 2, sers analysis method, dimensional flowerlike mos, cheap ag nps, 2 , 2 , cleaning sers substrate, environmental water 17β, environmental water, ag nps, r <, sers sources, sers signal, widely used, trace detection, thus enhancing, strong anti

Relation: https://figshare.com/articles/journal_contribution/Prepared_Three-Dimensional_Flowerlike_MoS_sub_2_sub_Ag_rGO_Nanocomposite_as_a_Self-Cleaning_SERS_Substrate_for_the_Trace_Detection_of_17_-Estradiol_in_Environmental_Water/24925278

الاتاحة: https://doi.org/10.1021/acssuschemeng.3c05861.s001
https://figshare.com/articles/journal_contribution/Prepared_Three-Dimensional_Flowerlike_MoS_sub_2_sub_Ag_rGO_Nanocomposite_as_a_Self-Cleaning_SERS_Substrate_for_the_Trace_Detection_of_17_-Estradiol_in_Environmental_Water/24925278

المؤلفون: Enrico Luchinat, Letizia Barbieri, Ben Davis, Paul A. Brough, Matteo Pennestri, Lucia Banci

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Pharmacology, Biotechnology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, pharmacologically relevant targets, target molecule may, novel approach based, compounds toward hsp90α, native cellular environment, 19 , 1 , binding efficacy directly, based competition binding, observing fluorinated ligands, competition binding, intracellular target, fluorinated compound, effective compounds, approach could, cellular components, cellular background, thus aiding, powerful tool, living cells, invisible due, impractical due, human cells

Relation: https://figshare.com/articles/journal_contribution/Ligand-Based_Competition_Binding_by_Real-Time_sup_19_sup_F_NMR_in_Human_Cells/24991414

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01600.s001
https://figshare.com/articles/journal_contribution/Ligand-Based_Competition_Binding_by_Real-Time_sup_19_sup_F_NMR_in_Human_Cells/24991414

المؤلفون: Honoka Kawamukai, Shumpei Takishita, Kazumi Shimizu, Daisuke Kohda, Koichiro Ishimori, Tomohide Saio

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Hematology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, driven distribution shifts, distance distribution measurement, one possible strategy, targets dynamic proteins, intrinsically disordered proteins, visualizing conformational distribution, synthetic small molecules, solution structural biology, protein conformational studies, multidomain protein measured, conformational distribution, synthetic tag, pair small, including multidomain, important strategy, broad conformational, technical difficulties, target molecule, study used, study proposes, specific pair

Relation: https://figshare.com/articles/journal_contribution/Conformational_Distribution_of_a_Multidomain_Protein_Measured_by_Single-Pair_Small-Angle_X_ray_Scattering/24998302

الاتاحة: https://doi.org/10.1021/acs.jpclett.3c02600.s001
https://figshare.com/articles/journal_contribution/Conformational_Distribution_of_a_Multidomain_Protein_Measured_by_Single-Pair_Small-Angle_X_ray_Scattering/24998302

المؤلفون: Gary M. Chinigo, Emma L. McInturff, Scott W. Bagley, Richard W. Barnhart, David C. Blakemore, Lu Han, Taegyo Lee, Javier Magano, J. Christopher McWilliams, Sebastien Monfette, James J. Mousseau, Senliang Pan, Dylan Pedro, Hahdi H. Perfect, Jeffrey W. Raggon, Peter R. Rose, John Sagal, John I. Trujillo, Jared Van Haitsma, Michael G. Vetelino, Xiaojing Helen Yang

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Sociology, Immunology, Computational Biology, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, two elaborated amines, sulfinimine addition reaction, sterically congested amine, low yield due, highlighted improvements made, early process development, target molecule, subsequent enablement, sequential substitution, previously suffered, poor regioselectivity, original synthesis, kilogram manufacture, key iodopyrazole, high stereocontrol, enablement efforts, efficient construction, diethyl squarate, crystalline api, campaign include

