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المصدر: Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 793-803 (2021)مصطلحات موضوعية: Bcl-2, B-cell lymphoma 2, BAX, BCL2 Associated X, Health, Toxicology and Mutagenesis, Placenta, 010501 environmental sciences, Toxicology, 01 natural sciences, Nicotine, DNA, Deoxyribonucleic acid, 0302 clinical medicine, RA1190-1270, Lactation, HCL, Hydrogen Chloride, E2, Estradiol, s.c., subcutaneously, AMH, Anti-Müllerian hormone, ANOVA, analysis of variance, Follicular atresia, Regular Article, H&E, Hematoxylin and Eosin, Ca2+, calcium, ELISA, enzyme-linked immunosorbent assay, PBS, Phosphate-buffered saline, medicine.anatomical_structure, OS, oxidative stress, Veh, vehicle, Ni, nicotine, NMRI, Naval Medical Research Institute, IUGR, intrauterine growth restriction, cat.no, catalogue number, EtOH, ethanol, medicine.drug, GD, gestation day, Offspring, PND, Postnatal day, ROS, reactive-oxygen-species, Ovary, nAChRs, nicotinic acetylcholine receptors, SEM, standard error of the mean, WHO, World Health Organization, Andrology, 03 medical and health sciences, TUNEL, Terminal deoxynucleotidyl transferase dUTP nick end labeling, medicine, OFR, ovarian follicular reservoir, SPSS, statistical package for the social sciences, BMP, Bone morphogenetic protein, CTL, control, 0105 earth and related environmental sciences, Pregnancy, Ethanol, business.industry, Histology, i.p., intraperitoneally, medicine.disease, First-generation mice, Toxicology. Poisons, FSH, Follicle-stimulating hormone, business, 030217 neurology & neurosurgery, DAPI, 4′,6-diamidino-2-phenylindole
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المؤلفون: Suksan Changlek, Walla Alelwani, Arwa A. Makki, Naymul Karim, Mohammad Nasiruddin Rana, Md. Atiar Rahman, Jitbanjong Tangpong, Dina Hajjar
المصدر: Saudi Journal of Biological Sciences, Vol 27, Iss 12, Pp 3700-3710 (2020)
Saudi Journal of Biological Sciencesمصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Antioxidant, medicine.medical_treatment, H&E, Hematoxylin-Eosin, Thunbergia laurifolia Linn, TBS, Tris phosphate saline, Renal function, Pharmacology, medicine.disease_cause, 01 natural sciences, DNA, Deoxyribonucleic acid, COX-2, Cyclooxygenase-2, 03 medical and health sciences, ROS, reactive oxygen species, Anti-inflammation, TBARS, Thiobarbituric acid reactive substances, TUNEL, Terminal deoxynucleotidyl transferase dUTP nick end labeling, Pb, lead, medicine, MDA, Malondialdehyde, lcsh:QH301-705.5, ComputingMethodologies_COMPUTERGRAPHICS, Kidney, TNF-α, Tumor necrosis factor-alpha, Chemistry, BW, body weight, Vitamin E, TBST, Tris phosphate buffer saline with Tween 20, ELISA, enzyme-linked immunosorbent assay, GFR, Glomerular filtration rate, iNOS, Inducible nitric oxide synthase, Renotoxicity, 030104 developmental biology, medicine.anatomical_structure, lcsh:Biology (General), Oxidative stress, Lead acetate, Apoptosis, Toxicity, TL, Thunbergia laurifolia Linn, Lead (Pb), Original Article, General Agricultural and Biological Sciences, BUN, Blood urea nitrogen, 010606 plant biology & botany
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المؤلفون: Marie D. Ralff, Benedito A. Carneiro, Lanlan Zhou, Wen-I Chang, Rohinton Tarapore, Varun V. Prabhu, Joshua N. Honeyman, Attila A. Seyhan, Isacco Ferrarini, Alexander G. Raufi, Lindsey Carlsen, Martin Stogniew, Lee Schalop, Robyn Borsuk, Joshua E. Allen, Aakash Jhaveri, Cassandra Parker, Sara Morrow, Young Lee, Fabio Tavora, Wolfgang Oster, Jocelyn E. Ray, Kelsey E. Huntington, Howard Safran, Anna D Louie, Abed Rahman Kawakibi, Yiqun Zhang, Wafik S. El-Deiry
المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)مصطلحات موضوعية: DRD4, dopamine receptor D4, SCLC, small-cell lung cancer, Pyridines, medicine.medical_treatment, OXPHOS, oxidative phosphorylation, GIRK, G protein-coupled inwardly rectifying potassium channel, GnRH, gonadotropin-releasing hormone receptor, Receptors, G-Protein-Coupled, TNF-Related Apoptosis-Inducing Ligand, 0302 clinical medicine, NOAEL, no-observed-adverse-event-level, DSRCT, desmoplastic small round cell tumor, RECIST, Response Evaluation Criteria in Solid Tumors, Antineoplastic Combined Chemotherapy Protocols, ATRT, atypical teratoid rhabdoid tumor, AML, acute myeloid leukemia, DRD2, dopamine receptor D2, CLL, chronic lymphocytic leukemia, Clinical Studies as Topic, A2A, Adenosine 2A receptor, ONC201, RANO, Response Assessment in Neuro-Oncology, MTD, maximum tolerated dose, HGG, high-grade glioma, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, PFS, progression-free survival, DRD5, dopamine receptor D5, DRD3, dopamine receptor D3, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, CRC, colorectal cancer, Neoplastic Stem Cells, NK, natural killer, IHC, immunohistochemistry, cAMP, cyclic AMP, EC, endometrial cancer, Antineoplastic Agents, lcsh:RC254-282, TNBC, triple-negative breast cancer, WHO, World Health Organization, 03 medical and health sciences, DRD1, dopamine receptor D1, Review article, Cancer stem cell, Glioma, MCL, mantle cell lymphoma, SAR, structure–activity relationship, Humans, Protein kinase B, ISR, integrated stress response, Tumor microenvironment, TMZ, temozolomide, cCK18, caspase-cleaved cytokeratin 18, GDSC, Genomics of Drug Sensitivity in Cancer, medicine.disease, DNA-PKcs, DNA-activated protein kinase catalytic subunit, FLAIR, fluid-attenuated inversion recovery, 030104 developmental biology, DIPG, diffuse intrinsic pontine glioma, 0301 basic medicine, Cancer Research, ClpX, caseinolytic mitochondrial matrix peptidase chaperone subunit X, Drug Evaluation, Preclinical, CTCL, cutaneous T-cell lymphoma, NHL, non-Hodgkin’s lymphoma, Targeted therapy, Prostate cancer, AUC, area under the curve, Neoplasms, CML, chronic myelogenous leukemia, Clinical Trials as Topic, AMPK, AMP kinase, Chemistry, CK18, cytokeratin 18, MM, multiple myeloma, Imidazoles, TIC10, TRAIL-inducing compound 10, Endopeptidase Clp, TRAIL, TNF-associated apoptosis-inducing ligand, Mitochondria, Treatment Outcome, RP2D, recommended phase II dose, Disease Susceptibility, DLBCL, diffuse large B-cell lymphoma, PD, pharmacodynamic, Signal Transduction, imipridones, PC-PG, pheochromocytoma-paraganglioma, rhTRAIL, recombinant human TRAIL, ClpP, caseinolytic protease P, PK, pharmacokinetic, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, OS, overall survival, Immune system, PLC, phospholipase C, DR5, death receptor 5, NSCLC, non-small cell lung cancer, medicine, BRD, bromodomain, cancer, Animals, ALCL, anaplastic large cell lymphoma, PDX, patient-derived xenograft, Cancer, GBM, glioblastoma multiforme, ALL, acute lymphoblastic leukemia, CSC, cancer stem cell, GPCR, G protein coupled receptor, EGFR, epidermal growth factor receptor, Pyrimidines, Cancer research, 5-FU, 5-fluorouracil, HCC, hepatocellular carcinoma, ONC201, imipridones, cancer
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المؤلفون: Farah Khashab, May Al-Maghrebi, Nora Al-Kandari, Farah Al-Saleh, Fatemah Fadel
المصدر: Saudi Journal of Biological Sciences, Vol 27, Iss 8, Pp 2174-2184 (2020)
Saudi Journal of Biological Sciencesمصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, O2, molecular oxygen, PERK, pancreatic ER kinase, NADP, nicotinamide adenine dinucleotide phosphate, PCC, protein carbonyl content, DMSO, dimethyl sulfoxide, ST, seminiferous tubule, medicine.disease_cause, 01 natural sciences, ATF, activating transcription factor, eIF2α1, eukaryotic initiation factor 2α1, PVDF, polyvinylidene difluoride, chemistry.chemical_compound, DNA, deoxyribonucleic acid, PCR, polymerase chain reaction, UPR, unfolded protein response, ECL, electrochemiluminescence, TOS, testicular oxidative stress, ASK1, PARP, poly ADP-ribose polymerase, lcsh:QH301-705.5, ANOVA, analysis of variance, ATM, ataxia telangiectasia mutated, NADPH oxidase, RT, reverse transcription, biology, Chemistry, ELISA, enzyme-linked immunosorbent assay, BTB, blood-testis barrier, i.p., intraperitoneal, NOX, NADPH oxidase, JNK, c-Jun N-terminal Kinase, OS, oxidative stress, H2O2, hydrogen peroxide, IAP, inhibitors of apoptosis, p-, phosphorylated, RIPA, radioimmunoprecipitation assay, Germ cell apoptosis, General Agricultural and Biological Sciences, ER stress, kDa, kilodalton, phox, phagocyte oxidase, DNA damage, mRNA, messenger ribonucleic acid, H2AX, histone