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1Academic Journal
المؤلفون: Riglet, Lucie, Hok, Sophie, Kebdani-Minet, Naïma, Le Berre, Joëlle, Gourgues, Mathieu, Rozier, Frédérique, Bayle, Vincent, Bancel-Vallée, Lesli, Allasia, Valérie, Keller, Harald, da Rocha, Martine, Attard, Agnés, Fobis-Loisy, Isabelle
المساهمون: Sainsbury Laboratory Cambridge University (SLCU), University of Cambridge UK (CAM), Institut Sophia Agrobiotech (ISA), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Côte d'Azur (UniCA), Bayer Crop Science, Reproduction et développement des plantes (RDP), École normale supérieure de Lyon (ENS de Lyon), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Bordeaux Imaging Center (BIC), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Carl Zeiss SAS, ANR-14-CE11-0021,Invader,Réponse des épidermes végétaux aux intrusions cellulaires(2014), ANR-11-LABX-0028,SIGNALIFE,Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie(2011)
المصدر: ISSN: 0022-0957.
مصطلحات موضوعية: invasive growth, oomycete, pollen, cell wall, EIHM, vesicular trafficking, actin, Arabidopsis MAP: minutes after pollination LE : late endosome MVB : multivesicular bodies PM : plasma membrane TGN : trans Golgi network, Stigmatic cells response to invader invasion Highlight cell-cell interaction invasive growth oomycete pollen cell wall EIHM vesicular trafficking actin Arabidopsis MAP: minutes after pollination LE : late endosome MVB : multivesicular bodies PM : plasma membrane TGN : trans Golgi network, Stigmatic cells response to invader invasion Highlight cell-cell interaction, [SDV]Life Sciences [q-bio]
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المؤلفون: Liu Yuqing, Jiang Lixiang, Hung-Fat Tse, Wing-Hon Lai, Rui Wei, Jiayin Yang, Fu Jian, Yang Hu, Wai-Ling Tsang, Yiu-Lam Tse, Bo Yang, Miguel A. Esteban, Xueyu Hong, Ka-Wing Au, Kwong-Man Ng, Chi-Wa Cheng, Wai-In Ho, Na Li
المصدر: JHEP Reports
JHEP Reports, Vol 4, Iss 1, Pp 100389-(2022)مصطلحات موضوعية: Clustered regularly interspaced palindromic repeats (CRISPR)/Cas9, iPSC, induced pluripotent stem cell, RFLP, restriction fragment length polymorphism, Wilson’s disease, Single-stranded Oligodeoxynucleotide (ssODN), Cell, EB, embryoid body, RC799-869, Biology, ATPase copper transporting beta polypeptide (ATP7B), Cell therapy, iPSC-derived hepatocytes (iHeps), Internal Medicine, medicine, ATP7B, ATPase copper transporting beta, Immunology and Allergy, iHep(s), iPSC-derived hepatocyte(s), Induced pluripotent stem cell, ALB, albumin, AFP, alpha-fetoprotein, Hepatology, TGN, trans-Golgi network, Gastroenterology, Wild type, sgRNA, single guide RNA, Diseases of the digestive system. Gastroenterology, medicine.disease, Phenotype, Wilson's disease, ssODN, single-stranded oligodeoxynucleotide, WD, Wilson’s disease, medicine.anatomical_structure, gene correction, Hepatocyte, Cancer research, induced pluripotent stem cell (iPSC), Liver function, cell therapy, Research Article
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المؤلفون: Mitsuhiro Tomosugi, Hiroki Otani, Akari Shintani, Toshihisa Hatta, Junko Hatta, Takashi Mochizuki, Masahide Asano, Hiroki Shoji, Makoto Taniguchi, Keiichi Moriguchi, Hiroki Shimada, Hiromi Sakata-Haga, Tsuyoshi Tsukada, Daisuke Sakai
المصدر: JID Innovations, Vol 1, Iss 3, Pp 100024-(2021)
JID Innovationsمصطلحات موضوعية: WT, wild type, Transepidermal water loss, SG, stratum granulosum, Epidermis (botany), Chemistry, TGN, trans-Golgi network, Stratum granulosum, KC, keratinocyte, Dermatology, Lamellar granule, TLC, thin-layer chromatography, Molecular biology, medicine.anatomical_structure, Dermis, TEWL, transepidermal water loss, RL1-803, medicine, Original Article, Keratinocyte, TEM, transmission electron microscopy, Homeostasis, Barrier function
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المؤلفون: Nadine, Zimmann, Petr, Rada, Vojtěch, Žárský, Tamara, Smutná, Kristína, Záhonová, Joel, Dacks, Karel, Harant, Ivan, Hrdý, Jan, Tachezy
المصدر: Molecular & Cellular Proteomics : MCP
مصطلحات موضوعية: Proteomics, CP, cysteine protease, ST, sucrose-tris buffer, LAMP, lysosome-associated membrane glycoprotein, BFA, Brefeldin A, MPR, mannose 6-phopshate receptor, SNAP, soluble N-ethylmaleimide-sensitive-factor attachment protein, DMAP, DNA methyltransferase-associated protein, TMD, transmembrane domain, BA, β-amylase, TEAB, triethylammonium bicarbonate, Cysteine Proteases, Phagosomes, TSP, tetraspanin, MPR300, mannose 6-phopshate receptor 300, mCLCP, mutated cathepsin L-like cysteine peptidase, CD-MPR, cation-dependent mannose 6-phosphate receptor, LTS, lysosomal targeting sequence, LFQ MS, label-free quantitative mass spectrometry, MRH, mannose 6-phosphate receptor homology, SNARE, SNAP