المؤلفون: Stephen W. Kaldor

المصدر: MEDCHEM NEWS. 2007, 17(1):2

المؤلفون: Young K. Chen, Toufike Kanouni, Lee D. Arnold, Jason M. Cox, Elisabeth Gardiner, Kathryn Grandinetti, Ping Jiang, Stephen W. Kaldor, Catherine Lee, Chun Li, Eric S. Martin, Nichol Miller, Eric A. Murphy, Noel Timple, John S. Tyhonas, Angie Vassar, Tim S. Wang, Richard Williams, Ding Yuan, Robert S. Kania

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dimer compatible αc, biopharmaceutical properties suitable, 2787 ): overcoming, increased mapk signaling, core signaling component, activate dimeric signaling, mapk kinase cascade, v600e , exarafenib (< b, targeting raf alterations, kinase signaling, nras alterations, raf protein, raf dimers, various cancers, tumor efficacy

Relation: https://figshare.com/articles/journal_contribution/The_Discovery_of_Exarafenib_KIN-2787_Overcoming_the_Challenges_of_Pan-RAF_Kinase_Inhibition/25012735

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01830.s001
https://figshare.com/articles/journal_contribution/The_Discovery_of_Exarafenib_KIN-2787_Overcoming_the_Challenges_of_Pan-RAF_Kinase_Inhibition/25012735

المؤلفون: David J. Hosfield, Jiangchun Xu, Young K. Chen, Matt M. Kreilein, James Marvin Veal, Chon Lai, Christophe Severin, Toufike Kanouni, Stephen W. Kaldor, Lee N. Lawton, Robert Cho, Joselyn R. Del Rosario, Ryan Stansfield, Jeffrey A. Stafford, Natalie Y.-Y. Yuen, Shawn O’Connell, Paula Alessandra Tavares-Greco, Zhe Nie, Lihong Shi

المصدر: Journal of Medicinal Chemistry. 63:14522-14529

مصطلحات موضوعية: Cellular differentiation, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Organic Chemicals, 030304 developmental biology, ADME, Histone Demethylases, Flavin adenine dinucleotide, 0303 health sciences, biology, Tranylcypromine, Myeloid leukemia, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Histone, chemistry, Cell culture, biology.protein, Cancer research, Molecular Medicine, Demethylase, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ec0fbdb2c348ac2a377e0b118afeee
https://doi.org/10.1021/acs.jmedchem.0c00978

المؤلفون: Lihong Shi, Jiangchun Xu, A. Boloor, Stephen W. Kaldor, David J. Hosfield, J.M. Betancort, Jennifer Matuszkiewicz, James M. Veal, M.J. Bennett, Ryan Stansfield, Shawn M. O'Connell, Jeffrey A. Stafford, J.R. Del Rosario, Y. Wu

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:1811-1816

مصطلحات موضوعية: 0301 basic medicine, BRD4, Cell Survival, Clinical Biochemistry, Pharmaceutical Science, Cell Cycle Proteins, Computational biology, Molecular Dynamics Simulation, Crystallography, X-Ray, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, Drug Discovery, Humans, Structure–activity relationship, Epigenetics, Molecular Biology, Transcription factor, Binding Sites, Drug discovery, Chemistry, Organic Chemistry, Nuclear Proteins, Isoquinolines, Small molecule, Protein Structure, Tertiary, Bromodomain, 030104 developmental biology, Drug Design, Molecular Medicine, Pharmacophore, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31407f48e8a977590add29852567d58
https://doi.org/10.1016/j.bmcl.2018.04.016

المؤلفون: Shin-ichi Matsumoto, Jeffrey A. Stafford, Betty Lam, Zhe Nie, Noriko Uchiyama, Yan Liu, Lilly Zhang, Koki Hikami, Feher Victoria, Kiryanov Andre A, Nobuyuki Amano, David J. Hosfield, Srinivasa Reddy Natala, Robert J. Skene, Xiaodong Cao, Hua Zou, Christopher McBride, Yuichi Hikichi, Tomohiro Kawamoto, Stephen W. Kaldor, Takashi Ichikawa, Jones Benjamin

المصدر: Bioorganic & Medicinal Chemistry Letters. 23:3662-3666

مصطلحات موضوعية: Drug, Antitumor activity, Adult patients, Drug discovery, Chemistry, media_common.quotation_subject, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Polo-like kinase, Pharmacology, Biochemistry, PLK1, Small molecule, Drug Discovery, Molecular Medicine, Molecular Biology, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::095c494559927c4501b2a27cf758bee3
https://doi.org/10.1016/j.bmcl.2013.02.083

المؤلفون: Jeffrey J. Skelton, Karine Fabio, Robin D. G. Cooper, Robert F. Bruns, Gary A. Koppel, Stephen W. Kaldor, David C. Hunden, Bruce A. Dressman, Michael P. Clay, Mitchell I. Steinberg, Michael J. Brownstein, Neal G. Simon, Christophe Guillon, Craig F. Ferris, Marvin J. Miller, Michael O. Chaney, Shi-fang Lu, Ned D. Heindel