variant, IRE1, inositol requiring kinase 1, DAPI, diamidino phenylindole, CHOP, CCAAT-enhancer-binding protein homologous protein, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, Article, DDR, DNA damage response, Testicular ischemia Reperfusion Injury, ER, endoplasmic reticulum, Superoxide dismutase, Andrology, cDNA, complementary DNA, 03 medical and health sciences, ROS, reactive oxygen species, SOD, superoxide dismutase, GCA, germ cell apoptosis, medicine, IF, immunofluorescence, MDA, malondialdehyde, GRP78, glucose-related protein 78, medicine.disease, O2−, superoxide anion, Chk, checkpoint kinase, 8-OHdG, 8-hydroxy-2′-deoxyguanosine, 030104 developmental biology, lcsh:Biology (General), Oxidative stress, TRAF-2, tumor-necrosis-factor receptor-associated factor 2, SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis, Apocynin, H&E, hematoxylin and eosin, RNA, ribonucleic acid, γ-H2AX, 139 serine-phosphorylated histone variant, Unfolded protein response, biology.protein, ASK1, apoptosis signaling kinase 1, BSA, bovine serum albumin, gDNA, genomic DNA, SD, standard deviation, Reperfusion injury, 010606 plant biology & botany
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المؤلفون: Monish Ram, Makena, Myungjun, Ko, Allatah X, Mekile, Nanami, Senoo, Donna K, Dang, John, Warrington, Phillip, Buckhaults, C Conover, Talbot, Steven M, Claypool, Rajini, Rao
المصدر: Redox Biology
مصطلحات موضوعية: p53, ORAI1 Protein, ER, estrogen receptor, DNA damage Response, Breast Neoplasms, Oxygen consumption rate, Calcium-Transporting ATPases, ROS, reactive oxygen species, SOCE, store operated Ca2+ entry, TUNEL, Terminal deoxynucleotidyl transferase dUTP nick end labeling, ER+ breast cancer, Humans, Calcium Signaling, Ca2+ signaling, TNBC, triple negative breast cancer, Adenosine Triphosphatases, Secretory Pathway, Respiration, ROS, PR, progesterone receptor, SICE, store independent Ca2+ entry, Mitochondria, Doxorubicin, Calcium, Female, DNA Damage, Research Paper
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المؤلفون: Jephte Y. Akakpo, Qingyun Bai, Xiao Yang, Li Yang, Thomas Rülicke, Lili Ji, Kurt Zatloukal, Wen-Xing Ding, Hong-Min Ni, Hui Qian, Hartmut Jaeschke
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3791-3805 (2021)مصطلحات موضوعية: WT, wild type, 4EBP-1, translational initiation factor 4E binding protein-1, Macrophage, S6, ribosomal protein S6 kinase, NAC, N-acetylcysteine, Mitochondrion, LC3, microtubule-associated light chain 3, GSH, glutathione, GCL, glutamate cysteine ligase, KEAP1, Kelch-like ECH-associated protein-1, General Pharmacology, Toxicology and Pharmaceutics, Liver injury, KIR, KEAP1-interacting region, medicine.diagnostic_test, biology, digestive, oral, and skin physiology, Platelet, NRF2, nuclear factor erythroid 2-related factor 2, Original Article, DILI, medicine.drug, VWF, von Willebrand factor, medicine.medical_specialty, APAP, acetaminophen, NF-κB, nuclear factor-κB, RM1-950, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, Western blot, Von Willebrand factor, AILI, APAP-induced liver injury, Internal medicine, ALT, alanine aminotransferase, medicine, Autophagy, CYP2E1, cytochrome P450 2E, KC, Kupffer cells, PI3K/AKT/mTOR pathway, NPCs, non-parenchymal cells, Coagulation, APAP-AD, APAP-adducts, KO, knockout, Cell growth, business.industry, NQO1, NADPH quinone dehydrogenase 1, Hepatotoxicity, CLEC-2, C-type lectin-like receptor, medicine.disease, Acetaminophen, Endocrinology, biology.protein, H&E, hematoxylin and eosin, Liver regeneration, Therapeutics. Pharmacology, business, NAPQI, N-acetyl-p-benzoquinone imine
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المؤلفون: Karlheinz Peter, Henry N. Gordon, Aidan P.G. Walsh, Xiaowei Wang
المصدر: Advanced Drug Delivery Reviews
