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المصدر: Translational Research
مصطلحات موضوعية: pDC, Plasmacytoid dendritic cell, Review Article, Disease, Extracellular Traps, Health Services Accessibility, immune system diseases, Epidemiology, Pandemic, HCQ, Hydroxychloroquine, Lupus Erythematosus, Systemic, Th17, T helper 17, IL, Interleukin, skin and connective tissue diseases, sGC, Systemic glucocorticoids, AZA, Azathioprine, COVID-19, Coronavirus disease 2019, EBV, Epstein-Barr virus, education.field_of_study, LOF, Loss-of-function, TOR Serine-Threonine Kinases, TRAF, Tumor necrosis factor receptor-associated factor, General Medicine, Treg, Regulatory T cell, ISG, Interferon-stimulated gene, IFN, Interferon, ICU, Intensive care unit, Interferon Type I, Antibodies, Antiphospholipid, MASP-2, Manna-binding lectin associated serine protease-2, JAK, Janus kinase, MMF, Mycophenolate mofetil, NYC, New York City, TRIF, TIRdomain-containing adapter-inducing interferon-β, TLR, Toll-like receptor, medicine.drug, medicine.medical_specialty, SDH, Social determinants of health, Population, CYC, Cyclophosphamide, PI3K, Phosphatidylinositol 3-kinase, Immune system, STAT, Signal Transducer and Activator of Transcription, ACE2, Angiotensin-converting enzyme 2, Physiology (medical), medicine, Humans, NAC, N-Acetylcisteine, education, IFNAR, Interferon-α/β receptor, Autoimmune disease, Biochemistry, medical, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, Lupus erythematosus, SARS-CoV-2, business.industry, SLE, Systemic Lupus Erythematosus, Biochemistry (medical), TNF, Tumor necrosis factor, Public Health, Environmental and Occupational Health, COVID-19, mTOR, Mechanistic (mammalian) target of rapamycin, RT-PCR, Reverse transcription polymerase chain reaction, Complement System Proteins, medicine.disease, C5aR1, C5a receptor, NET, Neutrophil extracellular trap, MyD88, Myeloid differentiation primary response 88, Act-1, Adaptor protein NF-κ activator, TBK1, TANK-binding kinase 1, Immunology, IRF, Interferon regulatory factor, business, C-19-GRA, COVID-19 Global Rheumatology Alliance, Interferon type I, pS6, Ribosomal protein 6
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المؤلفون: Weiwei Zheng, Liyuan Yang, Lingping Sun, Tianjun Xu
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: PRR, pattern recognition receptor, IL-1, interlukin-1, Biochemistry, chemistry.chemical_compound, ceRNA, competing endogenous RNA, miRNA, microRNA, circRNA, TIM, TRAF-interacting motif, qPCR, quantitative real-time polymerase chain reaction, innate immunity, GFP, green fluorescent protein, Toll-like receptor, NLR, nucleotide-binding oligomerization domain-like receptor, microRNA, TRAF, tumor necrosis factor receptor–associated factor, Pattern recognition receptor, RPI, RNA immunoprecipitation assay, Cell biology, TRAF6, EPC, epithelioma papulosum cyprini cell, PAMP, pathogen-associated molecular pattern, Research Article, TLR, Toll-like receptor, Fish Proteins, circRNA, circular RNA, NF-κB, nuclear factor-κB, TAK1, TGF-β-activated kinase 1, Biology, MAVS, mitochondrial antiviral signaling, FBS, fetal bovine serum, Immunity, Animals, Molecular Biology, TNF Receptor-Associated Factor 6, Innate immune system, Competing endogenous RNA, IRF3, interferon regulatory factor 3, Pathogen-associated molecular pattern, NF-κB, RNA, Circular, ceRNA, Cell Biology, biochemical phenomena, metabolism, and nutrition, Immunity, Innate, MKC, M. miiuy kidney cell, Perciformes, MicroRNAs, chemistry, siRNA, small interfering RNA, MSpC, M. miiuy spleen cell, IRF3, MBrC, M. miiuy brain cell, RLR, retinoic-acid-inducible gene-I (RIG-I)-like receptor
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المؤلفون: Xingyi Guo, Zohreh Jahanafrooz, Loren Lipworth, Zhishan Chen, Jiandong Bao, Hongzhi Li
المصدر: Gene
