المؤلفون: Walderik W. Zomerman, Sabine L.A. Plasschaert, Siobhan Conroy, Frank J. Scherpen, Tiny G.J. Meeuwsen-de Boer, Harm J. Lourens, Sergi Guerrero Llobet, Marlinde J. Smit, Lorian Slagter-Menkema, Annika Seitz, Corrie E.M. Gidding, Esther Hulleman, Pieter Wesseling, Lisethe Meijer, Leon C. van Kempen, Anke van den Berg, Daniël O. Warmerdam, Frank A.E. Kruyt, Floris Foijer, Marcel A.T.M. van Vugt, Wilfred F.A. den Dunnen, Eelco W. Hoving, Victor Guryev, Eveline S.J.M. de Bont, Sophia W.M. Bruggeman

المصدر: Cell Reports, Vol 22, Iss 12, Pp 3206-3216 (2018)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124718302997; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/29d5a08e9ade4e27a193d73891378371

المؤلفون: Walderik W. Zomerman, Sophia W.M. Bruggeman, Eduardo Sabino de Camargo Magalhães, Harm Jan Lourens, Frank J. G. Scherpen, Eveline S. J. M. de Bont, Tosca. E. I. Martini, Marlinde J. Smit, Shanna M. Hogeling, Tiny G. J. Meeuwsen-de Boer, Sabine L. A. Plasschaert, Geesina C. Rozema-Huizinga, Inna Armandari

المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL)

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports, 11(1):16077. Nature Publishing Group

مصطلحات موضوعية: MAPK/ERK pathway, Male, Neurogenesis, Science, Developmental neurogenesis, CREB, Adult neurogenesis, Article, Mice, Neural Stem Cells, Cerebellum, TELOMERASE, medicine, FORSKOLIN, Animals, Humans, TRANSCRIPTION, Cerebellar Neoplasms, Cyclic AMP Response Element-Binding Protein, PHOSPHORYLATION, Transcription factor, Cells, Cultured, Progenitor, Cancer, Medulloblastoma, Neurons, Multidisciplinary, biology, PROLIFERATION, Cell Differentiation, medicine.disease, ELEMENT-BINDING PROTEIN, CNS cancer, Mice, Inbred C57BL, GDF7, CELLS, Cancer research, biology.protein, Phosphorylation, Medicine, Female, CAMP, Signal Transduction, Transcription Factors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd34b901125eb57feb5a6b2d298848a
https://doaj.org/article/4b52aa87cc92410bae837f1ba12b32f3

المؤلفون: Todd A. Alonzo, Sophia W.M. Bruggeman, Richard Aplenc, Anneke D. van Dijk, Steven M. Kornblau, E. Anders Kolb, Fieke W Hoff, Eveline S. J. M. de Bont, Amanda R. Leonti, Robert B. Gerbing, Peter P. Ruvolo, Soheil Meshinchi, Yihua Qiu, Alan S. Gamis, Gaye Jenkins, Terzah M. Horton

المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL)

المصدر: Blood
Blood, 137(8), 1050-1060. AMER SOC HEMATOLOGY

مصطلحات موضوعية: Male, Daunorubicin, medicine.medical_treatment, Immunology, Antineoplastic Agents, Biochemistry, Bortezomib, Heat Shock Transcription Factors, medicine, Humans, Point Mutation, HSF1, Child, Etoposide, Chemotherapy, Myeloid Neoplasia, business.industry, fungi, Infant, Cell Biology, Hematology, Prognosis, Chemotherapy regimen, Leukemia, Myeloid, Acute, Drug Resistance, Neoplasm, Child, Preschool, Cytarabine, Proteasome inhibitor, Cancer research, Female, business, Transcriptome, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a56397997e7c87ccfd8c04ca130809
https://research.rug.nl/en/publications/dc7c449f-09a3-48ed-b462-dc3b4e8ebc8a

المؤلفون: Jonas Seiler, Marin T Mondria, Irena Bockaj, Marcel A. T. M. van Vugt, Bjorn Bakker, Diana C.J. Spierings, Femke Ringnalda, Saskia L Meuleman, Mathilde J.C. Broekhuis, Ulrich Schüller, Floris Foijer, Hans Clevers, Colin Stok, Tosca. E. I. Martini, Eduardo Sabino de Camargo Magalhães, Hilda van den Bos, Yannick P Kok, Tiny G. J. Meeuwsen-de Boer, Inna Armandari, René Wardenaar, Petra L. Bakker, Sophia W.M. Bruggeman