receptor, CPBF1, cysteine protease-binding protein family 1, TYM, tryptone-yeast extract-maltose medium, nanoLC-MS, nano reverse-phase liquid chromatography mass spectrometry, NHS, N-hydroxysuccinimide, bHX, β-hexosaminidase, FITC, fluorescein isothiocyanate, SDC, sodium deoxycholate, MES, 2-[n-morpholino]-ethanesulfonic acid buffer, TLCK, tosyl-L-lysyl-chloromethane hydrochloride, glycosylation, proteome, PBS, phosphate-buffered saline, vATPase, vacuolar ATPase, CLCP, cathepsin L-like cysteine peptidase, LGF, large granule fraction, ER, endoplasmic reticulum, mannose 6-phosphate receptor, TCA, trichloracetic acid, Trichomonas vaginalis, Humans, GGA, Golgi-localized, γ-ear-containing, ADP ribosylation factor-binding protein, Cysteine, GlcNAc-PT, N-acetylglucosamine-1-phosphotransferase, s-LTS, lysosomal targeting sequence of soluble protein, TGN, trans Golgi network, UCE, uncovering enzyme, N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase, AP, acid phosphatase, Research, M6P, mannose 6-phosphate, CI-MPR, cation-independent mannose 6-phosphate receptor, LERP, lysosomal enzyme receptor protein, EDC, 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride, mBA, mutated β-amylase, CLQ, chloroquine, TBSR, Trichomonas beta-sandwich repeat protein, MS, mass spectrometry, BBS, borate buffered saline, phagolysosome, t-LTS, lysosomal targeting sequence of transmembrane protein, Lysosomes, cysteine peptidase, LF, lactoferrin, Peptide Hydrolases, HA, hemagglutinin
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المؤلفون: Bénédicte, Gaborit, Roland, Govers, Alexandre, Altié, Jean Michel, Brunel, Pierre, Morange, Franck, Peiretti
المساهمون: Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Membranes et cibles thérapeutiques (MCT), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Biomédicale des Armées (IRBA), Service de Santé des Armées, Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Brunel, Jean Michel
المصدر: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
Journal of Biological Chemistry, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
The Journal of Biological Chemistryمصطلحات موضوعية: O-GlcNacylation, HFD, high-fat diet, autophagy, Glycosylation, BACE1, β-secretase 1, ERLAD, ER-to-lysosome-associated degradation, liver, Models, Biological, Diabetes Mellitus, Experimental, ERAD, ER-associated degradation, ER, endoplasmic reticulum, APP, amyloid precursor protein, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, mental disorders, Animals, Aspartic Acid Endopeptidases, Humans, insulin receptor, BAF, Bafilomycin A1, TGN, trans Golgi network, Secretory Pathway, beta-secretase 1 (BACE1), Cholestanes, AD, Alzheimer disease, diabetes, Ubiquitin, Ubiquitination, PC, proprotein convertase, Hep G2 Cells, Endoplasmic Reticulum Stress, Receptor, Insulin, Disease Models, Animal, HEK293 Cells, proteasome, ESP, early secretory pathway, IR, insulin receptor, Proteolysis, Proteostasis, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, lysosome, Spermine, PTM, posttranslational modification, Amyloid Precursor Protein Secretases, HBP, hexosamine biosynthetic pathway, Protein Binding, Research Article
وصف الملف: application/pdf
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المؤلفون: Hiroyuki Sugimoto, Yasuhiro Horibata
المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100100-(2021)مصطلحات موضوعية: CHO-K1, Chinese hamster ovary-K1, HEK293, human embryonic kidney 293, Transferases (Other Substituted Phosphate Groups), BFA, brefeldin A, Biochemistry, Choline, Phosphotransferase, chemistry.chemical_compound, CPT1, choline phosphotransferase 1, PC, phosphatidylcholine, Endocrinology, DKO, double-KO, plasmanyl-PC, 1-alkyl-2-acyl-sn-glycerophosphocholine, plasmenyl-PE, 1-alkenyl-2-acyl-sn-glycerophosphoethanolamine, Cells, Cultured, Phospholipids, chemistry.chemical_classification, choline phosphotransferase 1, trans-Golgi network, food and beverages, PL, phospholipid, CRISPR, clustered regularly interspaced short palindromic repeats, Kennedy pathway, Diacylglycerol Cholinephosphotransferase, lipids (amino acids, peptides, and proteins), choline/ethanolamine phosphotransferase 1, Research Article, radiolabeling, Phospholipid, phospholipid metabolism, QD415-436, PE, phosphatidylethanolamine, DAG, 1,2-diacyl-sn-glycerol, Biosynthesis, Phosphatidylcholine, Humans, EPT1, ethanolamine phosphotransferase 1, phosphatidylcholine, CEPT1, choline/ethanolamine phosphotransferase 1, Phosphatidylethanolamine, Endoplasmic reticulum, TGN, trans-Golgi network, Cell Biology, plasmenyl-PC, 1-alkenyl-2-acyl-sn-glycerophosphocholine, Enzyme, HEK293 Cells, chemistry, phospholipid biosynthesis, PUFA, HA, hemagglutinin
