يعرض 1 - 20 نتائج من 288 نتيجة بحث عن '"Spirooxindole"', وقت الاستعلام: 0.65s تنقيح النتائج
  1. 1
    Academic Journal
    Fe3O4@gC3N4@Thiamine: a novel heterogeneous catalyst for the synthesis of heterocyclic compounds and microextraction of tebuconazole in food samples

    المؤلفون: Sahar Peiman, Behrooz Maleki, Milad Ghani

    المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-25 (2024)

    مصطلحات موضوعية: Nanocatalyst, Fe3O4@g-C3N4, HPLC–UV, MSPE, Heterocyclic compounds, Spirooxindole-pyran, Medicine, Science

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/2045-2322

    URL الوصول: https://doaj.org/article/70534c1e805b4a0a83388501e1faa4e5

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  2. 2
    Academic Journal
    Fe3O4@SiO2@NTMPThio-Cu: a sustainable and eco-friendly approach for the synthesis of heterocycle derivatives using a novel dendrimer template nanocatalyst

    المؤلفون: Sahar Peiman, Behrooz Maleki

    المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-28 (2024)

    مصطلحات موضوعية: Green chemistry, Magnetic nanoparticles, Dendrimer, Spirooxindole-pyran, Xanthene, Medicine, Science

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/2045-2322

    URL الوصول: https://doaj.org/article/56d066d72217488e9773464d168774e1

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  3. 3
    Academic Journal
    Novel spirooxindole-triazole derivatives: unveiling [3+2] cycloaddition reactivity through molecular electron density theory and investigating their potential cytotoxicity against HepG2 and MDA-MB-231 cell lines

    المؤلفون: Ihab Shawish, Samha Al Ayoubi, Ayman El-Faham, Ali Aldalbahi, Fardous F. El-Senduny, Farid A. Badria, Mar Ríos-Gutiérrez, Hassan H. Hammud, Sajda Ashraf, Zaheer Ul-Haq, Assem Barakat

    المصدر: Frontiers in Chemistry, Vol 12 (2024)

    مصطلحات موضوعية: spirooxindole, 32CA reactions, anticancer, molecular electron density (MED), cytotoxcicity, Chemistry, QD1-999

    وصف الملف: electronic resource

    Relation: https://www.frontiersin.org/articles/10.3389/fchem.2024.1460384/full; https://doaj.org/toc/2296-2646

    URL الوصول: https://doaj.org/article/d97f1fe1ec5a43139c9c8ac1d0181397

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  4. 4
    Academic Journal
    Nanoformulation of Spirooxindole and Methods for Treating Hepatocellular Carcinoma

    المؤلفون: Assem Barakat, Fardous F. El-Senduny, Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Yaseen A. M. M. Elshaier, Eman A. Mazyed, Farid A. Badria

    المصدر: Pharmaceutics, Vol 17, Iss 1, p 93 (2025)

    مصطلحات موضوعية: spirooxindole, nanoformulation, p53-MDM2, cancer research, hepatocellular carcinoma, Pharmacy and materia medica, RS1-441

    وصف الملف: electronic resource

    Relation: https://www.mdpi.com/1999-4923/17/1/93; https://doaj.org/toc/1999-4923

    URL الوصول: https://doaj.org/article/36d2be905117425e9f927ab8b1c4dac9

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  5. 5
    Academic Journal
    Multicomponent synthesis, structural and molecular dynamics simulation studies of a novel spirooxindole derivative

    المؤلفون: Mahesha, Majal Sapnakumari, B.S. Chethan, Thomas Jinkle, M.V. Deepa Urs, N.S. Lingegowda, N.K. Lokanath, S. Naveen

    المصدر: Chemical Physics Impact, Vol 8, Iss , Pp 100467- (2024)

    مصطلحات موضوعية: Spirooxindole, Dynamics simulation, Single crystal, Hirshfeld surface, XRD, DFT, Physics, QC1-999, Chemistry, QD1-999

    وصف الملف: electronic resource

    Relation: http://www.sciencedirect.com/science/article/pii/S2667022424000112; https://doaj.org/toc/2667-0224

    URL الوصول: https://doaj.org/article/5a5cb6018f094583918d7140552be9fa

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  6. 6
    Academic Journal
    Construction of diazepine-containing spiroindolines via annulation reaction of α-halogenated N-acylhydrazones and isatin-derived MBH carbonates

    المؤلفون: Xing Liu, Wenjing Shi, Jing Sun, Chao-Guo Yan

    المصدر: Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 1923-1932 (2023)

