المؤلفون: Shanu Jain, Sai P. Pydi, Young-Hwan Jung, Mirko Scortichini, Efrat L. Kesner, Tadeusz P. Karcz, Donald N. Cook, Oksana Gavrilova, Jürgen Wess, Kenneth A. Jacobson

المصدر: JCI Insight, Vol 6, Iss 10 (2021)

مصطلحات موضوعية: Metabolism, Medicine

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2379-3708

URL الوصول: https://doaj.org/article/415ac4152bc74c40af64da7ddcf8b9cd

المؤلفون: Zhiwei Wen (1689439), Veronica Salmaso (2609254), Young-Hwan Jung (3908977), Ngan B. Phung (8787740), Varun Gopinatth (10509097), Qasim Shah (12043177), Alexandra T. Patterson (12043180), John C. R. Randle (10509100), Zhoumou Chen (286777), Daniela Salvemini (286781), David I. Lieberman (6172415), Gregory S. Whitehead (12043183), Tadeusz P. Karcz (9217340), Donald N. Cook (9217346), Kenneth A. Jacobson (117993)

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Physiology, Pharmacology, Biotechnology, Evolutionary Biology, Infectious Diseases, Chemical Sciences not elsewhere classified, persistent key interactions, multiple polar groups, mouse asthma model, enhanced aqueous solubility, 1 ]­ hept, probe receptor affinity, high affinity naphthalene, fold higher affinity, displayed intermediate affinity, displayed higher affinity, rigidified piperidine derivatives, piperidine bridging moieties, bridged piperidine analogues, 42 , 34 , 30 , 24 , 143 , 1 , 50 , 14

Relation: https://figshare.com/articles/journal_contribution/Bridged_Piperidine_Analogues_of_a_High_Affinity_Naphthalene-Based_P2Y_sub_14_sub_R_Antagonist/19119322

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01964.s001

المؤلفون: Zhiwei, Wen, Veronica, Salmaso, Young-Hwan, Jung, Ngan B, Phung, Varun, Gopinatth, Qasim, Shah, Alexandra T, Patterson, John C R, Randle, Zhoumou, Chen, Daniela, Salvemini, David I, Lieberman, Gregory S, Whitehead, Tadeusz P, Karcz, Donald N, Cook, Kenneth A, Jacobson

المصدر: J Med Chem

مصطلحات موضوعية: Mice, Structure-Activity Relationship, Piperidines, Purinergic P2 Receptor Antagonists, Animals, Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::da62c41535c927994c70d1b42266cae7
https://pubmed.ncbi.nlm.nih.gov/35113556

المؤلفون: Kenneth A. Jacobson, Donald N. Cook, Tadeusz P Karcz, John C R Randle, John M. Bennett, Varun Gopinatth, Zhiwei Wen, Ngan B. Phung, Daniela Salvemini, Young-Hwan Jung, David I. Lieberman, Veronica Salmaso, Zhoumou Chen

المصدر: Journal of Medicinal Chemistry. 64:5099-5122

مصطلحات موضوعية: Stereochemistry, Triazole, Molecular Dynamics Simulation, 01 natural sciences, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Piperidines, Animals, Binding Sites, Disease Models, Animal, Drug Design, Humans, Molecular Docking Simulation, Neuralgia, Prodrugs, Purinergic P2 Receptor Antagonists, Receptors, Purinergic P2, Solubility, Triazoles, Amide, Receptors, Drug Discovery, Structure–activity relationship, Hydroxymethyl, Carboxylate, 030304 developmental biology, 0303 health sciences, Purinergic P2, Animal, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Zwitterion, Disease Models, Molecular Medicine, Bioisostere, Piperidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8619de0d7c2d74a8325f516dd55228e
https://doi.org/10.1021/acs.jmedchem.1c00164

