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1Academic Journal
المؤلفون: Kathleen M Gillooly, Claudine Pulicicchio, Mark A Pattoli, Lihong Cheng, Stacey Skala, Elizabeth M Heimrich, Kim W McIntyre, Tracy L Taylor, Daniel W Kukral, Shailesh Dudhgaonkar, Jignesh Nagar, Dana Banas, Scott H Watterson, Joseph A Tino, Aberra Fura, James R Burke
المصدر: PLoS ONE, Vol 12, Iss 7, p e0181782 (2017)
وصف الملف: electronic resource
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2
المؤلفون: Soo S. Ko, James Kempson, Yingru Zhang, Tracy L. Taylor, Kim W. McIntyre, James R. Burke, Luisa Salter-Cid, Shiuhang Yip, Celia D’Arienzo, Aberra Fura, Stacey Skala, Joseph A. Tino, Jun Dai, Chunlei Wang, Joel C. Barrish, Michael Galella, Kathleen M. Gillooly, Bei Wang, Dauh-Rurng Wu, Lorell Discenza, Xiaoping Hou, Arvind Mathur, Richard Rampulla, Dawn Sun, Scott H. Watterson, Mary T. Obermeier, Percy H. Carter, Mark A. Pattoli, Anurag S. Srivastava, Lihong Cheng, Rulin Zhao, Peng Li, Claudine Pulicicchio, Joseph Pawluczyk, Rodney Vickery
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Autoimmune disease, Atropisomer, biology, Stereochemistry, Carbazole, Organic Chemistry, medicine.disease, Biochemistry, Small molecule, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, biology.protein, Bruton's tyrosine kinase, Kinase activity, Chirality (chemistry), Tyrosine kinase
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3
المؤلفون: James R. Burke, Matthew B. Robers, James D Vasta, H. Ribeiro, B. Arey, G. Locke, Jonathan Lippy, Charu Chaudhry, Joseph A. Tino, Mark A. Pattoli, Stacey Skala, Andrew J. Tebben, Lixia Zhang, L. L. Ong, Scott H. Watterson, L. Monereau, Poncho Meisenheimer
المصدر: SLAS discovery : advancing life sciences RD. 25(2)
مصطلحات موضوعية: 0301 basic medicine, Cell signaling, 01 natural sciences, Biochemistry, Analytical Chemistry, 03 medical and health sciences, Agammaglobulinaemia Tyrosine Kinase, Fluorescence Resonance Energy Transfer, Bruton's tyrosine kinase, Structure–activity relationship, Humans, Kinase activity, Phosphorylation, Protein Kinase Inhibitors, biology, 010405 organic chemistry, Chemistry, Kinase, Phenotype, 0104 chemical sciences, Cell biology, High-Throughput Screening Assays, Kinetics, 030104 developmental biology, biology.protein, Molecular Medicine, Tyrosine kinase, Intracellular, Biotechnology
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4
المؤلفون: Richard Rampulla, Stacey Skala, Charu Chaudhry, Percy H. Carter, Alban Allentoff, Tracy L. Taylor, Ling Li, Andrew J. Tebben, Luisa Salter-Cid, Aberra Fura, Rulin Zhao, Ian M. Catlett, Richard A. Westhouse, Myra Beaudoin Bertrand, John E. Macor, Robin Moore, Celia D’Arienzo, Matt Pokross, Douglas G. Batt, Scott H. Watterson, Mary T. Obermeier, Qingjie Liu, Daniel Smith, Lorell Discenza, Michael Galella, Jun Dai, Arvind Mathur, Kathleen M. Gillooly, Elizabeth M. Heimrich, Jianqing Li, Zheng Yang, Michael Wallace, Kim W. McIntyre, James R. Burke, Mark A. Pattoli, Joseph A. Tino, Lihong Cheng, Naiyu Zheng, Rodney Vickery, Claudine Pulicicchio, Yifan Zhang, Qian Ruan, Paul A. Elzinga
المصدر: Journal of medicinal chemistry. 62(7)
مصطلحات موضوعية: Indoles, B-cell receptor, 01 natural sciences, Arthritis, Rheumatoid, 03 medical and health sciences, Inhibitory Concentration 50, Mice, Piperidines, immune system diseases, In vivo, hemic and lymphatic diseases, Drug Discovery, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Animals, Humans, Lupus Erythematosus, Systemic, Receptor, Protein Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, biology, Dose-Response Relationship, Drug, Kinase, Drug discovery, Chemistry, breakpoint cluster region, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Macaca fascicularis, Cancer research, biology.protein, Molecular Medicine, Tyrosine kinase
