المؤلفون: Lu Tang, Hua Tian, Qi Min, Huili You, Mengshuang Yin, Liqiong Yang, Yueshui Zhao, Xu Wu, Mingxing Li, Fukuan Du, Yu Chen, Shuai Deng, Xiaobing Li, Meijuan Chen, Li Gu, Yuhong Sun, Zhangang Xiao, Wanping Li, Jing Shen

المصدر: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-35 (2024)

مصطلحات موضوعية: RNA modification, Cancer drug resistance, Small molecule modulators, m6A, m5C, m7G, Medicine, Cytology, QH573-671

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1478-811X

URL الوصول: https://doaj.org/article/bf3e86d37ca64ad1ae63b32316260502

المؤلفون: Guotai Feng, Yongya Wu, Yuan Hu, Wen Shuai, Xiao Yang, Yong Li, Liang Ouyang, Guan Wang

المصدر: Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-45 (2024)

مصطلحات موضوعية: N6-methyladenosine, Cancer therapy, Mechanism, Drug targets, Small molecule modulators, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1756-8722

URL الوصول: https://doaj.org/article/1ecab64517f24c6189cf2de766499dc0

المؤلفون: Sarfaraj Niazi, C. P. Kavana, H. K. Aishwarya, Chandan Dharmashekar, Anisha Jain, Tanveer A. Wani, Chandan Shivamallu, Madhusudan N. Purohit, Shiva Prasad Kollur

المصدر: Frontiers in Chemistry, Vol 12 (2024)

مصطلحات موضوعية: leukemia, MDM2, p53, cancer therapy, drug discovery, small molecule modulators, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fchem.2024.1366370/full; https://doaj.org/toc/2296-2646

URL الوصول: https://doaj.org/article/c2f25805b5ad445c8b6aa5f65cb2137a

المؤلفون: Yazhen Wang, Yang Zhou, Lianyi Yang, Lei Lei, Bin He, Jun Cao, Huile Gao

المصدر: Advanced Science, Vol 11, Iss 1, Pp n/a-n/a (2024)

مصطلحات موضوعية: cancer therapies, PD‐L1, regulatory mechanisms, small‐molecule modulators, spatial heterogeneity, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2198-3844

URL الوصول: https://doaj.org/article/a79a0c57761449dba37540cdf91eb938

المؤلفون: Jinny Claire Lee, Ryan J. Shirey, Lewis D. Turner, Hyeri Park, Luke L. Lairson, Kim D. Janda

المصدر: Results in Chemistry, Vol 7, Iss , Pp 101349- (2024)

مصطلحات موضوعية: High-throughput screen, PLD3, PLD4, Small molecule modulators, Immune regulators, Exonuclease, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211715624000456; https://doaj.org/toc/2211-7156

URL الوصول: https://doaj.org/article/cc3b7d81355b40c5bcdbda876efff1c1

المؤلفون: Ryszard Pluta

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: cancer, autophagy, therapy, small-molecule modulators, new strategies, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1145255/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/535247532e954a7ab9aab9a5bfd968f3

المؤلفون: David Figueredo Picón, Rachid Skouta

المصدر: Cancers; Volume 15; Issue 14; Pages: 3731

مصطلحات موضوعية: squalene synthase (SQS), cholesterol, ferroptosis, lipid peroxidation, small-molecule modulators of SQS

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/cancers15143731

الاتاحة: https://doi.org/10.3390/cancers15143731

المؤلفون: Chunyong Ding, Zilan Song, Ancheng Shen, Tingting Chen, Ao Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2272-2298 (2020)

مصطلحات موضوعية: Immunotherapy, Anti-tumor, cGAS, STING, TBK1, Small molecule modulators, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383519316946; https://doaj.org/toc/2211-3835

URL الوصول: https://doaj.org/article/584c536a461c4f82aa0ae7ac4cded3ab

المؤلفون: Simon Miller, Tsuyoshi Hirota

المصدر: Frontiers in Physiology, Vol 13 (2022)

