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1Academic Journal
المؤلفون: Jialing Liu, Xingqiang Lai, Yingying Bao, Wenfeng Xie, Zhishan Li, Jieying Chen, Gang Li, Tao Wang, Weijun Huang, Yuanchen Ma, Jiahao Shi, Erming Zhao, Andy Peng Xiang, Qiuli Liu, Xiaoyong Chen
المصدر: Frontiers in Immunology, Vol 13 (2022)
مصطلحات موضوعية: mesenchymal stem cells, experimental colitis, regulatory B cells, THBS1, TGFβ (transforming growth factor β), Immunologic diseases. Allergy, RC581-607
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: Pei-Yu Chen, Martin A. Schwartz, Michael Simons
المصدر: Frontiers in Cardiovascular Medicine, Vol 7 (2020)
مصطلحات موضوعية: endothelial-to-mesenchymal transition (EndMT), inflammation, TGFβ (transforming growth factor β), FGF (fibroblast growth factor), endothelium, atherosclerotic plaques, Diseases of the circulatory (Cardiovascular) system, RC666-701
وصف الملف: electronic resource
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3
المؤلفون: Guolong Liao, Hanqi Lei, Xiangwei Yang, Xing Fu, Fu Shi, Donggen Jiang, Haiyun Xiong, Yafei Yang, Yu-Peng Feng, Jun Pang, Bing-Biao Lin
المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 4941-4953 (2021)مصطلحات موضوعية: Microarray, DFS, disease-free survival, MDSCs, myeloid-derived suppressor cells, AUC, Area under the dose-response curve, Biochemistry, k-NN, K-nearest neighbor, GEP, gene expression profile, Androgen deprivation therapy, Transcriptome, CTLA-4, cytotoxic T-lymphocyte associated protein-4, chemistry.chemical_compound, Prostate cancer, DEmiRs, differentially expressed miRNAs, SCNAs, somatic copy number alterations, Structural Biology, TGFβ, transforming growth factor β, BCR, biochemical recurrence, ICB, immune checkpoint blockade, GEO, Gene Expression Omnibus, NTP, Nearest template prediction, TMB, tumor mutation burden, PD-1, programmed cell death protein-1, NEPC, neuroendocrine prostate cancer, Computer Science Applications, NMF, non-negative matrix factorization, CCLs, cancer cell lines, Tregs, regulatory T cells, miRNAs, EMT, epithelial-mesenchymal transition, mCRPC, metastatic castration-resistant prostate cancer, Biotechnology, Research Article, FDR, false discovery rate, SubMap, Subclass mapping, Molecular subtypes, Biophysics, PCa, prostate cancer, Biology, KEGG, Kyoto Encyclopedia of Genes and Genomes, Olaparib, OS, overall survival, GSEA, Gene Set Enrichment Analysis, microRNA, GO, Gene Ontology, ssGSEA, single-sample gene set enrichment analysis, Genetics, medicine, TNAs, tumor neoantigens, PTEN, miRNAs, microRNAs, IFN, interferon, ADT, androgen deprivation therapy, ComputingMethodologies_COMPUTERGRAPHICS, Taxane, medicine.disease, PD-L1, programmed death-ligand 1, chemistry, Cancer research, biology.protein, TCGA, The Cancer Genome Atlas, MIRcor, miRNA-correlated, AR, androgen receptor, Heterogeneity, TP248.13-248.65, CAFs, cancer-associated fibroblasts
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المؤلفون: Maria Teresa Majorini, Mario Milani, Eloise Mastrangelo, Federica Cossu, Simone Camelliti, Luca Sorrentino, Daniele Lecis
المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 6366-6374 (2021)مصطلحات موضوعية: Virtual screening, Programmed cell death, IAP-antagonist, TGFβ, transforming growth factor-β, medicine.medical_treatment, Biophysics, TRAF, TNF receptor associated factor, Biochemistry, NF-kB, nuclear factor kappa-light-chain-enhancer of activated B cells, chemistry.chemical_compound, Structural Biology, Genetics, medicine, IAP, inhibitor of apoptosis proteins, NF-kB, SM, Smac-mimetic, ComputingMethodologies_COMPUTERGRAPHICS, TNF, tumor necrosis factor, Inhibitor of apoptosis proteins, Drug discovery, Cancer, NF-κB, TAK1, (TGFβ)-activated kinase, medicine.disease, Baculoviral IAP repeat, BIR, baculoviral IAP repeat, Computer Science Applications, XIAP, Cytokine, chemistry, Apoptosis, Cancer cell, Cancer research, Tumor necrosis factor alpha, TP248.13-248.65, TAB, TAK1 binding protein, Research Article, Biotechnology
