المؤلفون: Johnson K., Chang-Claude J., Critchley A. -M., Kyriacou C., Lavers S., Rattay T., Seibold P., Webb A., West C., Symonds R. P., Talbot C. J., Azria D., Brookes A., Burr T., Davidson S., De Ruysscher D., Dunning A., Elliott R., Gutierrez Enriquez S., Lambin P., Rancati T., Rosenstein B., Talbot C., Thierens H., Valdagni R., Vega A., Veldeman L., Wenz F., Yuille M.

المساهمون: K. Johnson, J. Chang-Claude, A.-. Critchley, C. Kyriacou, S. Laver, T. Rattay, P. Seibold, A. Webb, C. West, R.P. Symond, C.J. Talbot, D. Azria, A. Brooke, T. Burr, S. Davidson, D. De Ruysscher, A. Dunning, R. Elliott, S. Gutierrez Enriquez, P. Lambin, T. Rancati, B. Rosenstein, C. Talbot, H. Thieren, R. Valdagni, A. Vega, L. Veldeman, F. Wenz, M. Yuille

مصطلحات موضوعية: Adverse reaction, breast cancer, circadian rhythm, genetics, Settore MED/36 - Diagnostica per Immagini e Radioterapia

Relation: info:eu-repo/semantics/altIdentifier/pmid/30389261; info:eu-repo/semantics/altIdentifier/wos/WOS:000453925200006; volume:31; issue:1; firstpage:9; lastpage:16; numberofpages:8; journal:CLINICAL ONCOLOGY; http://hdl.handle.net/2434/657017; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85055679002

الاتاحة: http://hdl.handle.net/2434/657017
https://doi.org/10.1016/j.clon.2018.10.001

المؤلفون: Seibold P., Webb A., Aguado-Barrera M. E., Azria D., Bourgier C., Brengues M., Briers E., Bultijnck R., Calvo-Crespo P., Carballo A., Choudhury A., Cicchetti A., Classen J., Delmastro E., Dunning A. M., Elliott R. M., Farcy-Jacquet M. -P., Gabriele P., Garibaldi E., Gomez-Caamano A., Gutierrez-Enriquez S., Higginson D. S., Johnson K., Lobato-Busto R., Molla M., Muller A., Payne D., Peleteiro P., Post G., Rancati T., Rattay T., Reyes V., Rosenstein B. S., De Ruysscher D., De Santis M. C., Schafer J., Schnabel T., Sperk E., Symonds R. P., Stobart H., Taboada-Valladares B., Talbot C. J., Valdagni R., Vega A., Veldeman L., Ward T., Weissenberger C., West C. M. L., Chang-Claude J.

المساهمون: P. Seibold, A. Webb, M.E. Aguado-Barrera, D. Azria, C. Bourgier, M. Brengue, E. Brier, R. Bultijnck, P. Calvo-Crespo, A. Carballo, A. Choudhury, A. Cicchetti, J. Classen, E. Delmastro, A.M. Dunning, R.M. Elliott, M.-. Farcy-Jacquet, P. Gabriele, E. Garibaldi, A. Gomez-Caamano, S. Gutierrez-Enriquez, D.S. Higginson, K. Johnson, R. Lobato-Busto, M. Molla, A. Muller, D. Payne, P. Peleteiro, G. Post, T. Rancati, T. Rattay, V. Reye, B.S. Rosenstein, D. De Ruysscher, M.C. De Santi, J. Schafer, T. Schnabel, E. Sperk, R.P. Symond, H. Stobart, B. Taboada-Valladare, C.J. Talbot, R. Valdagni, A. Vega, L. Veldeman, T. Ward, C. Weissenberger, C.M.L. West, J. Chang-Claude

مصطلحات موضوعية: Biomarker, Breast cancer, Late radiotherapy side effect, Lung cancer, Prediction model, Prostate cancer, Settore MED/36 - Diagnostica per Immagini e Radioterapia

Relation: info:eu-repo/semantics/altIdentifier/pmid/31146072; info:eu-repo/semantics/altIdentifier/wos/WOS:000482210600009; volume:138; firstpage:59; lastpage:67; numberofpages:9; journal:RADIOTHERAPY AND ONCOLOGY; http://hdl.handle.net/2434/656911; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85066086421

الاتاحة: http://hdl.handle.net/2434/656911
https://doi.org/10.1016/j.radonc.2019.04.034

