المؤلفون: Ernesto Callegari, Jian Lin, Susanna Tse, Theunis C. Goosen, Vaishali Sahasrabudhe

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 127-136 (2021)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2163-8306

URL الوصول: https://doaj.org/article/eb9d11a32b87407ab4a97d4886d3051e

المؤلفون: Daniel LETTIERE, Joseph CHEN, Kathleen E. BIDDLE, Martin FINKELSTEIN, Masanori HIZUE, Masanori KOBAYASHI, Stephane THIBAULT, Susanna TSE, Theodore R. JOHNSON, Wenyue HU, Xavier PALAZZI, Yazdi K. PITHAVALA, 小林 雅典, 檜杖 昌則

المصدر: Annual Meeting of the Japanese Society of Toxicology. 2022, :P-158

المؤلفون: Kathleen Biddle, Xavier Palazzi, Yazdi K. Pithavala, Susanna Tse, Daniel J. Lettiere, Stephane Thibault, Martin Finkelstein, Joseph Chen, Theodore R. Johnson, Wenyue Hu

المصدر: Toxicological Sciences. 182:183-194

مصطلحات موضوعية: Agonist, Lung Neoplasms, Lactams, CYP3A, medicine.drug_class, Lactams, Macrocyclic, Aminopyridines, Pharmacology, Toxicology, In vivo, Carcinoma, Non-Small-Cell Lung, Constitutive androstane receptor, medicine, Animals, Cytochrome P-450 CYP3A, Humans, Anaplastic lymphoma kinase, Drug Interactions, Pregnane X receptor, Chemistry, Cytochrome P-450 CYP3A Inducers, Lorlatinib, Macaca fascicularis, Liver, Toxicity, Pyrazoles

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddac3b9563dd56f1e91555a7044a1a7b
https://doi.org/10.1093/toxsci/kfab056

المؤلفون: Vaishali Sahasrabudhe, Susanna Tse, Jian Lin, Ernesto Callegari, Theunis C. Goosen

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 127-136 (2021)
CPT: Pharmacometrics & Systems Pharmacology

مصطلحات موضوعية: Adult, Male, Physiologically based pharmacokinetic modelling, Mefenamic acid, Pharmacology, Models, Biological, Isozyme, Article, Mefenamic Acid, chemistry.chemical_compound, Pharmacokinetics, In vivo, medicine, Humans, Distribution (pharmacology), Cyclooxygenase Inhibitors, Drug Interactions, Pharmacology (medical), Glucuronosyltransferase, Dapagliflozin, Sodium-Glucose Transporter 2 Inhibitors, Uridine, Chemistry, Research, lcsh:RM1-950, Articles, Middle Aged, Bridged Bicyclo Compounds, Heterocyclic, Healthy Volunteers, lcsh:Therapeutics. Pharmacology, Area Under Curve, Modeling and Simulation, UDP-Glucuronosyltransferase 1A9, Female, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4d96f6c1e54241999ac0829b9886f8
https://doaj.org/article/eb9d11a32b87407ab4a97d4886d3051e

المؤلفون: Bei Kang Ge, Chieko Muto, Jian Liu, Yanke Yu, Jian Lin, Susanna Tse, Yinhua Li, Jing Liu, Yuko Mori, Rajendar K Mittapalli

المصدر: International Journal of Medical Sciences

مصطلحات موضوعية: China, PBPK, Physiologically based pharmacokinetic modelling, Chinese, Ethnic PK, Metabolic Clearance Rate, Modeling & Simulation, General Medicine, Computational biology, PK Parameters, Biology, Prognosis, Models, Biological, Current analysis, Asian People, Japan, Pharmacokinetics, Predictive Value of Tests, Japanese, Humans, Computer Simulation, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7622ef81bf4dd9b185d2cfa1bd34e17
https://doi.org/10.7150/ijms.65040

المؤلفون: Guoying Tai, Pradeep Sharma, Vijay V. Upreti, Jun Chen, Sheila Annie Peters, Andy Z. X. Zhu, Ying-Hong Wang, Susanna Tse, Tycho Heimbach, Binfeng Xia, Ming Zheng, Italo Poggesi, Vaishali Dixit, Alice Tsai, Mohamad Shebley, Stephen D. Hall, Yuan Chen, Neil Parrott, Jan Snoeys

المصدر: Clinical Pharmacology and Therapeutics

مصطلحات موضوعية: Drug, Physiologically based pharmacokinetic modelling, medicine.medical_specialty, Drug Industry, media_common.quotation_subject, White Paper, Models, Biological, Severity of Illness Index, 030226 pharmacology & pharmacy, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Internal medicine, Severity of illness, medicine, Humans, Computer Simulation, Pharmacology (medical), media_common, Pharmacology, Dose-Response Relationship, Drug, business.industry, Liver Diseases, Hepatic impairment, Clinical study design, Area under the curve, White Papers, Dose–response relationship, Area Under Curve, 030220 oncology & carcinogenesis, Kidney Diseases, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92589b8c4ba572806030e55fbfab40e2
https://doi.org/10.1002/cpt.2125