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المؤلفون: Oliver G. McDonald, M. Kay Washington, Fang Yan, Yilin Deng, Anna L. Means, D. Brent Polk, Sari Acra, Richard M. Peek
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1327-1345 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, H3K4me, histone H3 on the lysine 4 methylation, Probiotic Function Factor, RC799-869, LGG, Lactobacillus rhamnosus GG, IEC, intestinal epithelial cell, Epigenesis, Genetic, ZO-1, zonula occludens-1, Mice, 0302 clinical medicine, Pregnancy, Transforming Growth Factor beta, Gene expression, TGFβ, transforming growth factor β, IFN-γ, interferon-γ, Setd1β, su(var)3-9, enhancer-of-zeste and trithorax domain–containing 1β, Intestinal Mucosa, Original Research, Histone Methyltransferase, Intestinal Epithelial Cell, TNF, tumor necrosis factor, Mice, Inbred BALB C, IBD, inflammatory bowel disease, Gastroenterology, ELISA, enzyme-linked immunosorbent assay, Diseases of the digestive system. Gastroenterology, Colitis, RT-PCR, reverse- transcription polymerase chain reaction, mRNA, messenger RNA, ChIP, chromatin immunoprecipitation, medicine.anatomical_structure, Prenatal Exposure Delayed Effects, Histone methyltransferase, shRNA, short hairpin RNA, Female, 030211 gastroenterology & hepatology, medicine.symptom, Regulatory T cell, Treg, regulatory T cell, Mice, Transgenic, Inflammation, Biology, Regulatory T Cell, 03 medical and health sciences, Histone H3, FBS, fetal bovine serum, DSS, dextran sulfate sodium, medicine, Animals, Epigenetics, SV40, simian virus 40, Hepatology, Probiotics, Growth factor, TNBS, 2,4,6-trinitrobenzenesulfonic acid, Epithelial Cells, medicine.disease, WT, wild-type, EGFR, epidermal growth factor receptor, IL, interleukin, Mice, Inbred C57BL, MSIE, mouse small intestinal epithelial, 030104 developmental biology, YAMC, young adult mouse colonic, Cancer research
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المؤلفون: Globig, Anna-Maria, Sommer, Nikola Patricia, Wild, Katharina, Schardey, Josefine, Zoldan, Katharina, Thomann, Anne Kerstin, Schulte, Lucas-Alexander, Schreiner, Rupert, Reindl, Wolfgang, Klaus, Jochen, Schempp, Christoph Mathis, Hofmann, Maike, Thimme, Robert, Boettler, Tobias, Hasselblatt, Peter
المصدر: Cellular and Molecular Gastroenterology and Hepatology
مصطلحات موضوعية: Adult, Male, CXCR5, C-X-C chemokine receptor 5, PBMC, peripheral blood mononuclear cell, T Follicular Helper Cells, Biopsy, IBD, Primary Cell Culture, UST, ustekinumab, TFH, PD-1, programmed cell death protein 1, Young Adult, Crohn Disease, HBI, Harvey-Bradshaw index, CD, Crohn’s disease, TGFβ, transforming growth factor β, Humans, T Follicular Helper Cell, Intestinal Mucosa, Cells, Cultured, Original Research, TNF, tumor necrosis factor, ICOS, inducible T cell costimulator, Interleukin-12 Subunit p40, UST, Cell Differentiation, Middle Aged, Flow Cytometry, Healthy Volunteers, IL, interleukin, CXCL13, C-X-C chemokine ligand 13, Case-Control Studies, Ustekinumab, Female, TFH, follicular T helper, Crohn’s Disease
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المؤلفون: Jialing Liu, Xingqiang Lai, Yingying Bao, Wenfeng Xie, Zhishan Li, Jieying Chen, Gang Li, Tao Wang, Weijun Huang, Yuanchen Ma, Jiahao Shi, Erming Zhao, Andy Peng Xiang, Qiuli Liu, Xiaoyong Chen
مصطلحات موضوعية: Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, mesenchymal stem cells, experimental colitis, regulatory B cells, THBS1, TGFβ (transforming growth factor β)
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المؤلفون: Bernard L. Flynn, Ruth R Magaye, Xin Xiong, Peter J Meikle, Danny Liew, Feby Savira, Kevin Huynh, David M. Kaye, Bing Hui Wang, Christopher M. Reid
المصدر: International Journal of Cardiology. Heart & Vasculature