المصدر: Bioorganic & Medicinal Chemistry. 15:2054-2080

مصطلحات موضوعية: Models, Molecular, Vasopressin, Magnetic Resonance Spectroscopy, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, CHO Cells, Spectrometry, Mass, Fast Atom Bombardment, Pharmacology, Biochemistry, Article, Cricetulus, Dogs, Cricetinae, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, IC50, Chemistry, Organic Chemistry, Antagonist, Brain, Rats, Hormone receptor, Azetidines, Molecular Medicine, Ketoconazole, Luteinizing hormone, Antidiuretic Hormone Receptor Antagonists, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcea47a4dc266c2aa7647f92ba4147e5
https://doi.org/10.1016/j.bmc.2006.12.031

المؤلفون: Craig E. Dixon, Miles Goodman Siegel, Upinder Singh, Stephen W. Kaldor, Paul K. Isbester, Daniel J. Parks, Michael G. Organ, David J. Lavorato

المصدر: Tetrahedron Letters. 41:8407-8411

مصطلحات موضوعية: Olefin fiber, chemistry.chemical_compound, Ethanolamine, Chemistry, Organic Chemistry, Drug Discovery, Ethanolamines, Sequence (biology), Biochemistry, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ea5f6769148af4dbbe618f7f58385b2a
https://doi.org/10.1016/s0040-4039(00)01503-3

المؤلفون: Bruce A. Dressman, Upinder Singh, Stephen W. Kaldor

المصدر: Tetrahedron Letters. 39:3631-3634

مصطلحات موضوعية: chemistry.chemical_compound, Solid-phase synthesis, Primary (chemistry), chemistry, Organic Chemistry, Drug Discovery, Urea, Organic chemistry, Biochemistry, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e9fb4db0d73fa7cb10cc6c5b26e14860
https://doi.org/10.1016/s0040-4039(98)00652-2

المؤلفون: S. D. Hatch, Mark A. Muesing, Deborah A. Khalil, Nickolay Y. Chirgadze, Siegfried H. Reich, Vincent J. Kalish, Kenneth S. Su, Jeffrey A. Burgess, Krzysztof Appelt, Bruce A. Dressman, Penny P. Lubbehusen, Stephen W. Kaldor, Bhasker V. Shetty, Kristina M. Campanale, Jay F. Davies, David K. Clawson, John H. Tatlock, Maha B. Kosa, James E. Fritz, Amy K. Patick

المصدر: Journal of Medicinal Chemistry. 40:3979-3985

مصطلحات موضوعية: Male, Anti-HIV Agents, medicine.medical_treatment, Administration, Oral, Biological Availability, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, HIV-1 protease, Pharmacokinetics, Oral administration, In vivo, Drug Discovery, medicine, Animals, Structure–activity relationship, Nelfinavir, Protease, Dose-Response Relationship, Drug, biology, Chemistry, Callithrix, HIV Protease Inhibitors, Rats, Macaca fascicularis, Biochemistry, Enzyme inhibitor, HIV-1, biology.protein, Molecular Medicine, Female, Nelfinavir mesylate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a5e189e8078b8e21586a61aa6a6a51
https://doi.org/10.1021/jm9704098

المؤلفون: Miles Goodman Siegel, Stephen W. Kaldor

المصدر: Current Opinion in Chemical Biology. 1:101-106

مصطلحات موضوعية: Polymers, Chemistry, Chemistry, Organic, Indicators and Reagents, Nanotechnology, Polymer supported reagents, Biochemistry, Combinatorial chemistry, Organic Chemistry Phenomena, Analytical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6536b4e4694c60006ed69d0e52b4b04
https://doi.org/10.1016/s1367-5931(97)80115-9

المؤلفون: Stephen W. Kaldor, Leonard L. Winneroski, Michael A. Staszak, James E. Fritz, Scott Alan Frank, Michael E. LeTourneau, Jeffrey A. Ward, Margaret M. Faul, Steven E. Dunlap, John Arnold Werner, Huff Bret Eugene

المصدر: Tetrahedron. 53:8085-8104

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Hydride, Cyanide, Organic Chemistry, Drug Discovery, Cytidine, Biochemistry, Nucleoside, Combinatorial chemistry, Uridine, Hydroformylation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5687138dc3bc9a49bed9d6c2867d3a68
https://doi.org/10.1016/s0040-4020(97)00500-0

المؤلفون: Bruce A. Dressman, Jocelyn R. Grunwell, James E. Fritz, Patric James Hahn, Stephen W. Kaldor, Miles Goodman Siegel

المصدر: Tetrahedron Letters. 38:3357-3360

مصطلحات موضوعية: Chemistry, Covalent bond, Yield (chemistry), Organic Chemistry, Drug Discovery, Ion chromatography, Small Molecule Libraries, Sequence (biology), Biochemistry, Solution phase, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f5bb9ebaef2dd99583985493a6e4d381
https://doi.org/10.1016/s0040-4039(97)00650-3