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5
المؤلفون: Carolyn A. Weigelt, Xiaomei Gu, Stacey Skala, Paul Davies, Jenny Xie, John S. Sack, T. G. Murali Dhar, Melissa Yarde-Chinn, James Neels, Michael A. Poss, Stefan Ruepp, Robert J. Cherney, Christine Goldstein, Joseph A. Tino, Luisa Salter-Cid, Kevin Stefanski, Vojkan Susulic, Rajeev S. Bhide, Xiaoxia Yang, Anurag S. Srivastava, Zheming Ruan, Lan-Ying Qin, Cornelius Lyndon A M, Ruth Bosnius
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:855-861
مصطلحات موضوعية: 0301 basic medicine, Class I Phosphatidylinositol 3-Kinases, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Piperazines, Autoimmune Diseases, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, In vivo, Drug Discovery, Animals, Humans, Protein Isoforms, Amines, Piperazine, Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Amine derivatives, Binding Sites, Triazines, Organic Chemistry, Alternative treatment, Molecular Docking Simulation, Disease Models, Animal, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Microsomes, Liver, Molecular Medicine, Lead compound
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المؤلفون: Jun Dai, Arvind Mathur, Lihong Cheng, Kim W. McIntyre, Dawn Sun, Joseph A. Tino, Shiuhang Yip, Douglas G. Batt, Jodi K. Muckelbauer, James R. Burke, Joel C. Barrish, Rodney Vickery, Celia D’Arienzo, Luisa Salter-Cid, Qingjie Liu, Tracy L. Taylor, Hua Gong, Mark A. Pattoli, Elizabeth M. Heimrich, Yingru Zhang, Andy J. Tebben, Myra Beaudoin Bertrand, Kathleen M. Gillooly, Chiehying Chang, Percy H. Carter, Scott H. Watterson, Mary T. Obermeier, Claudine Pulicicchio, Aberra Fura, Chunlei Wang, Michael Galella, Charles M. Langevine, Sarah C. Traeger, Lorell Discenza, Peng Li, Yifan Zhang, Qing Shi, Stacey Skala, Dauh-Rurng Wu, Richard Rampulla, George V. De Lucca
المصدر: Journal of Medicinal Chemistry. 59:9173-9200
مصطلحات موضوعية: 0301 basic medicine, Atropisomer, biology, 010405 organic chemistry, medicine.drug_class, Kinase, Chemistry, Stereochemistry, B-cell receptor, Carboxamide, 01 natural sciences, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, immune system diseases, hemic and lymphatic diseases, Drug Discovery, medicine, biology.protein, Molecular Medicine, Structure–activity relationship, Bruton's tyrosine kinase, Transferase, Tyrosine kinase
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7
المؤلفون: Carolyn A. Weigelt, Xiaomei Gu, Lan-Ying Qin, Christine B. Goldstine, Sylwia Stachura, Jenny Xie, Zheming Ruan, T. G. Murali Dhar, Donna L. Pedicord, Michael A. Poss, Luisa Salter-Cid, Rajeev S. Bhide, Percy H. Carter, James Neels, John S. Sack, Stefan Ruepp, Kevin Stefanski, Paul Davies, Stacey Skala
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:4256-4260
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, chemical and pharmacologic phenomena, Phosphatidylinositol 3-Kinases, Biochemistry, PI3K signaling, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Animals, Protein Isoforms, Structure–activity relationship, Amines, Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Binding Sites, biology, Triazines, Chemistry, Arthritis, Organic Chemistry, Protein Structure, Tertiary, Molecular Docking Simulation, Disease Models, Animal, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Keyhole limpet hemocyanin, Protein Binding, Collagen-induced arthritis