International Journal of Cardiology: Heart & Vasculature, Vol 35, Iss, Pp 100837-(2021)مصطلحات موضوعية: RPS6, ribosomal protein S6, S1PR1, sphingosine -1-phosphate receptor 1, MMP2, matrix metalloproteinase 2, Sphingolipid, MA3PK, mitogen activated protein kinase kinase kinase, chemistry.chemical_compound, S1P, sphingosine-1 Phosphate, Sph, sphingosine, TIMP1, tissue inhibitor of metalloproteinase 1, TGFβ, transforming growth factor β, Medicine, S1PR1, Cardiac fibroblasts, biology, Dihydrosphingosine, Cell biology, S1PRs, sphingosine 1 phosphate receptor 1-5, Collagen synthesis, Sphingosine kinase 1, Coll1a1, collagen 1a1, mTOR, mammalian target for rapamycin, d7dhSph, deuterated dihydrosphingosine, lipids (amino acids, peptides, and proteins), MAPK, mitogren activated protein kinase, Cardiology and Cardiovascular Medicine, Ceramide, Cer, ceramide, SK1, sphingosine kinase 1, TAK1, transforming growth factor β activating kinase 1, CTGF, connective tissue growth factor, TGFβ, TGF beta signaling pathway, Diseases of the circulatory (Cardiovascular) system, Cer1P, ceramide 1 phosphate, Sphingosine-1-phosphate, NCF, neonatal cardiac fibroblasts, ComputingMethodologies_COMPUTERGRAPHICS, Original Paper, dhCer, dihydroceramide, Sphingosine, business.industry, dhS1P, dihydrosphingosine 1 phosphate, Degs1, dihydroceramide desaturase 1 gene, chemistry, RC666-701, ECM, extracellular matrix inhibitor of nuclear kappa B (NFKβ) kinase alpha and beta (IKKα/β), Akt, protein kinase B, biology.protein, MI, myocardial infarct, business, Des-1, dihydroceramide desaturase 1 enzyme, Transforming growth factor
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المؤلفون: Hilde Herrema, Torsten P. M. Scheithauer, Albert K. Groen, Max Nieuwdorp, Jeffrey Kroon, Abraham S. Meijnikman
المصدر: JHEP Reports
مصطلحات موضوعية: Senescence, obesity, NAFLD, non-alcoholic fatty liver disease, MiDAS, mitochondrial dysfunction-associated senescence, TGFβ, transforming growth factor-β, NASH, non-alcoholic steatohepatitis, LSEC, liver sinusoidal endothelial cell, Senescence-associated beta-galactosidase, MCP1/CCL2, monocyte chemoattractant protein-1, Review, SASP, senescence-associated secretory phenotype, Biology, DDR, DNA damage response, Proinflammatory cytokine, ROS, reactive oxygen species, Cyclin-dependent kinase, Rb, retinoblastoma factor, Internal Medicine, medicine, Immunology and Allergy, cellular senescence, KC, Kupffer cell, NAFL, non-alcoholic fatty liver, TNFα, tumour necrosis factor-α, Senolytic, ATM, ataxia telangiectasia mutated, Hepatology, SA-β gal, senescence-associated beta-galactosidase, Fatty liver, Gastroenterology, non-alcoholic fatty liver disease, C/EBPα, CCAAT- enhancer-binding protein, medicine.disease, CDK, cyclin dependent kinase, Telomere, IL-, interleukin, senolytics, Cancer research, biology.protein, non-alcoholic steatohepatitis, SCAP, senescence-associated antiapoptotic pathways, Steatohepatitis, FFAs, free fatty acids, qPCR, quantitative PCR, HCC, hepatocellular carcinoma
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المؤلفون: Hiroko Ida-Yonemochi, Takuichi Sato, Hayato Ohshima, Junko Matsuyama, Angela Quispe-Salcedo
المصدر: Regenerative Therapy
Regenerative Therapy, Vol 15, Iss, Pp 216-225 (2020)مصطلحات موضوعية: 0301 basic medicine, Molar, DAP, Double antibiotic paste, Glass ionomer cement, Dentistry, H2O2, Hydrogen peroxide, Polyvinyl alcohol, DCs, Dendritic cells, SCAP, Stem cells of the apical papilla, chemistry.chemical_compound, DPC, Direct pulp capping, DNA, Deoxyribonucleic acid, 0302 clinical medicine, TAC-P, Triple antibiotic combination and propylene glycol, mRNA, Messenger ribonucleic acid, P, Propylene glycol, Cell differentiation, Pcna, Proliferating cell nuclear antigen, cDNA, Complementary deoxyribonucleic acid, Sox 10, SRY-related HMG-box 10, Cell proliferation, Pulp necrosis, lcsh:R5-920, HLA-DR-immunopositive cells, Human Leukocyte Antigen – DR isotype-immunopositive cells, Chemistry, lcsh:Cytology, αTCP, Alpha tricalcium phosphate, Minocycline, mTAP, Modified triple antibiotic paste, FGFs, Fibroblast growth factors, PBS, Phosphate-buffered saline, ANOVA, One-way analysis