نتائج البحث - "Spies, M. Ashley"

1

Academic Journal

Renin and renin blockade have no role in complement activity

المؤلفون: Zhang, Yuzhou, Martin, Bertha, Spies, M. Ashley, Roberts, Sarah M., Nott, Joel, Goodfellow, Renee X., Nelson, Angela F.M., Blain, Samantha J., Redondo, Elena, Nester, Carla M., Smith, Richard J.H.

المساهمون: NIH, National Institute of Diabetes and Digestive and Kidney Diseases

المصدر: Kidney International ; volume 105, issue 2, page 328-337 ; ISSN 0085-2538

الاتاحة: http://dx.doi.org/10.1016/j.kint.2023.11.005
https://api.elsevier.com/content/article/PII:S0085253823007822?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0085253823007822?httpAccept=text/plain

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2

Academic Journal

Therapeutic disruption of RAD52–ssDNA complexation via novel drug-like inhibitors

المؤلفون: Bhat, Divya S, Malacaria, Eva, Biagi, Ludovica Di, Razzaghi, Mortezaali, Honda, Masayoshi, Hobbs, Kathryn F, Hengel, Sarah R, Pichierri, Pietro, Spies, M Ashley, Spies, Maria

المساهمون: National Institutes of Health, University of Iowa Center for Biocatalysis and Bioprocessing, NIH-sponsored Predoctoral Training Program in Biotechnology, Free Radicals and Radiation Biology

المصدر: NAR Cancer ; volume 5, issue 2 ; ISSN 2632-8674

الاتاحة: http://dx.doi.org/10.1093/narcan/zcad018
https://academic.oup.com/narcancer/article-pdf/5/2/zcad018/57073989/zcad018.pdf

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3

Academic Journal

A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein

المؤلفون: Bhat, Divya S., Spies, M. Ashley, Spies, Maria

المصدر: DNA Repair ; volume 120, page 103421 ; ISSN 1568-7864

الاتاحة: http://dx.doi.org/10.1016/j.dnarep.2022.103421
https://api.elsevier.com/content/article/PII:S1568786422001549?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1568786422001549?httpAccept=text/plain

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4

Academic Journal

Decrypting a cryptic allosteric pocket in H. pylori glutamate racemase

المؤلفون: Chheda, Pratik Rajesh, Cooling, Grant T., Dean, Sondra F., Propp, Jonah, Hobbs, Kathryn F., Spies, M. Ashley

المساهمون: U.S. Department of Health & Human Services | National Institutes of Health

المصدر: Communications Chemistry ; volume 4, issue 1 ; ISSN 2399-3669

الاتاحة: http://dx.doi.org/10.1038/s42004-021-00605-z
https://www.nature.com/articles/s42004-021-00605-z.pdf
https://www.nature.com/articles/s42004-021-00605-z

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5

Academic Journal

Allosteric Tuning of Caspase‐7: Establishing the Nexus of Structure and Catalytic Power

المؤلفون: Hobbs, Kathryn F., Propp, Jonah, Vance, Nicholas R., Kalenkiewicz, Andrew, Witkin, Katie R., Spies, M. Ashley

المصدر: Chemistry – A European Journal ; volume 29, issue 40 ; ISSN 0947-6539 1521-3765

الاتاحة: http://dx.doi.org/10.1002/chem.202301621

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6

Academic Journal

Allosteric Tuning of Caspase‐7: A Fragment‐Based Drug Discovery Approach

المؤلفون: Vance, Nicholas R., Gakhar, Lokesh, Spies, M. Ashley

المساهمون: National Institute of General Medical Sciences

المصدر: Angewandte Chemie International Edition ; volume 56, issue 46, page 14443-14447 ; ISSN 1433-7851 1521-3773

الاتاحة: http://dx.doi.org/10.1002/anie.201706959
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201706959
https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201706959

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7

Academic Journal

Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy

المؤلفون: Hengel, Sarah R., Spies, M. Ashley, Spies, Maria

المساهمون: NIH, University of Iowa

المصدر: Cell Chemical Biology ; volume 24, issue 9, page 1101-1119 ; ISSN 2451-9456

الاتاحة: http://dx.doi.org/10.1016/j.chembiol.2017.08.027
https://api.elsevier.com/content/article/PII:S2451945617303252?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2451945617303252?httpAccept=text/plain

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8

Academic Journal

A stereochemical journey around spirocyclic glutamic acid analogs

المؤلفون: Chernykh, Anton V., Chernykh, Alla V., Radchenko, Dmytro S., Chheda, Pratik Rajesh, Rusanov, Eduard B., Grygorenko, Oleksandr O., Spies, M. Ashley, Volochnyuk, Dmitriy M., Komarov, Igor V.