مصطلحات موضوعية: PEI, polyethylenimine, BNT162b2, BioNTech COVID-19 mRNA vaccine, medicine.medical_treatment, Genetic enhancement, microbubble, Pharmaceutical Science, DSPE-PEG2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[polyethylene glycol-2000], VCAM-1, vascular cell adhesion molecule-1, Targeted therapy, DNA, deoxyribonucleic acid, miRNA, microRNA, Medicine, Ultrasonics, sonoporation, Molecular Targeted Therapy, gene transfer, CD105, endoglin, cluster of differentiation 105, MAdCAM-1, mucosal addressin cell adhesion molecule 1, GFP, green fluorescence protein, COVID-19, coronavirus disease 2019, DSPC, distearoylphosphatidylcholine, DPPC, dipalmitoylphosphatidylcholine, LNP, lipid nanoparticle, DOTAP, 1,2-dioleoyl-3-trimethylammonium propane, mRNA1273, Moderna COVID-19 mRNA vaccine, Gene Transfer Techniques, eGFP, enhanced green fluorescence protein, pDNA, plasmid DNA, targeted therapy, VEGF, vascular endothelial growth factor, mRNA, messenger RNA, GDNF, glial cell line–derived neurotrophic factor, DSPE, 1,2-distearoyl-sn-glycero-3-phosphorylethanolamine, Nurr1, orphan nuclear receptor, BDNF, brain-derived neurotrophic factor, MI, myocardial infarction, shRNA, short hairpin RNA, C4F10, decafluorobutane, OTC, ornithine transcarbamylase, SF6, sulfur hexafluoride, Man-PEG2000, mannose-binding polyethylene glycol-2000, UTGD, ultrasound-targeted gene delivery, Coronavirus disease 2019 (COVID-19), NB, nanobubble, I/R, ischemia/reperfusion, Computational biology, Gene delivery, CVD, cardiovascular disease, AKT, protein kinase B, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, Article, Viral vector, DSPC-PEG2K-Mal, distearoylphosphatidylcholine-N-[maleimide(polyethylene glycol)-2000], SPIO-NP, fluorinated iron oxide nanoparticle, PEGylated-PEI-SH, polyethylene glycol-polyethylenimine-thiol, Animals, Humans, Timp3, tissue inhibitor of metalloproteinase 3, Platelet activation, DSTAP, 1,2-distearoyl-3-trimethylammonium-propane, ComputingMethodologies_COMPUTERGRAPHICS, PEG, polyethylene glycol, TA, tibialis anterior, AAA, abdominal aortic aneurysm, MMP2, matrix metallopeptidase-2, PNA, peptide nucleic acid, business.industry, C3F8, octafluoropropane, SCF, stem cell factor, COVID-19, DC-CHOL, DC-cholesterol, Genetic Therapy, nucleic acid, siRNA, small interfering RNA, Liposomes, IFN-β, interferon-β, RNA, ribonucleic acid, Nanoparticles, Ultrasonic sensor, PMO, phosphorodiamidate morpholino oligomer, ultrasonic irradiation, business, Sonoporation, MRI, magnetic resonance imaging, MB, microbubble
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المؤلفون: Randolph Ruiz Rodriguez, Fumiko Nakazeki, Takeshi Kimura, Chiharu Otani, Yuya Ide, Sijia Xu, Takahiro Horie, Akira Kakizuka, Toshimitsu Watanabe, Koh Ono, Yui Miyasaka, Satoshi Koyama, Yasuhide Kuwabara, Naritatsu Saito, Masamichi Yamamoto, Tomohiro Nishino, Shin Watanabe, Yasuhiro Nakashima, Tomohiro Yamasaki, Masahiro Kimura, Hitoo Nishi, Motoko Yanagita, Masataka Nishiga, Shuhei Tsuji, Tetsushi Nakao
المصدر: JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 701-714 (2019)
JACC: Basic to Translational Scienceمصطلحات موضوعية: 0301 basic medicine, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_treatment, 030204 cardiovascular system & hematology, HF, heart failure, PRECLINICAL RESEARCH, 0302 clinical medicine, CMR, cardiac magnetic resonance, Medicine, LV, left ventricular/ventricle, TTC, triphenyltetrazolium chloride, Myocardial infarction, I/R, ischemia and reperfusion, FS, fractional shortening, IHD, ischemic heart disease, myocardial infarction, H2O2, hydrogen peroxide, MI, myocardial infarction, Cardiology, cardiovascular system, AAR, area at risk, ATPase, adenosine triphosphatase, ER stress, KUS121, Kyoto University Substance 121, Cardiology and Cardiovascular Medicine, IBMPFD, inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia, medicine.medical_specialty, ATP, adenosine triphosphate, Ischemia, CHOP, C/EBP homologous protein, FRET, fluorescence resonance energy transfer, ER, endoplasmic reticulum, 03 medical and health sciences, Reperfusion therapy, Internal medicine, KUS121, EF, ejection fraction, cardiovascular diseases, PCI, percutaneous coronary intervention, business.industry, Endoplasmic reticulum, TUNEL, terminal deoxynucleotidyl transferase dUTP nick-end labeling, BiP, immunoglobulin heavy chain-binding protein, Percutaneous coronary intervention, medicine.disease, Infarct size, ATP, VCP, valosin-containing protein, 030104 developmental biology, LAD, left anterior descending artery, lcsh:RC666-701, Unfolded protein response, business, Reperfusion injury