    مصطلحات موضوعية: acylhydrazone, annulation, azepine, mbh carbonate, spirooxindole, Science, Organic chemistry, QD241-441

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/1860-5397

    URL الوصول: https://doaj.org/article/3a3601cc6f4f4304b4f956fffd4ed997

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  7. 7
    Academic Journal
    Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules

    المؤلفون: Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, Matti Haukka, Marwa M. Abu-Serie, Alexander Dömling, Luis R. Domingo, Yaseen A. M. M. Elshaier

    المصدر: Frontiers in Pharmacology, Vol 15 (2024)

    مصطلحات موضوعية: spirooxindole, benzimidazole, MEDT, p53, MDM2 inhibitors, NF-κB, Therapeutics. Pharmacology, RM1-950

    وصف الملف: electronic resource

    Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1358089/full; https://doaj.org/toc/1663-9812

    URL الوصول: https://doaj.org/article/5d3a1efadfec43fd8edce7702b73e676

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  8. 8
    Academic Journal
    Selective construction of dispiro[indoline-3,2'-quinoline-3',3'-indoline] and dispiro[indoline-3,2'-pyrrole-3',3'-indoline] via three-component reaction

    المؤلفون: Ziying Xiao, Fengshun Xu, Jing Sun, Chao-Guo Yan

    المصدر: Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 1234-1242 (2023)

    مصطلحات موضوعية: cascade reaction, dimedone, isatin, 3-methyleneoxindole, multicomponent reaction, spirooxindole, Science, Organic chemistry, QD241-441

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/1860-5397

    URL الوصول: https://doaj.org/article/123efc3345b64f4bbf79cade30c4ce74

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  9. 9
    Academic Journal
    Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer cells

    المؤلفون: Mohamed S. Nafie, Abdullah Mohammed Al-Majid, M. Ali, Abdulmajeed Abdullah Alayyaf, Matti Haukka, Sajda Ashraf, Zaheer Ul-Haq, Ayman El-Faham, Assem Barakat

    المصدر: Frontiers in Chemistry, Vol 12 (2024)

    مصطلحات موضوعية: spirooxindole, [3+2] cycloaddition, breast cancer (MCF-7 and MDA-MB-231), EGFR, CDK-2, molecular dynamics, Chemistry, QD1-999

    وصف الملف: electronic resource

    Relation: https://www.frontiersin.org/articles/10.3389/fchem.2024.1364378/full; https://doaj.org/toc/2296-2646

    URL الوصول: https://doaj.org/article/c5aee876059544519e4d3186d086f71f

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  10. 10
    Academic Journal
    Design, stereoselective synthesis and anticancer efficacy of a new class of functionalized pyrrolizidine heterocyclic hybrids

    المؤلفون: Raju Suresh Kumar, Dhaifallah M. Al-thamili, Khloud Ibrahim Al-Shemaimari, Faruq Mohammad, Mohamad Altaf, Rashid Ayub

    المصدر: Journal of King Saud University: Science, Vol 36, Iss 1, Pp 103009- (2024)

    مصطلحات موضوعية: Cycloaddition reaction, Spirooxindole-pyrrolizidines, Anticancer activity, ROS generation, Caspase-3 activity, Apoptosis, Science (General), Q1-390

    وصف الملف: electronic resource

    Relation: http://www.sciencedirect.com/science/article/pii/S1018364723004718; https://doaj.org/toc/1018-3647

    URL الوصول: https://doaj.org/article/9fcccf38421146bba0402ae0f605ea08

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  11. 11
    Academic Journal
    Asymmetric synthesis of enantiopure tetracyclic dispirooxindolopyrrolidine-piperidones via microwave-assisted multicomponent reaction: crystallographic analysis, antimicrobial activity and in silico studies

    المؤلفون: Jelizi, Hanen, Toumi, Amani, Abdella, Faiza I.A., Daoud, Ismail, Boudriga, Sarra, Alshamari, Asma, Alanazi, Tahani Y.A., Alrashdi, Ahlam Abdulrahman, Edziri, Hayet, Knorr, Michael, Kirchhoff, Jan-Lukas, Strohmann, Carsten

    المساهمون: Laboratoire de Chimie Hétérocyclique, Produits Naturels et Réactivité Monastir (CHPNR), Département de Chimie Monastir, Faculté des Sciences de Monastir (FSM), Université de Monastir - University of Monastir (UM)-Université de Monastir - University of Monastir (UM)-Faculté des Sciences de Monastir (FSM), Université de Monastir - University of Monastir (UM)-Université de Monastir - University of Monastir (UM), University of Hail, University of Biskra Mohamed Khider, Faculté des Sciences Tlemcen, Université de Tlemcen, Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives Monastir (LR99ES27), Université de Monastir - University of Monastir (UM)-Faculté de Pharmacie Monastir (FPHM), Univers, Théorie, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC), Technische Universität Dortmund Dortmund (TU)

    المصدر: ISSN: 0022-2860.