of variance, BMPs, Bone morphogenetic proteins, TUNEL assay, Terminal deoxynucleotidyl transferase dUTP nick end labeling assay, HE, Hematoxylin-eosin, Original Article, lcsh:Medicine (General), medicine.drug, MP, Macrogol (M) mixed with propylene glycol (P), Macrogol, Oct 3/4 A, Octamer binding transcription factor 3/4 A, Biomedical Engineering, CH, Calcium hydroxide, MTA, Mineral trioxide aggregate, Biomaterials, 03 medical and health sciences, Birc5, Baculoviral IAP Repeat Containing 5, Dental cavity preparation, stomatognathic system, Anti-bacterial agents, TGFβ, Transforming growth factor β, medicine, lcsh:QH573-671, RNA, Ribonucleic acid, β-actin, Beta-actin, DPSCs, Dental pulp stem cells, REP, Regenerative endodontic procedures, Mice (crlj:CD1), Oct 3/4 B, Octamer binding transcription factor 3/4 B, MHC, Major histocompatibility complex, AZAN, Azocarmine and aniline blue, RT, Reverse transcription, business.industry, TAC, Triple antibiotic combination (a mixture of metronidazole, ciprofloxacin, and minocycline), TAS, Triple antibiotic solution, MSCs, Mesenchymal stem cells, Ct, Cycle threshold, Dental pulp, Metronidazole, stomatognathic diseases, 030104 developmental biology, Tris–HCl buffer, Tris (hydroxymethyl) aminomethane (THAM) hydrochloride buffer, Yap1, Yes-associated protein 1, GM-CSF, Granulocyte-macrophage colony-stimulating factor, Pulp (tooth), TAP, Triple antibiotic paste, business, qRT-PCR, Quantitative real-time polymerase chain reaction, 030217 neurology & neurosurgery, M, Macrogol, Developmental Biology
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المؤلفون: Matjaz Rokavec, Nassim Bouznad, Heiko Hermeking
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 783-802 (2019)مصطلحات موضوعية: 0301 basic medicine, Colorectal cancer, medicine.medical_treatment, miR, microRNA, Metastasis, COAD, colonic adenocarcinomas, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, Cell Movement, miRNA, microRNA, TGFβ, transforming growth factor β, Original Research, Membrane Glycoproteins, Gastroenterology, Prognosis, mRNA, messenger RNA, ZEB1, Zinc Finger E-Box Binding Homeobox 1, microRNAs, Gene Expression Regulation, Neoplastic, READ, rectal adenocarcinomas, Cytokine, CMS, consensus molecular subtype, CRC, colorectal cancer, qPCR, quantitative polymerase chain reaction, 030211 gastroenterology & hepatology, Nidogen1, EMT, epithelial-mesenchymal transition, Colorectal Neoplasms, wt, wild-type, Epithelial-Mesenchymal Transition, DOX, doxycycline, Biology, cDNA, complementary DNA, 03 medical and health sciences, Paracrine signalling, CM, conditioned medium, FBS, fetal bovine serum, Cell Line, Tumor, Paracrine Communication, microRNA, medicine, Humans, Neoplasm Invasiveness, Epithelial–mesenchymal transition, lcsh:RC799-869, NID1, nidogen-1, Hepatology, VIM, vimentin, DNA Methylation, medicine.disease, digestive system diseases, 030104 developmental biology, siRNA, small interfering RNA, Drug Resistance, Neoplasm, Tumor progression, Cell culture, VSV, Vesicular Stomatitis Virus, Culture Media, Conditioned, Tumor Progression, Cancer research, TCGA, The Cancer Genome Atlas, lcsh:Diseases of the digestive system. Gastroenterology, Tumor Suppressor Protein p53, MAPK, mitogen-activated protein kinase
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المؤلفون: Kanchan Bisht, Marie-Ève Tremblay, Kaushik P. Sharma
المصدر: Neurobiology of Stress, Vol 9, Iss, Pp 9-21 (2018)