وصف الملف: application/pdf
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المؤلفون: Lotteau, S, Ivarsson, N, Yang, Z, Restagno, D, Colyer, J, Hopkins, P, Weightman, A, Himori, K, Yamada, T, Bruton, J, Steele, D, Westerblad, H, Calaghan, S
المصدر: JACC: Basic to Translational Science
مصطلحات موضوعية: FKBP12, FK506 binding protein (calstabin), exercise, statin, HMG CoA, 3-hydroxy-3-methylglutaryl coenzyme A, nutritional and metabolic diseases, Ca2+, calcium, SR, sarcoplasmic reticulum, calcium leak, GAS, gastrocnemius, RyR, ryanodine receptor, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, RNS, reactive nitrogen species, PRECLINICAL RESEARCH, FDB, flexor digitorum brevis, PGC1α, peroxisome proliferator-activated receptor γ co-activator 1α, ROS, reactive oxygen species, HADHA, hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, SOD, superoxide dismutase, L-NAME, N(ω)-nitro-L-arginine methyl ester, ryanodine receptor, lipids (amino acids, peptides, and proteins), cardiovascular diseases, NOS, nitric oxide synthase, myopathy
وصف الملف: application/pdf
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المؤلفون: George Gardner, Evangelia G. Kranias, Guo-Chang Fan, Guan-Sheng Liu, Jiang Qian, Yutian Li, Nathan Robbins, Kobra Haghighi, Jack Rubinstein, Burns C. Blaxall, Min Jiang, Joshua G. Travers
المصدر: JACC: Basic to Translational Science
مصطلحات موضوعية: inorganic chemicals, 0301 basic medicine, WT, wild type, STAT3, signal transducer and activator of transcription 3, heart failure, I/R, ischemia/reperfusion, 030204 cardiovascular system & hematology, environment and public health, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, fibroblast, Ccl2, C-C motif chemokine ligand 2, 03 medical and health sciences, Paracrine signalling, PRECLINICAL RESEARCH, 0302 clinical medicine, Downregulation and upregulation, In vivo, TG, transgenic, Col1a1, collagen 1A1, medicine, Hsp, heat shock protein, Col3A1, collagen 3A1, Fibroblast, Postn, periostin, TGF, transforming growth factor, remodeling, Hsp20, IL-6, TNF, tumor necrosis factor, business.industry, fungi, medicine.disease, 3. Good health, Cell biology, Blockade, ECM, extra-cellular matrix, IL, interleukin, enzymes and coenzymes (carbohydrates), 030104 developmental biology, medicine.anatomical_structure, Ccl3, C-C motif chemokine ligand 3, Heart failure, bacteria, Phosphorylation, SMA, smooth muscle actin, Cardiology and Cardiovascular Medicine, business, Ex vivo
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المؤلفون: Wen-Xing Ding, Hartmut Jaeschke, David S Umbaugh, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Nga T. Nguyen, Jephte Y. Akakpo, Anup Ramachandran
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)مصطلحات موضوعية: GSSG, glutathione disulfide, LOOH, lipid hydroperoxides, NQO1, NAD(P)H:quinone oxidoreductase 1, TLR, toll like receptor, HNE, 4-hydroxynonenal, NAC, N-acetylcysteine, Apoptosis, Review, Bioinformatics, SMAC/DIABLO, second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI, GSH, glutathione, General Pharmacology, Toxicology and Pharmaceutics, Liver injury, Innate immunity, BSO, buthionine sulfoximine, mTORC1, mammalian target of rapamycin complex 1, MCP-1, monocyte chemoattractant protein-1, Mitochondria, CYP, cytochrome P450 enzymes, GPX4, glutathione peroxidase 4, NRF2, nuclear factor erythroid 2-related factor 2, KEAP1, Kelch-like ECH-associated protein 1, LPO, lipid peroxidation, NF-κB, nuclear factor κB, medicine.drug, DMSO, dimethylsulfoxide, Inflammatory response, Gclm, glutamate–cysteine ligase modifier subunit, HMGB1, high mobility group box protein 1, APAP, acetaminophen, ARE, antioxidant response element, RM1-950, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, UGT, UDP-glucuronosyltransferases, Necrotic cell, MPT, mitochondrial permeability transition, Acetaminophen hepatotoxicity, NRF2, ROS, reactive oxygen species, EndoG, endonuclease G, medicine, Autophagy, Injury mechanisms, Ferroptosis, MnSOD, manganese superoxide dismutase, Antipyretic drugs, MDA, malondialdehyde, Drug metabolism, business.industry, ATG, autophagy-related genes, PUFAs, polyunsaturated fatty acids, Liver failure, medicine.disease, CAD, caspase-activated DNase, Gclc, glutamate–cysteine ligase catalytic subunit, Acetaminophen, LC3, light chain 3, AIF, apoptosis-inducing factor, AMPK, AMP-activated protein kinase, DAMPs, damage-associated molecular patterns, JNK, c-jun N-terminal kinase, Therapeutics. Pharmacology, LAMP, lysosomal-associated membrane protein, business, NAPQI, N-acetyl-p-benzoquinone imine, FSP1, ferroptosis suppressing protein 1, MAP kinase, mitogen activated protein kinase