    مصطلحات موضوعية: Microwave-assisted synthesis, multicomponent reaction, 3-dipolar cycloaddition, spirooxindole, piperidone, 1SC-XRD analysis, antimicrobial activity, molecular docking studies, [CHIM]Chemical Sciences

    Time: 1

    Relation: hal-04524612; https://hal.science/hal-04524612; https://hal.science/hal-04524612/document; https://hal.science/hal-04524612/file/1-s2.0-S0022286024006252-main.pdf

    الاتاحة: https://hal.science/hal-04524612
    https://hal.science/hal-04524612/document
    https://hal.science/hal-04524612/file/1-s2.0-S0022286024006252-main.pdf
    https://doi.org/10.1016/j.molstruc.2024.138104

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  12. 12
    Academic Journal
    Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer cells

    المؤلفون: Nafie, Mohamed S., Al-Majid, Abdullah Mohammed, Ali, M., Alayyaf, Abdulmajeed Abdullah, Haukka, Matti, Ashraf, Sajda, Ul-Haq, Zaheer, El-Faham, Ayman, Barakat, Assem

    مصطلحات موضوعية: spirooxindole, [3+2] cycloaddition, breast cancer (MCF-7 and MDA-MB-231), EGFR, CDK-2, molecular dynamics, syöpätaudit, lääkehoito, rintasyöpä, syöpäsolut, inhibiittorit

    وصف الملف: application/pdf; fulltext

    Relation: Frontiers in Chemistry; 12; CONVID_212334450

    الاتاحة: http://urn.fi/URN:NBN:fi:jyu-202404162944

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  13. 13
    Academic Journal
    Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules

    المؤلفون: Barakat, Assem, Alshahrani, Saeed, Al-Majid, Abdullah Mohammed, Alamary, Abdullah Saleh, Haukka, Matti, Abu-Serie, Marwa, M., Dömling, Alexander, Domingo, Luis, R., Elshaier, Yaseen A. M. M.

    مصطلحات موضوعية: spirooxindole, benzimidazole, MEDT, p53, MDM2 inhibitors, NF-kappa B, CDK (cyclin-dependent kinase), electron dencity theory, induced apoptosis, mutant p53, inhibitors, participation, localization, exploration, design, lääkekemia, inhibiittorit, mutaatiot, bioaktiiviset yhdisteet, syöpäsolut, proteiinit, heterosykliset yhdisteet, eturauhassyöpä, karsinoomat, rintasyöpä, farmakologia

    وصف الملف: application/pdf; fulltext

    Relation: Frontiers in Pharmacology; 15; CONVID_213503986

    الاتاحة: http://urn.fi/URN:NBN:fi:jyu-202405153592

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  14. 14
    Academic Journal
    Corrigendum: Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity

    المؤلفون: Qian Zhao, Shan-Shan Xiong, Can Chen, Hong-Ping Zhu, Xin Xie, Cheng Peng, Gu He, Bo Han

    المصدر: Frontiers in Oncology, Vol 13 (2023)

    مصطلحات موضوعية: multitarget drugs, histone deacetylase inhibitors, MDM2 inhibitors, spirooxindole, dual inhibitors, anticancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

    وصف الملف: electronic resource

    Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1259550/full; https://doaj.org/toc/2234-943X

    URL الوصول: https://doaj.org/article/5d394718039840a5970976271195073a

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  15. 15
    Academic Journal
    Copper-catalyzed multicomponent reactions for the efficient synthesis of diverse spirotetrahydrocarbazoles

    المؤلفون: Shao-Cong Zhan, Ren-Jie Fang, Jing Sun, Chao-Guo Yan

    المصدر: Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 796-808 (2022)

    مصطلحات موضوعية: diels–alder reaction, indole, indolo-2,3-quinodimethane, levy reaction, tetrahydrocarbazole, spirooxindole, Science, Organic chemistry, QD241-441

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/1860-5397

    URL الوصول: https://doaj.org/article/7082fc47bd3944589456bf05c014907d

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  16. 16
    Academic Journal
    Tri(n-butyl)phosphine-promoted domino reaction for the efficient construction of spiro[cyclohexane-1,3'-indolines] and spiro[indoline-3,2'-furan-3',3'-indolines]

