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1Academic Journal
المؤلفون: Parvinder Kaur, Santanu Datta, Radha Krishan Shandil, Naveen Kumar, Nanduri Robert, Upneet K Sokhi, Supreeth Guptha, Shridhar Narayanan, Anand Anbarasu, Sudha Ramaiah
المصدر: PLoS ONE, Vol 11, Iss 5, p e0154513 (2016)
وصف الملف: electronic resource
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المؤلفون: Vijender Panduga, Manoranjan Panda, Radha Shandil, Shridhar Narayanan, Naveen Kumar, M Sreenivasaiah, Monalisa Chatterji, Pravin S. Shirude, Claire Sadler, Vasan K. Sambandamurthy, Tommasi Ruben A, Supreeth Guptha, Jyothi Mahadevaswamy, Meenakshi Mallya, Pravin Iyer, Sreevalli Sharma, Vasanthi Ramachandran, Christopher B. Cooper, Anisha Ambady, Ashwini Narayan, Manjunatha M R, Khisi Mdluli, Scott Butler
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: chemistry.chemical_classification, Benzimidazole, Scaffold, Molecular model, biology, 010405 organic chemistry, medicine.drug_class, Organic Chemistry, Active site, Antimycobacterial, biology.organism_classification, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, Mycobacterium tuberculosis, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Enzyme, chemistry, Drug Discovery, medicine, biology.protein, Clinical progression
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المؤلفون: Manoranjan Panda, Anandkumar Raichurkar, Neela Dinesh, Vinayak Hosagrahara, Naveen Kumar, K.R. Prabhakar, Suresh Rudrapatna, Gayathri Balakrishnan, Amit K. Gupta, Vasan K. Sambandamurthy, Karthikeyan Kandaswamy, Stefan Kavanagh, Ramanatha Saralaya, Lalit kumar Jena, Shridhar Narayanan, Suresh Solapure, Robert Nanduri, V. Balasubramanian, Meenakshi Mallya, Ashwini Narayan, Sowmya Bharath, Vijender Panduga, Vikas Shinde, Jitendar Reddy, Khisi Mdluili, Christopher B. Cooper, Parvinder Kaur, Shahul Hameed P, Sreevalli Sharma, Supreeth Guptha, Kakoli Mukherjee, Sudha Ravishankar, Radha Shandil, Pravin Iyer, Shankar D. Markad, Vasanthi Ramachandran, Takahiro Yano, Jyothi Bhat, Harvey Rubin, Subramanyam J. Tantry
المصدر: MedChemComm. 7:1022-1032
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, chemistry.chemical_classification, Scaffold, ATP synthase, 030106 microbiology, Organic Chemistry, Assay, Pharmaceutical Science, Biology, biology.organism_classification, Biochemistry, Pyrazolopyrimidine, Mycobacterium tuberculosis, 03 medical and health sciences, chemistry.chemical_compound, Enzyme, chemistry, Drug Discovery, Quinazoline, biology.protein, Molecular Medicine, Bedaquiline
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المؤلفون: Sandesh Jatheendranath, Gayathri Balakrishnan, Sreenivasaiah Menasinakai, Sudha Ravishankar, Vasanthi Ramachandran, Sreevalli Sharma, Charles J. Eyermann, Anisha Ambady, Suresh Rudrapatna, Naina Vinay Mudugal, Disha Awasthy, Umender Sharma, Supreeth Guptha, Vasan K. Sambandamurthy, Radha Nandishaiah, Folkert Reck
المصدر: Tuberculosis. 95:589-598
مصطلحات موضوعية: Microbiology (medical), Time Factors, Genotype, Phenotypic screening, Immunology, Antitubercular Agents, Microbiology, DNA gyrase, Mycobacterium tuberculosis, chemistry.chemical_compound, Bacterial Proteins, Drug Discovery, Humans, Molecular Targeted Therapy, Gene, Genetics, Gene knockdown, Microbial Viability, biology, Topoisomerase, Gene Expression Regulation, Bacterial, biology.organism_classification, Phenotype, Infectious Diseases, DNA Topoisomerases, Type I, chemistry, Gene Knockdown Techniques, biology.protein, DNA supercoil, Topoisomerase I Inhibitors, DNA
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المؤلفون: Sreevalli Sharma, Monalisa Chatterji, Ashwini Narayan, Sudha Ravishankar, Vasanthi Ramachandran, Vaishali Humnabadkar, Supreeth Guptha, Shahul Hameed, Praveena Manjrekar, Murugan Chinnapattu, K.R. Prabhakar
المصدر: Antimicrobial Agents and Chemotherapy. 58:6165-6171