Relation: https://figshare.com/articles/journal_contribution/Early_Process_Development_of_PF-07054894_a_Squaramide-Based_Antagonist_of_C_C_Chemokine_Receptor_Type_6_CCR6_/25109284

الاتاحة: https://doi.org/10.1021/acs.oprd.3c00451.s001
https://figshare.com/articles/journal_contribution/Early_Process_Development_of_PF-07054894_a_Squaramide-Based_Antagonist_of_C_C_Chemokine_Receptor_Type_6_CCR6_/25109284

المؤلفون: Minghong Li, Xi He, Chaolin Wu, Li Wang, Xin Zhang, Xiangnan Gong, Xiping Zeng, Yingzhou Huang

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Biotechnology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, spectral analysis technology, simulated exhaled breath, promising new approach, optimal structure parameters, realize sers identification, good sers performance, accurate sers identification, deep learning offers, flexible porous film, based film sensors, gaseous analyte detection, deep learning, sers detection, performed based, reproducible detection, sers spectrum, film consisting, gaseous molecules, gaseous molecule, gaseous biomarker, target molecule, surface plasmon, results point, nanowire network

Relation: https://figshare.com/articles/journal_contribution/Deep_Learning_Enabled_SERS_Identification_of_Gaseous_Molecules_on_Flexible_Plasmonic_MOF_Nanowire_Films/25126649

الاتاحة: https://doi.org/10.1021/acssensors.3c02519.s001
https://figshare.com/articles/journal_contribution/Deep_Learning_Enabled_SERS_Identification_of_Gaseous_Molecules_on_Flexible_Plasmonic_MOF_Nanowire_Films/25126649

المؤلفون: Hanno Schmidt, Katharina Mauer, Manuel Glaser, Bahram Sayyaf Dezfuli, Sören Lukas Hellmann, Ana Lúcia Silva Gomes, Falk Butter, Rebecca C. Wade, Thomas Hankeln, Holger Herlyn

المصدر: BMC Genomics, Vol 23, Iss 1, Pp 1-16 (2022)

مصطلحات موضوعية: Parasites, Anthelmintics, Target molecule, Virtual ligand screening, Active ingredients, Medical genomics, Biotechnology, TP248.13-248.65, Genetics, QH426-470

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1471-2164

URL الوصول: https://doaj.org/article/a3b5918acef8482ea504a636b130d8eb

المؤلفون: Yao Yu, Qiaoyu Li, Wen Shi, Yuxin Yang, Hongpeng He, Junbiao Dai, Guobin Mao, Yingxin Ma

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Plant Biology, Chemical Sciences not elsewhere classified, without entailing adjustments, nucleic acid targets, easily customizable design, t4 dna polymerase, platform includes single, stranded dna comprising, generating fluorescence signals, crrna recognition region, mediated programmable aptasensor, cas12a activity crispr, cpas platform allows, stranded dna, programmable aptasensor, fluorescence signals, mediated aptasensors, locker dna, cleavage activity, urgent need, thereby activating, target molecule, specific binding

Relation: https://figshare.com/articles/journal_contribution/Programmable_Aptasensor_for_Regulating_CRISPR_Cas12a_Activity/24794853

الاتاحة: https://doi.org/10.1021/acssensors.3c01881.s001
https://figshare.com/articles/journal_contribution/Programmable_Aptasensor_for_Regulating_CRISPR_Cas12a_Activity/24794853

المؤلفون: Julian Bauer, Andreas Reichl, Philip Tinnefeld

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Sociology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, recently revealed correlations, epigenetic disease markers, two modified nucleotides, revealing subtle differences, molecule hybridization kinetics, epigenetic modifications depends, provide increased sensitivity, disease also render, transient binding kinetics, epigenetic cytosine modifications, epigenetic modifications, two modifications, cytosine modifications, transient binding, subtle changes, target molecule

Relation: https://figshare.com/articles/journal_contribution/Kinetic_Referencing_Allows_Identification_of_Epigenetic_Cytosine_Modifications_by_Single-Molecule_Hybridization_Kinetics_and_Superresolution_DNA-PAINT_Microscopy/24919513