Neurobiology of Stressمصطلحات موضوعية: 0301 basic medicine, Physiology, TNFα, tumor necrosis factor-α, medicine.disease_cause, Biochemistry, lcsh:RC346-429, 0302 clinical medicine, Endocrinology, Neuroinflammation, LTP, long-term potentiation, CR, complement receptor, DAM, disease associated microglia, TGFβ, transforming growth factor β, MGnD, microglia with a neurodegenerative phenotype, Chronic stress, Dark microglia, FAD, Familial Alzheimer's disease, Microglial phenotypes, FCRLS, Fc receptor-like S scavenger receptor, biology, Microglia, Neurodegeneration, lcsh:QP351-495, Alzheimer's disease, 3. Good health, medicine.anatomical_structure, AD, Alzheimer's disease, ABCA7, ATP-binding cassette transporter A7, TYROBP, TYRO protein tyrosine kinase binding protein, TMEM119, transmembrane protein 119, Amyloid beta, DAP12, DNAX-activation protein 12, BDNF, brain derived neurotrophic factor, Stress, CNS, central nervous system, Neuroprotection, TLR, Toll-like receptors, lcsh:RC321-571, CD11b, cluster of differentiation molecule 11B, 03 medical and health sciences, Cellular and Molecular Neuroscience, APOE, Apolipoprotein E, ROS, reactive oxygen species, PS, presenilin, APP, amyloid precursor protein, medicine, Aβ, Amyloid beta, CD33, cluster of differentiation 33, Molecular Biology, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, VSI: Stress and the Pathogenesis of Alzheimer’s Disease, lcsh:Neurology. Diseases of the nervous system, GR, glucocorticoid receptor, Endocrine and Autonomic Systems, business.industry, NFT, neurofibrillary tangles, mPFC, medial prefrontal cortex, IBA1, ionized calcium-binding adapter molecule 1, Synaptic remodeling, NADPH, nicotinamide adenine dinucleotide phosphate, medicine.disease, MR, mineralocorticoid receptor, IL, interleukin, 030104 developmental biology, lcsh:Neurophysiology and neuropsychology, Synaptic plasticity, biology.protein, HPA axis, hypothalamic pituitary adrenocortical axis, TREM2, triggering receptor expressed in myeloid cells 2, business, Neuroscience, 030217 neurology & neurosurgery, Oxidative stress, CRF, corticotropin releasing factor
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المؤلفون: Yanyong Xu, Kavita Jadhav, Yingdong Zhu, Yuan-Yuan Li, Takhar Kasumov, Jiesi Xu, Yang Xu, Luciano Adorini, Yoon Kwang Lee, Yanqiao Zhang, Liya Yin
المصدر: Molecular Metabolism, Vol 9, Iss, Pp 131-140 (2018)
Molecular Metabolismمصطلحات موضوعية: Male, 0301 basic medicine, Col1α1, collagen type 1 α1, NS, not significant, Receptors, Cytoplasmic and Nuclear, PPARγ, peroxisome proliferation-activated receptor γ, Receptors, G-Protein-Coupled, Mice, IL-1β, interleukin 1β, SHP, small heterodimer partner, α-Sma, alpha smooth muscle actin (α-Sma), HFD, high fat diet, Non-alcoholic Fatty Liver Disease, Tgfβ, transforming growth factor β, Receptor, TG, triglyceride, Bile acid, Chemistry, TGR5, GLP-1, glucagon-like peptide-1, Hep G2 Cells, Peroxisome, G protein-coupled bile acid receptor, 3. Good health, TNFα, tumor necrosis factor α, Pck1, phosphoenoylpyruvate carboxylase 1, TGR5, G protein coupled bile acid receptor (GPBAP), Lipogenesis, BA, bile acid, G6pc, glucose 6-phosphatase, Small heterodimer partner, Original Article, Agonist, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, lcsh:Internal medicine, Timp1, tissue inhibitor of metalloproteinase 1, medicine.drug_class, NASH, non-alcoholic steatohepatitis, Hypercholesterolemia, Diet, High-Fat, Bile Acids and Salts, 03 medical and health sciences, FXR, farnesoid X receptor, Farnesoid X receptor, NAFLD, Internal medicine, medicine, Animals, Humans, Obesity, lcsh:RC31-1245, Molecular Biology, CEBPα, CCAAT/enhancer-binding protein α, DIO, diet-induced obesity, Cell Biology, Atherosclerosis, Mice, Inbred C57BL, BAT, brown adipose tissue, 030104 developmental biology, Endocrinology
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المؤلفون: J. Emanuel Ramos de Carvalho, Reinier O. Schlingemann, Ilse M. C. Vogels, Milan T. Verwoert, Cornelis J.F. Van Noorden, Eric Reits, Ingeborg Klaassen
المساهمون: Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Graduate School, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Cardiovascular Sciences, Medical Biology, Ophthalmology, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation
المصدر: Biochemistry and Biophysics Reports, Vol 13, Iss, Pp 83-92 (2018)
Biochemistry and Biophysics Reports