مصطلحات موضوعية: TMPRSS2, Transmembrane protease serine 2, DNAH3, Dynein axonemal heavy chain 3, eQTL, Expression quantitative trait locus, DPP, Dipeptidyl peptidase, Genome-wide association study, Review, Transcriptome, NKRF, Nuclear factor-kB-repressing factor, TOM, Translocase of the outer membrane, LZTFL1, Leucine zipper transcription factor like 1, IFIT3, Interferon induced protein with tetratricopeptide repeats 3, GWAS, HDL, High-density lipoprotein, M, Membrane, NAPSA, Napsin A aspartic peptidase, Virus-host interactome analyses, TBK1, TANK binding kinase 1, TRAF, Tumor necrosis factor receptor-associated factor, General Medicine, RIPK1, Receptor-interacting serine/threonine protein kinase 1, MLKL, Mixed lineage kinase domain-like protein, PTPN22, Protein tyrosine phosphatase non-receptor type 22, MARK2, Microtubule affinity regulating kinase 2, AP-MS, Affinity purification mass spectrometry, TANK, TRAF family member associated NFKB activator, CCRL2, C-C motif chemokine receptor like 2, PRPF3, U4/U6 small nuclear ribonucleoprotein Prp3, TRAF2, TNF receptor associated factor 2, SRP, Signal recognition particle, WGS, Whole genome sequencing, CCR2, CC-chemokine receptor 2, Genetics, Humans, ApoA1, Apolipoprotein A1, KEAP1, Kelch like ECH associated protein 1, ACE2, Angiotensin converting enzyme-2, Genetic association, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, LC, Liquid chromatography, spTWAS, Splicing-transcriptome-wide association study, del, Deletion, Cryoelectron Microscopy, Computational Biology, Proteins, TWAS, Transcriptome-wide association study, S, Spike, SACM1L, SAC1 like phosphatidylinositide phosphatase, I/D, Insertion/Deletion, HGI, Host Genetics Initiative, Candidate gene, PGLS, 6-Phosphogluconolactonase, E, Envelope, PWAS, Protein-transcriptome-wide association study, IFNAR, Interferon-alpha/beta receptor, (*), STOP codon, SLC6A20, Solute carrier family 6 member 20, Crystallography, X-Ray, Interactome, Genome, XCR1, X-C motif chemokine receptor 1, PASC, Post-acute sequelae of SARS-CoV-2 infection, HLA, Human leukocyte antigens, SRPK1, SRSF protein kinase 1, XYLT1, Xylosyltransferase 1, CryoEM, Cryo-electron microscopy, N, Nucleocapsid, WNT3, Wnt family member 3, GnomAD, Genome Aggregation Database, IL, Interleukin, KIT, KIT proto-oncogene, receptor tyrosine kinase, PRSS1, Serine protease 1, ORFs, Open reading frames, PALS1, Protein associated with LIN7 1, MAGUK family member, SNP, Single nucleotide polymorphism, COVID-19, Coronavirus disease 2019, WES, Whole exome sequencing, TYK2, Tyrosine kinase 2, IFN, Type I interferons, HLA, Human leukocyte antigen, ICU, Intensive care unit, NSPs, Non-structural proteins, Host-Pathogen Interactions, SIGMAR1, Sigma nonopioid receptor 1, OAS, Oligoadenylate synthase, MBL2, Mannose-binding lectin 2, GWAS, Genome-wide association study, NSF, N-ethylmaleimide-sensitive factor, ERGIC, Endoplasmic reticulum Golgi intermediate compartment, RBD, Receptor binding domain, TWAS, TLE1, Transducin-like enhancer protein 1, PRKACA, Protein kinase A catalytic subunit alpha, Biology, Bioinformatics analysis, FYCO1, FYVE and coiled-coil domain autophagy adaptor 1, fs, Frameshift mutation, ESP, Exome Sequencing Project, LCN1P1, Lipocalin 1 pseudogene 1, Gene, GNL3, G protein nucleolar 3, Innate immune system, Host Microbial Interactions, SARS-CoV-2, PLG, Plasminogen, COVID-19, ACE, Angiotensin-converting enzyme, POFUT1, Protein O-Fucosyltransferase 1, PGES-2, Prostaglandin E synthase type 2, TLR7, Toll-like receptor 7, FOXP4, Forkhead box P4, PUF60, Poly(U)-binding-splicing factor 60, POGLUT, Protein O-glucosyltransferase 1 precursor, Genome-Wide Association Study