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Stem Cell Aging Leukemia and Lymphoma (SALL), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Obstetrics and gynaecology

المصدر: PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics, 17(11). Public Library of Science
PLoS genetics, 17(11):1009868. PUBLIC LIBRARY SCIENCE
PLoS Genetics, Vol 17, Iss 11, p e1009868 (2021)
Bočkaj, I, Martini, T E I, de Camargo Magalhães, E S, Bakker, P L, Meeuwsen-de Boer, T G J, Armandari, I, Meuleman, S L, Mondria, M T, Stok, C, Kok, Y P, Bakker, B, Wardenaar, R, Seiler, J, Broekhuis, M J C, van den Bos, H, Spierings, D C J, Ringnalda, F C A, Clevers, H, Schüller, U, van Vugt, M A T M, Foijer, F & Bruggeman, S W M 2021, ' The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma ', PLoS Genetics, vol. 17, no. 11, e1009868, pp. e1009868 . https://doi.org/10.1371/journal.pgen.1009868
PLoS Genetics, 17(11):e1009868. Public Library of Science
PLoS Genetics

مصطلحات موضوعية: Genome instability, CHROMATIN, Cancer Research, Mutant, QH426-470, Biochemistry, Pediatrics, Histones, Antibiotics, Medicine and Health Sciences, Cell Cycle and Cell Division, Child, Neurological Tumors, Genetics (clinical), CHAPERONE, Brain Neoplasms, Chromosome Biology, Antimicrobials, HIGH-GRADE, Drugs, Glioma, Chromatin, Cell biology, Gene Expression Regulation, Neoplastic, Nucleic acids, Histone, Oncology, Neurology, Cell Processes, Doxycycline, Cellular Structures and Organelles, HISTONE H3.3, CHROMOSOME SEGREGATION, Research Article, DNA Replication, DNA damage, INTRINSIC PONTINE GLIOMAS, Mitosis, Biology, Microbiology, Genomic Instability, MCM PROTEINS, COMMON FRAGILE SITES, Antimalarials, Malignant Tumors, Microbial Control, Nuclear Bodies, DNA-binding proteins, medicine, Genetics, Humans, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Pharmacology, Cell Nucleus, Biology and life sciences, HUMAN-CELLS, DNA replication, Proteins, Cancers and Neoplasms, DNA, Cell Biology, medicine.disease, DNA-DAMAGE, biology.protein

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d157360aabb1f0585911942661e0904
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604337/?tool=EBI

المؤلفون: Marlinde J. Smit, Inna Armandari, Irena Bockaj, Tosca E.I. Martini, Walderik W. Zomerman, Zillah Siragna, Tiny G.J. Meeuwsen, Frank J.G. Scherpen, Mirthe H. Schoots, Martha Ritsema, Wilfred F.A. den Dunnen, Eelco W. Hoving, Judith T.M.L. Paridaen, Gerald de Haan, Victor Guryev, Sophia W.M. Bruggeman

مصطلحات موضوعية: Medulloblastoma, animal structures, biology, Cilium, medicine.disease, Embryonic stem cell, Hedgehog signaling pathway, Transcriptome, biology.protein, Cancer research, medicine, Sonic hedgehog, Smoothened, Progenitor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::535a36301885b2630f59fe6d1ed84097
https://doi.org/10.1101/2021.01.22.427790

المؤلفون: Anneke D. van Dijk, Fieke W Hoff, Terzah M. Horton, Steven M. Kornblau, Yihua Qiu, Sophia W.M. Bruggeman, Eveline S. J. M. de Bont

المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL)

المصدر: Blood, 136. AMER SOC HEMATOLOGY

مصطلحات موضوعية: Mutation, Myeloid, Immunology, Myeloid leukemia, Cell Biology, Hematology, Methylation, Biology, medicine.disease_cause, Biochemistry, medicine.anatomical_structure, Histone, Histone methylation, DNA methylation, Cancer research, medicine, biology.protein, Epigenetics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45502e92253532119b040e96e075a835
https://research.rug.nl/en/publications/9c46b344-e146-497b-b774-6e8ab1e127ca

المؤلفون: Steven M. Kornblau, Yihua Qiu, Terzah M. Horton, Eveline S. J. M. de Bont, Elias Jabbour, Sophia W.M. Bruggeman, Anneke D. van Dijk, Fieke W Hoff

