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المؤلفون: Songsong Wang, Peng Li, Liang Zou, Jianbo Xiao, Feiya Sheng
المصدر: Journal of Advanced Research
مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, SREBPs, sterol regulatory element binding proteins, SREBP2, sterol regulatory element-binding protein 2, SHP, small heterodimer partner, chemistry.chemical_compound, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, LXRα, liver X receptor α, VLDL, very low-density lipoprotein, Multidisciplinary, TG, triglyceride, Bile acid, Chemistry, Fatty liver, FGF15/19, fibroblast growth factor 15/19, Cholesterol, WB, Western blot, ACC, Acetyl-CoA carboxylase, 030220 oncology & carcinogenesis, Lipogenesis, Quercetin, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, Bile acid metabolism, SDS, sodium dodecyl sulfate, TGR5, Takeda G-protein-coupled receptor 5, medicine.drug_class, Hyperoside, LC-MS, the combination of high-performance liquid chromatography and mass spectrometry, Article, Bile Acids and Salts, pACC, phosphorylated ACC, 03 medical and health sciences, Label-free proteomics, FXR, farnesoid X receptor, CYP27A1, sterol 27-hydroxylase, NAFLD, Internal medicine, medicine, Animals, Cholesterol metabolism, Liver X receptor, ComputingMethodologies_COMPUTERGRAPHICS, BAs, bile acids, SREBP1, sterol regulatory element-binding protein 1, Targeted metabolomics, Lipid Metabolism, CYP7A1, cholesterol 7α-hydroxylase, medicine.disease, Rats, TC, total cholesterol, QC, quality control, AMPK, AMP-activated protein kinase, 030104 developmental biology, Endocrinology, PMSF, phenylmethylsulfonyl fluoride, Apo, apolipoprotein, BSH, bile salt hydrolase, Farnesoid X receptor
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المؤلفون: Justine Gillard, Laure-Alix Clerbaux, Bart Staels, Anne Tailleux, Isabelle Leclercq, Laure B. Bindels, Maxime Nachit, Christine Sempoux
المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie
المصدر: JHEP reports, vol. 4, no. 1, pp. 100387
JHEP Reports, Vol 4, Iss 1, Pp 100387-(2022)
JHEP reports, Vol. 4, no.1, p. 100387 [1-13] (2022)
JHEP Reportsمصطلحات موضوعية: HFD, high-fat diet, CYP7A1, CYP8B1, sterol 12α-hydroxylase, WDF, western and high-fructose diet, FABP6, OGTT, oral glucose tolerance test, FGF15, RC799-869, ASBT, apical sodium-dependent BA transporter, chemistry.chemical_compound, OST, organic solute transporter, βMCA, β-muricholic acid, SHP, small heterodimer protein, WDF, CYP27A1, SHP, TNFα, Immunology and Allergy, LCA, lithocholic acid, DCA, FABP6, fatty acid binding protein 6, FGFR4, fibroblast growth factor receptor 4, CA, cholic acid, NAS, NAFLD activity score, CA, CYP7B1, CYP7B1, oxysterol 7α-hydroxylase, Bile acid, WT, αMCA, ND, normal diet, TGR5, Takeda G-protein coupled receptor 5, Chemistry, LCA, Deoxycholic acid, TLCA, TGR5, Gastroenterology, NASH, GLP-1, glucagon-like peptide-1, Diseases of the digestive system. Gastroenterology, G protein-coupled bile acid receptor, TNFα, tumor necrosis factor α, FXR, BA, bile acid, LPS, lipopolysaccharide, Research Article, CYP2A12, bile acid 7α-hydroxylase, ωMCA, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, ωMCA, ω-muricholic acid, LPS, normal diet, Normal diet, βMCA, medicine.drug_class, NASH, non-alcoholic steatohepatitis, education, tumor necrosis factor α, BA, digestive system, metabolic syndrome, CDCA, chenodeoxycholic acid, CYP2A12, CYP27A1, sterol 27-hydroxylase, Internal medicine, NAFLD, Internal Medicine, medicine, OGTT, CYP7A1, cholesterol 7α-hydroxylase, DCA, deoxycholic acid, FGF15, fibroblast growth factor 15, FXR, Farnesoid X receptor, TLCA, tauro-lithocholic acid, WT, wild-type, αMCA, α-muricholic acid, wild-type, CYP8B1, Hepatology, OST, medicine.disease, Endocrinology, NAS, FGFR4, CDCA, HFD, ND, Steatohepatitis, GLP-1, ASBT