المؤلفون: Angel M. Padilla, Wei Wang, Tsutomu Akama, David S. Carter, Eric Easom, Yvonne Freund, Jason S. Halladay, Yang Liu, Sarah A. Hamer, Carolyn L. Hodo, Gregory K. Wilkerson, Dylan Orr, Brooke White, Arlene George, Huifeng Shen, Yiru Jin, Michael Zhuo Wang, Susanna Tse, Robert T. Jacobs, Rick L. Tarleton

المصدر: Nature microbiology. 7(10)

مصطلحات موضوعية: Microbiology (medical), Primates, Trypanosoma cruzi, Immunology, Genetics, Animals, Chagas Disease, Prodrugs, Cell Biology, Applied Microbiology and Biotechnology, Microbiology, Trypanocidal Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a107b3816471fc4544d97ceaccbbe5e
https://pubmed.ncbi.nlm.nih.gov/36195774

المؤلفون: Sriram Krishnaswami, Susanna Tse, Pankaj Gupta, Martin E. Dowty, Sujatha Menon

المصدر: Journal of Clinical Pharmacology

مصطلحات موضوعية: Male, Administration, Oral, Pharmacology, 030226 pharmacology & pharmacy, 0302 clinical medicine, Piperidines, Medicine, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Pharmacology (medical), Drug Interactions, Renal Insufficiency, Infusions, Intravenous, media_common, Janus kinase inhibitor, Cytochrome P-450 Enzyme Inducers, tofacitinib, Liver Diseases, Middle Aged, Ulcerative colitis, Healthy Volunteers, 030220 oncology & carcinogenesis, Female, Drug, Adult, renal impairment, Physiologically based pharmacokinetic modelling, PBPK, hepatic impairment, drug‐drug interactions, media_common.quotation_subject, Models, Biological, Drug Administration Schedule, 03 medical and health sciences, Psoriatic arthritis, Young Adult, Pharmacokinetics, Physiologically Based Pharmacokinetic Modeling, Humans, Simcyp, Computer Simulation, Dosing, Protein Kinase Inhibitors, Tofacitinib, business.industry, active renal secretion, modeling, medicine.disease, Cytochrome P-450 CYP2C19, Pyrimidines, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d727630e1f3e4874c7250688c42dd8
https://pubmed.ncbi.nlm.nih.gov/32592424

المؤلفون: Angela C. Doran, Peter Lockwood, Thomas A. Comery, R. Scott Obach, Aarti Sawant-Basak, Hongying Gao, Jessica Mancuso, Susanna Tse, Klaas Schildknegt

المصدر: Drug Metabolism and Disposition. 46:934-942

مصطلحات موضوعية: Pharmacology, CYP2D6, biology, CYP3A, Metabolite, Antagonist, Pharmaceutical Science, Cytochrome P450, Metabolism, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, 030220 oncology & carcinogenesis, medicine, Microsome, biology.protein, Ketoconazole, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f12639f175a31b7dcb982ff48b0dc0c2
https://doi.org/10.1124/dmd.118.080457

المؤلفون: Cornelis E. C. A. Hop, Swapan Chowdhury, Douglas K. Spracklin, Simone Schadt, Christoph Funk, W. Griffith Humphreys, Angus N. R. Nedderman, Fumihiko Igarashi, Josh Yuan, Chandra Prakash, Frank Runge, Holger Scheible, Mark Kagan, S. Cyrus Khojasteh, Piet Swart, R. Scott Obach, Bojan Bister, Alexander David James, Susanna Tse

المصدر: BASE-Bielefeld Academic Search Engine

مصطلحات موضوعية: 0301 basic medicine, Drug Industry, Metabolite, Pharmaceutical Science, Human metabolism, Computational biology, 030226 pharmacology & pharmacy, Food and drug administration, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Animals, Humans, Medicine, Drug Interactions, Safety testing, Pharmaceutical industry, Pharmacology, United States Food and Drug Administration, business.industry, United States, 030104 developmental biology, Pharmaceutical Preparations, chemistry, Drug development, Inactivation, Metabolic, Experimental methods, business, Drug metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c0739606a23742034a3be6254e08fa
https://doi.org/10.1124/dmd.117.079848

المؤلفون: R. Scott Obach, Ellen Evans, Nasir K. Khan, Jessica Whritenour, Changhua Ji, Susanna Tse, Xu Zhu, Michelle Hemkens, Gregory S. Walker, Martin Finkelstein, Mausumee Guha, Ernesto Callegari