المؤلفون: Zhiwei Wen, Veronica Salmaso, Young-Hwan Jung, Ngan B. Phung, Varun Gopinatth, Qasim Shah, Alexandra T. Patterson, John C. R. Randle, Zhoumou Chen, Daniela Salvemini, David I. Lieberman, Gregory S. Whitehead, Tadeusz P. Karcz, Donald N. Cook, Kenneth A. Jacobson

مصطلحات موضوعية: Mice, Structure-Activity Relationship, Animals, Piperidines, Purinergic P2 Receptor Antagonists, Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a16138dcf66e0cf8b0d97c43fac4e0
http://hdl.handle.net/11577/3459804

المؤلفون: Gregory S. Whitehead, Tadeusz P. Karcz, Dilip K. Tosh, Young-Hwan Jung, Zhiwei Wen, Ryan G. Campbell, Varun Gopinatth, Zhan-Guo Gao, Kenneth A. Jacobson, Donald N. Cook

مصطلحات موضوعية: Pharmacology, Pharmacology (medical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddab2d317b599110bf79f6e32515bd8
https://ruj.uj.edu.pl/xmlui/handle/item/303815

المؤلفون: Young-Hwan Jung, Sai Prasad Pydi, Jürgen Wess, Efrat L Kesner, Tadeusz P Karcz, Shanu Jain, Mirko Scortichini, Kenneth A. Jacobson, Oksana Gavrilova, Donald N. Cook

المصدر: JCI Insight

مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, medicine.medical_specialty, medicine.drug_class, Lipolysis, Adipose tissue, Type 2 diabetes, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Internal medicine, Adipocyte, medicine, Adipocytes, Glucose homeostasis, Animals, Obesity, Receptor, Chemistry, Diabetes, General Medicine, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Metabolism, Glucose, 030220 oncology & carcinogenesis, Receptors, Purinergic P2Y, Purinergic P2Y Receptor Antagonists, Endogenous agonist, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac55fa96e124f3dc71a03e8fa72e7bc
http://europepmc.org/articles/PMC8262345

المؤلفون: Ken Jacobson, Donald N. Cook, Mirko Scortichini, Sai Prasad Pydi, Oksana Gavrilova, Efrat L Kesner, Young-Hwan Jung, Tadeusz P Karcz, Jürgen Wess, Shanu Jain

المصدر: The FASEB Journal. 35

مصطلحات موضوعية: medicine.medical_specialty, Chemistry, Lipid mobilization, Biochemistry, chemistry.chemical_compound, Endocrinology, Internal medicine, Adipocyte, Genetics, medicine, Glucose homeostasis, Whole body, Receptor, Molecular Biology, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::170a36868db8a95bfb267ce03b654b97
https://doi.org/10.1096/fasebj.2021.35.s1.02001

المؤلفون: Young-Hwan, Jung, Veronica, Salmaso, Zhiwei, Wen, John M, Bennett, Ngan B, Phung, David I, Lieberman, Varun, Gopinatth, John C R, Randle, Zhoumou, Chen, Daniela, Salvemini, Tadeusz P, Karcz, Donald N, Cook, Kenneth A, Jacobson

المصدر: J Med Chem

مصطلحات موضوعية: Binding Sites, Receptors, Purinergic P2, Molecular Dynamics Simulation, Triazoles, Article, Molecular Docking Simulation, Disease Models, Animal, Mice, Structure-Activity Relationship, Piperidines, Solubility, Drug Design, Purinergic P2 Receptor Antagonists, Animals, Humans, Neuralgia, Prodrugs

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::2538a8e3308d6a52460a78072272a801
https://pubmed.ncbi.nlm.nih.gov/33787273

المؤلفون: Leesa J. Deterding, Sara A. Grimm, Donald N. Cook, Jason Williams, Gregory S. Whitehead, Tadeusz P Karcz, Keiko Nakano, Hideki Nakano, Kenneth A. Jacobson