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المؤلفون: Yoshitake Cho, Anne N. Murphy, Alex Liang, Shamim Khosrowjerdi, Oliver R. Zhang, Robert S. Ross, Aleksander Andreyev, Kayla Lam, Ruixia Li, Shizuko Tachibana, Yoh Arita
المصدر: The Journal of Biological Chemistry
The Journal of biological chemistry, vol 297, iss 1مصطلحات موضوعية: 0301 basic medicine, mitochondrial biogenesis, ATP5B, Messenger, NCM, neonatal cardiomyocytes, Muscle Proteins, cardiomyocytes, Mitochondrion, PGC-1, PPARgamma coactivator 1, SDHb, succinate dehydrogenase complex iron–sulfur subunit B, Inbred C57BL, Cardiovascular, Biochemistry, Medical and Health Sciences, OxPhos, oxidative phosphorylation, Oxidative Phosphorylation, Mice, Cox, cytochrome c oxidase, oxidative metabolism, Receptors, Myocyte, Protein Isoforms, 2.1 Biological and endogenous factors, OCR, oxygen consumption rate, Perm1, peroxisome proliferator-activated receptor coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator, muscle 1, Aetiology, Organelle Biogenesis, Heart development, LDH, lactate dehydrogenase, Intracellular Signaling Peptides and Proteins, Heart, Biological Sciences, Cell Hypoxia, Cell biology, Mitochondria, Mitochondrial, Heart Disease, 5.1 Pharmaceuticals, medicine.symptom, Development of treatments and therapeutic interventions, Mito, mitochondrial, Cardiac, Transcription, Oxidation-Reduction, Perm1, NDUFS3, NADH dehydrogenase [ubiquinone] iron–sulfur protein 3, Research Article, Programmed cell death, Biochemistry & Molecular Biology, Heart Ventricles, Down-Regulation, ATP5b, ATP synthase F1 subunit beta, Biology, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, Promoter Regions, 03 medical and health sciences, H/R, hypoxia-reoxygenation, UQCRC2, ubiquinol-cytochrome C reductase core protein 2, Genetic, Coactivator, medicine, Genetics, COXIV, cytochrome c oxidase subunit IV, Animals, Humans, Molecular Biology, Heart Failure, Myocytes, 030102 biochemistry & molecular biology, Cell Biology, DNA, Hypoxia (medical), Estrogen, Oxygen, ERR, estrogen-related receptor, 030104 developmental biology, Mitochondrial biogenesis, SERCA, Sarco/endoplasmic reticulum Ca2+-ATPase, Protein Biosynthesis, Musculoskeletal, Chemical Sciences, RNA, Transcription Factors
وصف الملف: application/pdf
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المؤلفون: Vichununt, Kerdput, Cheng, Nilbu-Nga, Nattpawit, Kaewnoonual, Arunporn, Itharat, Suriya, Pongsawat, Wisuit, Pradidarcheep
المصدر: Journal of Traditional and Complementary Medicine
مصطلحات موضوعية: Hua-Khao-Yen, TAA, thioacetamide, ALP, alkaline phosphatase, glypican3, PBS, phosphate-buffered saline, Traditional medicine, GPC3, glypican3, AST, aspartate aminotransferase, DM, Dioscorea membranacea, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, digestive system diseases, SF, sorafenib, Reticulin, GGT, γ-glutamyltransferase, ALT, alanine aminotransferase, Original Article, HCC, hepatocellular carcinoma, neoplasms, Liver cancer, DEN, diethylnitrosamine
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المؤلفون: Yun Seok Kim, Sang Geon Kim, Min Sung Joo, Ja Hyun Koo, Tae Hyun Kim
المصدر: EBioMedicine
