المؤلفون: Michael Thomas (279566), Stephen Brand (798331), Manu De Rycker (8377947), Fabio Zuccotto (1533349), Iva Lukac (593803), Peter G. Dodd (2143435), Eun-Jung Ko (5507792), Sujatha Manthri (800548), Kate McGonagle (10708757), Maria Osuna-Cabello (2834318), Jennifer Riley (309910), Caterina Pont (5959331), Frederick Simeons (10708760), Laste Stojanovski (1282575), John Thomas (3125013), Stephen Thompson (1346436), Elisabet Viayna (1828396), Jose M. Fiandor (2272426), Julio Martin (8377944), Paul G. Wyatt (473658), Timothy J. Miles (2029051), Kevin D. Read (165019), Maria Marco (2272447), Ian H. Gilbert (146934)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biotechnology, Infectious Diseases, Plant Biology, Chemical Sciences not elsewhere classified, Visceral Leishmaniasis, cryo-EM structure, GSK, impact, proteasome inhibition, candidate, developable compounds, vivo efficacy, scaffold-hopping exercise, chemistry program, phenotypic screen, VL, Preclinical Candidate, Proteasome Inhibitors, East Africa, Scaffold-Hopping Strategy, chemistry design

Relation: https://figshare.com/articles/journal_contribution/Scaffold-Hopping_Strategy_on_a_Series_of_Proteasome_Inhibitors_Led_to_a_Preclinical_Candidate_for_the_Treatment_of_Visceral_Leishmaniasis/14494877

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00047.s001

المؤلفون: Caterina Pont, Elisabet Viayna, Stephen Brand, Ian H. Gilbert, Peter George Dodd, Iva Lukac, Laste Stojanovski, Maria Osuna-Cabello, Jennifer Riley, Sujatha Manthri, Kate McGonagle, Timothy J. Miles, Julio Martin, Fabio Zuccotto, Frederick R. C. Simeons, John Thomas, Maria L. Marco, Paul G. Wyatt, Kevin D. Read, Stephen Thompson, Jose M. Fiandor, Michael G. Thomas, Manu De Rycker, Eun-Jung Ko

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Proteasome Endopeptidase Complex, Pyridines, Phenotypic screening, In silico, Antiprotozoal Agents, Drug Evaluation, Preclinical, Protozoan Proteins, Computational biology, Molecular Dynamics Simulation, Scaffold hopping, 01 natural sciences, Article, Cell Line, 03 medical and health sciences, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, East africa, Animals, Humans, 030304 developmental biology, 0303 health sciences, Binding Sites, Drug discovery, Chemistry, medicine.disease, 3. Good health, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Protein Subunits, Visceral leishmaniasis, Proteasome, Solubility, Drug Design, Molecular Medicine, Leishmaniasis, Visceral, Proteasome Inhibitors, Half-Life, Leishmania donovani

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023548cc95d4d9c556b1402e19227eb9
http://europepmc.org/articles/PMC8154566

المؤلفون: Michael G. Thomas, Maria L. Marco, John Thomas, Daniel Spinks, Ian H. Gilbert, Laste Stojanovski, Frederick R. C. Simeons, Ola Epemolu, Sujatha Manthri, Claire Naylor, Timothy J. Miles, Manu De Rycker, Suzanne Norval, Susan Wyllie, Stephen Patterson, Jennifer Riley, Maria Osuna-Cabello, Richard J. Wall, Jose M. Fiandor, Paul G. Wyatt, Kevin D. Read, Stephen Thompson

المصدر: Journal of Medicinal Chemistry. 63:9523-9539

مصطلحات موضوعية: 0303 health sciences, Chemistry, Pharmacology, medicine.disease, 01 natural sciences, Parasitic infection, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Visceral leishmaniasis, In vivo, Drug Discovery, Toxicity, medicine, Molecular Medicine, Water chemistry, Structure–activity relationship, Inhibitory concentration 50, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c2075363d9d5006cac4eca5979afbbe9
https://doi.org/10.1021/acs.jmedchem.0c00705

المؤلفون: Andrea Nühs, Manu De Rycker, Sujatha Manthri, Eamon Comer, Christina A Scherer, Stuart L Schreiber, Jean-Robert Ioset, David W Gray

المصدر: PLoS Neglected Tropical Diseases, Vol 9, Iss 9, p e0004094 (2015)

مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC4583543?pdf=render; https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