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المؤلفون: Timothy K. Soh, Luca Mascheroni, Vivienne Connor, Katharina M. Scherer, James D. Manton, Clemens F. Kaminski, Colin M. Crump
المساهمون: Scherer, Katharina [0000-0002-2042-5407], Crump, Colin [0000-0001-9918-9998], Kaminski, Clemens [0000-0002-5194-0962], Apollo - University of Cambridge Repository
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Cytoplasm, organelle, viruses, Golgi Apparatus, PFU, plaque forming unit, Herpesvirus 1, Human, medicine.disease_cause, Virus Replication, Biochemistry, ICP0, infected cell protein, FOV, field of view, Multiplicity of infection, TGN46, trans-Golgi network protein 46, Genes, Reporter, Chlorocebus aethiops, gM, glycoprotein M, TEMED, tetramethylethylenediamine, eYFP, enhanced yellow fluorescent protein, mIFP, monomeric infrared fluorescent protein, SIM, structured illumination microscopy, gC, glycoprotein C, MOI, multiplicity of infection, Plaque-forming unit, cytoskeleton, APS, ammonium persulfate, Cell biology, HFF, human foreskin fibroblast, AC, assembly compartment, RIG-1, retinoic acid-inducible gene I, symbols, microscopy, DMEM, Dulbecco's modified eagle's medium, fluorescence, Single-Cell Analysis, host–pathogen interaction, Research Article, HSV-1, herpes simplex virus-1, microscopic imaging, Host–pathogen interaction, Biology, MAVS, mitochondrial antiviral-signaling protein, Virus, 03 medical and health sciences, symbols.namesake, Capsid, Spatio-Temporal Analysis, herpesvirus, FBS, fetal bovine serum, PBS, phosphate buffered saline, medicine, MTOC, microtubule organizing center, Animals, Humans, hpi, hours post infection, Molecular Biology, Vero Cells, RLR, RIG-1-like receptors, HCMV, human cytomegalovirus, SiR, silicon rhodamine, 030102 biochemistry & molecular biology, TGN, trans-Golgi network, Virus Assembly, Cell Biology, Golgi apparatus, 030104 developmental biology, Herpes simplex virus, Viral replication, Microscopy, Fluorescence, BAC, bacterial artificial chromosome, TOM20, translocase of the outer membrane, BSA, bovine serum albumin, EEA1, early endosome antigen 1
وصف الملف: application/pdf
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المؤلفون: Gabriel Talaia, Margarida Casal, Hernâni Gerós, Sandra Paiva, Rosana Maria Abreu Alves, Cláudia Barata-Antunes, Robert Mans
المساهمون: Universidade do Minho
المصدر: Computational and Structural Biotechnology Journal, 19
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1713-1737 (2021)مصطلحات موضوعية: EMCs, eisosome membrane compartments, Signaling pathways, Ubiquitylation, AP, adaptor protein, Arrestins, Endocytic cycle, Fe, iron, PVE, prevacuolar endosome, Review, Biochemistry, VPS, vacuolar protein sorting, IF, inward-facing, APC, amino acid-polyamine-organocation, TRY, titer, rate and yield, 0302 clinical medicine, MVB, multi vesicular bodies, Ubiquitin, Structural Biology, Met, methionine, Mn, manganese, MCCs/eisosomes, Ub, ubiquitin, Cu, copper, Zn, Zinc, Cell factories, Glu, glutamic acid, 0303 health sciences, Arts, arrestin‐related trafficking adaptors, biology, Chemistry, C-terminus, carboxyl-terminus, NCS2, nucleobase cation symporter family 2, Endocytosis, Computer Science Applications, Ubiquitin ligase, Cell biology, fAATs, fungal AA transporters, Nutrient transporters, ACT, amino Acid/Choline Transporter, 030220 oncology & carcinogenesis, PM, plasma membrane, NAT, nucleobase Ascorbate Transporter, Signal transduction, ESCRT, endosomal sorting complex required for transport, Lys, lysine, TMSs, transmembrane segments, TORC1, target of rapamycin complex 1, Biotechnology, N-terminus, amino-terminus, Conformational changes, Trp, tryptophan, PEST, proline (P), glutamic acid (E), serine (S), and threonine (T), Saccharomyces cerevisiae, Biophysics, OF, outward-facing, Asp, aspartic acid, LID, loop Interaction Domain, ER, endoplasmic reticulum, H+, proton, 03 medical and health sciences, Genetics, NH4+, ammonium, GAAC, general amino acid control, 030304 developmental biology, ComputingMethodologies_COMPUTERGRAPHICS, Arg, arginine, Science & Technology, Structure-function, TGN, trans-Golgi network, Fungi, C, carbon, MFS, major facilitator superfamily, Transporter, Tyr, tyrosine, biology.organism_classification, LAT, L-type Amino acid Transporter, Cytosol, MCPs, membrane compartments of Pma1, AAs, amino acids, Metabolism, NCS1, nucleobase/Cation Symporter 1, biology.protein, YAT, yeast Amino acid Transporter, Aspergilli, MCCs, membrane compartments containing the arginine permease Can1, W/V, weight per volume, Endocytic signals, DUBs, deubiquitinating enzymes, N, nitrogen, TP248.13-248.65
وصف الملف: application/pdf
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المؤلفون: Hironori Inaba, Takao Nakata, Qianqian Miao