مصطلحات موضوعية: Mutant, Biology, medicine.disease_cause, chemistry.chemical_compound, Biosynthesis, Escherichia coli, medicine, Pharmacology (medical), Peptide Synthases, Mechanisms of Action: Physiological Effects, Pharmacology, chemistry.chemical_classification, Alanine, DNA ligase, Escherichia coli Proteins, Membrane Transport Proteins, Uridine Diphosphate N-Acetylmuramic Acid, Infectious Diseases, Enzyme, chemistry, Biochemistry, Mutation, Pseudomonas aeruginosa, Peptidoglycan, Efflux, Bacterial Outer Membrane Proteins
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المؤلفون: Parvinder Kaur, Anisha Ambady, Sreevalli Sharma, Vinayak Hosagrahara, Ashwini Narayan, Vasanthi Ramachandran, Suresh Rudrapatna, Supreeth Guptha, Pravin S. Shirude, Vasan K. Sambandamurthy, Jyothi Mahadevaswamy, Ramachandran Sreekanth A, Kavitha Nagalapur, Anandkumar Raichurkar, Naina Hegde, Manoranjan Panda, Vaishali Humnabadkar
المصدر: Journal of Medicinal Chemistry. 57:4761-4771
مصطلحات موضوعية: Pyridones, medicine.drug_class, Antitubercular Agents, Microbial Sensitivity Tests, Pharmacology, Antimycobacterial, Mycobacterium tuberculosis, Structure-Activity Relationship, Minimum inhibitory concentration, Bacterial Proteins, Catalytic Domain, Drug Resistance, Bacterial, Drug Discovery, medicine, Gene, biology, Chemistry, Active site, biology.organism_classification, Resistance mutation, In vitro, Molecular Docking Simulation, Alcohol Oxidoreductases, Biochemistry, Docking (molecular), Mutation, biology.protein, Pyrazoles, Molecular Medicine, Oxidoreductases
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المؤلفون: Nilanjana Roy Choudhury, Balachandra Bandodkar, Vasanthi Ramachandran, Ramachandran Sreekanth A, Chaitanya Kumar Kedari, Kakoli Mukerjee, Parvinder Kaur, Manoranjan Panda, Supreeth Guptha, Sreevalli Sharma, Subramanyam J. Tantry
المصدر: ACS Medicinal Chemistry Letters. 5:491-495
مصطلحات موضوعية: Drug, Tuberculosis, biology, business.industry, media_common.quotation_subject, Organic Chemistry, Drug resistance, Hit to lead, Bioinformatics, biology.organism_classification, medicine.disease, Biochemistry, Mycobacterium tuberculosis, Drug Discovery, Medicine, Potency, business, Cytotoxicity, Mode of action, media_common
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المؤلفون: Vasanthi Ramachandran, Manoranjan Panda, Vasan K. Sambandamurthy, Subramanyam J. Tantry, Nilanjana Roy Choudhury, Kakoli Mukherjee, Ramachandran Sreekanth A, Supreeth Guptha, Chaitanya Kumar Kedari, Sreevalli Sharma, V. K. Ramya
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4996-5001
مصطلحات موضوعية: Models, Molecular, Pyridines, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Antitubercular Agents, Pharmaceutical Science, Microbial Sensitivity Tests, Antimycobacterial, Biochemistry, Mycobacterium tuberculosis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Pyridine, medicine, Humans, Tuberculosis, Structure–activity relationship, Molecular Biology, biology, Chemistry, Organic Chemistry, biology.organism_classification, Amides, Molecular Medicine, Whole cell
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المؤلفون: Claire Sadler, Shubha Sriram, Naina Vinay Mudugal, Boudewijn L. M. de Jonge, Gajanan Shanbhag, David C. McKinney, Praveena Manjrekar, Paul Robert Fleming, Beena Paul, Charles J. Eyermann, Vasan K. Sambandamurthy, Anisha Ambady, Sudha Ravishankar, Parvinder Kaur, Murugan Chinnapattu, Anandkumar Raichurkar, Shahul Hameed P, Chaitanyakumar Kedari, Supreeth Guptha, Manoranjan Panda, Vaishali Humnabadkar
المصدر: ACS chemical biology. 9(10)
مصطلحات موضوعية: Microbial Sensitivity Tests, Biology, medicine.disease_cause, Biochemistry, Bacterial cell structure, Microbiology, chemistry.chemical_compound, Structure-Activity Relationship, Biosynthesis, medicine, Escherichia coli, Structure–activity relationship, Humans, Enzyme Inhibitors, Peptide Synthases, chemistry.chemical_classification, Alanine, Molecular Structure, General Medicine, biology.organism_classification, Uridine Diphosphate N-Acetylmuramic Acid, Anti-Bacterial Agents, Enzyme, Pyrimidines, chemistry, Models, Chemical, Pseudomonas aeruginosa, Molecular Medicine, Pyrazoles, Peptidoglycan, Efflux, Protein Kinases, Bacteria