URL الوصول: https://doaj.org/article/cd8f4a6be22a43ea90005eb819ad4238

المؤلفون: Ian H. Gilbert, Sandra Carvalho, Stephen Thompson, Lorna MacLean, Fabio Zuccotto, Susan Wyllie, Timothy J. Miles, Lalitha Sastry, Ignacio Cotillo, Manu De Rycker, Juan A. Bueren-Calabuig, Sonia Moniz, Rachel Milne, Albane Kessler, Maria L. Marco, Julio Martin, Richard J. Wall, Alan H. Fairlamb, Juan Cantizani-Perez, Michael G. Thomas, Stephen Patterson, Sujatha Manthri

المصدر: ACS Infectious Diseases

مصطلحات موضوعية: 0301 basic medicine, Phenotypic screening, Trypanosoma cruzi, 030106 microbiology, Leishmania donovani, Computational biology, Biology, Article, drug target, 03 medical and health sciences, parasitic diseases, Drug Discovery, medicine, Humans, Chagas Disease, Antiparasitic Agents, Cytochrome b, Drug discovery, Cytochromes b, medicine.disease, biology.organism_classification, 3. Good health, High-Throughput Screening Assays, 030104 developmental biology, Infectious Diseases, Visceral leishmaniasis, Mechanism of action, cytochrome b, Coenzyme Q – cytochrome c reductase, Leishmaniasis, Visceral, medicine.symptom, mechanism of action

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbdbdb72ed0d785ae1f89aec7a44bf2
http://europepmc.org/articles/PMC7076694

المؤلفون: Kevin D. Read, Sabrinia D. Crouch, Juan Miguel-Siles, Stephen Thompson, Lorna MacLean, Timothy J. Miles, Franck Martin, Alain Claude-Marie Daugan, Suzanne Norval, Laste Stojanovski, Gloria Fra, John Thomas, Frederick R. C. Simeons, Sujatha Manthri, Jose M. Fiandor, César Guerrero, Myriam Ajakane, Maria Osuna-Cabello, Paul G. Wyatt, Manu De Rycker, Lorna Campbell, Claire J. MacKenzie, Ian H. Gilbert, Jennifer Riley, Yoko Shishikura, Michael G. Thomas, Raul F. Velasco

المصدر: RSC Medicinal Chemistry. 11:1168-1177

مصطلحات موضوعية: Pharmacology, 0303 health sciences, 030306 microbiology, business.industry, Organic Chemistry, Pharmaceutical Science, medicine.disease, Biochemistry, 03 medical and health sciences, Visceral leishmaniasis, In vivo, Drug Discovery, medicine, Molecular Medicine, Identification (biology), business, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::907889087930243eaf8e578bd0ada172
https://doi.org/10.1039/d0md00203h

المؤلفون: Louise A. Walker, Ali Floyd, Nicola R. Stanley-Wall, Margarita Kalamara, Sarah J. Coulthurst, Karen Stephenson, Geoffrey M. Gadd, Chih-Yu Hsu, Marina Fomina, John Thomas, Megan Bergkessel, Manu De Rycker, Amy Cameron, Ailsa Mackintosh, Lewis Houghton, Thibault Rosazza, Xia Kang, Saria Mansoor, Erin Hardee, Sujatha Manthri, Helge C. Dorfmueller

مصطلحات موضوعية: medicine.medical_specialty, Engineering, business.industry, medicine, Medical physics, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a608ef55c8751ed6350a71425e8e92bd
https://doi.org/10.20933/100001214

المؤلفون: Craig G Simpson, Sujatha Manthri, Katarzyna Dorota Raczynska, Maria Kalyna, Dominika Lewandowska, Branislav Kusenda, Monika Maronova, Zofia Szweykowska-Kulinska, Artur Jarmolowski, Andrea Barta, John W S Brown

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.biochemsoctrans.org/content/ppbiost/38/2/667.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1038.6807; http://www.biochemsoctrans.org/content/ppbiost/38/2/667.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1038.6807
http://www.biochemsoctrans.org/content/ppbiost/38/2/667.full.pdf

المؤلفون: Sujatha Manthri, M Lucia, Luis Izquierdo, Alvaro Acosta-serrano, Michael A J Ferguson

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://glycob.oxfordjournals.org/content/18/5/367.full.pdf.

مصطلحات موضوعية: ALG3/mannosyltransferase/N-glycosylation/ Trypanosoma

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.496.2258; http://glycob.oxfordjournals.org/content/18/5/367.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.496.2258
http://glycob.oxfordjournals.org/content/18/5/367.full.pdf

المؤلفون: Lorna MacLean, Rod J. Dillon, Ali Floyd, Sujatha Manthri, Sarah Cook, Nina Svensen, David Horn, Lalitha Shastry, Holly Yeoman, Michael A. J. Ferguson, Alan R. Prescott, Christy Paterson, Alan H. Fairlamb, Lesley Pearson, Jen Southern, John Thomas, Kevin D. Read