    المؤلفون: Hui Zheng, Ying Han, Jing Sun, Chao-Guo Yan

    المصدر: Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 669-679 (2022)

    مصطلحات موضوعية: isatin, spiro[cyclohexane-1,3'-indoline], spiro[indoline-3,2'-furan-3',3''-indoline], spirooxindole, tri(n-butyl)phosphine, Science, Organic chemistry, QD241-441

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/1860-5397

    URL الوصول: https://doaj.org/article/8d31c2b464a64800bb6144370e602b67

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  17. 17
    Academic Journal
    Diastereoselective synthesis of spiro[chromane-3,3′-indolines] and spiro[chromane-3,2′-indenes] via DBU promoted formal [4 + 2]cycloaddition reaction

    المؤلفون: Daqian Wang, Jing Sun, Chao-Guo Yan

    المصدر: Green Synthesis and Catalysis, Vol 3, Iss 1, Pp 53-58 (2022)

    مصطلحات موضوعية: ortho-Quinone methide, para-Quinone methide, Indene-1,3-dione, Spirooxindole, [4 + 2] cycloaddition, Chemical technology, TP1-1185, Biochemistry, QD415-436

    وصف الملف: electronic resource

    Relation: http://www.sciencedirect.com/science/article/pii/S2666554921000855; https://doaj.org/toc/2666-5549

    URL الوصول: https://doaj.org/article/f5af1cb1759f4fb8877086b108bdcc0f

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  18. 18
    Academic Journal
    Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold

    المؤلفون: Tuan-Anh M. Nguyen, Dagny Grzech, Khoa Chung, Zhicheng Xia, Trinh-Don Nguyen, Thu-Thuy T. Dang

    المصدر: Frontiers in Plant Science, Vol 14 (2023)

    مصطلحات موضوعية: kratom, cytochrome P450, spirooxindole, CYP71, secoyohimbane, Plant culture, SB1-1110

    وصف الملف: electronic resource

    Relation: https://www.frontiersin.org/articles/10.3389/fpls.2023.1125158/full; https://doaj.org/toc/1664-462X

    URL الوصول: https://doaj.org/article/0122f565b7344705acbec756a7913021

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  19. 19
    Academic Journal
    Formal Catalytic Cleavage of C(sp 2 )–C(sp 2 ) Bonds Enabled the Construction of Dihydropyran-Fused Indoles

    المؤلفون: Pan-Pan Li, Binfang Yuan, Shi-Cui Fang, Hui-Xin Xiao, Shao-Qun Cai, Bin Pan, Wu Liang, Fei Du

    مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Biotechnology, Developmental Biology, Infectious Diseases, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tethered carbamoyl chlorides, formal catalytic cleavage, electrocyclic ring opening, catalyzed domino heck, density functional theory, catalyzed domino reaction, functional groups, reaction mechanism, reaction conditions, studies suggested, strategy used, starting materials, spirooxindole intermediate, selective scission, nmr studies, fused indoles, electrocyclization mechanism, complementary synthesis, aryl bromides

    Relation: https://figshare.com/articles/journal_contribution/Formal_Catalytic_Cleavage_of_C_sp_sup_2_sup_C_sp_sup_2_sup_Bonds_Enabled_the_Construction_of_Dihydropyran-Fused_Indoles/24530432

    الاتاحة: https://doi.org/10.1021/acscatal.3c04122.s001
    https://figshare.com/articles/journal_contribution/Formal_Catalytic_Cleavage_of_C_sp_sup_2_sup_C_sp_sup_2_sup_Bonds_Enabled_the_Construction_of_Dihydropyran-Fused_Indoles/24530432

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  20. 20
    Academic Journal
    Chemo-/Regio-Selective Synthesis of Novel Functionalized Spiro[pyrrolidine-2,3′-oxindoles] under Microwave Irradiation and Their Anticancer Activity

    المؤلفون: Richa Sharma, Lalit Yadav, Ali Adnan Nasim, Ravi Kant Yadav, Rui Hong Chen, Neha Kumari, Fan Ruiqi, Ashoke Sharon, Nawal Kishore Sahu, Sirish Kumar Ippagunta, Paolo Coghi, Vincent Kam Wai Wong, Sandeep Chaudhary

    المصدر: Molecules ; Volume 28 ; Issue 18 ; Pages: 6503

    مصطلحات موضوعية: anticancer, spirooxindole, [3+2] cycloaddition, azomethine ylide, microwave

    جغرافية الموضوع: agris

    وصف الملف: application/pdf

    Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules28186503

    الاتاحة: https://doi.org/10.3390/molecules28186503

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