المصدر: Chemical research in toxicology. 33(1)

مصطلحات موضوعية: Antineoplastic Agents, 010501 environmental sciences, Pharmacology, Toxicology, 01 natural sciences, Drug Hypersensitivity, 03 medical and health sciences, chemistry.chemical_compound, Prostate cancer, Nitriles, Phenylthiohydantoin, medicine, Androgen Receptor Antagonists, Enzalutamide, Animals, Humans, Lymphocytes, Bovine serum albumin, 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, biology, Apalutamide, General Medicine, Glutathione, medicine.disease, Rash, Androgen receptor, Mice, Inbred C57BL, Disease Models, Animal, chemistry, Thiohydantoins, Benzamides, biology.protein, Hepatocytes, Female, medicine.symptom, Cysteine, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5db11f83432284463dddc9ecece07d9
https://pubmed.ncbi.nlm.nih.gov/31538772

المؤلفون: Raymond Chen, Marc B. Brown, Avinash G. Thombre, Thean Yeoh, Susanna Tse, Robert North

المصدر: International journal of pharmaceutics. 576

مصطلحات موضوعية: Boron Compounds, Male, Swine, Skin Absorption, Pharmaceutical Science, Biological Availability, Human skin, 02 engineering and technology, Absorption (skin), Pharmacology, Administration, Cutaneous, 030226 pharmacology & pharmacy, Permeability, Dermatitis, Atopic, Ointments, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, In vivo, medicine, Animals, Humans, Skin, integumentary system, Chemistry, Crisaborole, Atopic dermatitis, Middle Aged, 021001 nanoscience & nanotechnology, medicine.disease, Bridged Bicyclo Compounds, Heterocyclic, Propylene Glycol, Bioavailability, Swine, Miniature, Female, Dermatologic Agents, 0210 nano-technology, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2633dcfa75be3646cbd7e14cd4eeed89
https://pubmed.ncbi.nlm.nih.gov/31759994

المؤلفون: Heidi J. Einolf, Susanna Tse, Tonika Bohnert, Sirimas Sudsakorn, Ying-Hong Wang, David Moore, Jim Keirns, Ling He, Robert L. Walsky, Rangaraj Narayanan, Wanping Geng, Aarti Patel, Louis Leung, W. George Lai, Xiaoqing Yang, Ralph Stearns, Dieter Lang, Michael Sinz, Yuan Chen, Chuang Lu, Jan Wahlstrom, Ian Templeton

المصدر: Drug Metabolism and Disposition. 44:1399-1423

مصطلحات موضوعية: Drug, Drug Industry, Computer science, media_common.quotation_subject, Population, Decision tree, Pharmaceutical Science, Pharmacology, Risk Assessment, 030226 pharmacology & pharmacy, Substrate Specificity, 03 medical and health sciences, 0302 clinical medicine, Species Specificity, New chemical entity, Drug Discovery, Animals, Humans, Computer Simulation, Drug Interactions, education, Biotransformation, media_common, education.field_of_study, Decision Trees, Perspective (graphical), Models, Theoretical, Enzymes, Kinetics, Identification (information), Drug metabolizing enzymes, Pharmaceutical Preparations, Risk analysis (engineering), 030220 oncology & carcinogenesis, Risk assessment

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ff752216b7095cfbd939b67f0dd8ae
https://doi.org/10.1124/dmd.115.069096

المؤلفون: Hidetomi Yamagami, Theunis C. Goosen, Susanna Tse, Jian Lin, Bimal Malhotra

المصدر: Journal of clinical pharmacologyReferences. 59(11)

مصطلحات موضوعية: Adult, Male, Physiologically based pharmacokinetic modelling, CYP2D6, Cmax, Pharmacology, 030226 pharmacology & pharmacy, 03 medical and health sciences, Cresols, 0302 clinical medicine, Pharmacokinetics, Cytochrome P-450 CYP2D6 Inhibitors, medicine, Fesoterodine, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), Drug Interactions, Benzhydryl Compounds, business.industry, Urinary Bladder, Overactive, Middle Aged, Thiazoles, Ketoconazole, Cytochrome P-450 CYP2D6, 030220 oncology & carcinogenesis, Cytochrome P-450 CYP3A Inhibitors, Acetanilides, Female, Tolterodine, Rifampin, business, Mirabegron, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb739f958a8d2b91b930dd1436b93ad
https://pubmed.ncbi.nlm.nih.gov/31090092

المؤلفون: Changhua Ji, Jessica Whritenour, G.S. Walker, Ellen Evans, Nasir K. Khan, R.S. Obach, Michelle Hemkens, M. Guha, Susanna Tse, Martin Finkelstein, Ernesto Callegari, Xu Zhu