مصطلحات موضوعية: On board, Geography, medicine, Ethnology, Digital footprint, Leishmaniasis, medicine.disease, Deep frozen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::22289aa4ef7b74e3bdc873e438349fab
https://doi.org/10.20933/100001171

المؤلفون: Ian A. Johnston, Sujatha Manthri, Richard Alderson, Alistair Smart, Patrick Campbell

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jeb.biologists.org/content/206/8/1337.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.773; http://jeb.biologists.org/content/206/8/1337.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.773
http://jeb.biologists.org/content/206/8/1337.full.pdf

المؤلفون: Victoriano, Corpas-Lopez, Sonia, Moniz, Michael, Thomas, Richard J, Wall, Leah S, Torrie, Dorothea, Zander-Dinse, Michele, Tinti, Stephen, Brand, Laste, Stojanovski, Sujatha, Manthri, Irene, Hallyburton, Fabio, Zuccotto, Paul G, Wyatt, Manu, De Rycker, David, Horn, Michael A J, Ferguson, Joachim, Clos, Kevin D, Read, Alan H, Fairlamb, Ian H, Gilbert, Susan, Wyllie

المصدر: ACS Infectious Diseases

مصطلحات موضوعية: Proteomics, Leishmania, Mice, Inbred BALB C, Proteome, Antiprotozoal Agents, Cosmids, Parasite Load, Article, High-Throughput Screening Assays, drug discovery, Mice, target validation, parasitic diseases, Animals, Humans, Leishmaniasis, Visceral, Pyrazoles, Female, thermal proteome profiling (TPP), Acyltransferases, N-myristoyltransferase, Leishmania donovani

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::d042f2cce6e2218071c03684d8874664
https://pubmed.ncbi.nlm.nih.gov/30380837

المؤلفون: Leah S, Torrie, Stephen, Brand, David A, Robinson, Eun Jung, Ko, Laste, Stojanovski, Frederick R C, Simeons, Susan, Wyllie, John, Thomas, Lucy, Ellis, Maria, Osuna-Cabello, Ola, Epemolu, Andrea, Nühs, Jennifer, Riley, Lorna, MacLean, Sujatha, Manthri, Kevin D, Read, Ian H, Gilbert, Alan H, Fairlamb, Manu, De Rycker

المصدر: ACS Infectious Diseases

مصطلحات موضوعية: kinetoplastids, tRNA synthetase, Molecular Structure, parasitic diseases, Drug Discovery, parasite, Antiprotozoal Agents, translation, Methionine-tRNA Ligase, Enzyme Inhibitors, Article, High-Throughput Screening Assays, Leishmania donovani

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::8857ac374ff4cc86c9c9d657faf2cfba
https://pubmed.ncbi.nlm.nih.gov/28967262

المؤلفون: Stephanie Gresham, Stephen Patterson, Laste Stojanovski, Fabio Zuccotto, Susan Wyllie, Matthew Berriman, Timothy J. Miles, Frederick R. C. Simeons, Nadine Homeyer, Lorna MacLean, Paul Connolly, Lalitha Sastry, Manu De Rycker, Rhiannon Lowe, Gerard Drewes, Sabrinia D. Crouch, David W. Gray, Thomas D. Otto, Sebastian Albrecht, Michael G. Thomas, Michael A. J. Ferguson, Sujatha Manthri, Michael D. Urbaniak, Markus Boesche, Hannah Pflaumer, Alan H. Fairlamb, Ian H. Gilbert, Sonja Ghidelli-Disse, Kevin D. Read, Paul G. Wyatt, Jose M. Fiandor, Susan Dixon

المصدر: Nature

مصطلحات موضوعية: 0301 basic medicine, Proteomics, Proteome, 030106 microbiology, Leishmania donovani, Druggability, Disease, Pharmacology, Pyrazolopyrimidine, Article, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Mice, Cyclin-dependent kinase, Medicine, Animals, Humans, Molecular Targeted Therapy, Multidisciplinary, biology, business.industry, Kinase, Reproducibility of Results, Leishmaniasis, biology.organism_classification, medicine.disease, Cyclin-Dependent Kinase 9, Cyclin-Dependent Kinases, 3. Good health, Molecular Docking Simulation, Disease Models, Animal, 030104 developmental biology, Visceral leishmaniasis, Pyrimidines, chemistry, biology.protein, Leishmaniasis, Visceral, Pyrazoles, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6f9bff9da702dd0f4d789ce1ce05a4
https://pubmed.ncbi.nlm.nih.gov/30076375

المؤلفون: Branislav Kusenda, Zofia Szweykowska-Kulinska, Andrea Barta, Artur Jarmolowski, John W. S. Brown, Dominika Lewandowska, Monika Maronova, Katarzyna Dorota Raczynska, Sujatha Manthri, Craig G. Simpson, Maria Kalyna