المؤلفون: Jaikuna, Tanwiwat, Vasquez Osorio, Eliana, Azria, D., Chang-Claude, J., De Santis, M. C., Gutiérrez-Enríquez, S., van Herk, Marcel, Hoskin, Peter J, Lambrecht, M., Lingard, Zoe, Seibold, P., Seoane, A., Sperk, E., Symonds, R. P., Talbot, C. J., Rancati, T., Rattay, T., Reyes, V., Rosenstein, B. S., de Ruysscher, D., Vega, A., Veldeman, L., Webb, A., West, Catharine M L, Aznar, Marianne Camille

المساهمون: Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Christie NHS Foundation Trust Hospital, Manchester

Relation: https://doi.org/10.1016/j.breast.2023.103578; Jaikuna T, Osorio EV, Azria D, Chang-Claude J, De Santis MC, Gutiérrez-Enríquez S, et al. Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy. Breast (Edinburgh, Scotland). 2023 Sep 11;72:103578. PubMed PMID: 37713940. Epub 2023/09/16. eng.; http://hdl.handle.net/10541/626563; Breast

الاتاحة: http://hdl.handle.net/10541/626563
https://doi.org/10.1016/j.breast.2023.103578

المؤلفون: Rammant, E., Deman, E., Poppe, L., Bultijnck, R., Dirix, P., De Meerleer, G., Haustermans, K., Van Hecke, A., Azria, D., Chang-Claude, J., Choudhury, Ananya, De Ruysscher, D., Lambrecht, M., Rosenstein, B. S., Seibold, P., Sperk, E., Symonds, R. P., Valdagni, R., Vega, A., Webb, A., West, Catharine M L, Veldeman, L., Fonteyne, V., Van Hoecke, S.

المساهمون: Ghent University, Dept. of Human Structure and Repair, Ghent, Belgium

مصطلحات موضوعية: demo, psy

Relation: http://hdl.handle.net/10541/625514

الاتاحة: http://hdl.handle.net/10541/625514

المؤلفون: Jandu, H., Veal, C. D., Azria, D., Chang-Claude, J., Dunning, A. M., De Ruysscher, D., Fachal, L., Gutierrez-Enriquez, S., Rancati, T., Rosenstein, B. S., De Santis, M. C., Seibold, P., Sperk, E., Symonds, R. P., Vega, A., Veldeman, L., Webb, A., West, Catharine M L, Talbot, C. J., Rattay, T.

المساهمون: University of Leicester, Department of Genetics and Genome Biology, Leicester

Relation: https://dx.doi.org/10.1016/S0959-8049(22)01452-6; Jandu H, Veal CD, Azria D, Chang-Claude J, Dunning AM, De Ruysscher D, et al. Genome wide association study of long-term patient-reported outcomes following radiotherapy for breast cancer - results from the REQUITE cohort study. European Journal of Cancer. 2022 Nov;175:S38-S. PubMed PMID: WOS:000897545400103.; http://hdl.handle.net/10541/626133; European Journal of Cancer

الاتاحة: http://hdl.handle.net/10541/626133
https://doi.org/10.1016/S0959-8049(22)01452-6

المؤلفون: Seibold, P., Barrera, M. E. A., Azria, D., Briers, E., Bultjinck, R., Cicchetti, A., Choudhury, Ananya, Gutierrez-Enriquez, S., Heger, T., Helmbold, I., Kaaks, R., Lambrecht, M., Rattay, T., Rosenstein, B. S., De Ruysscher, D., Sperk, E., Stobart, H., Symonds, R. P., Talbot, C. J., Valdagni, R., Vega, A., Veldeman, L. I. V., Ward, T., Webb, A., West, Catharine M L, Chang-Claude, J., Rancati, T.

المساهمون: German Cancer Research Center (DKFZ), Heidelberg, Deutschland

Relation: Seibold P, Barrera MEA, Azria D, Briers E, Bultjinck R, Cicchetti A, et al. Longitudinal course of global health-related quality of life and fatigue up to 5 years after radiotherapy in an international multicentre observational cohort of men with prostate cancer. Oncology Research and Treatment. 2022 Nov;45(SUPPL 3):214-. PubMed PMID: WOS:000883051700502.; http://hdl.handle.net/10541/625910; Oncology Research and Treatment

الاتاحة: http://hdl.handle.net/10541/625910

المؤلفون: Talbot, C., Webb, A., Harper, E., Azria, D., Choudhury, Ananya, de Ruysscher, D., Dunning, A., Elliott, R., Kerns, S., Lambrecht, M., Rancati, T., Rosenstein, B., Seibold, P., Sperk, E., Vega, A., Veldeman, L., Chang-Claude, J., West, Catharine M L, Rattay, T., Symonds, R. P.

