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1
المؤلفون: J.V.N. Vara Prasad, Lou Chupak, Frederick E. Boyer, Michael Melnick, K. Gavardinas, M. Patterson, Susan Elizabeth Hagen, Qizhu Ding, Michael D. Huband, Karina Romero, Samarendra N. Maiti, Michael R. Dermyer, Takushi Kaneko, Wenhua Jiao, Xiujuan Wu
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:5392-5397
مصطلحات موضوعية: Molecular Structure, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Gram-Positive Bacteria, Biochemistry, Chemical synthesis, Combinatorial chemistry, Anti-Bacterial Agents, Benzocycloheptenes, Structure-Activity Relationship, Gram-Negative Bacteria, Drug Discovery, Molecular Medicine, Molecular Biology, Oxazolidinones, Antibacterial agent
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2
المؤلفون: John M. Domagala, Susan Elizabeth Hagen
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Chemistry, medicine, Quinolone, Structural class, QUINOLONE ANTIBACTERIALS
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3
المؤلفون: Bradley D. Tait, Susan Elizabeth Hagen, Michael Lovdahl, Eric Andrew Zeikus, Carolyn Nouhan, Joanne Brodfuehrer, Donald Hupe, Christopher Andrew Gajda, John M. Domagala, Greg Zeikus, Elizabeth A. Lunney, Steve Vanderroest, Alexander Pavlovsky, Andrej Urumov, James Saunders, Stephen J. Gracheck, Eric Wise, Tod P. Holler
المصدر: Journal of Medicinal Chemistry. 44:2319-2332
مصطلحات موضوعية: medicine.medical_treatment, Drug Evaluation, Preclinical, Biological Availability, Sulfides, Pharmacology, Virus, Cell Line, Mice, Structure-Activity Relationship, Dogs, HIV Protease, Drug Discovery, medicine, Animals, Humans, Potency, HIV Protease Inhibitor, Protease inhibitor (pharmacology), Lymphocytes, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Protease, biology, Chemistry, HIV, virus diseases, Drug Resistance, Microbial, Stereoisomerism, HIV Protease Inhibitors, biology.organism_classification, Rats, Enzyme, Pyrones, Enzyme inhibitor, Mutation, Lentivirus, HIV-1, biology.protein, Molecular Medicine
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4
المؤلفون: Larry J. Markoski, Stephen J. Gracheck, Carolyn Nouhan, Peter J. Tummino, Steven VanderRoest, James Saunders, J. V. N. Vara Prasad, Krishna R. Iyer, Christopher Gajda, Fred E. Boyer, Donna Ferguson, Elizabeth A. Lunney, John M. Domagala, Bradley Dean Tait, Michael Sinz, Donald Hupe, Tod P. Holler, Susan Elizabeth Hagen, Edmund L. Ellsworth
المصدر: Bioorganic & Medicinal Chemistry Letters. 9:2217-2222
مصطلحات موضوعية: Models, Molecular, Dihydropyran, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Moiety, HIV Protease Inhibitor, Disulfides, Molecular Biology, chemistry.chemical_classification, Protease, Protease binding, Organic Chemistry, HIV, HIV Protease Inhibitors, Enol, chemistry, Pyrones, Molecular Medicine, Sulfonic Acids, Lactone
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5
المؤلفون: J. V. N. Vara Prasad, Donald Hupe, Elizabeth A. Lunney, John M. Domagala, Donna Ferguson, Greg Zeikus, Neil Graham, Peter J. Tummino, Susan Elizabeth Hagen, Caroline Nouhan, Tod P. Holler, Edmund L. Ellsworth
المصدر: Bioorganic & Medicinal Chemistry Letters. 9:2019-2024
مصطلحات موضوعية: Models, Molecular, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Hydrocarbons, Aromatic, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Sugar Alcohols, HIV Protease, HIV-1 protease, Drug Discovery, medicine, Structure–activity relationship, HIV Protease Inhibitor, Computer Simulation, Binding site, Molecular Biology, Binding Sites, Protease, Molecular Structure, biology, Bicyclic molecule, Organic Chemistry, Valine, HIV Protease Inhibitors, Hydrogen-Ion Concentration, chemistry, Pyrones, Pyran, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Software
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6
المؤلفون: Peter J. Tummino, James Saunders, Stephen J. Gracheck, Bradley Dean Tait, J. V. N. Vara Prasad, Joanne I. Brodfuehrer, Christopher Andrew Gajda, Krishna R. Iyer, Tod P. Holler, Susan Elizabeth Hagen, Steven VanderRoest, Edmund L. Ellsworth, Fred E. Boyer, Carolyn Nouhan, Donna Ferguson, Larry James Markoski, Michael Sinz, Donald Hupe, Elizabeth A. Lunney, John M. Domagala
المصدر: Bioorganic & Medicinal Chemistry Letters. 9:1481-1486
مصطلحات موضوعية: Models, Molecular, Anti-HIV Agents, Dihydropyran, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Thio, Carboxamide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Moiety, HIV Protease Inhibitor, Molecular Biology, Pyrans, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, HIV Protease Inhibitors, Kinetics, Enzyme inhibitor, biology.protein, Molecular Medicine, Lactone