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, rac1 GTP-Binding Protein, RHOA, Light, IP3, inositol-triphosphate, CDC42, GTPase, Biosensing Techniques, Biochemistry, IP3R, IP3 receptor, Calcium in biology, Madin Darby Canine Kidney Cells, Phosphoinositide Phospholipase C, Small GTPase, phospholipase C, cdc42 GTP-Binding Protein, Calcium signaling, LOV2, light-oxygen-voltage-sensing domain 2, PI(4,5)P2, phosphatidylinositol 4,5-bisphosphate, biology, Chemistry, Cell Differentiation, Cell biology, Organ Specificity, Guanine nucleotide exchange factor, Ras protein, signal transduction, Research Article, Light Signal Transduction, chemistry.chemical_element, inositol 1,4,5-triphosphate (IP3), Calcium, iLID, improved light-inducible dimer system, ER, endoplasmic reticulum, GEF, guanine nucleotide exchange factor, 03 medical and health sciences, NFAT transcription factor, PLC, phospholipase C, Dogs, Animals, Humans, Calcium Signaling, optogenetics, Molecular Biology, Cell Proliferation, calcium, 030102 biochemistry & molecular biology, TGN, trans-Golgi network, TRP channel, transient receptor potential channel, PI(4)P, phosphatidylinositol 4-phosphate, Cell Biology, RA domain, Ras association domain, 030104 developmental biology, HEK293 Cells, rap GTP-Binding Proteins, Gene Expression Regulation, Rho (Rho GTPase), GAP, GTPase activating protein, RBD, Ras/Rho binding domain, biology.protein, ras Proteins, ral GTP-Binding Proteins, rhoA GTP-Binding Protein, DAG, diacylglycerol, MS, mechanosensitive, HeLa Cells
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المؤلفون: Diego Sbardella, Alessandra di Masi, Giovanna De Simone, Magda Gioia, Giovanni Francesco Fasciglione, Massimo Coletta, Alessio Bocedi, Grazia R. Tundo, Donato Di Pierro, Paolo Ascenzi, Paolo Calligari, Chiara Ciaccio
المساهمون: Gioia, Magda, Ciaccio, Chiara, Calligari, Paolo, De Simone, Giovanna, Sbardella, Diego, Tundo, Grazia, Fasciglione, Giovanni Francesco, Di Masi, Alessandra, Di Pierro, Donato, Bocedi, Alessio, Ascenzi, Paolo, Coletta, Massimo
المصدر: Biochemical Pharmacology
مصطلحات موضوعية: 0301 basic medicine, AEBSF, 4-(2-aminomethyl)-benzene sulphonyl fluoride, HCoV-229E, Human Coronavirus – 229E, viruses, SARS-CoV-2, Severe Acute Respiratory Syndrome – 2, TMPRSS4, Trans-Membrane Protease Serine Protease-4, medicine.disease_cause, ZIKV, Zika virus, Virus Replication, Biochemistry, TGN, Trans-Golgi Network, 0302 clinical medicine, Drug Delivery Systems, ORF, Open Reading Frame, EVD, Ebola Virus Disease, HBV, Hepatitis B virus, A1AT, Alpha-1-Anti Trypsin, Receptor, HCoV-NL63, Human Coronavirus – NL63, Coronavirus, PCSK, Pro-protein Convertase Subtilisin/Kexin, MERS-CoV, Middle East Respiratory Syndrome coronavirus, BHH, BromHexine Hydrochloride, COVID-19, Coronavirus Disease – 19, Proteolytic enzymes, MHV-A59, Murine Hepatitis virus – A59, FDA, Food and Drug Agency, Translation (biology), ACE2, Angiotensin-Converting Enzyme receptor-2, nsp, non structural protein, 3D-QSAR, Three-dimensional Quantitative Structure-Activity Relationships, AMPK, Adenosine Monophosphate-activated Protein Kinase, Cell biology, 030220 oncology & carcinogenesis, HPV, Human Papillomavirus, Perspective, HCoV-HKU1, Human Coronavirus – HKU1, CDV, Canine Distemper virus, RSV, Respiratory Syncytial virus (RSV), Proteases, FPV, Feline Panleukopenia virus, Biology, Hel, helicase, Antiviral Agents, Virus, PLpro, Papain-like protease, 3Cpro, 3Chymotrypsin protease of rhinoviruses, 03 medical and health sciences, RdRp, RNA dependent RNA polymerase, Viral life cycle, SARS-CoV, Severe Acute Respiratory Syndrome coronavirus, S protein, Spike protein, medicine, HIV, Human Immunodeficiency virus, Animals, Humans, Protease Inhibitors, PC, Pro-protein Convertase, Settore BIO/10, TTSP, Type II Transmembrane Serine Proteases family, Phac, Phenyl-Acetyl, ComputingMethodologies_COMPUTERGRAPHICS, HPAIV, Highly Pathogenic Avian Influenza virus, Pharmacology, Dec, Decanoyl, pp, polyprotein, HCoV-OC43, Human Coronavirus-OC43, COVID-19, RBD, Receptor Binding Domain, JEV, Japanese Encephalitis virus, TMPRSS2, Trans-Membrane Protease Serine Protease-2, COVID-19 Drug Treatment, Mpro, Main protease, 030104 developmental biology, Viral replication, HAT, Human Airway Trypsin-like protease, CMK, Chloro-Methyl-Ketone, Peptide Hydrolases
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المؤلفون: Zinia D'Souza, Farhana S. Taher, Vladimir Lupashin
المصدر: Biochimica et Biophysica Acta. General Subjects