مصطلحات موضوعية: Male, 0301 basic medicine, Research paper, FPKM, Fragments Per Kilobase Million, TF, transcription factor, Receptors, Cytoplasmic and Nuclear, Apoptosis, Histones, Mice, 0302 clinical medicine, Super-enhancer, Protein Interaction Mapping, ChIP-seq, chromatin immunoprecipitation-sequencing, Protein Interaction Maps, GEO, Gene Expression Omnibus, Regulation of gene expression, DMEM, Dulbecco's modified Eagle's medium, Liver Diseases, General Medicine, HSC, hepatic stellate cell, SEM, standard error of mean, Cell biology, ChIP, chromatin immunoprecipitation, Enhancer Elements, Genetic, medicine.anatomical_structure, Liver, 030220 oncology & carcinogenesis, Hepatocyte, Liver disease, Protein Binding, Cell Survival, APAP, acetaminophen, Gene delivery, Biology, ITSX, insulin-transferrin-selenium X, LRH1, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Acute liver injury, medicine, Animals, Humans, natural sciences, Transcription factor, Gene, Acetaminophen, GO, gene ontology, Computational Biology, H3K27Ac, K27-acetylated histone H3, qRT-PCR, quantitative reverse-transcription polymerase chain reaction, RNA-seq, RNA-sequencing, Gene Ontology, 030104 developmental biology, Gene Expression Regulation, Hepatocytes, Hepatic stellate cell, TSS, transcription start site, Chromatin immunoprecipitation, Transcription Factors
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المؤلفون: Maureen Gannon, Peter A. Kropp, Xiaodong Zhu
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 841-856 (2019)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, PDAC, pancreatic ductal adenocarcinoma, Acinar Cells, Epithelium, Nr5a2, nuclear receptor subfamily 5, group A, member 2, Transcriptome, Mice, 0302 clinical medicine, Transcriptional regulation, Morphogenesis, MPC, multipotent pancreatic progenitor cell, Ptf1a, Pancreas transcription factor, 1a, Original Research, Gastroenterology, Gene Expression Regulation, Developmental, Cell Differentiation, Pancreas, Exocrine, Pancreas Development, Cell biology, Hepatocyte Nuclear Factor 6, medicine.anatomical_structure, Cym, Chymosin, 030211 gastroenterology & hepatology, Pancreas, Inhba, Inhibin, Beta A, Sox9, SRY-related HMG-box 9, ChIP-Seq, chromatin immunoprecipitation followed by high-throughput sequencing, RNA-Seq, RNA-sequencing, Hnf6, hepatocyte nuclear factor 6, Biology, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, ADM, acinar-to-ductal metaplasia, 03 medical and health sciences, CK19, Cytokeratin 19, medicine, Acinar cell, Animals, Ihh, Indian hedgehog, Mist1, muscle, intestine, stomach transcription factor 1, lcsh:RC799-869, Transcription factor, Hnf1β, hepatocyte nuclear factor 1β, Cell Proliferation, Pancreatic duct, Oc1, Onecut1, Hepatology, Base Sequence, Ptch2, Patched 2, Smo, Smoothened, HH, Hedgehog, Embryo, Mammalian, Spink 1, serine protease inhibitor Kazal type 1, 030104 developmental biology, Animals, Newborn, lcsh:Diseases of the digestive system. Gastroenterology, FOXA2, Pdx1, pancreatic and duodenal homeobox 1, Exocrine
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المؤلفون: David J. Lefer, Amy Scarborough, Traci T. Goodchild, Zhenwei Gong, Thomas E. Sharp, Eric S. Goetzman, Radhika Muzumdar, Pablo Spaletra, Murtuza J. Ali
المصدر: JACC: Basic to Translational Science
مصطلحات موضوعية: IV, intravenously, medicine.medical_specialty, Myocardial ischemia, adjunctive therapy, AAR, area-at-risk, RMBF, regional myocardial blood flow, acute myocardial infarction, Ischemic time, large animal model, Peptide, myocardial ischemia-reperfusion injury, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, cTnI, cardiac troponin I, PRECLINICAL RESEARCH, TBARS, thiobarbituric acid–reactive substances, Internal medicine, LAD, left anterior coronary artery, medicine, Clinical efficacy, Myocardial infarction, LV, left ventricular, chemistry.chemical_classification, business.industry, MI/R, myocardial ischemia/reperfusion, mitochondrial-derived peptide, Infarct size, medicine.disease, MDP, mitochondrial-derived peptide, STAT, signal transducer and activator of transcription, Bax, Bcl-2–associated X protein, HNG, S14G-humanin analogue, chemistry, MI, myocardial infarction, Cardiology, NIZ, nonischemic zone, Cardiology and Cardiovascular Medicine, business, ELISA, enzyme-linked immunoadsorbent assay, Reperfusion injury, h-FABP, heart fatty acid–binding protein, IGFBP3, insulin-like growth factor–binding protein-3, DAPI, 4′,6-diamidino-2-phenylindole, Large animal
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17
المؤلفون: Brown, Nicholas E., Paluch, Andrew M., Nashu, Madison A., Komurov, Kakajan, Waltz, Susan E.
المصدر: Neoplasia (New York, N.Y.)