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المؤلفون: Rochelle Thomas, Andrea L. Tatum, Mary Struthers, Linhui Julie Su, Pete Z. Cotter, Qihong Zhao, Paul R. Mangan, Ruchira Das Gupta, Irvith M. Carvajal, Zheng Lin, Victoria Jenny, Jenny Xie, Caryn Picarillo, Brigitte Devaux, Noah Ditto, Elizabeth M. Heimrich, Xiaoxia Yang, Luisa Salter-Cid, Kim W. McIntyre, Stacey Skala, Yunling Song, David J. Shuster, Virna Borowski
المصدر: Journal of Pharmacology and Experimental Therapeutics. 354:152-165
مصطلحات موضوعية: Encephalomyelitis, Autoimmune, Experimental, medicine.medical_treatment, Autoimmunity, Pharmacology, medicine.disease_cause, Interleukin-23, Myelin oligodendrocyte glycoprotein, Mice, Random Allocation, In vivo, medicine, Interleukin 23, Animals, Humans, Mice, Inbred BALB C, biology, business.industry, Interleukin-17, Experimental autoimmune encephalomyelitis, Antibodies, Monoclonal, Interleukin, medicine.disease, Coculture Techniques, Mice, Inbred C57BL, HEK293 Cells, Cytokine, NIH 3T3 Cells, biology.protein, Molecular Medicine, Female, Interleukin 17, business
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المؤلفون: Joseph A. Tino, Dana Banas, Jignesh Nagar, Claudine Pulicicchio, Kathleen M. Gillooly, Aberra Fura, Daniel W. Kukral, Mark A. Pattoli, Kim W. McIntyre, Scott H. Watterson, James R. Burke, Lihong Cheng, Tracy L. Taylor, Shailesh Dudhgaonkar, Stacey Skala, Elizabeth M. Heimrich
المصدر: PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0181782 (2017)مصطلحات موضوعية: 0301 basic medicine, B Cells, Physiology, medicine.medical_treatment, Arthritis, lcsh:Medicine, Osteoclasts, medicine.disease_cause, Biochemistry, Autoimmunity, Etanercept, White Blood Cells, 0302 clinical medicine, Animal Cells, Immune Physiology, Medicine and Health Sciences, Agammaglobulinaemia Tyrosine Kinase, Enzyme-Linked Immunoassays, lcsh:Science, Innate Immune System, B-Lymphocytes, Mice, Inbred BALB C, Multidisciplinary, Immune System Proteins, biology, Animal Models, Protein-Tyrosine Kinases, Body Fluids, Cytokine, Blood, Experimental Organism Systems, Rheumatoid arthritis, Cytokines, Female, Bone Remodeling, Cellular Types, Anatomy, Tyrosine kinase, medicine.drug, Research Article, Immune Cells, Immunology, Mouse Models, Rheumatoid Arthritis, Research and Analysis Methods, Antibodies, Autoimmune Diseases, 03 medical and health sciences, Model Organisms, Rheumatology, medicine, Bruton's tyrosine kinase, Animals, Humans, Bone Resorption, Antibody-Producing Cells, Immunoassays, Protein Kinase Inhibitors, 030203 arthritis & rheumatology, Blood Cells, business.industry, lcsh:R, RANK Ligand, Biology and Life Sciences, Proteins, Cell Biology, Molecular Development, medicine.disease, Arthritis, Experimental, 030104 developmental biology, Immune System, Antibody Formation, biology.protein, Cancer research, Immunologic Techniques, Leukocytes, Mononuclear, Methotrexate, lcsh:Q, Clinical Immunology, Clinical Medicine, business, Physiological Processes, Developmental Biology
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المؤلفون: Dezhi Xing, Carolyn A. Weigelt, Luisa Salter-Cid, Pirama Nayagam Arunachalam, Rodney B.W. Smith, Ling Li, Melissa Yarde, Jodi K. Muckelbauer, Jonathan Lippy, Mary Ellen Cvijic, Sidney Pitt, John S. Sack, Thatipamula Rp, Michael A. Poss, Paul Levesque, Robert J. Cherney, Ipsit Kundu, David Marcoux, Gary L. Schieven, Arvind Mathur, Qingjie Liu, Zheming Ruan, Rosemary Zhang, R M Fancher, Shweta Padmanabhan, Scott H. Watterson, Qing Shi, Mary T. Obermeier, Anurag S. Srivastava, Anuradha Gupta, Douglas G. Batt, James Neels, Joseph A. Tino, Kevin Stefanski, Percy H. Carter, Macor John E, John Hynes, Myra Beaudoin-Bertrand, Hao Lu, Kim W. McIntyre, Stacey Skala, Aberra Fura, Lan-Ying Qin, Cornelius Lyndon A M, James Hennan, Richard Rampulla, Bogdan Sleczka, Jenny Xie, Kallem Rajareddy, Jie Pan, Christine B. Goldstine, Hua Gong, Qian Ruan, Kathleen M. Gillooly, Donna L. Pedicord, Jingsong Fan, Rajeev S. Bhide, Stefan Ruepp
