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1Academic Journal
المؤلفون: María Peris-Celda, Josefa Carrión-Navarro, Irina Palacín-Aliana, Pilar Sánchez-Gómez, Ricardo Prat Acín, Noemi Garcia-Romero, Angel Ayuso-Sacido
المصدر: Frontiers in Oncology, Vol 12 (2022)
مصطلحات موضوعية: glioma, brain tumors, SuFu = suppressor of fused, migration, hedgehog glioma-associated oncogene 1 (GLI1), glioblastoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
وصف الملف: electronic resource
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المؤلفون: Xian Zeng, Dianwen Ju, Jiajun Fan, Yichen Wang, Jinghui Zhang, Jingyun Luan, Kai Yin, Mingming Nie
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 609-620 (2021)مصطلحات موضوعية: BCL-2, B cell lymphoma 2, G protein coupled receptor kinase 2, HH, Carcinogenesis, Hedgehog, HIF-1α, MDSCs, myeloid-derived suppressor cells, STAT3, signal transducer and activator of transcription 3, FOLFOX, oxaliplatin, Review, medicine.disease_cause, SMO, Smoothened, Immune tolerance, 0302 clinical medicine, βArr2, β-arrestin2, ATO, arsenic trioxide, hypoxia-inducible factor 1α, IFN-γ: interferon-γ, Medicine, General Pharmacology, Toxicology and Pharmaceutics, TGF-β, transforming growth factor β, 0303 health sciences, glioma-associated oncogene homologue, GRK2, Cancer stem cells, 5-Fu, 5-fluorouracil, TME, tumor microenvironment, IHH, Indian Hedgehog, VEGF, vascular endothelial growth factor, SHH, Sonic Hedgehog, Hedgehog signaling pathway, PD-L1, programmed cell death ligand-1, Tumor microenvironment, 030220 oncology & carcinogenesis, BMI-1, B cell-specific moloney murine leukemia virus insertion region-1, SUFU, Suppressor of Fused, Signal transduction, DHH, Desert Hedgehog, NK, natural killer, CSCs, cancer stem cells, and leucovorin, GLI, NOX4, NADPH Oxidase 4, ALK5, TGF-β receptor I kinase, PTCH, Patched, SNF5, sucrose non-fermenting 5, Gastrointestinal cancer, 03 medical and health sciences, ROS, reactive oxygen species, Immune system, Cancer stem cell, BCC, basal cell carcinoma, 030304 developmental biology, EGF, epidermal growth factor, IL-10/6, interleukin 10/6, ITCH, itchy E3 ubiquitin ligase, ch5E1, chimeric monoclonal antibody 5E1, business.industry, lcsh:RM1-950, WNT, Wingless/Integrated, PD-1, programmed cell death-1, SMAD3, mothers against decapentaplegic homolog 3, medicine.disease, lcsh:Therapeutics. Pharmacology, Drug resistance, Cancer research, PKA, protein kinase A, TAMs, tumor-related macrophages, sense organs, business, Hedgehog, CAFs, cancer-associated fibroblasts
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المؤلفون: María Peris-Celda, Josefa Carrión-Navarro, Irina Palacín-Aliana, Pilar Sánchez-Gómez, Ricardo Prat Acín, Noemi Garcia-Romero, Angel Ayuso-Sacido
مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, glioma, brain tumors, SuFu = suppressor of fused, migration, hedgehog glioma-associated oncogene 1 (GLI1), glioblastoma
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المؤلفون: Shauna Higgins, Ashley Wysong, Taylor Ogden, David Elbaum
المصدر: JAAD Case Reports, Vol 4, Iss 2, Pp 196-199 (2018)
JAAD Case Reportsمصطلحات موضوعية: 0301 basic medicine, Dermatology, medulloblastoma, Article, law.invention, 03 medical and health sciences, 0302 clinical medicine, basal cell carcinoma, law, lcsh:Dermatology, Medicine, BCC - Basal cell carcinoma, Basal cell carcinoma, PTCH1, patched 1, BCC, basal cell carcinoma, Medulloblastoma, business.industry, SUFU, suppressor of fused, lcsh:RL1-803, medicine.disease, Hedgehog signaling pathway, irradiation therapy, Gorlin syndrome, 030104 developmental biology, PTCH1, Hh, Hedgehog pathway, 030220 oncology & carcinogenesis, Mutation (genetic algorithm), Cancer research, Suppressor, GS, Gorlin syndrome, business, Smoothened, SMO, smoothened
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المصدر: JAAD Case Reports