Biochemistry and biophysics reports, 13, 83-92. Elsevier BVمصطلحات موضوعية: 0301 basic medicine, PPARγ, TGFβ, transforming growth factor-β, Biochemistry, chemistry.chemical_compound, 0302 clinical medicine, Gene expression, lcsh:QD415-436, AMD, age-related macular degeneration, lcsh:QH301-705.5, TIMP-1, tissue inhibitor of metalloproteinases-1, biology, FN EDA, fibronectin EDA domain, ECM, extracellular matrix, Cell biology, medicine.anatomical_structure, MMP-2, matrix metalloproteinase-2, ARPE-19, human retinal pigment epithelial cells, RPE, Epoxomicin, EMT, epithelial-mesenchymal transition, Research Article, medicine.drug, RPE, retinal pigment epithelium, Biophysics, Retina, CTGF, connective tissue growth factor, lcsh:Biochemistry, TGFβ, 03 medical and health sciences, PPARγ, peroxisome proliferator-associated receptor-γ, medicine, UPS, ubiquitin-proteasome system, IFNγ, interferon-γ, CNV, choroidal neovascularization, FN, fibronectin, Retinal pigment epithelium, Proteasome, CTGF, nAMD, neovascular age-related macular degeneration, Fibrosis, Fibronectin, 030104 developmental biology, lcsh:Biology (General), chemistry, 030221 ophthalmology & optometry, Proteasome inhibitor, biology.protein, Transforming growth factor
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المؤلفون: Chao Wu, Anna L. Means, James R. Goldenring, Anne R. Meyer, Charles L. Sawyers, Keith T. Wilson, R. Daniel Beauchamp, M. Kay Washington, Robert J. Coffey, Tanner J. Freeman, Hanbing An, Jinghuan Zi, Connie J. Weaver, Chanjuan Shi, J. Joshua Smith, Tasia D. Brown, Luke G. Woodbury, Natasha G. Deane, Paula Marincola-Smith, Chandrasekhar Padmanabhan, Jing Zhu, Bronson C. Wessinger, Sergey V. Novitskiy, Rupesh Chaturvedi
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 3, Pp 257-276 (2018)مصطلحات موضوعية: 0301 basic medicine, DMEM, Dulbecco's modified Eagle medium, STAT3, signal transducer and activator of transcription 3, Colorectal cancer, IBD, inflammatory bowel disease, Bone Morphogenetic Protein 2, medicine.disease_cause, Mice, AOM, azoxymethane, TGFβ, transforming growth factor β, DSS, dextran sodium sulfate, Intestinal Mucosa, Original Research, GFP, green fluorescent protein, Smad4 Protein, TNF, tumor necrosis factor, Colitis-Associated Carcinoma, Dextran Sulfate, Gastroenterology, APC, adenomatous polyposis coli, Colitis, R-SMAD, Receptor-SMAD, Intestinal epithelium, mRNA, messenger RNA, 3. Good health, Editorial, CRC, colorectal cancer, SFG, retroviral vector, LPS, lipopolysaccharide, Tumor necrosis factor alpha, CAC, colitis-associated carcinoma, medicine.symptom, Colorectal Neoplasms, Signal Transduction, IMCS4fl/fl, immortalized mouse colonoctye cell line with loxP-flanked Smad4 alleles, FDR, false discovery rate, sgRNA, single-guide RNA, PBS, phosphate-buffered saline, CCL20, Chemokine (C-C motif) ligand 20, WNT, wingless-type mouse mammary tumor virus integration site, Mice, Transgenic, Inflammation, Biology, YAMC, young adult mouse colon epithelial cells, Cell Line, Proinflammatory cytokine, Transforming Growth Factor beta1, TGFβ, 03 medical and health sciences, IMCS4null, immortalized mouse colonocyte cell line with deletion of the Smad4 alleles, FBS, fetal bovine serum, Cell Line, Tumor, medicine, Animals, Humans, lcsh:RC799-869, Hepatology, Carcinoma, Cancer, BMP, bone morphogenetic protein, PE, phycoerythrin, CRISPR/Cas9, Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9, medicine.disease, digestive system diseases, IL, interleukin, Mice, Inbred C57BL, UC, ulcerative colitis, 030104 developmental biology, HBSS, Hank's balanced salt solution, Cancer research, Colitis, Ulcerative, lcsh:Diseases of the digestive system. Gastroenterology, Tumor Necrosis Factor, Carcinogenesis, Transforming growth factor
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المؤلفون: Jessica Bauer, Yasna Jain, Taher A. Saif, Barbara Jung, Bashar Emon
المصدر: Computational and Structural Biotechnology Journal, Vol 16, Iss, Pp 279-287 (2018)