مصطلحات موضوعية: ARF, ADP ribosylation factor, Glycosylation, AP, adaptor protein, GEARs, COG-sensitive, integral membrane Golgi proteins, BFA, Brefeldin A, HEK, Human embryonic kidney, Cellular homeostasis, Golgi Apparatus, TRAPP, Transport Protein Particle complex, GARP, Golgi-associated retrograde protein, COG-CDG, Biochemistry, EM, Electron microscopy, Vesicle tethering, TGN, Trans-Golgi Network, chemistry.chemical_compound, 0302 clinical medicine, Congenital Disorders of Glycosylation, CDG, Congenital disorders of glycosylation, Golgi, CATCHR, Complexes associated with tethering containing helical rods, COG, Conserved oligomeric Golgi, HOPS, Homotypic fusion and vacuole Protein Sorting complex, Protein Interaction Maps, EELS, Enlarged endolysosomal structure, 0303 health sciences, Chemistry, Vesicle, RCA, Ricinus communis agglutinin, Cell biology, EARP, Endosome-associated recycling protein, symbols, PNA, Peanut agglutinin, NIHF, Non-Immune Hydrops Fetalis, KD, Knock-down, COG complex, GSL, Glycosphingolipis, PM, Plasma membrane, Endosome, HPA, Helix pomatia agglutinin, Biophysics, MTC, Multi-subunit Tethering Complexes, Y2H, Yeast two-hybrid, IEF, Isoelectric focusing, behavioral disciplines and activities, CHO, Chinese hamster ovary, Article, LVH, Left ventricular hypertrophy, 03 medical and health sciences, symbols.namesake, Cog, ER, Endoplasmic reticulum, mental disorders, CCD, COG complex dependent, PI4P, Phosphatidylinositol 4-phosphate, Animals, Humans, CCT, Coil-coiled tethers, Molecular Biology, 030304 developmental biology, fungi, KO, Knockout, Biological Transport, Golgi apparatus, HLH, Hemophagocytic lymphohistiocytosis, SNAP, Soluble NSF attachment protein, Adaptor Proteins, Vesicular Transport, Protein Subunits, Secretory protein, MS, mass spectrometry, Multiprotein Complexes, Mutation, CDG, SNARE, Soluble NSF (N-ethylmaleimide sensitive factor) attachment proteins (SNAP) receptor, TM, Transmembrane, human activities, 030217 neurology & neurosurgery, COPI/COPII, Coat protein complex I/complex II, WT, Wild type
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المؤلفون: David C. Gershlick, Danièle Stalder
المساهمون: Gershlick, David C [0000-0002-0602-210X], Apollo - University of Cambridge Repository, Gershlick, David [0000-0002-0602-210X]
مصطلحات موضوعية: 0301 basic medicine, CARTS, CARriers of the TGN to the cell Surface, GlcCer, glucosylceramidetol, BFA, Brefeldin A, Cell, Golgi Apparatus, medicine.disease_cause, Membrane Fusion, CI-MPR, cation-independent mannose-6 phosphate receptor, TIRF, total internal reflection fluorescence, PKD, Protein Kinase D, 0302 clinical medicine, Protein targeting, Secretory Pathway, RUSH, retention using selective hooks, SPCA1, secretory pathway calcium ATPase 1, SBP, streptavidin-binding peptide, Cell biology, CtBP3/BARS, C-terminus binding protein 3/BFA adenosine diphosphate–ribosylated substrate, Protein Transport, medicine.anatomical_structure, ts, temperature sensitive, symbols, ATP, adenosine triphosphate, VSV, vesicular stomatitis virus, Constitutive Secretion, Biology, TGN, trans-Golgi Network, ER, endoplasmic reticulum, 03 medical and health sciences, symbols.namesake, Golgi To Plasma Membrane Sorting, medicine, Extracellular, Animals, Humans, Secretion, SM, sphingomyelin, Endoplasmic reticulum, Cell Membrane, Cell Biology, Golgi apparatus, Post-golgi Carriers, Lipid Metabolism, Cytosol, 030104 developmental biology, Secretory protein, GPI-anchored proteins, glycosylphosphatidylinositol-anchored proteins, SNARE, soluble N-ethylmaleimide sensitive fusion protein attachment protein receptor, Pleomorphic Tubular Carriers, 030217 neurology & neurosurgery, PAUF, pancreatic adenocarcinoma up-regulated factor, Developmental Biology
وصف الملف: application/pdf
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المؤلفون: Rupam Paul, Sourav Banerjee, Samarpita Sen, Pratiksha Dubey, Saptarshi Maji, Anand K. Bachhawat, Rupak Datta, Arnab Gupta
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: DST, Department of Science and Technology, LmATP7-OE, LmATP7 overexpressing, SD-Ura, SD medium without uracil, Biochemistry, ICP–OES, inductively coupled plasma optical emission spectrometry, cDNA, complementary DNA, Mice, Lamp1/2, lysosome-associated membrane protein 1/2, ATP7, PDB, Protein Data Bank, ATP7A, Animals, ATOX1, antioxidant protein 1, Leishmaniasis, Molecular Biology, Cu, copper, IISER, Indian institute of Science Education and Research, Leishmania major, Leishmania, Mammals, DPBS, Dulbecco's PBS, HM, heavy metal, qRT–PCR, quantitative RT–PCR, TGN, trans-Golgi network, Cu-ATPase, CTR2, Cu transporter 2, Cell Biology, SD, synthetic defined, CTR1, Cu transporter 1, p.i., postinfection, copper, P-type ATPases, lysosome, LmATP7-Het, LmATP7 heterozygous deletion, host–pathogen interaction, Research Article, DAPI, 4′,6-diamidino-2-phenylindole
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المؤلفون: Todd R. Graham