المساهمون: University of Leicester, Leicester Cancer Research Centre, Leicester

Relation: Talbot C, Webb A, Harper E, Azria D, Choudhury A, de Ruysscher D, et al. Treatment time and circadian genotype interact to alter the severity of radiotherapy side-effects. Radiotherapy and Oncology. 2022 May;170:S321-S3. PubMed PMID: WOS:000806759200323.; http://hdl.handle.net/10541/625527; Radiotherapy and Oncology

الاتاحة: http://hdl.handle.net/10541/625527

المؤلفون: Rosas, C., Rattay, T., Azria, D., Elliott, Rebecca M, Gutierrez-Enriquez, S., Rancati, T., Rosenstein, B. S., De Ruysscher, D., Sperk, E., Stobart, H., Symonds, R. P., Talbot, C. J., De Santis, M. C., Vega, A., Veldeman, L., Webb, A., West, Catharine M L, Chang-Claude, J., Seibold, P.

المساهمون: German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg , Germany

Relation: Rosas C, Rattay T, Azria D, Elliott RM, Gutierrez-Enriquez S, Rancati T, et al. Determinants of fatigue and longitudinal changes up to 2 years post-radiotherapy for breast cancer. Radiotherapy and Oncology. 2022 May;170:S723-S4. PubMed PMID: WOS:000806764200351.; http://hdl.handle.net/10541/625517; Radiotherapy and Oncology

الاتاحة: http://hdl.handle.net/10541/625517

المؤلفون: Rattay, Tim, Symonds, R. P., Shokuhi, S., Talbot, C. J., Schnur, J. B.

مصطلحات موضوعية: breast, personalised medicine, qualitative research, radiogenomics, radiotherapy, toxicity

Relation: https://www.ncbi.nlm.nih.gov/pubmed/29287972; Clinical Oncology, 2017, 30 (3), pp. 151-157; https://www.sciencedirect.com/science/article/pii/S0936655517304934?via%3Dihub#!; http://hdl.handle.net/2381/41746; S0936-6555(17)30493-4

الاتاحة: https://www.sciencedirect.com/science/article/pii/S0936655517304934?via%3Dihub#!
http://hdl.handle.net/2381/41746
https://doi.org/10.1016/j.clon.2017.12.001

المؤلفون: Symonds, R. J., Lawson, D. A., Robinson, C. L.

المصدر: Teaching Mathematics and Its Applications: An International Journal of the IMA. 2007 26(3):134-144.

Peer Reviewed: Y

Page Count: 11

Descriptors: Teaching Styles, Teacher Characteristics, Physics, Teaching Methods, Minority Groups, Mathematics Instruction, Comparative Analysis, Control Groups, College Mathematics

المؤلفون: Kerns, S. L., Amidon Morlang, A., Lee, S. M., Peterson, D. R., Marples, B., Zhang, H., Bylund, K., Rosenzweig, D., Hall, W., De Ruyck, K., Rosenstein, B. S., Stock, R. G., Gómez-Caamaño, A., Vega, A., Sosa-Fajardo, P., Taboada-Valladares, B., Aguado-Barrera, M. E., Parker, C., Veldeman, L., Fonteyne, V., Bultijnck, R., Talbot, C. J., Symonds, R. P., Johnson, K., Rattay, T., Webb, A., Lambrecht, M., de Ruysscher, D., Vanneste, B., Choudhury, Ananya, Elliott, R. M., Sperk, E., Herskind, C., Veldwijk, M. R., Rancati, T., Avuzzi, B., Valdagni, R., Azria, D., Farcy Jacquet, M. P., Chang-Claude, J., Seibold, P., West, Catharine M L, Janelsins, M., Chen, Y., Messing, E., Morrow, G.

المساهمون: Department of Radiation Oncology, University of Rochester Medical Center, Rochester, United States. Electronic address: sarah_kerns@urmc.rochester.edu. Department of Radiation Oncology, University of Rochester Medical Center, Rochester, United States. Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, United States. Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, United States. Department of Radiation Oncology, Ghent University Hospital and Department of Human Structure and Repair, Ghent University, Ghent, Belgium. Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, United States, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, United States. Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, United States. Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain. Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain, Fundación Pública Galega de Medicina Xenómica-Servizo Galego de Saude (SERGAS), Santiago de Compostela, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Santiago de Compostela, Spain. Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain, Fundación Pública Galega de Medicina Xenómica-Servizo Galego de Saude (SERGAS), Santiago de Compostela, Spain. Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain, Fundación Pública Galega de Medicina Xenómica-Servizo Galego de Saude (SERGAS), Santiago de Compostela, Spain. Department of Uro-oncology, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton, United Kingdom. Leicester Cancer Research Centre, University of Leicester, United Kingdom. Department of Genetics and Genome Biology, University of Leicester, United Kingdom. KU Leuven, Radiation Oncology, Leuven, Belgium. KU Leuven, Radiation Oncology, Leuven, Belgium, Maastricht University Medical Center, Department of Radiation Oncology (Maastro Clinic), GROW School for Oncology and Developmental Biology, Maastricht, the Netherlands. Division of Cancer Sciences, the University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, the Netherlands. Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Department of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, Department of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, Department of Oncology and Hemato-oncology, Università degli Studi di Milano, Milan, Italy. Department of Radiation Oncology, Montpellier Cancer Institute, Université Montpellier, Inserm U1194, France. ICG Cancer Institute, Centre Hospitalier Universitaire de Nîmes, Nimes, France. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Cancer Epidemiology Group, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Germany. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Department of Surgery, University of Rochester Medical Center, Rochester, United States. Department of Urology, University of Rochester Medical Center, Rochester, United States.