مصطلحات موضوعية: Male, Original article, Apoptosis, urologic and male genital diseases, Mice, COPA, cancer outlier profile analysis, Transcriptional Regulator ERG, Animals, Humans, OE, overexpressing, ADT, androgen deprivation therapy, beta Catenin, Cell Proliferation, CRPC, castration-resistant prostate cancer, TUNEL, terminal deoxynucleotidyl transferase dUTP nick-end labeling, CSS, charcoal-stripped serum, NF-kappa B, Prostatic Neoplasms, Receptor Protein-Tyrosine Kinases, Immunohistochemistry, Gene Expression Regulation, Neoplastic, Prostatic Neoplasms, Castration-Resistant, Receptors, Androgen, Androgens, AR, androgen receptor, RTK, receptor tyrosine kinase, Biomarkers, Signal Transduction
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18
المؤلفون: Wei Wei, Zhigang Liu, Chao Zhang, Rami Khoriaty, Min Zhu, Bin Zhang
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: CDAII, congenital dyserythropoietic anemia type II, ZG, zymogen granule, Mutation, Missense, Vesicular Transport Proteins, TCA, trichloroacetic acid, Biochemistry, ER, endoplasmic reticulum, Mice, COPII, coat protein complex II, Larone syndrome, Pancreatitis, Chronic, Neo, neomycin, Animals, COPII, pancreas, TNF-α, tumor necrosis factor alpha, IGF-1, insulin-like growth factor 1, TEM, transmission electron microscopy, Molecular Biology, Anemia, Dyserythropoietic, Congenital, TUNEL, terminal deoxynucleotidyl transferase dUTP nick-end labeling, ES, embryonic stem, RBC, red blood cell, Cell Biology, GH, growth hormone, IL, interleukin, secretion, dyserythropoietic anemia, STAT, signal transducer and activator of transcription, Phenotype, GHR, growth hormone receptor, KI, knockin, Socs3, suppressor of cytokine signaling-3, growth hormone, GTT, glucose tolerance test, ER stress, JAK, Janus kinase, Research Article
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19
المؤلفون: Yunchen Lin, Jingyao Li, Xueying Huang, Ying Cai, Ting Xu, Le Yang, Jinxin Ou, Qing Zhang, Pei-Hui Wang, Xin Zhao, Junyu Huang, Taoshu Liu, Nanyan Yang, Miao Li, Haisheng Chen, Qinghuan Wang, Fei Li
المصدر: Biochimica et Biophysica Acta. Molecular Basis of Disease
مصطلحات موضوعية: DEGs, differentially expressed genes, Apoptosis, Inflammation, Biology, ACE2, angiotensin-converting enzyme 2, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, Article, Cell Line, Phosphatidylinositol 3-Kinases, ROS, reactive oxygen species, MERS-CoV, middle east respiratory syndrome coronavirus, RT-PCR, reverse transcription polymerase chain reaction, KEGG, kyoto encyclopedia of genes and genomes, Co-IP, Co-immunoprecipitation, Chlorocebus aethiops, Autophagy, medicine, Animals, Humans, Vero Cells, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, COVID-19, coronavirus disease 2019, TUNEL assay, SARS-CoV-2, TOR Serine-Threonine Kinases, TNF-α, tumor necrosis factor-alpha, COVID-19, Endothelial Cells, ELISA, enzyme-linked immunosorbent assay, IL, interleukin, Cell biology, HEK293 Cells, Terminal deoxynucleotidyl transferase, Spike Glycoprotein, Coronavirus, Molecular Medicine, medicine.symptom, Signal transduction, Reactive Oxygen Species, Proto-Oncogene Proteins c-akt, SARS-CoV-2, severe acute respiratory syndrome coronavirus-2, 3-MA, 3-methyladenine, Signal Transduction
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20
المؤلفون: Chengyuan Tang, Xiaofen Xiong, Xiaoxuan Xu, Lin Sun, Shuguang Yuan, Yachun Han, Xianghui Chen, Shikun Yang, Yashpal S. Kanwar, Fuyou Liu, Xuejing Zhu, Ming Yang, Li Xiao, Peng Gao
المصدر: Redox Biology
Redox Biology, Vol 16, Iss, Pp 32-46 (2018)مصطلحات موضوعية: 0301 basic medicine, Mitochondrial ROS, MFI, median fluorescence intensity, BUN, blood urea nitrogen, Clinical Biochemistry, TPP, triphenylphosphonium, AST, aspartate aminotransferase, Diabetic nephropathy, Mitochondrion, ECL, enhanced chemiluminescence, Biochemistry, MitoQ, chemistry.chemical_compound, 0302 clinical medicine, LDL, low-density lipoprotein, TBARS, thiobarbituric acid reactive substances, lcsh:QH301-705.5, chemistry.chemical_classification, MtROS, mitochondria reactive oxygen species, lcsh:R5-920, TG, triglyceride, Chemistry, BW, body weight, TXNIP, thioredoxin-interacting protein, MMT, methyl methane-thiosulphonate, 3. Good health, Cell biology, UA, uric acid, Mitochondria, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end-labeling, TRX, thioredoxin, KW, kidney weight, 030220 oncology & carcinogenesis, DCFDA, dichlorodihydrofluorescein diacetate, medicine.symptom, Thioredoxin, lcsh:Medicine (General), EMT, epithelial–mesenchymal transition, TXNIP, IHC, immunohistochemistry, Scr, serum creatinine, Research Paper, HbA1C, hemoglobin A1c, Inflammation, MSU, monosodium urate, MMP, mitochondrial transmembrane potential, MPTP, mitochondrial permeability transition pore, 03 medical and health sciences, DN, diabetic nephropathy, HE, hematoxylin-eosin, ALT, alanine aminotransferase, medicine, IF, immunofluorescence, MDA, malondialdehyde, Reactive oxygen species, BG, blood glucose, EM, electron microscopy, Organic Chemistry, Reactive oxygen species (ROS), medicine.disease, NLRP3 inflammasome, TC, total cholesterol, PAS, periodic acid-Schiff, 8-OHdG, 8-oxo-deoxyguanosine, 030104 developmental biology, lcsh:Biology (General), TRX/TXNIP