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المؤلفون: Seungil Han, Martin E. Dowty, Ralph P. Robinson, Steven E. Heasley, Peter T. Symanowicz, Jason Jussif, Thomas M. Harris, Neelu Kaila, Lu Wang, Matthew Frank Brown, Jeffrey M. Casavant, Nicole Caspers, Sarah H. Griffin, Mark J. Mitton-Fry, Martin Hegen, Johnson Timothy Allan, Tenbrink Ruth E, Mary Ellen Banker, Jonathan Langille, Mihir D. Parikh, Tsung H. Lin, Arindrajit Basak, Jean-Baptiste Telliez, James D. Clark, Strohbach Joseph Walter, Eric P. Arnold, Ray Unwalla, Li Li, Brian A. Duclos, Xin Yang, Mark Edward Flanagan, John David Trzupek, Michael L. Vazquez, Soojin Kwon, Ashley Edward Fenwick
المصدر: Journal of Medicinal Chemistry. 61:1130-1152
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Drug Evaluation, Preclinical, Arthritis, Inflammation, Pharmacology, Autoimmune Diseases, Substrate Specificity, Inhibitory Concentration 50, 03 medical and health sciences, Dogs, Immune system, Drug Discovery, medicine, Animals, Humans, Pyrroles, Tissue Distribution, Protein Kinase Inhibitors, Thrombopoietin, Sulfonamides, Tofacitinib, Chemistry, Janus Kinase 1, Janus Kinase 2, medicine.disease, Arthritis, Experimental, Rats, Pyrimidines, 030104 developmental biology, Tyrosine kinase 2, Molecular Medicine, medicine.symptom, Janus kinase, Tyrosine kinase, Cyclobutanes
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2
المؤلفون: Martin Hegen, David C. Wood, Patrik Rhönnstad, Felix Vajdos, Atli Thorarensen, Mark E. Schnute, Timothy Braden, Kimberly Crouse, Maria Sjöberg, John I. Trujillo, Ravi G. Kurumbail, Bolette Husman, Konrad F. Koehler, Mattias Wennerstål, Tomas Bonn, Joakim Löfstedt, Eva Backström-Rydin, Bo Carlsson, Aron Sundell, Ming Z. Chen, Steven E. Heasley, John David Trzupek, Annika Goos-Nilsson, Carol A. Menard, Peter Harris, James R. Kiefer, Martin Bengtsson, Leon P. Collis, Michael J. Prinsen, Philippe Nuhant, Jennifer Alley, Scott A. Long, Alexander E. Hromockyj, Andrew C. Flick, Johnny Sandberg, Christoph W. Zapf, Edouard Zamaratski, Xiao Hu, Lee Napierata, Björn Kauppi, Nicole Caspers, Kimberly F. Fennell, Robert E. Kyne, Gabriel Berstein, Neelu Kaila, Lars Kruger, Wei Li, Li Xing, Ray Unwalla, Elisabet Kallin, Matthew J. Pelc, Susan Fish, James Robert Blinn, Hjalmar Gullberg, Marvin J. Meyers, Scot Richard Mente, Chulho Choi, Falgun Shah, Mathias Färnegårdh, Dean Messing, Peter G. Jones, Yajuan Zhao, Alexandria P. Taylor, Maria Sandström, Charles W. Bolten, Daniel Nöteberg, Robin A. Weinberg, Tomasz Janosik, John D. Knafels, Anna Wilhelmsson
المصدر: Journal of medicinal chemistry. 61(23)
مصطلحات موضوعية: 0301 basic medicine, Drug Inverse Agonism, Stereochemistry, Pyridines, Retinoic acid, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Mice, RAR-related orphan receptor gamma, Drug Discovery, Inverse agonist, Animals, Humans, Benzamide, Receptor, Orphan receptor, 010405 organic chemistry, Nuclear Receptor Subfamily 1, Group F, Member 3, 0104 chemical sciences, Retinoic acid receptor, 030104 developmental biology, chemistry, Nuclear receptor, Drug Design, Molecular Medicine, Th17 Cells
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المؤلفون: John Robert Springer, Gina M. Jerome, Hayes Michael J, Michael T. Baratta, Daniel P. Walker, Graciela B. Arhancet, Alexander F. Shaffer, Jaime L. Masferrer, Ben S. Zweifel, Steven E. Heasley, Darin E. Jones, William M. Moore, Jeffrey S. Carter, Yvette M. Fobian, Michael L. Vazquez, Sue Metz
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:1114-1119
مصطلحات موضوعية: Inflammation, Drug discovery, Organic Chemistry, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Prostaglandin, Benzoxazole, Pharmacology, Biochemistry, In vitro, Bioavailability, Intramolecular Oxidoreductases, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, Pharmacokinetics, In vivo, Drug Discovery, Humans, Molecular Medicine, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Prostaglandin-E Synthases
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المؤلفون: Daniel P. Walker, Alexander F. Shaffer, William M. Moore, Michael T. Baratta, Sue Metz, Jeffrey A. Scholten, John Robert Springer, Jeffrey S. Carter, Hwang-Fun Lu, Steven E. Heasley, Yvette M. Fobian, Natasha M. Kablaoui, Francisco M. Franco, Li Xing, Shengtian Yang, Hanau Cathleen E, Michael L. Vazquez, Graciela B. Arhancet, Gina M. Jerome
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:1120-1126
مصطلحات موضوعية: Models, Molecular, musculoskeletal diseases, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Acyl glucuronide, Molecular Conformation, Pharmaceutical Science, Biochemistry, Molecular conformation, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Humans, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Prostaglandin-E Synthases, Biological evaluation, Benzoxazoles, Organic Chemistry, Benzoxazole, Intramolecular Oxidoreductases, chemistry, Drug Design, Molecular Medicine, lipids (amino acids, peptides, and proteins), Prostaglandin E