Computational and Structural Biotechnology Journalمصطلحات موضوعية: 0301 basic medicine, EMT, Epithelial to mesenchymal transition, VEGF, Vascular endothelial growth factor, TACs, Tumor-associated collagen signatures, IGFs, Insulin-like growth factors, IL-13, Interleukin-13, Review Article, LOX, Lysyl Oxidase, Biochemistry, Metastasis, SDF-1/CXCL12, Stromal cell-derived factor 1/C-X-C motif chemokine 12, Extracellular matrix, α-SMA, α-Smooth muscle actin, 0302 clinical medicine, Structural Biology, TNF-α, Tumor necrosis factor-α, HGF/SF, Hepatocyte growth factor/Scatter factor, Cancer, CSF-1, Colony stimulating factor 1, MMPs, Matrix metalloproteinases, 3. Good health, Computer Science Applications, Tumor biophysics, EGF, Epidermal growth factor, 030220 oncology & carcinogenesis, CAF, Cancer associated fibroblast, ECM stiffness, Growth factors, Biotechnology, Stromal cell, KGF, Keratinocyte growth factor, also FGF7, lcsh:Biotechnology, CYR61/CCN1, Cysteine-rich angiogenic inducer 61/CCN family member 1, Biophysics, Cancer metastasis, NO, Nitric oxide, 03 medical and health sciences, ECM, Extracellular matrix, IL-33, Interleukin-33, Stroma, lcsh:TP248.13-248.65, TGFβ, Transforming growth factor β, Genetics, medicine, IL-6, Interleukin-6, Tumor microenvironment, business.industry, technology, industry, and agriculture, medicine.disease, Activin/TGFβ, 030104 developmental biology, ADAMs, Adamalysins, CTGF, Connective tissue growth factor, Cancer cell, Cancer research, ANGPT2, Angiopoietin 2, business, FGF, Fibroblast growth factor
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المؤلفون: Zielinska, H. A., Holly, J. M.P., Bahl, A., Perks, C. M.
المصدر: Cancer Letters
Zielinska, H A, Holly, J M P, Bahl, A & Perks, C M 2018, ' Inhibition of FASN and ERα signalling during hyperglycaemia-induced matrix-specific EMT promotes breast cancer cell invasion via a caveolin-1-dependent mechanism ', Cancer Letters, vol. 419, pp. 187-202 . https://doi.org/10.1016/j.canlet.2018.01.028مصطلحات موضوعية: EMT, Epithelial to mesenchymal transition, MMP, Matrix metalloproteinase, Epithelial-Mesenchymal Transition, GLUT, Glucose transporter, Caveolin 1, TCA, tricarboxylic acid, Breast Neoplasms, Article, ns, not significant, Breast cancer, ECM, Extracellular matrix, FASN, Fatty acid synthase, PHGDH, Phosphoglycerate dehydrogenase, MCT, Monocarboxylate transporter, Cell Movement, Cell Line, Tumor, TGFβ, Transforming growth factor β, Hyperglycaemia, Humans, Neoplasm Invasiveness, G6PD, Glucose-6-phosphate dehydrogenase, Fibronectin, ERα, Estrogen receptor α, GFPT1, Glutamine–fructose-6 phosphateransaminase 1, Cell Proliferation, NS, Non-silencing, Epithelial to mesenchymal transition, LDH, Lactate dehydrogenase, Estrogen Receptor alpha, OXPHOS, Oxidative phosphorylation, MET, Mesenchymal to epithelial transition, Extracellular Matrix, Fatty Acid Synthase, Type I, Glucose, TALDO1, Transaldolase 1, Hyperglycemia, TKT, Transketolase, MCF-7 Cells, Female, RNA Interference, ICEP, Warburg effect, PARP, Poly(ADP-ribose) polymerase, Signal Transduction
وصف الملف: application/pdf
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المؤلفون: Tatsuo Okui, Toshiyuki Yoneda, Masahiro Hiasa, Kenji Hata
المصدر: Journal of Bone Oncology, Vol 30, Iss, Pp 100387-(2021)
Journal of Bone Oncologyمصطلحات موضوعية: HIF-1α, hypoxia-inducible transcription factor-1α, HMGB-1, high mobility group box-1, Bone microenvironment, ERK1/2, extracellular receptor kinase ½, PDAC, pancreatic ductal adenocarcinoma, CAP, cancer-associated pain, CXCL2, C-X-C Motif Chemokine Ligand 2, NI, nerve invasion, Review Article, VIP, vasoactive intestinal peptide, Diseases of the musculoskeletal system, TrkA, tyrosine kinase receptor type 1, Axonogenesis, CGRP, calcitonin gene-related peptide, IL-1β, interleukin 1β, RAMP1, receptor activity modifying protein 1, TGFβ, transforming growth factor β, NSAIDs, nonsteroidal anti-inflammatory drugs, RC254-282, Perineural invasion, CRPC, castration-resistant prostate cancer, Neurogenesis, MM, multiple myeloma, Nociceptors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Bone