المصدر: Journal of medicinal chemistry. 60(12)
مصطلحات موضوعية: 0301 basic medicine, Antigens, Differentiation, T-Lymphocyte, Male, ERG1 Potassium Channel, hERG, Drug Evaluation, Preclinical, Phosphatidylinositol 3-Kinases, Pharmacology, Pyrazole, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Antigens, CD, Drug Discovery, Structure–activity relationship, Potency, Animals, Humans, Lectins, C-Type, Phosphatidylinositol, Enzyme Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, biology, Kinase, Arthritis, Experimental, Isoenzymes, 030104 developmental biology, chemistry, Immune System Diseases, biology.protein, Molecular Medicine, Pyrazoles, Female, Efflux, Rabbits, Caco-2 Cells
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11
المؤلفون: Tracy L. Taylor, Douglas G. Batt, Lorell Discenza, ChiehYing J. Chang, Luisa Salter-Cid, Kim W. McIntyre, Myra Beaudoin Bertrand, Percy H. Carter, Yingru Zhang, Qingjie Liu, James R. Burke, Andrew J. Tebben, Zheng Yang, Joel C. Barrish, Rick Rampulla, Aberra Fura, Daniel W. Kukral, Joseph A. Tino, Punit Marathe, Huiping Zhang, Jun Dai, Qing Shi, Arvind Mathur, Kathleen M. Gillooly, Mark A. Pattoli, Mary T. Obermeier, Stacey Skala, Jodi K. Muckelbauer, George V. De Lucca, Rodney Vickery, Celia D’Arienzo
المصدر: Journal of medicinal chemistry. 59(17)
مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Stereochemistry, Carbazoles, Administration, Oral, Biological Availability, Carboxamide, Crystallography, X-Ray, Permeability, Cell Line, Arthritis, Rheumatoid, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 0302 clinical medicine, Dogs, In vivo, Drug Discovery, medicine, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Structure–activity relationship, Animals, Humans, Quinazolinones, biology, Carbazole, Protein-Tyrosine Kinases, Small molecule, Arthritis, Experimental, Macaca fascicularis, 030104 developmental biology, chemistry, Cell culture, 030220 oncology & carcinogenesis, Antirheumatic Agents, biology.protein, Microsomes, Liver, Molecular Medicine, Tyrosine kinase
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12
المؤلفون: Andrew J. Tebben, Wayne Vaccaro, Xiaoxia Yang, Kim W. McIntyre, Steven Sheriff, Nelly Aranibar, Dharmpal S. Dodd, Stacey Skala, Zheng Yang, Dawn K. Stetsko, Patric M Davis, Theresa Ziemba, Suzanne J. Suchard, Dominique Potin, Karishma Patel, Bang-Chi Chen, Joel C. Barrish, Zili Xiao, Albert J. DelMonte, Scott H. Watterson, Murray McKinnon, David R. Tortolani, Praveen Balimane, Pathanjali Kadiyala, Punit Marathe, Huiping Zhang, Michele Launay, Deborah Lee, ChiehYing Y. Chang, T. G. Murali Dhar
المصدر: Journal of Medicinal Chemistry. 53:3814-3830
مصطلحات موضوعية: biology, Chemistry, Cell adhesion molecule, Integrin, CD18, CD11a, Pharmacology, In vivo, Drug Discovery, biology.protein, Molecular Medicine, Structure–activity relationship, Cell adhesion, Ex vivo
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13
المؤلفون: Dawn K. Stetsko, Dominique Besse, Francois Caussade, Eric Nicolai, Brett R. Beno, Stacey Skala, Michele Launay, Dominique Potin, ChiehYing J. Chang, Suzanne J. Suchard, Patrice Malabre, Edwin J. Iwanowicz, Maud Fabreguette, Gordon Todderud, Daniel L. Cheney, Steven Sheriff, Joel C. Barrish, T. G. Murali Dhar, Diane Hollenbaugh