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المؤلفون: Joe T. Collins, Steven E. Heasley, Hwang-Fun Lu, Yvette M. Fobian, Allison MacInnes, Michael K. Mao, Tizah Evelyn Anjeh, Michael L. Vazquez, Daniel P. Walker
المصدر: Synlett. 2011:2959-2962
مصطلحات موضوعية: Chemistry, Organic Chemistry, Organic chemistry, Chiral resolution
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6
المؤلفون: Michael A. Tones, Paul A. Bradley, Graham L. Smith, Lee R. Roberts, Geoff E. Gymer, Katherine S. England, Fox David Nathan Abraham, Steven E. Heasley, Michelle Schmidt, Mark E. Bunnage, Yvette M. Fobian, Jerome Molette, David Fairman, Dack Kevin Neil
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6515-6518
مصطلحات موضوعية: chemistry.chemical_classification, GUCY1B3, Organic Chemistry, Clinical Biochemistry, GUCY1A3, Triazole, Guanylate Cyclase Stimulators, Enzyme Activators, Receptors, Cytoplasmic and Nuclear, Pharmaceutical Science, Triazoles, Biochemistry, chemistry.chemical_compound, Soluble Guanylyl Cyclase, Enzyme, chemistry, Guanylate Cyclase, Drug Discovery, Molecular Medicine, Organic chemistry, Molecule, Acids, Molecular Biology
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المؤلفون: Janet L. Wieber, James A. Nieman, Herbert M. Zerth, Brenda L. Schultz, Steven E. Heasley, Nancee L. Oien, Mary L. Knechtel, Ke Chen, Todd A. Hopkins, Michael W. Wathen, Kevin J. Stephanski, Richard A. Nugent, Sajiv Krishnan Nair
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:3039-3042
مصطلحات موضوعية: Herpesvirus 3, Human, medicine.drug_class, viruses, Clinical Biochemistry, Cytomegalovirus, Pharmaceutical Science, Carboxamide, DNA-Directed DNA Polymerase, Herpesvirus 1, Human, medicine.disease_cause, Antiviral Agents, Biochemistry, Chemical synthesis, Virus, Structure-Activity Relationship, Alphaherpesvirinae, Drug Discovery, medicine, Humans, Pyrroles, Molecular Biology, Herpesviridae, Polymerase, Nucleic Acid Synthesis Inhibitors, biology, Chemistry, Organic Chemistry, Varicella zoster virus, virus diseases, biology.organism_classification, In vitro, Solubility, Quinolines, biology.protein, Molecular Medicine
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المؤلفون: Sandra W. Curtiss, D. Joseph Rogier, Alan MacInnes, Brown David L, Mike B. Tollefson, Brian R. Bond, Yvette M. Fobian, Maddux Todd Michael, Dafydd R. Owen, Jeanne M. Rumsey, Brent V. Mischke, Jerry W. Cubbage, Alan G. Benson, Robert Hughes, Lena L Zhang, E. Jon Jacobsen, Steven E. Heasley, Joseph B. Moon, Ying Yu, John M. Molyneaux, Yi Zheng, Brad A. Acker, Blevis-Bal Radhika M, John N. Freskos, John K. Walker, Jennie L. Walgren
المصدر: Journal of Medicinal Chemistry. 53:2656-2660
مصطلحات موضوعية: Stereochemistry, Chemistry, Pharmacology, chemistry.chemical_compound, Spontaneously hypertensive rat, Orally active, Design synthesis, In vivo, cGMP-specific phosphodiesterase type 5, Drug Discovery, Molecular Medicine, Potency, Penetrant (biochemical), Biological evaluation
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المؤلفون: Richard A. Hohler, Taylor Wendy Dianne, Paul M. Herrinton, Eric P. Seest, Steven P. Tanis, Bruce Roy Evans, Matthew R. Hester, Timothy Parker, James A. Nieman, Steven E. Heasley, Perrault William R, Lester A. Dolak
المصدر: Tetrahedron: Asymmetry. 17:2154-2182
مصطلحات موضوعية: Inorganic Chemistry, Solvent, Chlorohydrins, chemistry.chemical_compound, Chemistry, Yield (chemistry), Aryl, Organic Chemistry, Organic chemistry, Noyori asymmetric hydrogenation, Physical and Theoretical Chemistry, Catalysis
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المؤلفون: Robert O, Hughes, D Joseph, Rogier, E Jon, Jacobsen, John K, Walker, Alan, Macinnes, Brian R, Bond, Lena L, Zhang, Ying, Yu, Yi, Zheng, Jeanne M, Rumsey, Jennie L, Walgren, Sandra W, Curtiss, Yvette M, Fobian, Steven E, Heasley, Jerry W, Cubbage, Joseph B, Moon, David L, Brown, Brad A, Acker, Todd M, Maddux, Mike B, Tollefson, Brent V, Mischke, Dafydd R, Owen, John N, Freskos, John M, Molyneaux, Alan G, Benson, Rhadika M, Blevis-Bal
المصدر: Journal of medicinal chemistry. 53(6)
مصطلحات موضوعية: Cyclic Nucleotide Phosphodiesterases, Type 5, Male, Dose-Response Relationship, Drug, Molecular Structure, Phosphodiesterase Inhibitors, Pyridines, Administration, Oral, Biological Availability, Brain, Blood Pressure, Phosphodiesterase 5 Inhibitors, Rats, Rats, Sprague-Dawley, Models, Chemical, Drug Design, Pyrazines, Rats, Inbred SHR, Animals, Humans