مصطلحات موضوعية: basal cell carcinoma syndrome, Pathology, medicine.medical_specialty, early onset, Case Report, Nevoid basal-cell carcinoma syndrome, Dermatology, 030207 dermatology & venereal diseases, 03 medical and health sciences, palmo-plantar pits, 0302 clinical medicine, basal cell carcinoma, nevoid basal cell carcinoma syndrome, PTCH, patched tumor suppressor, medicine, BCC - Basal cell carcinoma, Basal cell carcinoma, Basal cell, BCC, basal cell carcinoma, Early onset, business.industry, congenital, nevoid infantile, SUFU, suppressor of fused homolog, medicine.disease, Gorlin syndrome, 030220 oncology & carcinogenesis, Infantile onset, Basal cell carcinoma syndrome, business
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المؤلفون: Ananya Pal, Reshma Taneja, Hsin Yao Chiu
المصدر: Redox Biology, Vol 25, Iss, Pp-(2019)
Redox Biologyمصطلحات موضوعية: Oncology, BIO, 6-bromoindirubin-3′-oxime, FGFR, Fibroblast Growth Factor Receptor, Biochemistry, MCU, Mitochondrial Calcium Uniporter, 0302 clinical medicine, LiCl, Lithium Chloride, Rhabdomyosarcoma, IGF-1R, Insulin-like Growth Factor1 Receptor, Homeostasis, GSI, Gama Secretase Inhibitor, Molecular Targeted Therapy, SOD, Superoxide Dismutase, lcsh:QH301-705.5, PAX3/7-FOXO1, Paired Box Protein 3/7-Forkhead Box Protein O1, TXN, Thioredoxin, Combination chemotherapy, MYF5, Myogenic Factor 5, ARMS, Alveolar Rhabdomyosarcoma, NICD, Notch Intracellular Domain, SHH, Sonic Hedgehog, AKT, Protein Kinase B, SFRP, Secreted Frizzled Related Proteins, PDGF, Platelet Derived Growth Factor, P38MAPK, P38 Mitogen Activated Protein Kinase, SUFU, Suppressor of Fused, BRAF, Proto-oncogene B-Raf and V-Raf Murine Sarcoma Viral Oncogene Homolog B, DDAH1, Dimethylarginine Dimethylaminohydrolase 1, MICU1, Mitochondrial Calcium Uptake 1, RHOA, Ras Homolog Gene Family Member A, lcsh:Medicine (General), TPA, 2-O-tetradecanoylphorbol-13-acetate, Redox homeostasis, medicine.medical_specialty, IGF, Insulin-like Growth Factor, PRC2, Polycomb Repressive Complex 2, Therapeutics, Article, LKB1, Threonine Kinase, PTCH, Patched, WHO, World Health Organization, 03 medical and health sciences, KMT1A, K-methyltransferase 1 A, CSC, Cancer Stem Cell, Humans, ALK, Anaplastic Lymphoma Kinase, DLL1, Delta Like 1, Adverse effect, BCOR, BCL6 Corepressor, HEY1, Hairy and Enhancer of Split Related with YRPW Motif Protein 1, ATP2A3, ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+, medicine.disease, MYOD1, Myoblast Determination Protein, RBPJ, Recombining Binding Protein Suppressor of Hairless, Clinical trial, 030104 developmental biology, HAT, Histone Acetyltransferase, JAG1, Jagged 1, IC, Intracellular, TSA, Trichostatin A, 030217 neurology & neurosurgery, 2-ME, Methoxyestradiol, 0301 basic medicine, VANGL2, Van Gogh-like 2, Clinical Biochemistry, Drug resistance, SMO, Smoothened, Epigenesis, Genetic, VAC, Vincristine, Actinomycin D and Cyclophosphamide, Metastasis, NOSIP, Nitric Oxide Synthase Interacting Protein, COX7A1, Cytochrome c Oxidase Polypeptide 7A1, GLRX, Glutaredoxin, PI3K, Phosphatidylinositol-3-Kinase, TPC, Tumour Propagating Cells, DNMT, DNA Methyltransferase, LRP, Low Density Lipoprotein Receptor Related Protein, GSK3, Glycogen Kinase synthase, GLI, Glioma Associated Oncogene, lcsh:R5-920, VEGF, Vascular Endothelial Growth Factor, EMT, Epithelial to Mesenchymal Transition, FDA, US Food and Drug Administration, Soft tissue sarcoma, CK1α, Caesin Kinase 1 α, PCP, Planar Cell Polarity, HHIP, Hedgehog Interacting Protein, TCF/LEF, Transcription factor/Lymphoid Enhancer Binding Factor 1, SFK, YES/SRC family tyrosine kinase, HIF-1 α, Hypoxia Inducible Factor 1 α, CDK, Cyclin Dependent Kinase, ERK1/2, Extracellular Signal Regulated Kinase ½, JNK, Janus Kinase 1, EGFR, Epithelial Growth Factor Receptor, ICN1, Intracellular Notch