المؤلفون: Giuseppe Uras (10860385), Alessia Manca (11050335), Pengfei Zhang (32384), Zsuzsa Markus (11050338), Natalie Mack (11050341), Stephanie Allen (1488781), Marco Bo (3689965), Shengtao Xu (513564), Jinyi Xu (1748593), Marios Georgiou (11050344), Zheying Zhu (147286)

مصطلحات موضوعية: Neuroscience, Biological Engineering, Developmental Biology, Stem Cells, Artificial Intelligence and Image Processing, Endocrinology, Radiology and Organ Imaging, Autonomic Nervous System, Cellular Nervous System, Central Nervous System, Sensory Systems, Clinical Nursing: Tertiary (Rehabilitative), Decision Making, Rehabilitation Engineering, Biomedical Engineering not elsewhere classified, Signal Processing, Neurogenetics, Image Processing, Alzheimer’s disease, Aβ42, acetylcholinesterase, acetylcholinesterase inhibitors, Drosophila melanogaster, amyloid aggregation 3

Relation: https://figshare.com/articles/figure/Image_2_In_vivo_Evaluation_of_a_Newly_Synthesized_Acetylcholinesterase_Inhibitor_in_a_Transgenic_Drosophila_Model_of_Alzheimer_s_Disease_JPEG/14881407

الاتاحة: https://doi.org/10.3389/fnins.2021.691222.s002

المؤلفون: Giuseppe Uras (10860385), Alessia Manca (11050335), Pengfei Zhang (32384), Zsuzsa Markus (11050338), Natalie Mack (11050341), Stephanie Allen (1488781), Marco Bo (3689965), Shengtao Xu (513564), Jinyi Xu (1748593), Marios Georgiou (11050344), Zheying Zhu (147286)

مصطلحات موضوعية: Neuroscience, Biological Engineering, Developmental Biology, Stem Cells, Artificial Intelligence and Image Processing, Endocrinology, Radiology and Organ Imaging, Autonomic Nervous System, Cellular Nervous System, Central Nervous System, Sensory Systems, Clinical Nursing: Tertiary (Rehabilitative), Decision Making, Rehabilitation Engineering, Biomedical Engineering not elsewhere classified, Signal Processing, Neurogenetics, Image Processing, Alzheimer’s disease, Aβ42, acetylcholinesterase, acetylcholinesterase inhibitors, Drosophila melanogaster, amyloid aggregation 3

Relation: https://figshare.com/articles/figure/Image_1_In_vivo_Evaluation_of_a_Newly_Synthesized_Acetylcholinesterase_Inhibitor_in_a_Transgenic_Drosophila_Model_of_Alzheimer_s_Disease_JPEG/14881404

الاتاحة: https://doi.org/10.3389/fnins.2021.691222.s001

المؤلفون: Hong Yao (348216), Giuseppe Uras (10860385), Pengfei Zhang (32384), Shengtao Xu (513564), Ying Yin (176992), Jie Liu (15128), Shuai Qin (559692), Xinuo Li (10860388), Stephanie Allen (1488781), Renren Bai (6203324), Qi Gong (353167), Haiyan Zhang (176919), Zheying Zhu (147286), Jinyi Xu (1748593)

مصطلحات موضوعية: Biochemistry, Cell Biology, Neuroscience, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, kinase selectivity, Biological evaluation results, GSK, scopolamine-induced amnesia mice, GA-induced reduction, multifunctional profiles, SH-SY 5Y cells, 51.1 nM, Alzheimer, SH-SY 5Y neurons, Ser -396 sites, neurite damage, AChE, multitarget strategy, compound 27 g, Ser -199, cell viability, tau protein, IC 50, 89.3 nM, hybrid, pharmacokinetic properties

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Novel_Tacrine_Pyrimidone_Hybrids_as_Potent_Dual_AChE_GSK_3_Inhibitors_for_the_Treatment_of_Alzheimer_s_Disease/14659375

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00160.s001

المؤلفون: Hong Yao (348216), Giuseppe Uras (10860385), Pengfei Zhang (32384), Shengtao Xu (513564), Ying Yin (176992), Jie Liu (15128), Shuai Qin (559692), Xinuo Li (10860388), Stephanie Allen (1488781), Renren Bai (6203324), Qi Gong (353167), Haiyan Zhang (176919), Zheying Zhu (147286), Jinyi Xu (1748593)

مصطلحات موضوعية: Biochemistry, Cell Biology, Neuroscience, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, kinase selectivity, Biological evaluation results, GSK, scopolamine-induced amnesia mice, GA-induced reduction, multifunctional profiles, SH-SY 5Y cells, 51.1 nM, Alzheimer, SH-SY 5Y neurons, Ser -396 sites, neurite damage, AChE, multitarget strategy, compound 27 g, Ser -199, cell viability, tau protein, IC 50, 89.3 nM, hybrid, pharmacokinetic properties

Relation: https://figshare.com/articles/dataset/Discovery_of_Novel_Tacrine_Pyrimidone_Hybrids_as_Potent_Dual_AChE_GSK_3_Inhibitors_for_the_Treatment_of_Alzheimer_s_Disease/14659378

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00160.s002