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: TGN, trans-Golgi network, Cryoelectron Microscopy, Golgi Apparatus, DOPC, di-oleoyl-phosphatidyl-choline, PI4P, phosphatidylinositol-4-phosphate, DSSO, disuccinimidyl sulfoxide, Editors' Pick, Cell Biology, Biochemistry, Transcription Factor AP-1, GEF, guanine nucleotide exchange factor, PEG, polyethyleneglycol, PSM, polymer-supported lipid membrane, Molecular Biology, Research Article, AP, adapter protein
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المصدر: Virus Research
مصطلحات موضوعية: Rotavirus, 0301 basic medicine, Cancer Research, LP, late-penetrating, viruses, ReoT1L, mammalian reovirus type 1 Lang, medicine.disease_cause, Receptor, IGF Type 2, Virus entry, Mice, fluids and secretions, Vim, Vimentin, Protein Isoforms, RNA, Small Interfering, CI, cation-independent, Infectivity, LDH, lactate dehydrogenase, SORT1, Sortilin-1, CD, cation-dependent, virus diseases, CTSS, Cathepsin S, Infectious Diseases, Host-Pathogen Interactions, GM2AP, GM2 activator protein, LIMP2, lysosomal integral membrane protein 2, trans-Golgi Network, TGN, trans-golgi-network, Proteases, Genotype, Endosome, TLPs, triple-layered particles, CTSB, cathepsin B, Endosomes, CTSL1, Cathepsin L1, Biology, EP, early-penetrating, Article, Virus, Cathepsin, Cell Line, Microbiology, 03 medical and health sciences, Species Specificity, Viral entry, Virology, medicine, Animals, Humans, EEs, early endosomes, MEs, maturing endosomes, LEs, late endosomes, Biological Transport, Fibroblasts, Virus Internalization, Sortilin, Cathepsins, Macaca mulatta, Mannose-6-phosphate receptors, DLPs, double layered particles, Adaptor Proteins, Vesicular Transport, 030104 developmental biology, Gene Expression Regulation, Cytoplasm, Caco-2 Cells, M6PR, mannose-6-phosphate receptor(s)
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المؤلفون: Ruth E. Carmichael, Laura DiGiovanni, Michael Schrader, Peter K. Kim, Rechal Kumar, Beatriz S.C. Silva
المصدر: Biochim Biophys Acta Mol Cell Res
Biochimica et Biophysica Acta. Molecular Cell Researchمصطلحات موضوعية: 0301 basic medicine, Mdm, mitochondrial division and maintenance, FFAT motif, membrane contact sites, Golgi Apparatus, Mitochondrion, PBD, peroxisome biogenesis disorder, PLIN5, perilipin 5 protein, Lysosomal compartment, FFAT, two phenylalanines (FF) in an acidic tract, ERMES, ER-mitochondria encounter structure, 0302 clinical medicine, Num1, nuclear migration protein 1, Lipid droplet, MFF, mitochondrial fission factor, lipid metabolism, Acyl-CoA binding domain containing protein, Osh, oxysterol-binding protein homology, ATF6α, activating transcription factor 6α, Chemistry, TMEM135, transmembrane protein 135, Peroxisome, DRP1, dynamin-related protein 1, Mitochondria, Cell biology, PTPIP51, protein tyrosine phosphatase interacting protein 51, IP3R, 1,4,5-trisphosphate receptor, PM, plasma membrane, INF2, inverted formin 2, symbols, OMM, outer mitochondrial membrane, IMM, inner mitochondrial membrane, Cell physiology, ORP, oxysterol-binding protein related protein, ATP, adenosine triphosphate, TAG, triacylglycerol, MCS, membrane contact site, Endosome, TBC1D15, TBC1 domain family member 15, Endosomes, Article, ACBD, acyl-CoA binding domain containing protein, ER, endoplasmic reticulum, DMT1, divalent metal transporter 1, 03 medical and health sciences, symbols.namesake, ROS, reactive oxygen species, VAP, vesicle-associated membrane protein (VAMP)–associated protein, PEX, peroxin (peroxisome biogenesis factor), Organelle, Peroxisomes, MIGA2, Mitoguardin 2 protein, Humans, ABCD1, ATP binding cassette subfamily D member 1, DGAT2, diacylglycerol O-acyltransferase 2, Molecular Biology, CRAC, calcium release-activated channel, MIRO1, mitochondrial Rho GTPase 1, PI(4)P, phosphatidylinositol-4-phosphate, TGN, trans-Golgi network, Cell Membrane, STARD3, StAR related lipid transfer domain containing protein 3, VPS13, vacuole protein sorting-associated protein 13, Lipid Droplets, Cell Biology, Golgi apparatus, MAM, mitochondria-ER association membrane, VLCFA, very long-chain fatty acid, PPV, pre-peroxisomal vesicle, OSBP, oxysterol-binding protein, 030104 developmental biology, PI(4,5)P2, phosphatidylinositol-4,5-bisphosphate, Lysosomes, 030217 neurology & neurosurgery, NPC1, Niemann-Pick C1 protein
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المؤلفون: Dengke Tian, Liang Xin, Minge Wan, Xie Xiaolin, Zhang Dezhu, Wenqiang Cao, Liang Chengyuan, Liu Yuzhi, Li Han, Hong Liu, Xueqi Fu
المصدر: Biomedicine & Pharmacotherapy
Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111313-(2021)مصطلحات موضوعية: 0301 basic medicine, Coronaviruses, medicine.medical_treatment, viruses, Review, Pharmacology, chemistry.chemical_compound, 0302 clinical medicine, nsps, Non-structural proteins, Chloroquine, Medicine, CoV, Coronavirus, CQ, Chloroquine, HA, Haemagglutinin, Molecular Targeted Therapy, Enzyme Inhibitors, DAAs, Direct-acting antiviral agents, biology, FDA, US Food and Drug Administration, Therapies, Investigational, HTAs, Host-targeting antivirals, MERS-CoV, Middle East respiratory syndrome coronavirus, General Medicine, Small molecule, PIP2, Phosphatidylinositol 4,5-bisphosphate, RMP, Ribavirin monophosphate, IFN, Interferon, N, Nucleocapsid protein, COVID-19, 2019 Coronavirus disease, HIV, Human immunodeficiency virus, RBV, Ribavirin, NIAID, National Institute of Allergy and Infectious Diseases, 030220 oncology & carcinogenesis, 6MP, 6-Mercaptopurine, BSAs, Broad-spectrum antiviral drugs, RDP, Ribavirin diphosphate, EBOV, Ebola virus, Transmembrane serine protease (TMPRSS2), GTP, Guanosine triphosphate, medicine.drug, 3CLpro, 3C-Like protease, DHODH, Dihydroorotate dehydrogenase, 6TG, 6-Thioguanine, Papain-like protease (PLpro), TGN, Trans-Golgi network, RM1-950, Favipiravir, TMPRSS2, HyCoSuL, Hybrid Combinatorial Substrate Library, Antiviral Agents, PP2A, Protein phosphatase 2A, SARS-CoV, Severe acute respiratory syndrome coronavirus, WHO, World Health Organization, CPE, Cytopathic effect, PLpro, Papain-like protease, 03 medical and health sciences, EUA, Emergency use authorization, IRF3, Interferon regulatory factor 3, SAR, Structure-activity relationship, ACE2, Angiotensin-converting enzyme 2, S, Spike protein, SKP2, S-Phase kinase-associated protein 2, Humans, RdRp, RNA-dependent RNA polymerase, RTP, Ribavirin triphosphate, BECN1, Beclin1, ComputingMethodologies_COMPUTERGRAPHICS, Serine protease, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, Protease, HC, QHydroxychloroquine, business.industry, SARS-CoV-2, Ribavirin, fungi, COVID-19, PC, Pro-protein convertase, DHO, Dihydroorotate, M, Membrane protein, RNA-dependent RNA polymerase (RdRp), COVID-19 Drug Treatment, AMPK, AMP-activated protein kinase, CMK, Decanoyl-RVKR-chloromethylketone, Mpro, Main protease, 030104 developmental biology, chemistry, 3C-like protease (3CLpro), E, Envelope protein, biology.protein, Dihydroorotate dehydrogenase, GM1, Monosialotetrahexosylganglioside 1, LPV/r, Lopinavir/ritonavir, Therapeutics. Pharmacology, ELs, Endolysosomes, business, IMPDH, Inosine monophosphate dehydrogenase
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المؤلفون: Miyako Nakano, Eiji Miyoshi, Masato Kitano, Kazuki Nakajima, Yoichiro Harada, Saki Itoyama, Yasuhiko Kizuka, Tomoaki Sobajima, Akihiro Harada, Ryo Misaki, Naoyuki Taniguchi
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, sialyltransferase, Glycosylation, RCA120, Ricinus Communis Agglutinin 120, SDS-PAGE, SDS-polyacrylamide gel electrophoresis, Golgi Apparatus, DKD cells, HeLa cells in which both Rab11a and Rab11b are stably knocked down, NeuAc, CMP-N-acetylneuraminic acid, vWF, von Willebrand factor, glycosyltransferase, B4GALNT2, beta-1,4-N-acetylgalactosaminyltransferase 2, Biochemistry, ConA, concanavalin A lectin, B4GALT1, beta-1,4-galactosyltransferase 1, chemistry.chemical_compound, ManNAz, N-azidoacetylmannosamine, N-linked glycosylation, ST8SIA1, Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase, TBS, tris-buffered saline, IKO, intestine-specific Rab11a knockout, PhoSL, Pholiota squarrosa lectin, LC-ESI-MS, liquid chromatography–electrospray ionization–mass spectrometry, FUT8, fucosyltransferase 8, chemistry.chemical_classification, glycan, Gene knockdown, biology, Chemistry, PNGase F, peptide N-glycosidase F, Editors' Pick, SiaNAz, N-azidoacetyl sialic acid, Cell biology, Protein Transport, PM, plasma membrane, symbols, trans-Golgi Network, Research Article, Endo H, endoglycosidase H, Endosome, membrane traffic, α2,3-sialylation, ER, endoplasmic reticulum, 03 medical and health sciences, Endoglycosidase H, symbols.namesake, CHX, cycloheximide, sLeX, sialyl-LewisX, MAM, Maackia amurensis lectin, ST6GAL1, Beta-galactoside alpha-2,6-sialyltransferase 1, Animals, Humans, COG, conserved oligomeric Golgi, ST3GAL4, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4, Molecular Biology, PGC, post-Golgi compartment, posttranslational modification, 030102 biochemistry & molecular biology, TGN, trans-Golgi network, Endoplasmic reticulum, Cell Biology, Golgi apparatus, L4-PHA, Phaseolus vulgaris Leucoagglutinin lectin, Sialyltransferases, Rats, EIC, extracted ion chromatogram, carbohydrates (lipids), 030104 developmental biology, rab GTP-Binding Proteins, Rab11, ST3GAL4, GlcAT-P, glucuronyltransferase-P, PVDF, poly(vinylidene fluoride), SSA, Sambucus sieboldiana lectin, biology.protein, Glycoprotein, HeLa Cells
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19
المصدر: Pharmacological Research