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:1161-1164
مصطلحات موضوعية: Scaffold, Endothelium, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Hydantoin, chemical and pharmacologic phenomena, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Beta (finance), Molecular Biology, Inflammation, Bicyclic molecule, Hydantoins, Organic Chemistry, hemic and immune systems, Adhesion, Bridged Bicyclo Compounds, Heterocyclic, Intercellular Adhesion Molecule-1, Lymphocyte Function-Associated Antigen-1, In vitro, Cell biology, medicine.anatomical_structure, chemistry, Design synthesis, Drug Design, Molecular Medicine, HeLa Cells, Protein Binding
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المؤلفون: Scott H, Watterson, Zili, Xiao, Dharmpal S, Dodd, David R, Tortolani, Wayne, Vaccaro, Dominique, Potin, Michele, Launay, Dawn K, Stetsko, Stacey, Skala, Patric M, Davis, Deborah, Lee, Xiaoxia, Yang, Kim W, McIntyre, Praveen, Balimane, Karishma, Patel, Zheng, Yang, Punit, Marathe, Pathanjali, Kadiyala, Andrew J, Tebben, Steven, Sheriff, Chiehying Y, Chang, Theresa, Ziemba, Huiping, Zhang, Bang-Chi, Chen, Albert J, DelMonte, Nelly, Aranibar, Murray, McKinnon, Joel C, Barrish, Suzanne J, Suchard, T G, Murali Dhar
المصدر: Journal of medicinal chemistry. 53(9)
مصطلحات موضوعية: Structure-Activity Relationship, Hydantoins, Nicotinic Acids, Humans, Immunologic Factors, Lymphocyte Function-Associated Antigen-1
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15
المؤلفون: Stacey Skala, T. G. Murali Dhar, Dawn K. Stetsko, Murray McKinnon, Dominique Potin, Patricia M. Davis, Suzanne J. Suchard, Kim W. McIntyre, Joel C. Barrish, David J. Shuster, Vojkan Susulic, Michele Launay, Luisa Salter-Cid
المصدر: Journal of immunology (Baltimore, Md. : 1950). 184(7)
مصطلحات موضوعية: Inflammatory arthritis, T cell, Immunology, Anti-Inflammatory Agents, Arthritis, Inflammation, Enzyme-Linked Immunosorbent Assay, Thiophenes, Mice, Immune system, medicine, Cell Adhesion, Immunology and Allergy, Animals, Humans, Spiro Compounds, Cell Proliferation, business.industry, Antagonist, medicine.disease, Arthritis, Experimental, Lymphocyte Function-Associated Antigen-1, Disease Models, Animal, medicine.anatomical_structure, Rheumatoid arthritis, Experimental pathology, Cytokines, medicine.symptom, Lymphocyte Culture Test, Mixed, business
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المؤلفون: Dominique, Potin, Michele, Launay, Francoise, Monatlik, Patrice, Malabre, Maud, Fabreguettes, Andre, Fouquet, Magali, Maillet, Eric, Nicolai, Loïc, Dorgeret, François, Chevallier, Dominique, Besse, Monique, Dufort, François, Caussade, Syed Z, Ahmad, Dawn K, Stetsko, Stacey, Skala, Patricia M, Davis, Praveen, Balimane, Karishma, Patel, Zheng, Yang, Punit, Marathe, Jennifer, Postelneck, Robert M, Townsend, Valentina, Goldfarb, Steven, Sheriff, Howard, Einspahr, Kevin, Kish, Mary F, Malley, John D, DiMarco, Jack Z, Gougoutas, Pathanjali, Kadiyala, Daniel L, Cheney, Ravindra W, Tejwani, Denette K, Murphy, Kim W, Mcintyre, Xiaoxia, Yang, Sam, Chao, Leslie, Leith, Zili, Xiao, Arvind, Mathur, Bang-Chi, Chen, Daugh-Rurng, Wu, Sarah C, Traeger, Murray, McKinnon, Joel C, Barrish, Jeffrey A, Robl, Edwin J, Iwanowicz, Suzanne J, Suchard, T G Murali, Dhar
المصدر: Journal of medicinal chemistry. 49(24)
مصطلحات موضوعية: Graft Rejection, Models, Molecular, Molecular Structure, Stereoisomerism, Pneumonia, Thiophenes, Crystallography, X-Ray, Lymphocyte Function-Associated Antigen-1, Mice, Structure-Activity Relationship, Dogs, Cell Adhesion, Animals, Humans, Transplantation, Homologous, Spiro Compounds