المصدر: Annals of Oncology. 30:v767-v768

مصطلحات موضوعية: business.industry, viruses, Drug allergy, Apalutamide, Model protein, Covalent binding, Hematology, Pharmacology, medicine.disease, In vitro, chemistry.chemical_compound, Oncology, chemistry, Shareholder, medicine, Enzalutamide, business, Immune activation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ed05d1fca9e9cdaa2b66100d0b54e6d6
https://doi.org/10.1093/annonc/mdz268.019

المؤلفون: Aarti, Sawant-Basak, R Scott, Obach, Angela, Doran, Peter, Lockwood, Klaas, Schildknegt, Hongying, Gao, Jessica, Mancuso, Susanna, Tse, Thomas A, Comery

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 46(7)

مصطلحات موضوعية: Sulfonamides, Imidazoles, Piperazines, Cytochrome P-450 CYP2C19, Isoenzymes, Ketoconazole, Cytochrome P-450 CYP2D6, Receptors, Serotonin, Hepatocytes, Microsomes, Liver, Cytochrome P-450 CYP3A Inhibitors, Humans, Drug Interactions, Piperazine, Selective Serotonin Reuptake Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::888ea6f505d4ba0405fbd8ec06a7a1fe
https://pubmed.ncbi.nlm.nih.gov/29695615

المؤلفون: W. Griffith Humphreys, Alana Upthagrove, Zhaopie Zeng, Bo Wen, Chandra Prakash, Suresh K. Balani, Heng-Keang Lim, Weichao Chen, Sekhar Surapaneni, Donghui Cui, Anthony J. Lee, Susanna Tse, Christopher MacLauchlin, Ling He, Jialin Mao, Robert L. Walsky, W. George Lai, Hongbin Yu

المصدر: Drug Metabolism and Disposition. 43:620-630

مصطلحات موضوعية: Drug, Prescription Drugs, Drug Industry, media_common.quotation_subject, Metabolite, Pharmaceutical Science, Guidelines as Topic, Pharmacology, Risk Assessment, Food and drug administration, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, In vivo, Cytochrome P-450 Enzyme Inhibitors, Humans, Drug Interactions, Fellowships and Scholarships, Prescribed drugs, media_common, biology, United States Food and Drug Administration, Cytochrome P450, Drug interaction, United States, Europe, chemistry, Area Under Curve, Government Regulation, biology.protein, Drug metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2cf1c4ea6b879d4785b1d10476993d
https://doi.org/10.1124/dmd.114.059345

المؤلفون: Avijit Ghosh, Rob Chambers, Susanna Tse, Zhengyin Yan, Mark G. Qian, Stacy Ho, Paul Harradine, Li Di, Caroline A. Lee, Everett J. Perkins, Robert Fricke, Sean Eckley, J. Cory Kalvass, Christopher Breen, Punit Marathe, Maciej J. Zamek-Gliszczynski

المصدر: Journal of pharmaceutical sciences. 106(12)

مصطلحات موضوعية: Drug Industry, Chemistry, Concordance, Phosphate buffered saline, Drug-drug interaction, Pharmaceutical Science, Blood Proteins, Pharmacology, 030226 pharmacology & pharmacy, Lower limit, 03 medical and health sciences, Plasma, 0302 clinical medicine, Pharmaceutical Preparations, 030220 oncology & carcinogenesis, Econometrics, Cutoff, Animals, Humans, Drug Interactions, Dextran coated charcoal, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709055b1d85aea4cd9d15823d6e6b9a3
https://pubmed.ncbi.nlm.nih.gov/28927987

المؤلفون: Misaki, Suzuki, Susanna, Tse, Midori, Hirai, Yoichi, Kurebayashi

المصدر: The Kobe journal of medical sciences. 62(6)

مصطلحات موضوعية: Adult, Male, Cross-Over Studies, Pharmacogenomic Variants, Articles, Middle Aged, Models, Theoretical, Healthy Volunteers, White People, Young Adult, Pyrimidines, Asian People, Piperidines, Humans, Female, Pyrroles, Protein Kinase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::36775d9e06c517c5f54a3904ce84f00d
https://pubmed.ncbi.nlm.nih.gov/28490712

المؤلفون: Joseph Chen, Angela Wolford, Theodore R. Johnson, Theunis C. Goosen, Yazdi K. Pithavala, Susanna Tse, Jian Lin

المصدر: Drug Metabolism and Pharmacokinetics. 35:S49

مصطلحات موضوعية: Pharmacology, Modeling and simulation, Physiologically based pharmacokinetic modelling, Pharmacokinetics, Chemistry, Itraconazole, medicine, Pharmaceutical Science, Pharmacology (medical), Drug interaction, Lorlatinib, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d9e81655594dd346e32f7053c7fefb6f
https://doi.org/10.1016/j.dmpk.2020.04.090