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المؤلفون: Claudia M. van Tiel, Roy Schrijver, Dorothee Atzler, Aldo Jongejan, Oliver Soehnlein, Marnix Lameijer, Menno P.J. de Winther, Francois Fay, Suzanne A. B. M. Aarts, Barbara Zarzycka, Bram Slütter, Christian Weber, Jun Tang, Perry D. Moerland, Norbert Gerdes, Boris Bleijlevens, Myrthe den Toom, Raphaël Duivenvoorden, Esther Lutgens, Tom Seijkens, Linda Beckers, Pascal J. H. Kusters, Remco T. A. Megens, Marion J.J. Gijbels, Gijs Kooij, Cornelis van 't Veer, Johan Kuiper, Gerry A. F. Nicolaes, Gert Vriend, Louis Boon, Edward A. Fisher, Willem J. M. Mulder, Samantha Baxter, Johan Duchene, Maria Aslani, Marten A. Hoeksema
المساهمون: Biomedische Technologie, Promovendi CD, Biochemie, Moleculaire Genetica, Pathologie, RS: CARIM - R3.06 - The vulnerable plaque: makers and markers, RS: CARIM - R2.06 - Intermediate cardiac metabolism, RS: CARIM - R3.07 - Structure-function analysis of the chemokine interactome for therapeutic targeting and imaging in atherosclerosis, RS: CARIM - R1.01 - Blood proteins & engineering, Medical Biochemistry, ACS - Amsterdam Cardiovascular Sciences, Graduate School, Other departments, Center of Experimental and Molecular Medicine, APH - Methodology, Epidemiology and Data Science, APH - Personalized Medicine, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Other Research, Nephrology, ACS - Atherosclerosis & ischemic syndromes, ACS - Pulmonary hypertension & thrombosis, Molecular cell biology and Immunology, Amsterdam Neuroscience - Neuroinfection & -inflammation
المصدر: Journal of the American College of Cardiology, 71(5), 527-542. Elsevier Science
Journal of the American College of Cardiology
Journal of the American College of Cardiology, 71(5), 527-542
Journal of the American College of Cardiology, 71, 5, pp. 527-542
Journal of the American College of Cardiology, 71(5), 527-542. Elsevier USA
Seijkens, T T P, van Tiel, C M, Kusters, P J H, Atzler, D, Soehnlein, O, Zarzycka, B, Aarts, S A B M, Lameijer, M, Gijbels, M J, Beckers, L, den Toom, M, Slütter, B, Kuiper, J, Duchene, J, Aslani, M, Megens, R T A, van ‘t Veer, C, Kooij, G, Schrijver, R, Hoeksema, M A, Boon, L, Fay, F, Tang, J, Baxter, S, Jongejan, A, Moerland, P D, Vriend, G, Bleijlevens, B, Fisher, E A, Duivenvoorden, R, Gerdes, N, de Winther, M P J, Nicolaes, G A, Mulder, W J M, Weber, C & Lutgens, E 2018, ' Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis ', Journal of the American College of Cardiology, vol. 71, no. 5, pp. 527-542 . https://doi.org/10.1016/j.jacc.2017.11.055, https://doi.org/10.1016/j.jacc.2017.11.055
Journal of the American College of Cardiology, 71, 527-542مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, MECHANISM, rHDL, recombinant high-density lipoprotein, Cell Culture Techniques, 030204 cardiovascular system & hematology, PHENOTYPE, THERAPY, Monocytes, ACTIVATION, immunology, Mice, DC, dendritic cell, 0302 clinical medicine, Cell Movement, TRAF, tumor necrosis factor receptor-associated factor, CD40, Medicine, Propiophenones, Aniline Compounds, biology, nanotechnology, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, BMDM, bone marrow-derived macrophage, Plaque, Atherosclerotic, 3. Good health, medicine.anatomical_structure, Apoe, apolipoprotein E, Tumor necrosis factor alpha, medicine.symptom, Cardiology and Cardiovascular Medicine, CD40-TRAF6 INTERACTIONS, Signal Transduction, Bioinformatics, CD40 Ligand, INHIBITION, Inflammation, CVD, cardiovascular disease, Article, 03 medical and health sciences, Immune system, Animals, Humans, TNF Receptor-Associated Factor 6, SMI, small molecule inhibitor, business.industry, Monocyte, Macrophages, Germinal center, drug development, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Immunoglobulin class switching, inflammation, CELLS, Cancer research, biology.protein, IMMUNE-SYSTEM, atherosclerosis, business, Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19]
وصف الملف: application/pdf
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المؤلفون: Hedger, M.P.