Relation: https://dx.doi.org/10.1016/j.radonc.2022.01.014; Kerns SL, Amidon Morlang A, Lee SM, Peterson DR, Marples B, Zhang H, et al. Use of angiotensin converting enzyme inhibitors is associated with reduced risk of late bladder toxicity following radiotherapy for prostate cancer. Vol. 168, Radiotherapy and Oncology. Elsevier BV; 2022. p. 75–82.; http://hdl.handle.net/10541/625084; Radiotherapy and Oncology

الاتاحة: http://hdl.handle.net/10541/625084
https://doi.org/10.1016/j.radonc.2022.01.014

المؤلفون: Webb, A. J., Harper, E., Rattay, T., Aguado-Barrera, M. E., Azria, D., Bourgier, C., Brengues, M., Briers, E., Bultijnck, R., Chang-Claude, J., Choudhury, Ananya, Cicchetti, A., De Ruysscher, D., De Santis, M. C., Dunning, A. M., Elliott, R. M., Fachal, L., Gómez-Caamaño, A., Gutiérrez-Enríquez, S., Johnson, K., Lobato-Busto, R., Kerns, S. L., Post, G., Rancati, T., Reyes, V., Rosenstein, B. S., Seibold, P., Seoane, A., Sosa-Fajardo, P., Sperk, E., Taboada-Valladares, B., Valdagni, R., Vega, A., Veldeman, L., Ward, T., West, C. M., Symonds, R. P., Talbot, C. J.

المساهمون: Department of Genetics and Genome Biology, University of Leicester, Leicester, UK

Relation: https://dx.doi.org/10.1016/j.ebiom.2022.104269; Webb AJ, Harper E, Rattay T, Aguado-Barrera ME, Azria D, Bourgier C, et al. Treatment time and circadian genotype interact to influence radiotherapy side-effects. A prospective European validation study using the REQUITE cohort. EBioMedicine. 2022 Oct;84:104269. PubMed PMID: 36130474. Pubmed Central PMCID: PMC9486558. Epub 2022/09/22. eng.; http://hdl.handle.net/10541/625677; EBioMedicine

الاتاحة: http://hdl.handle.net/10541/625677
https://doi.org/10.1016/j.ebiom.2022.104269

المؤلفون: Aldraimli, M., Osman, S., Grishchuck, D., Ingram, Samuel, Lyon, R., Mistry, A., Oliveira, J., Samuel, R., Shelley, L. E. A., Soria, D., Dwek, M. V., Aguado-Barrera, M. E., Azria, D., Chang-Claude, J., Dunning, A., Giraldo, A., Green, S., Gutiérrez-Enríquez, S., Herskind, C., van Hulle, H., Lambrecht, M., Lozza, L., Rancati, T., Reyes, V., Rosenstein, B. S., de Ruysscher, D., de Santis, M. C., Seibold, P., Sperk, E., Symonds, R. P., Stobart, H., Taboada-Valadares, B., Talbot, C. J., Vakaet, V. J. L., Vega, A., Veldeman, L., Veldwijk, M. R., Webb, A., Weltens, C., West, Catharine M L, Chaussalet, T. J., Rattay, T.

المساهمون: Health Innovation Ecosystem, University of Westminster, London

Relation: https://dx.doi.org/10.1016/j.adro.2021.100890; Aldraimli M, Osman S, Grishchuck D, Ingram S, Lyon R, Mistry A, et al. Development and Optimization of a Machine-Learning Prediction Model for Acute Desquamation After Breast Radiation Therapy in the Multicenter REQUITE Cohort. Vol. 7, Advances in Radiation Oncology. Elsevier BV; 2022. p. 100890.; http://hdl.handle.net/10541/625351; Advances in Radiation Oncology

الاتاحة: http://hdl.handle.net/10541/625351
https://doi.org/10.1016/j.adro.2021.100890

المؤلفون: Talbot, C., Webb, A., Harper, E., Azria, D., Choudhury, Ananya, De Ruysscher, D., Dunning, A., Elliott, R., Kerns, S., Lambrecht, M., Rancati, T., Rosenstein, B., Seibold, P., Sperk, E., Vega, A., Veldeman, L., Chang-Claude, J., West, C., Rattay, T., Symonds, R. P.