المساهمون: Enamine, National Institutes of Health, Ministry of Education and Science of Ukraine, National Academy of Sciences of Ukraine

المصدر: Organic & Biomolecular Chemistry ; volume 20, issue 15, page 3183-3200 ; ISSN 1477-0520 1477-0539

الاتاحة: http://dx.doi.org/10.1039/d2ob00146b
http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00146B

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9

Academic Journal

Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells

المؤلفون: Hengel, Sarah R, Malacaria, Eva, Folly da Silva Constantino, Laura, Bain, Fletcher E, Diaz, Andrea, Koch, Brandon G, Yu, Liping, Wu, Meng, Pichierri, Pietro, Spies, M Ashley, Spies, Maria

المساهمون: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, National Institutes of Health, Associazione Italiana per la Ricerca sul Cancro, Nando and Elsa Peretti Foundation, University of Iowa, American Cancer Society

المصدر: eLife ; volume 5 ; ISSN 2050-084X

الاتاحة: http://dx.doi.org/10.7554/elife.14740
https://cdn.elifesciences.org/articles/14740/elife-14740-v2.pdf
https://cdn.elifesciences.org/articles/14740/elife-14740-v2.xml
https://elifesciences.org/articles/14740

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10

Academic Journal

Inhibition of Pseudomonas aeruginosa ExsA DNA-Binding Activity by N -Hydroxybenzimidazoles

المؤلفون: Marsden, Anne E., King, Jessica M., Spies, M. Ashley, Kim, Oak K., Yahr, Timothy L.

المساهمون: Office of Extramural Research, National Institutes of Health

المصدر: Antimicrobial Agents and Chemotherapy ; volume 60, issue 2, page 766-776 ; ISSN 0066-4804 1098-6596

الاتاحة: http://dx.doi.org/10.1128/aac.02242-15
https://journals.asm.org/doi/pdf/10.1128/AAC.02242-15

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11

Academic Journal

Biosynthesis of a Novel Glutamate Racemase Containing a Site-Specific 7-Hydroxycoumarin Amino Acid: Enzyme–Ligand Promiscuity Revealed at the Atomistic Level

المؤلفون: Dean, Sondra F., Whalen, Katie L., Spies, M. Ashley

المساهمون: National Institute of General Medical Sciences

المصدر: ACS Central Science ; volume 1, issue 7, page 364-373 ; ISSN 2374-7943 2374-7951

الاتاحة: http://dx.doi.org/10.1021/acscentsci.5b00211
https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5b00211

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12

Academic Journal

Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction

المؤلفون: Subramanyam, Shyamal, Jones, William T., Spies, Maria, Spies, M. Ashley

مصطلحات موضوعية: Genome Integrity, Repair and Replication

وصف الملف: text/html

Relation: http://nar.oxfordjournals.org/cgi/content/short/41/19/9020; http://dx.doi.org/10.1093/nar/gkt691

الاتاحة: http://nar.oxfordjournals.org/cgi/content/short/41/19/9020
https://doi.org/10.1093/nar/gkt691

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13

Academic Journal

Back Cover: In silico Optimization of a Fragment‐Based Hit Yields Biologically Active, High‐Efficiency Inhibitors for Glutamate Racemase (ChemMedChem 10/2013)

المؤلفون: Whalen, Katie L., Chau, Anthony C., Spies, M. Ashley

المصدر: ChemMedChem ; volume 8, issue 10, page 1720-1720 ; ISSN 1860-7179 1860-7187

الاتاحة: http://dx.doi.org/10.1002/cmdc.201390044
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcmdc.201390044
http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201390044/fullpdf