الاتاحة: https://doi.org/10.1021/acsnano.3c08451.s001
https://figshare.com/articles/journal_contribution/Kinetic_Referencing_Allows_Identification_of_Epigenetic_Cytosine_Modifications_by_Single-Molecule_Hybridization_Kinetics_and_Superresolution_DNA-PAINT_Microscopy/24919513

المؤلفون: T. M. Mohiuddin, Chaoyu Zhang, Wenjie Sheng, Marwah Al-Rawe, Felix Zeppernick, Ivo Meinhold-Heerlein, Ahmad Fawzi Hussain

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 3; Pages: 2655

مصطلحات موضوعية: cancer therapy, NIR-PIT, ICD, antitumor host immunity, target molecule

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pharmacology; https://dx.doi.org/10.3390/ijms24032655

الاتاحة: https://doi.org/10.3390/ijms24032655

المؤلفون: Aki Furusawa, Ryuhei Okada, Fuyuki Inagaki, Hiroaki Wakiyama, Takuya Kato, Hideyuki Furumoto, Hiroshi Fukushima, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi

المصدر: OncoImmunology, Vol 11, Iss 1 (2022)

مصطلحات موضوعية: cancer, near-infrared photoimmunotherapy (nir-pit), target molecule, melanoma, cd29, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2162-402X

URL الوصول: https://doaj.org/article/c84b464ade6a4b16a0279abd843ce507

المؤلفون: Peter, Jerine S, Panchal, Nagesh Kishan, Nair, Aishwaria V, Joshi, Kshitija, Sosa, Andrews Shobhy, Sabina, Evan Prince¹

المصدر: RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY 14(1):146-152. 2021

المؤلفون: Lucía Abarca-Cabrera (14246727), Lianxin Xu (14246730), Sonja Berensmeier (1515184), Paula Fraga-García (6037502)

مصطلحات موضوعية: Biochemistry, Immunology, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, present exciting data, enhancing biomass exploitation, bovine serum albumin, 40 g g, 39 g g, 13 g g, triggering intended interactions, high adsorption capacity, maximum adsorption capacity, oleate adsorption capacity, bsa adsorption capacity, fatty acid ), maximum capacity, fatty acid, nano interactions, vision set, unexpected behavior, target molecule, system ’, study attempts, structural organization, sodium oleate, results show, physicochemical characteristics, organic anion

Relation: https://figshare.com/articles/journal_contribution/Competition_at_the_Bio-nano_Interface_A_Protein_a_Polysaccharide_and_a_Fatty_Acid_Adsorb_onto_Magnetic_Nanoparticles/21710463

الاتاحة: https://doi.org/10.1021/acsabm.2c00812.s001

المؤلفون: Robert S. Treß (12035729), Christof Hättig (1666012), Sebastian Höfener (1487740)

مصطلحات موضوعية: Biophysics, Biotechnology, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, strong nuclear attraction, mean absolute deviation, frozen solvent approximation, frozen density embedding, effective embedding potential, conventional embedding potential, 2 )) scheme, complex systems employing, state electron spill, proposed approach leads, diffuse basis functions, local excited states, diffuse functions, excited states, charge spill, employing pseudopotentials, electron pseudopotentials, target molecule, tackle excited, supermolecular calculations, sufficiently compensated, resulting potentials, repulsive enough, repulsive contributions, present work, pauli repulsion

Relation: https://figshare.com/articles/journal_contribution/Employing_Pseudopotentials_to_Tackle_Excited-State_Electron_Spill-Out_in_Frozen_Density_Embedding_Calculations/19111352

الاتاحة: https://doi.org/10.1021/acs.jctc.1c00732.s001

المؤلفون: Isaiah O. Betinol (11949779), Yutao Kuang (11949782), Jolene P. Reid (6235811)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Biological Sciences not elsewhere classified, Information Systems not elsewhere classified, include additional substrates, efficient synthetic routes, considerable synthetic effort, statistical modeling tools, guiding target synthesis, explore modern reactions, target molecule, statistical models, successfully developed, organocatalysis practitioners, organocatalysis exemplifies, generate materials, enantioselective reactions, different catalysts, case study, broad set, accurately distinguish