metastasis, CABP, cancer-associated bone pain, VEGF, vascular endothelial growth factor, Sensory nerves, DRG, dorsal root ganglion, SN, sensory nerves, RTX, resiniferatoxin, TNFα, tumor necrosis factor α, AN, autonomic nerve, CREB, cyclic AMP-responsive element-binding protein, Oncology, BDNF, brain-derived neurotrophic factor, Nociceptor, OA, osteoarthritis, lipids (amino acids, peptides, and proteins), medicine.symptom, SRE, skeletal-related event, RAGE, receptor for advanced glycation end products, animal structures, HUVECs, human umbilical vein endothelial cells, PACAP, pituitary adenylate cyclase-activating peptide, NGF, nerve growth factor, a3V-H+-ATPase, a3 isoform vacuolar proton pump, NPY, neuropeptide Y, TRPV1, GDNF, glial-derived neurotrophic factor, CNS, central nervous system, RANKL, receptor activator of NF-κB ligand, MOR, mu-opioid receptor, BMSC, bone marrow stromal cells, CXCL1, C-X-C Motif Chemokine Ligand 1, PGE2, prostaglandin E2, medicine, CALCRL, calcitonin receptor-like receptor, Bone pain, SP, substance P, Tumor microenvironment, business.industry, HSCs, hematopoietic stem cells, PanIN, pancreatic intraepithelial neoplasia, Cancer, BMP, bone morphogenetic protein, Cancer-associated bone pain, PD-1, programmed cell death-1, medicine.disease, G-CSF, granulocyte colony-stimulating factor, COX, cyclooxygenase, PD-L1, programmed death-ligand 1, nervous system, OPG, osteoprotegerin, RC925-935, Cancer research, HGF, hepatocyte growth factor, CCL2, C–C motif chemokine 2, PNI, perineural invasion, business, NE, norepinephrine
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المؤلفون: Cai-Yuan Wu, Dong-Ming Kuang, Yuan Wei
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 783-784 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: PBL, peripheral blood lymphocyte, B Cells, Circadian clock, PBS, phosphate-buffered saline, IFNγ, interferon γ, RC799-869, SPL, spleen lymphocyte, B7-H1 Antigen, IM, invasive margin, AOM, azoxymethane, Text mining, FBS, fetal bovine serum, Circadian Clocks, PDL1, DSS, dextran sulfate sodium, PD-L1, CD, Crohn’s disease, TGFβ, transforming growth factor β, IEL, intraepithelial lymphocyte, MFI, mean fluorescence intensity, Th, T helper, Original Research, B-Lymphocytes, CT, tumor center, Hepatology, biology, business.industry, Gastroenterology, CJ, chronic jet lag, PDL1, Programmed cell death 1 ligand 1, MCP-1, monocyte chemoattractant protein-1, Diseases of the digestive system. Gastroenterology, Colitis, WT, wild-type, digestive system diseases, mRNA, messenger RNA, qRT-PCR, quantitative reverse-transcription polymerase chain reaction, IL, interleukin, ChIP, chromatin immunoprecipitation, Bmal1, Breg, regulatory B, UC, ulcerative colitis, CRC, colorectal cancer, biology.protein, Colitis-Associated Colorectal Cancer, DMEM, Dulbecco’s modified Eagle medium, GranzB, _, business, Neuroscience
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20
المؤلفون: Libin Jin, Minfei Yang, Bing Liu, Hui-min Tao, Zhengming Yang
المصدر: Journal of Bone Oncology, Vol 9, Iss, Pp 15-20 (2017)
Journal of Bone Oncologyمصطلحات موضوعية: 0301 basic medicine, lcsh:Diseases of the musculoskeletal system, Integrin, Estrogen receptor, Estrogen receptor β, Biology, Inhibitor of apoptosis, lcsh:RC254-282, Anti-tumor, OD, optical density, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, FBS, fetal bovine serum, NC, control, TGFβ, transforming growth factor β, Regulatory mechanism, LY294002, PAGE, SDS-polyacrylamide gel electrophoresis, Viability assay, Protein kinase B, PI3K/AKT/mTOR pathway, Osteosarcoma, ERβ, Estrogen receptor β, CCK-8, Cell counting kit 8, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Molecular biology, EGFR, epidermal growth factor receptor, 030104 developmental biology, Oncology, chemistry, Cell culture, 030220 oncology & carcinogenesis, biology.protein, lcsh:RC925-935, Research Article
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