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7
المؤلفون: Elizabeth A. Lunney, Frederick E. Boyer, J. V. N. Vara Prasad, Stephen J. Gracheck, Carolyn Nouhan, Edmund L. Ellsworth, Bradley Dean Tait, Donna Ferguson, Susan Elizabeth Hagen, Steven VanderRoest, Larry J. Markoski, James Saunders, Harriet W. Hamilton, B. A. Steinbaugh, Peter J. Tummino, John M. Domagala, Donald Hupe, Christopher Gajda
المصدر: Journal of Medicinal Chemistry. 40:3707-3711
مصطلحات موضوعية: Chemical Phenomena, Anti-HIV Agents, Stereochemistry, Chemical synthesis, Virus, Mice, Structure-Activity Relationship, HIV-1 protease, In vivo, Drug Discovery, medicine, Animals, Structure–activity relationship, chemistry.chemical_classification, biology, Chemistry, Physical, Chemistry, HIV Protease Inhibitors, In vitro, Kinetics, Biochemistry, Pyrones, HIV-1, biology.protein, Molecular Medicine, Ritonavir, Lactone, medicine.drug
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8
المؤلفون: John W. Erickson, Donald Hupe, Eric T. Baldwin, J. R. Rubin, and Sergei V. Gulnik, Christine Humblet, Susan Elizabeth Hagen, Christopher Gajda, Harriet W. Hamilton, Carolyn Nouhan, Beishan Liu, J. V. N. Vara Prasad, Neil Graham, Edmund L. Ellsworth, Peter J. Tummino, John M. Domagala, Alexander Pavlovsky, Donna Ferguson, Elizabeth A. Lunney, T. N. Bhat, Bradley Dean Tait, Stephen J. Gracheck
المصدر: Journal of Medicinal Chemistry. 40:3781-3792
مصطلحات موضوعية: Anti-HIV Agents, Stereochemistry, medicine.medical_treatment, Thio, Crystallography, X-Ray, Chemical synthesis, Structure-Activity Relationship, HIV Protease, Coumarins, Drug Discovery, medicine, Structure–activity relationship, chemistry.chemical_classification, Binding Sites, Protease, biology, Active site, Stereoisomerism, HIV Protease Inhibitors, Amino acid, Enzyme, chemistry, Pyrones, Enzyme inhibitor, Drug Design, HIV-1, biology.protein, Molecular Medicine
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9
المؤلفون: Christopher Gajda, Bradley Dean Tait, Peter J. Tummino, Harriet W. Hamilton, Susan Elizabeth Hagen, Alexander Pavlovsky, Donna Ferguson, Elizabeth A. Lunney
المصدر: Bioorganic & Medicinal Chemistry Letters. 6:719-724
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Enzyme, Pyran, Drug Discovery, Molecular Medicine, HIV Protease Inhibitor, Molecular Biology, Alkyl
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10
المؤلفون: Takeshi Nakamura, Wataru Watanabe, Hidetsura Cho, Eric C Nordby, Peter Craig Weber, Harriet W. Hamilton, Susan Elizabeth Hagen, Stefanie L Boulware, Gisele Nishiguchi, Stephen J. Gracheck, John D Domagala, Satoru Ikeda
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:2981-2983
مصطلحات موضوعية: Alkylation, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Herpesvirus 1, Human, Thiophenes, Virus Replication, Ring (chemistry), Antiviral Agents, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Stereospecificity, Therapeutic index, Drug Discovery, Potency, Molecular Biology, Organic Chemistry, Azepines, Diazepine, Lac Operon, chemistry, Viral replication, Lactam, Molecular Medicine, Indicators and Reagents
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11
المؤلفون: Edgardo Laborde, Steven VanderRoest, Mel C. Schroeder, John S. Kiely, Mark J. Suto, Themis E. Joannides, John M. Domagala, Martin A. Shapiro, Josephine A. Sesnie, Susan Elizabeth Hagen
المصدر: Journal of Medicinal Chemistry. 36:871-882
مصطلحات موضوعية: Pyrrolidines, Stereochemistry, Microbial Sensitivity Tests, Mice, Structure-Activity Relationship, Cricetulus, Anti-Infective Agents, In vivo, Cricetinae, Drug Discovery, Animals, Topoisomerase II Inhibitors, Moiety, Structure–activity relationship, Naphthyridines, Antibacterial agent, 4-Quinolones, Bicyclic molecule, Chemistry, Stereoisomerism, Biological activity, Molecular Medicine, Female, Phototoxicity, Antibacterial activity, Fluoroquinolones
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12
المؤلفون: Susan Elizabeth Hagen, John M. Domagala
المصدر: ChemInform. 22
مصطلحات موضوعية: chemistry.chemical_compound, Trimethylsilyl, Hydrogen, Chemistry, Fluorine, Chlorine, chemistry.chemical_element, Moiety, Molecule, General Medicine, Oxazoline, Protecting group, Medicinal chemistry
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13