المساهمون: University of Leicester, Genetics, Leicester, United Kingdom

Relation: Talbot C, Webb A, Harper E, Azria D, Choudhury A, De Ruysscher D, et al. Circadian rhythm effects on radiotherapy toxicity. Radiotherapy and Oncology. 2021;161:S1635-S.; http://hdl.handle.net/10541/624850; Radiotherapy and Oncology

الاتاحة: http://hdl.handle.net/10541/624850

المؤلفون: Symonds, R. P.

المصدر: BMJ: British Medical Journal, 2001 Nov 01. 323(7321), 1107-1110.

URL الوصول: https://www.jstor.org/stable/25227022

المؤلفون: Symonds, R. P.

المصدر: BMJ: British Medical Journal, 2001 Oct 01. 323(7316), 815-815.

URL الوصول: https://www.jstor.org/stable/25468085

المؤلفون: Aldraimli, M., Soria, D., Grishchuck, D., Ingram, Samuel, Lyon, R., Mistry, A., Oliveira, J., Samuel, R., Shelley, L. E. A., Osman, S., Dwek, M. V., Azria, D., Chang-Claude, J., Gutiérrez-Enríquez, S., De Santis, M. C., Rosenstein, B. S., De Ruysscher, D, Sperk, E., Symonds, R. P., Stobart, H., Vega, A., Veldeman, L., Webb, A., Talbot, C. J., West, Catharine M L, Rattay, T, Chaussalet, T. J.

المساهمون: The Health Innovation Ecosystem, University of Westminster, London, UK

Relation: https://dx.doi.org/10.1016/j.compbiomed.2021.104624; Aldraimli M, Soria D, Grishchuck D, Ingram S, Lyon R, Mistry A, et al. A data science approach for early-stage prediction of Patient’s susceptibility to acute side effects of advanced radiotherapy. Computers in Biology and Medicine. 2021 Aug;135:104624.; http://hdl.handle.net/10541/624412; Computers in Biology and Medicine

الاتاحة: http://hdl.handle.net/10541/624412
https://doi.org/10.1016/j.compbiomed.2021.104624

المؤلفون: McCormack, M, Kadalayil, L, Hackshaw, A, Hall-Craggs, M A, Symonds, R P, Warwick, V, Simonds, H, Fernando, I, Hammond, M, James, L, Feeney, A, Ledermann, J A

المصدر: British Journal of Cancer ; volume 108, issue 12, page 2464-2469 ; ISSN 0007-0920 1532-1827

الاتاحة: http://dx.doi.org/10.1038/bjc.2013.230
http://www.nature.com/articles/bjc2013230.pdf
http://www.nature.com/articles/bjc2013230

المؤلفون: Moneef, M. A., Sherwood, B. T., Bowman, Karen Julia, Kockelbergh, R. C., Symonds, R. P., Steward, W. P., Mellon, J. K., Jones, G. D.

المصدر: PubMed ; http://www.ncbi.nlm.nih.gov/pubmed/

مصطلحات موضوعية: Carcinoma, Transitional Cell, Cell Death, Cell Line, Tumor, Cell Survival, Comet Assay, DNA Damage, DNA Repair, Humans, Predictive Value of Tests, Radiation Tolerance, Tumor Stem Cell Assay, Urinary Bladder Neoplasms

Relation: British Journal of Cancer, 2003, 89 (12), pp. 2271-2276; http://hdl.handle.net/2381/16061; http://www.nature.com/bjc/journal/v89/n12/full/6601333a.html; 6601333

الاتاحة: http://hdl.handle.net/2381/16061
http://www.nature.com/bjc/journal/v89/n12/full/6601333a.html
https://doi.org/10.1038/sj.bjc.6601333

المؤلفون: Symonds, R P, Lord, K, Mitchell, A J, Raghavan, D

المصدر: British Journal of Cancer ; volume 107, issue 7, page 1017-1021 ; ISSN 0007-0920 1532-1827

الاتاحة: http://dx.doi.org/10.1038/bjc.2012.240
http://www.nature.com/articles/bjc2012240.pdf
http://www.nature.com/articles/bjc2012240