Relation: https://figshare.com/articles/journal_contribution/Guiding_Target_Synthesis_with_Statistical_Modeling_Tools_A_Case_Study_in_Organocatalysis/18428729

الاتاحة: https://doi.org/10.1021/acs.orglett.1c04134.s001

المؤلفون: Hideyuki Furumoto, Takuya Kato, Hiroaki Wakiyama, Aki Furusawa, Peter L. Choyke, Hisataka Kobayashi

المصدر: Biomedicines; Volume 10; Issue 4; Pages: 846

مصطلحات موضوعية: near-infrared photoimmunotherapy (NIR-PIT), cancer, endoscopy, target molecule

وصف الملف: application/pdf

Relation: Immunology and Immunotherapy; https://dx.doi.org/10.3390/biomedicines10040846

الاتاحة: https://doi.org/10.3390/biomedicines10040846

المؤلفون: Toyoshi Umezu

المصدر: Heliyon, Vol 7, Iss 6, Pp e07329- (2021)

مصطلحات موضوعية: l-menthol, Target molecule, Binding assay, Central nervous system stimulant, Locomotion, Science (General), Q1-390, Social sciences (General), H1-99

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844021014328; https://doaj.org/toc/2405-8440

URL الوصول: https://doaj.org/article/62dac062b3524272ab6e116ff79bf280

المؤلفون: 谷, 浩由輝

مصطلحات موضوعية: 犬組織球性肉腫, 治療標的分子, SHP2, Canine histiocytic sarcoma, Therapeutic target molecule

وصف الملف: PDF; application/pdf

URL الوصول: https://ndlsearch.ndl.go.jp/books/R100000039-I12154546

Degree: 博士（獣医学） -- 日本獣医生命科学大学

المؤلفون: Elliott P. Mueller (11888197), Alex L. Sessions (506389), Peter E. Sauer (11888200), Gabriella M. Weiss (11888203), John M. Eiler (1741225)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Biotechnology, Ecology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, microbial carbon cycling, 5 ‰ uncertainty, 2 , 13 , 1 , hydrogen isotope biogeochemistry, orbitrap method presented, molecular targets used, using optimized ionization, studying biogeochemical processes, including central metabolites, molecular targets amenable, h /< sup, acetate could provide, using acetate, molecules amenable, isotope compositions, electrospray ionization, orbitrap parameters, useful constraint, target molecule

Relation: https://figshare.com/articles/journal_contribution/Simultaneous_High-Precision_Measurements_of_sup_2_sup_H_and_sup_13_sup_C_in_Nanomole_Quantities_of_Acetate_Using_Electrospray_Ionization-Quadrupole-Orbitrap_Mass_Spectrometry/17705869

الاتاحة: https://doi.org/10.1021/acs.analchem.1c04141.s001

المؤلفون: Thomas E. La Cruz (10893382), Francisco González-Bobes (1508401), Martin D. Eastgate (1314654), Chris Sfouggatakis (1676419), Bin Zheng (45359), Nathaniel Kopp (1663762), Yi Xiao (135101), Yu Fan (111503), Kay A. Galindo (11242375), Charles Pathirana (5624069), Michael A. Galella (2065051), Joerg Deerberg (2010787)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Genetics, Biotechnology, Ecology, Immunology, Chemical Sciences not elsewhere classified, Scalable Asymmetric Synthesis, synthesis, allylic amination desymmetrization ., cis triamino cyclohexane core, process chemistry groups, Bristol Myers Squibb, approach, BMS -813160 BMS -813160, target molecule, Freidinger-type pyrrolidone preparation

Relation: https://figshare.com/articles/journal_contribution/Scalable_Asymmetric_Synthesis_of_the_All_i_Cis_i_Triamino_Cyclohexane_Core_of_BMS-813160/15125023

الاتاحة: https://doi.org/10.1021/acs.joc.1c01162.s001