Domain 1, Oxidation-Reduction, BRD, BET-containing Proteins, IHH, Indian Hedgehog Protein, Transcription, SP, Specificity Transcription Factor, BET, Bromodomain and extra-terminal, MST1, Macrophage Stimulating 1, TXNDC12, Thioredoxin Domain-containing Protein 12, MEK, Mitogen Activated Protein Kinase, Signalling, EZH2, Enhancer of Zeste Homolog 2, mTOR, (PI3K)-AKT-mammalian target of rapamycin, HES1, Hairy and Enhancer of Split-1, NOS1, Nitric Oxide Synthase 1, Internal medicine, RASSF4, Ras Association domain family member 4, medicine, ERMS, Embryonal Rhabdomyosarcoma, PTK2, Protein Tyrosine Kinase 2, Epigenetics, S6K1, S6 Kinase 1, DZNep, Deazaneplanocin A, MOB1, Mps One Binder Kinase Activator-like 1, SAHA, Suberoylanilide Hydroxamic Acid, DHH, Desert Hedgehog Protein, 5-aza-dc, 5-aza-2′-deoxycytidine, business.industry, GTP, Guanosine-5′-triphosphate, Organic Chemistry, YAP, Yes Associated Protein 1, PPP, Picropodophyllin, PDX, Patient Derived Xenograft, SETD2, SET Domain Containing 2, Oxidative Stress, lcsh:Biology (General), PcG, Polycomb group, AP1, Activator Protein 1, MEF2C, Myocyte Enhancer Factor 2C, SOX2, Sex determining Region Y-box 2, business, ROS, Reactive Oxygen Species
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المؤلفون: Alex C. Holliday, David T. Luyimbazi, George R. Collins, Douglas J. Grider, Nathan M. Johnson, Mariana A Phillips
المصدر: JAAD Case Reports
JAAD Case Reports, Vol 3, Iss 3, Pp 222-224 (2017)مصطلحات موضوعية: Pathology, medicine.medical_specialty, Case Report, Dermatology, mBCC, metastatic basal cell carcinoma, Metastasis, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, basal cell carcinoma, lcsh:Dermatology, Medicine, metastasis, BCC - Basal cell carcinoma, Basal cell carcinoma, dermatopathology, Hedgehog, BCC, basal cell carcinoma, p63, metastatic basal cell carcinoma, business.industry, SUFU, suppressor of fused, lcsh:RL1-803, medicine.disease, Metastatic basal cell carcinoma, HH, hedgehog, mismatch repair, 030220 oncology & carcinogenesis, Immunohistochemistry, DNA mismatch repair, Dermatopathology, business, IHC, immunohistochemistry
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المؤلفون: Mari-Liis Kauts, Piia Uusen, Kairit Tints, Alla Piirsoo, Marko Piirsoo, Toomas Neuman, Mart Loog, Lagle Kasak
المصدر: Biochimica et Biophysica Acta
مصطلحات موضوعية: Indoles, GliACT, transcriptional activator form of Gli proteins, Cellular differentiation, Signal transduction, TGF-β, Transforming Growth Factor β, Ptch, patched, Mice, 0302 clinical medicine, Transforming Growth Factor beta, Neoplasms, ASCs, adipose tissue derived stromal cells, Sonic hedgehog, Cells, Cultured, HSC, Hedgehog signaling complex, 0303 health sciences, biology, integumentary system, qRT-PCR, quantitative real-time PCR, Gene Expression Regulation, Developmental, Nuclear Proteins, Cell Differentiation, Protein kinase inhibitor, Ulk3, unc-51-like kinase 3, 3. Good health, Cell biology, AP, alkaline phosphatase, RNAi, RNA interference, WB, Western blot, Gli proteins, 030220 oncology & carcinogenesis, Differentiation, shRNA, short hairpin RNA, Sufu, Suppressor of Fused, animal structures, Inhibitor, medicine.drug_class, Kruppel-Like Transcription Factors, Protein Serine-Threonine Kinases, Zinc Finger Protein Gli2, Zinc Finger Protein GLI1, Article, 03 medical and health sciences, GLI1, Shh, Sonic Hedgehog, medicine, Animals, Humans, Hedgehog Proteins, Pyrroles, Kinase activity, GliFL, full-length Gli proteins, Transcription factor, Molecular Biology, 030304 developmental biology, Smo, Smoothened, Multipotent Stem Cells, Transforming growth factor beta, Cell Biology, Molecular biology, Multipotent cells, Oxindoles, siRNA, small interfering RNA, Leukocytes, Mononuclear, biology.protein, Propionates, Transcription Factors
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