المصدر: Comprehensive Toxicology
مصطلحات موضوعية: lymphocytes, steroidogenesis, Tr1, T regulatory 1, NK, cell natural killer cell, LH, luteinizing hormone, MAP, mitogen-activated protein, Jak/Stat, Janus kinase/signal transducers and activators of transcription, 16:0a-LPC, 1-palmitoyl-sn-glycero-3-phosphocholine, TRADD, TNFR-associated death domain protein, MIF, macrophage migration inhibitory factor, Leydig cell, Aire, autoimmune regulator, TRAF, tumor necrosis factor receptor-associated factor, 18:1a-LPC, 1-oleoyl-sn-glycero-3-phosphocholine, GC, glucocorticoid, TGF, transforming growth factor, Crry, complement receptor-related protein, NLR, Nod-like receptor, P450scc, cholesterol side-chain cleavage complex, StAR, steroidogenic acute regulatory, TNF, tumor necrosis factor, TCR, T cell receptor, PGES, PGE synthase, Th cell, helper T cell, AID, acquired immune deviation, Sertoli cell, macrophages, LPC, lysoglycerophosphatidylcholine, EDS, ethane dimethane sulfonate, nNOS, neuronal NOS, iNOS, inducible nitric oxide synthase, TxAS, thromboxane A synthase, LPS, lipopolysaccharide, RIG, retinoic acid-inducible gene, hCG, human chorionic gonadotropin, TNFR, TNF receptor, PAMP, pathogen-associated molecular pattern, TLR, Toll-like receptor, Tx, thromboxane, immunoregulation, IFNAR, IFNα receptor, TIR, Toll/IL1R, PMN, polymorphonuclear phagocyte, Treg, regulatory T cell, IL1ra, IL1 receptor antagonist, sperm, Article, ROS, reactive oxygen species, nitric oxide, MyD88, myeloid differentiation primary response protein 88, AP1, activated protein 1, eNOS, endothelial NOS, Nod, nucleotide binding oligomerization domain, MHC, major histocompatibility complex, IFN, interferon, PG, prostaglandin, PAF, platelet-activating factor, prostanoids, HLA, human leukocyte antigen, EAO, experimental autoimmune orchitis, HMGB1, high mobility group box chromosomal protein 1, PLA2, phospholipase A2, PGI, prostacyclin, BMP, bone morphogenetic protein, CTL, cytotoxic T lymphocyte, FADD, Fas-associated death domain protein, immunity, cytokines, spermatogenesis, IL, interleukin, TRIF, TIR domain-containing adaptor protein inducing interferon β, COX, cyclooxygenase, PPARγ, peroxisome proliferator-activated receptor γ, 20:4a-LPC, 1-arachidonyl-sn-glycero-3-phosphocholine, FasL, Fas ligand, Jnk, Jun N-terminal kinase, toll-like receptors, APC, antigen-presenting cell, inflammation, RLH, RIG-like helicase, NFκB, nuclear factor kappa B, seminal plasma, P450c17, 17α-hydroxylase/C17-C20 lyase, FSH, follicle-stimulating hormone, BAMBI, BMP and activin membrane-bound inhibitor, 18:2a-LPC, 1-linoleoyl-sn-glycero-3-phosphocholine, ICE, IL1 converting enzyme, NKT cell, natural killer T cell, IL1R, interleukin 1 receptor, IRF, interferon regulatory factor, PC, phosphocholine