المصدر: Clinical Lymphoma, Myeloma & Leukemia

مصطلحات موضوعية: RPPA, Oncology, Cancer Research, medicine.medical_specialty, IDH1, Context (language use), Submitted Abstracts, acute lymphoblastic leukemia, acute myeloid leukemia, proteomics, AML, Internal medicine, medicine, Acute leukemia, business.industry, Genetic heterogeneity, H3K27Me3, Reverse phase protein lysate microarray, Cancer, Myeloid leukemia, Hematology, medicine.disease, medicine.anatomical_structure, Bone marrow, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ec9aacd51dd877d8dc35a1ea5a8a4b
https://doi.org/10.1016/s2152-2650(20)30761-8

المؤلفون: Anders E. Kolb, Todd A. Alonzo, Steven M. Kornblau, Richard Aplenc, Peter P. Ruvolo, Fieke W Hoff, Sophia W.M. Bruggeman, Eveline S. J. M. de Bont, Anneke D. van Dijk, Yihua Qiu, Terzah M. Horton, Robert B. Gerbing, Alan S. Gamis

المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL)

المصدر: Blood, 134. AMER SOC HEMATOLOGY

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Bortezomib, business.industry, Venetoclax, Daunorubicin, Immunology, Phases of clinical research, Cell Biology, Hematology, medicine.disease, Biochemistry, Chemotherapy regimen, Leukemia, chemistry.chemical_compound, chemistry, Internal medicine, medicine, Cytarabine, business, Etoposide, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f464c8a18efd61bbd5608892c0b4f8b
https://research.rug.nl/en/publications/b633c36a-c056-43aa-9f76-2dde7e698a15

المؤلفون: E. Anders Kolb, Amina A. Qutub, Richard Aplenc, Steven M. Kornblau, Sophia W.M. Bruggeman, Wendy Hu, Yihua Qiu, Eveline S. J. M. de Bont, Todd A. Alonzo, Fieke W Hoff, Alan S. Gamis, Terzah M. Horton

المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL)

المصدر: Blood, 132(Suppl.1). AMER SOC HEMATOLOGY

مصطلحات موضوعية: business.industry, Daunorubicin, Bortezomib, fungi, Immunology, Wild type, Cell Biology, Hematology, Biochemistry, CEBPA, Cancer research, Proteasome inhibitor, medicine, Cytarabine, business, Survival analysis, Etoposide, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f137213307ec5e1464f01df4d87cbc4
https://doi.org/10.1182/blood-2018-99-110730

المؤلفون: Wilfred F. A. den Dunnen, Irena Bockaj, Judith T.M.L. Paridaen, Victor Guryev, Eelco W. Hoving, Gerald de Haan, Zillah Siragna, Mirthe H. Schoots, Tosca. E. I. Martini, Tiny G. J. Meeuwsen-de Boer, Frank J. G. Scherpen, Marlinde J. Smit, Martha Ritsema, Sophia W.M. Bruggeman, Inna Armandari, Walderik W. Zomerman

المصدر: Neuro-Oncology. 21:ii104-ii104

مصطلحات موضوعية: Medulloblastoma, Cancer Research, Mutation, animal structures, Cilium, Cell of origin, Cancer, Erinaceidae, Biology, medicine.disease, medicine.disease_cause, biology.organism_classification, Hedgehog signaling pathway, Oncology, embryonic structures, medicine, Cancer research, Neurology (clinical), Signal transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710172dc6d539dee463bd2156d8db0d7
https://doi.org/10.1093/neuonc/noz036.167

المؤلفون: Gaetano Gargiulo, Matteo Cesaroni, Cesare Lancini, Sophia W.M. Bruggeman, Michela Serresi, Danielle Hulsman, Maarten van Lohuizen, Nienke A. de Vries

المصدر: Cancer Cell. 23(5):660-676

مصطلحات موضوعية: Cancer Research, Biology, Bone morphogenetic protein, Mice, Neural Stem Cells, RNA interference, Transforming Growth Factor beta, Proto-Oncogene Proteins, Animals, Homeostasis, Humans, Cell Nucleus, Polycomb Repressive Complex 1, Activating Transcription Factor 3, Endoplasmic reticulum, Cell Biology, Endoplasmic Reticulum Stress, Chromatin, AP-1 transcription factor, Oncology, BMI1, Bone Morphogenetic Proteins, Unfolded protein response, Cancer research, Neoplastic Stem Cells, RNA Interference, Stem cell, Glioblastoma, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49483174d224b54b1abd10ba2f338f58