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المؤلفون: Eknath Bellale, Maruti Naik, Varun VB, Anisha Ambady, Ashwini Narayan, Sudha Ravishankar, Vasanthi Ramachandran, Parvinder Kaur, Robert McLaughlin, James Whiteaker, Sapna Morayya, Supreeth Guptha, Sreevalli Sharma, Anandkumar Raichurkar, Disha Awasthy, Vijayshree Achar, Prakash Vachaspati, Balachandra Bandodkar, Manoranjan Panda, Monalisa Chatterji
المصدر: Journal of medicinal chemistry. 57(15)
مصطلحات موضوعية: medicine.drug_class, Antitubercular Agents, Virulence, Drug resistance, Microbial Sensitivity Tests, Pharmacology, Antimycobacterial, Polymorphism, Single Nucleotide, Mycobacterium tuberculosis, Small Molecule Libraries, Mice, Structure-Activity Relationship, Bacterial Proteins, Drug Discovery, Drug Resistance, Bacterial, medicine, Structure–activity relationship, Animals, Humans, Ligand efficiency, biology, Drug discovery, Chemistry, biology.organism_classification, Two-component regulatory system, High-Throughput Screening Assays, Thiazoles, Biochemistry, Mutation, Molecular Medicine, Protein Kinases
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المؤلفون: Monalisa Chatterji, João Neres, Sreevalli Sharma, Prashanti Madhavapeddi, Vijender Panduga, James D. Whiteaker, Suresh Rudrapatna, Chandan Narayan, Krishna Koushik, Laurent R. Chiarelli, Gajanan Shanbhag, Vaishali Humnabadkar, Gopinath Gorai, Claudia Binda, Sandeep R. Ghorpade, Radha Shandil, Neeraj Dhar, Maria Rosalia Pasca, Stefan Kavanagh, Vasan K. Sambandamurthy, M. R. Manjunatha, K.R. Prabhakar, Vijayashree Achar, John D. McKinney, Neela Dinesh, Naina Hegde, Praveena Manjrekar, François Signorino-Gelo, Parvinder Kaur, Shridhar Narayanan, Jitendar Reddy, Subramanyam J. Tantry, Ashwini Narayan, Sandesh Jatheendranath, Lalit kumar Jena, Tommasi Ruben A, Jyothi Mahadevaswamy, Disha Awasthy, Ramanatha Saralaya, Manoranjan Panda, Bob McLaughlin, Anisha Ambady, Vinayak Hosagrahara, Pravin Iyer, Chandramohan Bathula, Maruti Naik, Giovanna Riccardi, Supreeth Guptha, Sudha Ravishankar, Vasanthi Ramachandran
المصدر: Journal of medicinal chemistry. 57(12)
مصطلحات موضوعية: Stereochemistry, medicine.drug_class, Mutant, Antitubercular Agents, Microbial Sensitivity Tests, Quinolones, Antimycobacterial, Mycobacterium tuberculosis, chemistry.chemical_compound, Structure-Activity Relationship, Bacterial Proteins, Piperidines, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Drug Resistance, Bacterial, medicine, Potency, Animals, Humans, Rats, Wistar, IC50, chemistry.chemical_classification, biology, Chemistry, Stereoisomerism, biology.organism_classification, Combinatorial chemistry, Amides, In vitro, Molecular Docking Simulation, Alcohol Oxidoreductases, Kinetics, Enzyme, Mutation, Molecular Medicine, Piperidine, Oxidoreductases, Genome, Bacterial, Protein Binding
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122-Phenylindole and Arylsulphonamide: Novel Scaffolds Bactericidal against Mycobacterium tuberculosis
المؤلفون: Lava Kumar Naviri, Vasanthi Ramachandran, Vaishali Humnabadkar, Monalisa Chatterji, Radha Nandishaiah, Ashwini Narayan, Sreevalli Sharma, Gopinath Gorai, Neela Dinesh, Lalit kumar Jena, Parvinder Kaur, Gayathri Balakrishnan, Pallavi Khadtare, Manoranjan Panda, Pravin Iyer, Maruti Naik, Sandeep R. Ghorpade, Supreeth Guptha, Jyothi Bhat
المصدر: ACS medicinal chemistry letters. 5(9)
مصطلحات موضوعية: chemistry.chemical_classification, biology, business.industry, medicine.drug_class, INHA, Organic Chemistry, Drug resistance, Hit to lead, biology.organism_classification, Antimycobacterial, Biochemistry, In vitro, Microbiology, Mycobacterium tuberculosis, Enzyme, chemistry, Drug Discovery, Medicine, Mode of action, business