المؤلفون: Emma R. McKinney, J. Tang, Stephen W. Kaldor, James E. Fritz

المصدر: Bioorganic & Medicinal Chemistry Letters. 6:3041-3044

مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Combinatorial chemistry, Isocyanate, Solution phase, Scavenger (chemistry), chemistry.chemical_compound, chemistry, Covalent bond, Drug Discovery, Molecular Medicine, Organic chemistry, Whole cell, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5199fa2a38c1dff31e148cf0d1faaa1e
https://doi.org/10.1016/s0960-894x(96)00560-4

المؤلفون: James E. Fritz, Bruce A. Dressman, Miles Goodman Siegel, Patric James Hahn, Stephen W. Kaldor

المصدر: Tetrahedron Letters. 37:7193-7196

مصطلحات موضوعية: Nucleophile, Chemistry, Organic Chemistry, Drug Discovery, Electrophile, Organic chemistry, Small Molecule Libraries, Amine gas treating, Biochemistry, Non peptide, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0afe25ab697c93271e3cf2266914c125
https://doi.org/10.1016/0040-4039(96)01636-x

المؤلفون: Stephen W. Kaldor, Bruce A. Dressman, Larry A. Spangle

المصدر: Tetrahedron Letters. 37:937-940

مصطلحات موضوعية: chemistry.chemical_classification, Carbamate, Stereochemistry, medicine.medical_treatment, Organic Chemistry, Hydantoin, Cleavage (embryo), Biochemistry, Amino acid, chemistry.chemical_compound, Solid-phase synthesis, chemistry, Drug Discovery, medicine, Hydroxymethyl, Polystyrene, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4be3b5122d84e355fc0a8d03b81b75d1
https://doi.org/10.1016/0040-4039(95)02395-x

المؤلفون: Bruce A. Dressman, J. M. Labus, Allen D. Kline, Beverly A. Heinz, M. Hammond, F. W. Chadwell, Stephen W. Kaldor

المصدر: Bioorganic & Medicinal Chemistry Letters. 5:2021-2026

مصطلحات موضوعية: chemistry.chemical_classification, Picornain 3C, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Glutarimide, Peptide, medicine.disease_cause, Biochemistry, Aldehyde, In vitro, Glutamine, chemistry.chemical_compound, Enzyme, Drug Discovery, medicine, Molecular Medicine, Rhinovirus, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2e650f9e93040a235149721269ed9496
https://doi.org/10.1016/0960-894x(95)00345-t

المؤلفون: Brian M. Shamblin, Marzoni Gifford P, Stephen W. Kaldor, Anthony J. Trippe, James E. Fritz

المصدر: Synthetic Communications. 25:2475-2482

مصطلحات موضوعية: Scale (ratio), Chemistry, Yield (chemistry), Organic Chemistry, Analytical chemistry, Enantiomeric excess, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d9036b6efc3527f006152b5b850653c1
https://doi.org/10.1080/00397919508015453

المؤلفون: Vincent J. Kalish, Krzysztof Appelt, Jay F. Davies, Mark J. Pino, B.‐W. Wu, Stephen W. Kaldor, Dzuy Nyugen, L. Musick, Bruce A. Dressman, John H. Tatlock, Reich Siegfried Heinz

المصدر: Bioorganic & Medicinal Chemistry Letters. 5:727-732

مصطلحات موضوعية: Drug, Protease, biology, Stereochemistry, medicine.medical_treatment, media_common.quotation_subject, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Cocrystal, chemistry.chemical_compound, HIV-1 protease, chemistry, Drug Discovery, medicine, biology.protein, Molecular Medicine, Structure based, Amine gas treating, Molecular Biology, media_common, Benzoic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7a562555c8de1485992b95539a7e10dc
https://doi.org/10.1016/0960-894x(95)00103-z

المؤلفون: Stephen W. Kaldor, Bruce A. Dressman, M. Hammond, S. D. Hatch, Penny P. Lubbehusen, Krzysztof Appelt, Jeffrey A. Burgess, Angela J. Baxter, M. Wiskerchen, Mark A. Muesing

المصدر: Bioorganic & Medicinal Chemistry Letters. 5:721-726

مصطلحات موضوعية: chemistry.chemical_classification, Protease, biology, Stereochemistry, medicine.medical_treatment, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Amino acid, Isophthalic acid, chemistry.chemical_compound, HIV-1 protease, chemistry, Drug Discovery, biology.protein, medicine, Molecular Medicine, Molecular Biology, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e5da868918a50f52ba1aae2c407adf6c
https://doi.org/10.1016/0960-894x(95)00102-y

المؤلفون: Marlys Hammond, Krzysztof Appelt, S. D. Hatch, James E. Fritz, Mark A. Muesing, MaryAnn Wiskerchen, Angela J. Baxter, Stephen W. Kaldor, Thomas Alan Crowell

المصدر: Bioorganic & Medicinal Chemistry Letters. 5:715-720

مصطلحات موضوعية: chemistry.chemical_classification, Protease, biology, Peptidomimetic, Stereochemistry, medicine.medical_treatment, Organic Chemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Enzyme, chemistry, HIV-1 protease, Drug Discovery, medicine, biology.protein, Molecular Medicine, Molecular Biology, Binding affinities

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::37a5ace23b8223baf77c9d9b479e8579
https://doi.org/10.1016/0960-894x(95)00101-x