المؤلفون: Pieter Wesseling, Sophia W.M. Bruggeman, Annika Seitz, Tiny G. J. Meeuwsen-de Boer, Wilfred F. A. den Dunnen, Walderik W. Zomerman, Anke van den Berg, Frank J. G. Scherpen, Eelco W. Hoving, Frank A.E. Kruyt, Esther Hulleman, Marcel A. T. M. van Vugt, Harm Jan Lourens, Eveline S. J. M. de Bont, Sergi Guerrero Llobet, Daniël O. Warmerdam, Lorian Slagter-Menkema, Marlinde J. Smit, Siobhan Conroy, Victor Guryev, Lisethe Meijer, Léon C van Kempen, Corrie Gidding, Floris Foijer, Sabine L. A. Plasschaert

المصدر: Neuro-Oncology. 20:i136-i136

مصطلحات موضوعية: chemistry.chemical_classification, Medulloblastoma, Cancer Research, biology, Functional analysis, DNA damage, Peptide, medicine.disease, Abstracts, Oncology, chemistry, Apoptosis, biology.protein, medicine, Cancer research, Protein biosynthesis, Phosphorylation, Neurology (clinical), Sonic hedgehog

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3be40bc42980d3aa62be344984ecbd
https://doi.org/10.1093/neuonc/noy059.481

المؤلفون: Maarten van Lohuizen, Sophia W.M. Bruggeman

المصدر: Cell Cycle. 5:1281-1285

مصطلحات موضوعية: Senescence, Kinase, Stem Cells, Cell Cycle, Cell Biology, Cell cycle, Biology, Embryonic stem cell, Cell biology, BMI1, Animals, Humans, Progenitor cell, Stem cell, Molecular Biology, Cellular Senescence, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor Proteins, Protein Binding, Developmental Biology, Adult stem cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418efd3b65adcda01bc8771561ada299
https://doi.org/10.4161/cc.5.12.2806

المؤلفون: Maarten van Lohuizen, Jacqueline J.L. Jacobs, Sophia W.M. Bruggeman, Yvan Arsenijevic, Petra van der Stoop, Ellen Tanger, Danielle Hulsman, Silvia Marino, Merel E. Valk-Lingbeek, Karin Kieboom, Carly Leung

المصدر: Genes & Development. 19:1438-1443

مصطلحات موضوعية: Heterozygote, Lymphoid Tissue, Cellular differentiation, macromolecular substances, Biology, Research Communications, Mice, Cerebellum, Proto-Oncogene Proteins, Tumor Suppressor Protein p14ARF, Genetics, Animals, RNA, Messenger, Progenitor cell, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Cell Proliferation, Mice, Knockout, Neurons, Polycomb Repressive Complex 1, Cell growth, Genes, p16, Multipotent Stem Cells, Nuclear Proteins, Cell Differentiation, Neural stem cell, body regions, Mice, Inbred C57BL, Repressor Proteins, BMI1, Multipotent Stem Cell, Cancer research, Stem cell, Cell aging, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62514df7f026dd4462d7ae75e06c786
https://doi.org/10.1101/gad.1299305

المؤلفون: Sophia W.M. Bruggeman, Maarten van Lohuizen, Merel E. Valk-Lingbeek

المصدر: Cell. 118(4):409-418

مصطلحات موضوعية: Genetics, BMI1, Cancer stem cell, Biochemistry, Genetics and Molecular Biology(all), Cellular differentiation, Polycomb-group proteins, Stem cell, Biology, Embryonic stem cell, General Biochemistry, Genetics and Molecular Biology, Adult stem cell, Chromatin, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249c8aad26d08e5053ad0f44910b11fa

المؤلفون: Wilfred F. A. den Dunnen, Frank J. G. Scherpen, Sophia W.M. Bruggeman, Geesina C. Huizinga, Walderik W. Zomerman, Eelco W. Hoving, Eveline S. J. M. de Bont, Sabine L. A. Plasschaert, Harm Jan Lourens

المصدر: Cancer Research. 77:5826-5826

مصطلحات موضوعية: 0301 basic medicine, Medulloblastoma, Cancer Research, Gene knockdown, 030102 biochemistry & molecular biology, biology, Recurrent Medulloblastoma, medicine.disease, CREB, Molecular biology, 03 medical and health sciences, Oncology, medicine, biology.protein, Cancer research, Phosphorylation, Viability assay, CREB1, EP300

