المؤلفون: Sebastian Pomplun, Muhammad Jbara, Carly K. Schissel, Susana Wilson Hawken, Ann Boija, Charles Li, Isaac Klein, Bradley L. Pentelute

المصدر: ACS Central Science, Vol 7, Iss 8, Pp 1408-1418 (2021)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2374-7951

URL الوصول: https://doaj.org/article/f510c4e0886a49d7a7adb95522e6ac22

المؤلفون: Sebastian Pomplun (1714333), Muhammad Jbara (2591704), Carly K. Schissel (7353260), Susana Wilson Hawken (11229793), Ann Boija (156451), Charles Li (3396221), Isaac Klein (11170562), Bradley L. Pentelute (1247046)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Immunology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Computational Biology, Space Science, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, enrichment analysis, flow technology, attenuate oncogenic MYC-driven tran., RNA sequencing, covalent dimers display DNA binding., 549 cancer cells, heterodimeric protein complexes, dimeric transcription factor complexes, MYC-driven cancer cell growth, flow synthesis, MYC-driven transcription, cancer cell proliferation, transcription factor MYC, gene transcription

Relation: https://figshare.com/articles/journal_contribution/Parallel_Automated_Flow_Synthesis_of_Covalent_Protein_Complexes_That_Can_Inhibit_MYC-Driven_Transcription/15104101

الاتاحة: https://doi.org/10.1021/acscentsci.1c00663.s001

المؤلفون: Ozgur Oksuz, Jonathan E Henninger, Robert Warneford-Thomson, Ming M Zheng, Hailey Erb, Kalon J Overholt, Susana Wilson Hawken, Salman F Banani, Richard Lauman, Adrienne Vancura, Anne L Robertson, Nancy M Hannett, Tong I Lee, Leonard I. Zon, Roberto Bonasio, Richard A. Young

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f26928fddc2278ca573e0a0d65d77f09
https://doi.org/10.1101/2022.09.27.509776

المؤلفون: Arup K. Chakraborty, John Mantiega, Anthony A. Hyman, Ann Boija, Mrityunjoy Kar, Patrick M. McCall, Jesse M. Platt, Charles H. Li, Mengyang Fan, Victoria E. Clark, Tong Lee, Alessandra Dall’Agnese, Jonathan E. Henninger, Krishna Shrinivas, Ido Sagi, Phillip A. Sharp, Dylan J. Taatjes, Tim-Michael Decker, Tinghu Zhang, Jing-Ke Weng, Eliot L. Coffey, Lena K. Afeyan, Alicia V. Zamudio, Nathanael S. Gray, Benjamin R. Sabari, Isaac A. Klein, Richard A. Young, Nancy M. Hannett, Young-Tae Chang, Ozgur Oksuz, Yang Guo, Susana Wilson Hawken

المصدر: Cancer Research. 81:GS3-10

مصطلحات موضوعية: Cisplatin, Cancer Research, Chemistry, Cell, Small molecule, In vitro, MED1, Cell biology, chemistry.chemical_compound, medicine.anatomical_structure, Oncology, Live cell imaging, In vivo, medicine, DNA, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::813421c57b00b902403b00605df75237
https://doi.org/10.1158/1538-7445.sabcs20-gs3-10

المؤلفون: Susana Wilson Hawken, Stephen L. Buchwald, Sebastian Pomplun, Ann Boija, Bradley L. Pentelute, Carly K. Schissel, Isaac A. Klein, Muhammad Jbara, Jacob Rodriguez

المصدر: Journal of the American Chemical Society. 143(30)

مصطلحات موضوعية: Models, Molecular, Dimer, 010402 general chemistry, Protein Engineering, 01 natural sciences, Biochemistry, Catalysis, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, chemistry.chemical_compound, Colloid and Surface Chemistry, Transcription (biology), Humans, Transcription factor, 030304 developmental biology, Cell Proliferation, 0303 health sciences, RNA, General Chemistry, DNA, Protein tertiary structure, 0104 chemical sciences, chemistry, Covalent bond, Indicators and Reagents, Small molecule binding, Protein Multimerization, Palladium, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f094a401bec8cff03c4d0b1c35f053ab
https://pubmed.ncbi.nlm.nih.gov/34289685