المؤلفون: Martin A. Shapiro, Joseph P. Sanchez, D. L. Szotek, Alexander James Bridges, J. C. Sesnie, E. T. Joannides, Rocco D. Gogliotti, Ruth A. Bucsh, Susan Elizabeth Hagen, John M. Domagala, Carl L. Heifetz
المصدر: ChemInform. 23
مصطلحات موضوعية: chemistry.chemical_compound, Trifluoromethyl, Chemistry, Group (periodic table), General Medicine, Phototoxicity, Medicinal chemistry
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14
المؤلفون: Stephen J. Gracheck, Josephine A. Sesnie, John M. Domagala, Susan Elizabeth Hagen, Michael Andrew Stier, Mark J. Suto
المصدر: ChemInform. 25
مصطلحات موضوعية: Side effect, In vivo, Stereochemistry, Chemistry, Potency, Moiety, General Medicine, Cytotoxicity, Antibacterial activity, Phototoxicity, In vitro
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15
المؤلفون: Susan Elizabeth Hagen, Bradley Dean Tait, Elizabeth A. Lunney, Christopher Gajda, Alexander Pavlovsky, Donna Ferguson, Harriet W. Hamilton, Peter J. Tummino
المصدر: ChemInform. 27
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Enzyme, Chemistry, Pyran, Stereochemistry, HIV Protease Inhibitor, General Medicine, Alkyl
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16
المؤلفون: Susan Elizabeth Hagen, Joseph P. Sanchez
المصدر: Current Opinion on Therapeutic Patents. 2:2031-2035
مصطلحات موضوعية: Pharmacology, Commerce, Chemistry, medicine.drug_class, medicine, Quinolone, Quarter (Canadian coin)
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17
المصدر: Journal of Medicinal Chemistry. 34:1155-1161
مصطلحات موضوعية: chemistry.chemical_classification, 4-Quinolones, Chemical Phenomena, Molecular Structure, Chemistry, Stereochemistry, Carboxylic acid, Biological activity, Microbial Sensitivity Tests, Gram-Positive Bacteria, Methylation, In vitro, Structure-Activity Relationship, Anti-Infective Agents, In vivo, Gram-Negative Bacteria, Drug Discovery, Molecular Medicine, Moiety, Potency, Antibacterial activity, Antibacterial agent
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18
المؤلفون: John M. Domagala, Susan Elizabeth Hagen
المصدر: Journal of Heterocyclic Chemistry. 27:1609-1616
مصطلحات موضوعية: Steric effects, chemistry.chemical_compound, chemistry, Trimethylsilyl, Bicyclic molecule, Organic Chemistry, Chlorine, chemistry.chemical_element, Organic chemistry, Moiety, Oxazoline, Protecting group, Enone
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19
المؤلفون: Tong Zhu, Guo Liang Lu, Amy M. Ottolini, Freddy Rivault, Keith R. Marotti, Chris Limberakis, Themis E. Joannides, Clarke Taylor, Adrian Blaser, William A. Denny, Murphy Sean T, Mark R. Rauckhorst, Edmund L. Ellsworth, Jeremy T. Starr, Heather L. Case, Michael Stier, Susan Elizabeth Hagen, Jeff B. Smaill, Michael D. Huband
المصدر: Bioorganicmedicinal chemistry letters. 17(8)
مصطلحات موضوعية: Fastidious organism, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, medicine.disease_cause, Gram-Positive Bacteria, Biochemistry, Microbiology, Structure-Activity Relationship, In vivo, Drug Discovery, Drug Resistance, Bacterial, Gram-Negative Bacteria, Nitriles, medicine, Animals, Humans, Molecular Biology, Antibacterial agent, biology, Molecular Structure, Chemistry, Mutagenicity Tests, Organic Chemistry, Biological activity, In vitro, Anti-Bacterial Agents, Rats, Staphylococcus aureus, biology.protein, Molecular Medicine, Genotoxicity, Fluoroquinolones
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20
المؤلفون: Peter J. Tummino, J.V.N. Vara Prasad, Steven VanderRoest, Stephen J. Gracheck, Larry James Markoski, A. Urumov, Joanne Brodfuehrer, Michael Sinz, Donald Hupe, Elizabeth A. Lunney, S V Gulnik, Neil Graham, Alexander Palovsky, James M. Sanders, Edmund L. Ellsworth, John M. Domagala, Christopher Andrew Gajda, Carolyn Nouhan, Susan Elizabeth Hagen, Frederick E. Boyer, Krishna R. Iyer, Tod P. Holler, Greg Zeikus, John W. Erickson, Donna Ferguson, Eric Andrew Zeikus, Bradley D. Tait
المصدر: Journal of medicinal chemistry. 43(5)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Dihydropyran, medicine.medical_treatment, Substituent, Biological Availability, Crystallography, X-Ray, Chemical synthesis, Cell Line, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Moiety, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Lymphocytes, Arylsulfonates, Pyrans, chemistry.chemical_classification, Sulfonyl, Sulfonamides, Protease, Aromatic amine, Stereoisomerism, HIV Protease Inhibitors, Combinatorial chemistry, Sulfonamide, chemistry, HIV-1, Molecular Medicine