وصف الملف: application/pdf
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المؤلفون: Rumei, Li, Anna, Palmiotti, Hilde D, de Vries, Milaine V, Hovingh, Martijn, Koehorst, Niels L, Mulder, Yue, Zhang, Kim, Kats, Vincent W, Bloks, Jingyuan, Fu, Henkjan J, Verkade, Jan Freark, de Boer, Folkert, Kuipers
المصدر: Journal of Lipid Research
مصطلحات موضوعية: Male, obesity, humanized mouse model, Cyp2c70, cytochrome P450, family 2, subfamily C, polypeptide 70, CK19, cytokeratin 19, WTD, Western-type high-fat diet, Bile Acids and Salts, CDCA, chenodeoxycholic acid, Mice, Cytochrome P-450 Enzyme System, Non-alcoholic Fatty Liver Disease, MCA, muricholic acid, scWAT, subcutaneous white adipose tissue, OTU, operational taxonomic unit, Animals, TEM, transmission electron microscopy, TGR5, Takeda G protein-coupled receptor 5, Mice, Knockout, bile acids, CA, cholic acid, BW, body weight, fat absorption, Cyp2c70, Fatty Liver, Mice, Inbred C57BL, BAT, brown adipose tissue, PL, phospholipid, DCA, deoxycholic acid, Diet, Western, BSTFA, N,O-bis(trimethylsilyl) trifluoroacetamide, BA, bile acid, fatty liver disease, Female, NAFLD, nonalcoholic fatty liver disease, NASH, nonalcoholic steatohepatitis, Cyp8b1, Research Article
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المؤلفون: Geyang Xu, Miao Peng, Heng Zhang, Linxi Chen, Hanbing Li, Tingfeng Qin, Zhi Li, Zhaoqi Huang, Weizhen Zhang, Hening Zhai
المصدر: EBioMedicine
EBioMedicine, Vol 32, Iss, Pp 201-214 (2018)مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, lcsh:Medicine, Mice, Obese, Deoxycholic acid, mTORC1, Receptors, G-Protein-Coupled, DCA, Deoxycholic acid, chemistry.chemical_compound, Mice, Glucagon-Like Peptide 1, S6K1, Ribosomal protein subunit 6 kinase 1, Receptor, GLP-1, Glucagon-like peptide-1, TGR5, Takeda G protein-coupled receptor 5, lcsh:R5-920, biology, Chemistry, mTOR, mechanistic target of rapamycin, digestive, oral, and skin physiology, TGR5, General Medicine, Middle Aged, G protein-coupled bile acid receptor, mTORC1, mechanistic target of rapamycin complex 1, ip, Intraperitoneal, biological phenomena, cell phenomena, and immunity, lcsh:Medicine (General), Signal Transduction, Research Paper, medicine.medical_specialty, Gastric Bypass, P70-S6 Kinase 1, Mechanistic Target of Rapamycin Complex 1, Cholesterol 7 alpha-hydroxylase, General Biochemistry, Genetics and Molecular Biology, Bile Acids and Salts, 03 medical and health sciences, Raptor, Regulatory-associated protein of mechanistic target of rapamycin, RYGB, Internal medicine, medicine, Animals, Humans, Obesity, Mechanistic target of rapamycin, Cyp7a1, Cytochrome P450 family 7 subfamily A member 1, RYGB, Roux-en-Y gastric bypass, lcsh:R, nutritional and metabolic diseases, S6, Ribosomal protein S6, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Gene Expression Regulation, FXR, Farnesoid X receptor, biology.protein, BAs, Bile acids, Farnesoid X receptor, Insulin Resistance, GLP-1