المؤلفون: Arup K. Chakraborty, Jesse M. Platt, Ozgur Oksuz, Tim-Michael Decker, Nathanael S. Gray, Richard A. Young, Yang Eric Guo, Jonathan E. Henninger, John C. Manteiga, Mengyang Fan, Patrick M. McCall, Alicia V. Zamudio, Eliot L. Coffey, Alessandra Dall’Agnese, Phillip A. Sharp, Lena K. Afeyan, Isaac A. Klein, Nancy M. Hannett, Krishna Shrinivas, Victoria E. Clark, Benjamin R. Sabari, Ann Boija, Mrityunjoy Kar, Charles H. Li, Anthony A. Hyman, Dylan J. Taatjes, Jing-Ke Weng, Susana Wilson Hawken, Ido Sagi, Tinghu Zhang, Young-Tae Chang, Tong Ihn Lee

المصدر: Science
PMC

مصطلحات موضوعية: chemistry.chemical_classification, Drug, Multidisciplinary, Chemistry, SARS-CoV-2, Biomolecule, media_common.quotation_subject, Cancer, COVID-19, Nucleocapsid Proteins, medicine.disease, Phosphoproteins, Small molecule, In vitro, Article, Disease therapy, Drug activity, medicine, Biophysics, Antineoplastic Drugs, Coronavirus Nucleocapsid Proteins, Humans, media_common

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58dbfd9ca343e2e0aae160b9eb4e7eba
https://europepmc.org/articles/PMC7735713/

المؤلفون: Young-Tae Chang, Isaac A. Klein, Anthony A. Hyman, Richard A. Young, Lena K. Afeyan, Susana Wilson Hawken, Dylan J. Taatjes, Ann Boija, Mengyang Fan, Arup K. Chakraborty, Phillip A. Sharp, Nathanael S. Gray

المصدر: Journal of Clinical Oncology. 39:3131-3131

مصطلحات موضوعية: Cancer Research, medicine.anatomical_structure, Membrane, Oncology, business.industry, Cell, Organelle, medicine, Cancer, medicine.disease, business, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::343c288425b60548e7be77597eec1413
https://doi.org/10.1200/jco.2021.39.15_suppl.3131

المؤلفون: Brian J. Abraham, Benjamin R. Sabari, Alicia V. Zamudio, Dylan J. Taatjes, Nancy M. Hannett, Jonathan E. Henninger, Tim-Michael Decker, Ozgur Oksuz, Ann Boija, Ibrahim I Cisse, Eliot L. Coffey, Susana Wilson Hawken, Isaac A. Klein, Tong I. Lee, Jan-Hendrik Spille, Lena K. Afeyan, Charles H. Li, Alessandra Dall’Agnese, John C. Manteiga, Richard A. Young, Jurian Schuijers

المساهمون: Massachusetts Institute of Technology. Department of Biology, Massachusetts Institute of Technology. Department of Physics, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology. Computational and Systems Biology Program

المصدر: Mol Cell
PMC

مصطلحات موضوعية: STAT3 Transcription Factor, Transcription, Genetic, Biology, Article, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Mediator, Coactivator, Animals, Humans, natural sciences, Smad3 Protein, Enhancer, Molecular Biology, Transcription factor, Wnt Signaling Pathway, beta Catenin, 030304 developmental biology, Regulation of gene expression, 0303 health sciences, Mediator Complex, Wnt signaling pathway, JAK-STAT signaling pathway, Cell Biology, Cell biology, TGF-beta Superfamily Proteins, Intrinsically Disordered Proteins, STAT Transcription Factors, Enhancer Elements, Genetic, Gene Expression Regulation, Signal transduction, 030217 neurology & neurosurgery, Signal Transduction, Transcription Factors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7185548d26f43e122d2f61bcdefc827
https://pubmed.ncbi.nlm.nih.gov/31563432

المؤلفون: Muhammad Jbara (2591704), Sebastian Pomplun (1714333), Carly K. Schissel (7353260), Susana Wilson Hawken (11170559), Ann Boija (156451), Isaac Klein (11170562), Jacob Rodriguez (3114627), Stephen L. Buchwald (1307121), Bradley L. Pentelute (1247046)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Cancer, Computational Biology, Space Science, Chemical Sciences not elsewhere classified, OAC, disease pathogenesis, milligram quantities, covalent Max-Max homodimer, covalent helical dimers, oncogenic Myc-driven transcription, bioactive compounds, flow peptide chemistry, tumor cell proliferation, cancer cells, RNA sequencing, Myc expression, flow chemistry, engineering Bioactive Dimeric Trans., Myc-dependent transcription, 6 μ M, molecule binding pockets, TF mimetics, target DNA-binding site

Relation: https://figshare.com/articles/journal_contribution/Engineering_Bioactive_Dimeric_Transcription_Factor_Analogs_via_Palladium_Rebound_Reagents/15034754

الاتاحة: https://doi.org/10.1021/jacs.1c05666.s001