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3dd6915fa484710771559e7eb9a81122
https://doi.org/10.1158/1538-7445.am2017-5826

المؤلفون: Floris Foijer, Irena Bockaj, Sophia W.M. Bruggeman

المصدر: BioEssays. 39:1700084

مصطلحات موضوعية: 0301 basic medicine, Genetics, Chromosome segregation, 03 medical and health sciences, 030104 developmental biology, MEDLINE, Biology, Chromosome separation, General Biochemistry, Genetics and Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::db79779b85d528ad65a80cf90db3cdc2
https://doi.org/10.1002/bies.201700084

المؤلفون: Tessa Buckle, Olaf van Tellingen, Bob C. Hamans, Anton Berns, Maarten van Lohuizen, John Zevenhoven, Sophia W.M. Bruggeman, Danielle Hulsman, Jos H. Beijnen, Hilda de Vries, Nienke A. de Vries, William P.J. Leenders

المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL)

المصدر: Clinical Cancer Research, 16, 13, pp. 3431-41
Clinical Cancer Research, 16(13), 3431-3441. AMER ASSOC CANCER RESEARCH
Clinical Cancer Research, 16, 3431-41

مصطلحات موضوعية: Genetically modified mouse, Cancer Research, Pathology, medicine.medical_specialty, Transgene, Genetic Vectors, Mice, Transgenic, ASTROCYTE-SPECIFIC EXPRESSION, RAT-BRAIN, Transfection, ACTIVATION, Proto-Oncogene Proteins p21(ras), Mice, Translational research [ONCOL 3], Proto-Oncogene Proteins, Glioma, medicine, Animals, Bioluminescence imaging, PTEN, TUMOR-SUPPRESSOR, IN-VIVO, LENTIVIRAL VECTORS, Temozolomide, biology, ADP-Ribosylation Factors, Brain Neoplasms, business.industry, HUMAN GLIOBLASTOMA, Genes, p16, Lentivirus, PTEN Phosphohydrolase, Cancer, Genes, p53, medicine.disease, NERVOUS-SYSTEM, MALIGNANT GLIOMAS, Disease Models, Animal, Oncology, ras Proteins, Cancer research, biology.protein, Stem cell, business, STEM-CELLS, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203013ed529fe287a3677892bc3a026d
https://hdl.handle.net/2066/89506

المؤلفون: Maarten van Lohuizen, Bas van Steensel, Lodewyk F. A. Wessels, Wouter Meuleman, Irina Solovei, Stefan Gräf, Ron M. Kerkhoven, Sophia W.M. Bruggeman, Marcel J. T. Reinders, Paul Flicek, Wim Brugman, Ludo Pagie, Daan Peric-Hupkes

المصدر: Molecular cell. 38(4)

مصطلحات موضوعية: Regulation of gene expression, Genetics, Neurons, Genome, Nuclear Lamina, Cellular differentiation, Cell Differentiation, Cell Biology, Biology, Embryonic stem cell, Cell biology, Mice, Transcription (biology), Astrocytes, Gene expression, Nuclear lamina, Animals, Humans, Cell Lineage, Drosophila, Molecular Biology, Gene, Chromosome Positioning, Embryonic Stem Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fef1f8b2f304d3d180bc9f4f643add
https://pubmed.ncbi.nlm.nih.gov/20569682

المؤلفون: Maarten van Lohuizen, Sophia W.M. Bruggeman, Danielle Hulsman

المصدر: Biochimica et biophysica acta. 1790(5)

مصطلحات موضوعية: Integrins, Integrin, Cell, Biophysics, Receptors, Cell Surface, macromolecular substances, Biology, medicine.disease_cause, Biochemistry, Extracellular matrix, Mice, Proto-Oncogene Proteins, medicine, Cell Adhesion, Animals, Cell adhesion, Molecular Biology, Cyclin-Dependent Kinase Inhibitor p16, Regulation of gene expression, Neurons, Polycomb Repressive Complex 1, Stem Cells, Nuclear Proteins, Neural stem cell, Cell biology, Extracellular Matrix, Repressor Proteins, medicine.anatomical_structure, Gene Expression Regulation, BMI1, biology.protein, Collagen, Carcinogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfca4f017f5fc2725dd3d7bce8623a9
https://pubmed.ncbi.nlm.nih.gov/19298843