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14

Academic Journal

Flooding Enzymes: Quantifying the Contributions of Interstitial Water and Cavity Shape to Ligand Binding Using Extended Linear Response Free Energy Calculations

المؤلفون: Whalen, Katie L., Spies, M. Ashley

المصدر: Journal of Chemical Information and Modeling ; volume 53, issue 9, page 2349-2359 ; ISSN 1549-9596 1549-960X

الاتاحة: http://dx.doi.org/10.1021/ci400244x
https://pubs.acs.org/doi/pdf/10.1021/ci400244x

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15

Academic Journal

Biochemical Analysis of a β- d -Xylosidase and a Bifunctional Xylanase-Ferulic Acid Esterase from a Xylanolytic Gene Cluster in Prevotella ruminicola 23

المؤلفون: Dodd, Dylan, Kocherginskaya, Svetlana A., Spies, M. Ashley, Beery, Kyle E., Abbas, Charles A., Mackie, Roderick I., Cann, Isaac K. O.

المصدر: Journal of Bacteriology ; volume 191, issue 10, page 3328-3338 ; ISSN 0021-9193 1098-5530

الاتاحة: http://dx.doi.org/10.1128/jb.01628-08
https://journals.asm.org/doi/pdf/10.1128/JB.01628-08

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16

Academic Journal

Molecular Basis for the Selectivity and Specificity of Ligand Recognition by the Family 16 Carbohydrate-binding Modules from Thermoanaerobacterium polysaccharolyticum ManA

المؤلفون: Bae, Brian, Ohene-Adjei, Samuel, Kocherginskaya, Svetlana, Mackie, Roderick I., Spies, M. Ashley, Cann, Isaac K.O., Nair, Satish K.

المصدر: Journal of Biological Chemistry ; volume 283, issue 18, page 12415-12425 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1074/jbc.m706513200
https://api.elsevier.com/content/article/PII:S0021925820493445?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925820493445?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1074/jbc.M706513200

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17

Academic Journal

Functional Comparison of the Two Bacillus anthracis Glutamate Racemases

المؤلفون: Dodd, Dylan, Reese, Joseph G., Louer, Craig R., Ballard, Jimmy D., Spies, M. Ashley, Blanke, Steven R.

المصدر: Journal of Bacteriology ; volume 189, issue 14, page 5265-5275 ; ISSN 0021-9193 1098-5530

الاتاحة: http://dx.doi.org/10.1128/jb.00352-07
https://journals.asm.org/doi/pdf/10.1128/JB.00352-07

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18

Academic Journal

An Atomistic Understanding of Allosteric Inhibition of Glutamate Racemase: a Dampening of Native Activation Dynamics

المؤلفون: Witkin, Katie R., Vance, Nicholas R., Caldwell, Colleen, Li, Quinn, Yu, Liping, Spies, M. Ashley

المصدر: ChemMedChem ; volume 15, issue 4, page 376-384 ; ISSN 1860-7179 1860-7187

الاتاحة: http://dx.doi.org/10.1002/cmdc.201900642
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900642
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cmdc.201900642

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19

Book

Integrating Experimental and In Silico HTS in the Discovery of Inhibitors of Protein–Nucleic Acid Interactions

المؤلفون: Li, Quinn, Folly da Silva Constantino, Laura, Spies, M. Ashley

المصدر: Methods in Enzymology ; Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair ; page 243-273 ; ISSN 0076-6879 ; ISBN 9780128139790

الاتاحة: http://dx.doi.org/10.1016/bs.mie.2017.11.036
https://api.elsevier.com/content/article/PII:S0076687917303749?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0076687917303749?httpAccept=text/plain

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20

Academic Journal

Elucidating the Catalytic Power of Glutamate Racemase by Investigating a Series of Covalent Inhibitors

المؤلفون: Vance, Nicholas R., Witkin, Katie R., Rooney, Patrick W., Li, Yalan, Pope, Marshall, Spies, M. Ashley

المساهمون: National Institutes of Health

المصدر: ChemMedChem ; volume 13, issue 23, page 2514-2521 ; ISSN 1860-7179 1860-7187

الاتاحة: http://dx.doi.org/10.1002/cmdc.201800592
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcmdc.201800592
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201800592
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cmdc.201800592

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