المصدر: Biochemical Society Transactions. 38:667-671

مصطلحات موضوعية: Genetics, Gene Expression Profiling, Alternative splicing, Exonic splicing enhancer, Gene Expression Regulation, Developmental, Plant Development, TAF9, Plants, Biology, Models, Biological, Biochemistry, Cell biology, Alternative Splicing, Exon, Splicing factor, SR protein, Gene Expression Regulation, Plant, RNA splicing, Precursor mRNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a79d722a1efd40d278c9edbbe9f16d
https://doi.org/10.1042/bst0380667

المؤلفون: Sujatha Manthri, Ian A. Johnston, Daniel J. Macqueen, Margaret L. Delbridge

المصدر: Molecular Biology and Evolution. 27:1886-1902

مصطلحات موضوعية: Models, Molecular, Nonsynonymous substitution, Protein Conformation, Molecular Sequence Data, Gene mutation, Biology, Synteny, 03 medical and health sciences, Negative selection, 0302 clinical medicine, Molecular evolution, Genetics, Animals, Humans, Gene family, Amino Acid Sequence, Molecular Biology, Gene, Phylogeny, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Mammals, 0303 health sciences, Phylogenetic tree, Calpain, Sequence Analysis, DNA, Biological Evolution, Gene Expression Regulation, Sequence Alignment, 030217 neurology & neurosurgery, Functional divergence

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb14387206a31dfdcc8a4e88d53a603
https://doi.org/10.1093/molbev/msq071

المؤلفون: Alvaro Acosta-Serrano, Luis Izquierdo, Michael A. J. Ferguson, M. Lucia S. Güther, Sujatha Manthri

المصدر: Glycobiology. 18:367-383

مصطلحات موضوعية: Glycan, Glycosylation, Molecular Sequence Data, Trypanosoma brucei brucei, Mutant, Protozoan Proteins, Oligosaccharides, Trypanosoma brucei, Mannosyltransferases, Models, Biological, Biochemistry, N-glycan processing, N-linked glycosylation, Animals, Amino Acid Sequence, Cloning, Molecular, Procyclin, chemistry.chemical_classification, biology, Wild type, biology.organism_classification, Cell biology, carbohydrates (lipids), chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Mutation, biology.protein, Glycoprotein, Sequence Alignment, Gene Deletion, Variant Surface Glycoproteins, Trypanosoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6694ee770859b2fa373b18db95ac6eb5
https://doi.org/10.1093/glycob/cwn014

المؤلفون: Ronald Luijkx, David Nickell, Sujatha Manthri, Alistair Dingwall, Ian A. Johnston, Patrick Campbell, Ralph Bickerdike, Richard Alderson

المصدر: Aquaculture. 237:281-300

مصطلحات موضوعية: photoperiodism, business.industry, Ecology, Flesh, Production cycle, Aquatic Science, Biology, biology.organism_classification, Continuous light, Animal science, Aquaculture, Muscle fibre, Salmo, business, Smoltification

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7dc31ecf505dc7632ed86375d1b1d974
https://doi.org/10.1016/j.aquaculture.2004.04.026

المؤلفون: Ian A. Johnston, Patrick Campbell, David Nickell, Richard Alderson, Alisdair Smart, Sujatha Manthri

المصدر: Journal of Experimental Biology. 206:3425-3435

مصطلحات موضوعية: Time Factors, Physiology, Acclimatization, Myoblasts, Skeletal, Photoperiod, Salmo salar, Aquatic Science, Plasticity, Muscle hypertrophy, Animal science, Animals, Sexual maturity, Seawater, Progenitor cell, Muscle fibre, Salmo, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Cell Nucleus, photoperiodism, Analysis of Variance, biology, Body Weight, Anatomy, biology.organism_classification, Immunohistochemistry, Insect Science, Muscle Fibers, Fast-Twitch, Animal Science and Zoology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efaaaaff6cd7828cb9e825423f450804
https://doi.org/10.1242/jeb.00577

المؤلفون: David Whyte, Alistair Dingwall, David Mitchell, Sujatha Manthri, Richard Alderson, Ian A. Johnston, David Nickell, Patrick Campbell, Craig Selkirk, Billy Robertson

المصدر: Aquaculture. 210:259-283

مصطلحات موضوعية: Low protein, Flesh, Fish farming, Skeletal muscle, Anatomy, Aquatic Science, Biology, biology.organism_classification, Fish measurement, Feed conversion ratio, Animal science, medicine.anatomical_structure, medicine, Salmo, Salmonidae

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ed97e692daffeb5c09391d0fc70e506a
https://doi.org/10.1016/s0044-8486(01)00862-6