المصدر: J Clin Invest

مصطلحات موضوعية: 0301 basic medicine, Uridine Diphosphate Glucose, Inflammation, Allergic sensitization, 03 medical and health sciences, 0302 clinical medicine, Medicine, Eosinophilia, Humans, Asthma, Interleukin-13, business.industry, General Medicine, Eosinophil, respiratory system, medicine.disease, respiratory tract diseases, Eosinophils, 030104 developmental biology, medicine.anatomical_structure, Glucose, 030220 oncology & carcinogenesis, Immunology, medicine.symptom, business, Airway, CCL24, Glucocorticoid, medicine.drug, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3aa73acd8bf5689d23ffa4c3f65510
https://europepmc.org/articles/PMC8011887/

المؤلفون: Steven Dudas, Zhan-Guo Gao, Jinha Yu, Zhiwei Wen, Tadeusz P Karcz, John M. Bennett, Kenneth A. Jacobson, Sierra Duca, Ngan B. Phung, Daniela Salvemini, Young-Hwan Jung, Veronica Salmaso, Donald N. Cook, Zhoumou Chen

المصدر: J Med Chem

مصطلحات موضوعية: Benzimidazole, Stereochemistry, Protein Conformation, Triazole, Molecular Dynamics Simulation, 01 natural sciences, Article, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Receptors, Drug Discovery, Purinergic P2 Receptor Antagonists, Moiety, Animals, Humans, HEK293 Cells, Molecular Docking Simulation, Neuralgia, Receptors, Purinergic P2, Solubility, Triazoles, Drug Design, 030304 developmental biology, Indole test, 0303 health sciences, Purinergic P2, Chemistry, Chinese hamster ovary cell, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Piperidine, Conjugate, Quinuclidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e1e7f295e8914ed6cd6052e64fe4cb
https://europepmc.org/articles/PMC8040948/

المؤلفون: Donald N. Cook, Gentaro Izumi, Seddon Y. Thomas, Alexander Medvedev, Hideki Nakano, Hong Soon Kang, Gregory S. Whitehead, Keiko Nakano, Anton M. Jetten, Tadeusz P Karcz, Sergei S. Makarov

المصدر: JCI Insight. 4

مصطلحات موضوعية: 0301 basic medicine, Inflammation, Allergic sensitization, Mice, 03 medical and health sciences, 0302 clinical medicine, RAR-related orphan receptor gamma, Hypersensitivity, Respiratory Hypersensitivity, medicine, Animals, Inverse agonist, Receptor, Lung, Asthma, business.industry, Interleukin-17, Dust, Pneumonia, General Medicine, Nuclear Receptor Subfamily 1, Group F, Member 3, respiratory system, medicine.disease, Neutrophilia, respiratory tract diseases, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, Th17 Cells, medicine.symptom, Airway, business, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d465e2168b15ac16b5cd7ca75bed2642
https://doi.org/10.1172/jci.insight.125528

المؤلفون: Young-Hwan Jung (3908977), Veronica Salmaso (2609254), Zhiwei Wen (1689439), John M. Bennett (9217343), Ngan B. Phung (8787740), David I. Lieberman (6172415), Varun Gopinatth (10509097), John C. R. Randle (10509100), Zhoumou Chen (286777), Daniela Salvemini (286781), Tadeusz P. Karcz (9217340), Donald N. Cook (9217346), Kenneth A. Jacobson (117993)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Physiology, Evolutionary Biology, Ecology, Immunology, Cancer, Computational Biology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, P 2Y 14 R antagonists, Piperidine Bioisosteres, analogue, amidomethyl ester prodrugs, piperidine bioisostere, 3- aminopropynyl 19, 15 nM, Zwitterionic Character, P 2Y 14 R affinity, MRS, receptor binding, receptor affinity, phenyl ring, terminal piperidine moieties, vivo application, vivo efficacy, triazole series, extracellular loops

Relation: https://figshare.com/articles/journal_contribution/Structure_Activity_Relationship_of_Heterocyclic_P2Y_sub_14_sub_Receptor_Antagonists_Removal_of_the_Zwitterionic_Character_with_Piperidine_Bioisosteres/14351425

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00164.s001