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المؤلفون: Jyothi Mahadevaswamy, Naina Hegde, Shridhar Narayanan, Vijender Panduga, Ashwini Narayan, Ramesh R. Kale, Pravin Iyer, Claire Sadler, Parvinder Kaur, Abhishek Srivastava, Chandramohan Bathula, Vinayak Hosagrahara, Sowmya Bharath, K. G. Vishwas, Chandan Narayan, Suresh Solapure, Prashanti Madhavapeddi, James D. Whiteaker, Maruti Naik, Vaishali Humnabadkar, Nilanjana Roy Choudhury, Supreeth Guptha, Monalisa Chatterji, Humphrey Gardner, Anisha Ambady, K.R. Prabhakar, Radha Shandil, Vasan K. Sambandamurthy, Disha Awasthy, Vasanthi Ramachandran, Vijaykamal Ahuja, Jitendar Reddy, Robert E. McLaughlin, Shahul Hameed, Sreevalli Sharma, Pravin S. Shirude, Naveen Kumar, Manjunatha Ramaiah, Vikas Shinde
المصدر: Journal of medicinal chemistry. 56(23)
مصطلحات موضوعية: Scaffold, Tuberculosis, Indoles, biology, Antitubercular Agents, Mycobacterium tuberculosis, biology.organism_classification, medicine.disease, In vitro, Rats, Alcohol Oxidoreductases, Mice, Bacterial Proteins, In vivo, Immunology, Drug Discovery, Tuberculosis, Multidrug-Resistant, Cancer research, medicine, Molecular Medicine, Animals, Enzyme Inhibitors, Oxidoreductases
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المؤلفون: Sunita M. de Sousa, C. N. Naveen Kumar, Anandkumar Raichurkar, Kale Manoj Ganpat, Krishna Koushik, M. R. Manjunatha, David Waterson, Vasan K. Sambandamurthy, Vikas Shinde, K. N. Mahesh Kumar, Jitendar Reddy, Julie A. Tucker, Prashanti Madhavapeddi, Derek Ogg, Sandeep R. Ghorpade, Shubhada Barde, Halesha D. Basavarajappa, Shahul Hameed P, Samit Ganguly, V. K. Ramya, Lalit kumar Jena, Vijender Panduga, Vijaykamal Ahuja, Prakash Vachaspati, David C. McKinney, Jayashree Giridhar, Anirban Ghosh, Sheshagiri Gaonkar, Supreeth Guptha, P. Ann Boriack-Sjodin, Suresh Rudrapatna, Sreevalli Sharma, Usha Kranthi, Vaishali Humnabadkar
المصدر: Journal of medicinal chemistry. 56(21)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Pyridines, Antitubercular Agents, DNA gyrase, Mycobacterium tuberculosis, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, Ribose, Structure–activity relationship, Animals, Topoisomerase II Inhibitors, Tuberculosis, Urea, Homology modeling, IC50, Mice, Inbred BALB C, biology, Dose-Response Relationship, Drug, Molecular Structure, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, In vitro, Disease Models, Animal, chemistry, Biochemistry, DNA Gyrase, Molecular Medicine, Pharmacophore
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المؤلفون: Lalit kumar Jena, Jitendar Reddy, Francesca Boldrin, Marcello Ventura, Ashwini Narayan, Meenakshi Mallya, Vasanthi Ramachandran, Ruben C. Hartkoorn, Shankar D. Markad, Riccardo Manganelli, Manoranjan Panda, Supreeth Guptha, Giulia Degiacomi, Neela Dinesh, Radha Shandil, Parvinder Kaur, Subramanyam J. Tantry, Sreenivasaiah Menasinakai, Chandan Narayan, Stewart T. Cole, Gajanan Shanbhag, Sreevalli Sharma, Sandeep R. Ghorpade, D. Bhattacharjee, Disha Awasthy, Gayathri Balakrishnan, C. N. Naveen Kumar
مصطلحات موضوعية: Whole cell screen, medicine.drug_class, Stereochemistry, Mutant, hERG, Clinical Biochemistry, Antitubercular Agents, Pharmaceutical Science, Microbial Sensitivity Tests, medicine.disease_cause, Antimycobacterial, Biochemistry, Mycolic acid, Mycobacterium tuberculosis, Hypoxic conditions, MmpL3, Non-replicating phase, ss18b, Molecular Biology, Molecular Medicine, Organic Chemistry, Drug Discovery3003 Pharmaceutical Science, 3003, Mice, Structure-Activity Relationship, Piperidines, Drug Discovery, Drug Resistance, Bacterial, Matrix Metalloproteinase 13, medicine, Animals, Spiro Compounds, Hypoxia, chemistry.chemical_classification, Mutation, biology, Bacteria, Drug discovery, biology.organism_classification, Lipids, High-Throughput Screening Assays, chemistry, Lipophilicity, biology.protein, Genome, Bacterial
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