مصطلحات موضوعية: IL-17, interleukin-17, HFE, hemochromatosis gene, DMT1, divalent metal-ion transporter 1, RA, rheumatoid arthritis, AnxA5, annexinA5, Disease, TNF-α, tumor necrosis factor-α, 0302 clinical medicine, HCMV, Human Cytomegalovirus, LEL, late endosome-lysosome, HAMP, hepcidin, Homeostasis, CQ, Chloroquine, IFN-γ, interferon-γ, IL-6, interleukin-6, MOI, multiplicity of infection, Coronavirus, RBC, red blood cell, HIV-1, Human Deficiency Virus 1, FT, ferritin, ERGIC, endoplasmic reticulum-Golgi intermediate compartment, 030220 oncology & carcinogenesis, NK, natural killer, Chloroquine/hydroxychloroquine, IL-1β, interleukin-1β, APS, anti-phospholipid syndrome, Pneumonia, Viral, IgG, immunoglobulin G, ACE2, angiotensin-converting enzyme 2, Antiviral Agents, Article, Betacoronavirus, 03 medical and health sciences, HAEC, human aortic endotelial cell, Pharmacokinetics, Humans, mAb, monoclonal antibody, ERFE, erythroferrone, Th, T helper, ARDS, acute respiratory distress syndrome, Pharmacology, S, viral spike protein, TGN, trans-Golgi network, SLE, systemic lupus erythematosus (SLE), Hydroxychloroquine, HP, haptoglobin, JAK/STAT3, Janus kinase/signal transducers and activators of transcription 3, β2GPI, β2-glicoprotein I, eNOX, endosomal NADPH oxidase, 030104 developmental biology, APC, antigen-presenting cell, COPD, chronic obstructive pulmonary disease, EE, early endosome, TF, tissue factor, Immunology, IL-4, interleukin-4, TMPRSS2, transmembrane serine protease 2, EPO, erythropoietin, MAPK, mitogen-activated protein kinase, TRPML1/MCOLN1, mucolipin 1, 0301 basic medicine, IDA, iron deficiency anemia, medicine.disease_cause, DC, dendritic cell, NET, neutrophil extracellular trap, HUVEC, human umbilical vein endothelial cell, Chloroquine, TFR1, transferrin receptor 1, ID, iron deficiency, IFN1, type interferon, Sars-Cov-2, IL-13, interleukin-13, M, viral envelope membrane protein, ICU, intensive care unit, HPX, hemopexin, MMP, matrix metalloproteinase, aPL, anti-phospholipid, HCV, hepatitis C virus, BMP/SMAD, bone morphogenetic/small mother against decapentaplegic, LPS, lipopolysaccharide, medicine.symptom, VCAM-1, vascular cellular adhesion molecule 1, Coronavirus Infections, FPN1, ferroportin 1, TLR, Toll-like receptor, medicine.drug, IDU, infectious disease unit, Coronavirus disease 2019 (COVID-19), STEAP3, metalloreductase six-transmembrane epithelial antigen of the prostate 3, Iron, TGT, thrombin generating time, Inflammation, CME, clathrin-mediated endocytosis, HH, hemochromatosis, NP, virus nucleoprotein, ER, endoplasmic reticulum, medicine, IL-12, interleukin-12, Aminoquinolines, COVID-19, Sars-Cov-2 infection, eNOS, endothelial nitric oxide synthetase, Pandemics, COVID-19, Thrombosis, PICALM, phosphatidylinositol binding clathrin assembly protein, ComputingMethodologies_COMPUTERGRAPHICS, business.industry, HCQ, hydroxychloroquine, COVID-19 Drug Treatment, MHC, Major Histocompatibility Complex, NOX2, NADPH oxidase 2, MHV-3, mouse hepatitis virus type 3, business, LF, lactoferrin
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المؤلفون: Diana D. H. Thomas, Michelle M. Cooley, Scott W. Messenger, Fred S. Gorelick, Michelle A. Falkowski, Luis A. Fernandez, Guy E. Groblewski, Benjamin K. August, Elaina K. Jones
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 6, Pp 695-709 (2015)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: WT, wild type, AP, adaptor protein, ZG, zymogen granule, CCK, cholecystokinin, DMSO, dimethyl sulfoxide, BFA, brefeldin A, PIKFYVE, chemistry.chemical_compound, PIKfyve, phosphatidylinositol 3-phosphate 5-kinase, GTP, guanosine triphosphate, Endosome, Trypsin, Trypsinogen activation, Late endosome, Original Research, GDP, guanosine diphosphate, LY294002, 2-morpholin-4-yl-8-phenylchromen-4-one, LDH, lactate dehydrogenase, Gastroenterology, Cell biology, PI(3)P, phosphatidylinositol 3-phosphate, RE, recycling endosome, medicine.medical_specialty, LAMP1, lysosome-associated membrane protein, Phosphatidylinositol 3,5-bisphosphate, Biology, PI, phosphatidylinositol, Exocytosis, MRP, minor-regulated pathway, VAMP8, vesicle-associated membrane protein 8, Internal medicine, medicine, Secretion, lcsh:RC799-869, PI(3,5)P2, phosphatidylinositol-3,5-bisphosphate, Hepatology, TGN, trans-Golgi network, Phosphatidylinositol 3-phosphate, DMEM, Dulbecco’s minimal essential medium, PIKfyve, YM201636, 6-amino-N-[3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenyl]pyridine-3-carboxamide, Vps34, phosphatylinositol 3-kinase, Endocrinology, EE, early endosome, Pancreatitis, chemistry, Zymogen activation, CLP, constitutive-like pathway, GFP, green fluorescent protein, lcsh:Diseases of the digestive system. Gastroenterology, LE, late endosome, HA, hemagglutinin