مصطلحات موضوعية: cryptochromes, circadian clock, X-ray crystallography, small-molecule modulators, isoform selectivity, Physiology, QP1-981

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2022.837280/full; https://doaj.org/toc/1664-042X

URL الوصول: https://doaj.org/article/28c01b3dd6a74c058185a7c9b3eed859

المؤلفون: Sheng-Nan Wu, Chao-Liang Wu, Hsin-Yen Cho, Chi-Wu Chiang

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 9453

مصطلحات موضوعية: voltage-dependent hysteresis, hyperpolarization-activated cation current, erg -mediated K + current, M-type K + current, L-type Ca 2+ current, persistent Na + current, small-molecule modulators

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Biology; https://dx.doi.org/10.3390/ijms23169453

الاتاحة: https://doi.org/10.3390/ijms23169453

المؤلفون: Ribeiro, Rodrigo Filipe Nunes

المساهمون: Rei, Ana Patrícia Freitas, Maia, João Manuel Baliza Santiago, Silva, Maria Manuel da Cruz

مصطلحات موضوعية: Ritmo Circadiano, Cronoterapia, Pequenas Moléculas Moduladoras, Doenças Associadas ao Ritmo Circadiano, Ensaios Clínicos, Circadian Rhythm, Chronotherapy, Small Molecule Modulators, Clock-related Diseases, Clinical Trials

الاتاحة: http://hdl.handle.net/10316/88258

المؤلفون: Shenzhen Huang, Xinwei Jiao, Dingli Lu, Xiaoting Pei, Di Qi, Zhijie Li

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1267-1286 (2020)

مصطلحات موضوعية: circadian rhythm, clock proteins, post-modification targets, small-molecule modulators, circadian rhythm-related disease, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/7fe9d9dc0b454800b2b38969eb615cb8

المؤلفون: Viviano, Monica, Cipriano, Alessandra, Fabbrizi, Emanuele, Feoli, Alessandra, Castellano, Sabrina, Sbardella, Gianluca, Mai, Antonello, Milite, Ciro, Rotili, Dante

المساهمون: Viviano, Monica, Cipriano, Alessandra, Fabbrizi, Emanuele, Feoli, Alessandra, Castellano, Sabrina, Sbardella, Gianluca, Mai, Antonello, Milite, Ciro, Rotili, Dante

مصطلحات موضوعية: Epigenetic, bromodomain, BD1, BET, cancer selective inhibition, small molecule modulators

Relation: volume:34; issue:7; firstpage:529; lastpage:545; numberofpages:17; journal:EXPERT OPINION ON THERAPEUTIC PATENTS; https://hdl.handle.net/11573/1729427

الاتاحة: https://hdl.handle.net/11573/1729427
https://doi.org/10.1080/13543776.2024.2327300

المؤلفون: Xie J, Zhu XY, Liu LM, Meng ZQ

المصدر: Cancer Management and Research, Vol Volume 10, Pp 153-166 (2018)

مصطلحات موضوعية: solute carrier, digestive system neoplasms, carcinogenesis, tumor progression, chemoresistance, small molecule modulators, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.dovepress.com/solute-carrier-transporters-potential-targets-for-digestive-system-neo-peer-reviewed-article-CMAR; https://doaj.org/toc/1179-1322

URL الوصول: https://doaj.org/article/e30d61104a8446a7a6858a1624a8524c

المؤلفون: Lemke, Jana, Gollasch, Maik, Tsvetkov, Dmitry, Schulig, Lukas

المصدر: Expert Opin Drug Discov ; ISSN:1746-045X ; Volume:20 ; Issue:1

مصطلحات موضوعية: K(V)7, KCNQ, drug discovery, hypertension, potassium channels, small molecule modulators, structure–activity relationship

Relation: https://doi.org/10.1080/17460441.2024.2438226; https://pubmed.ncbi.nlm.nih.gov/39627683

الاتاحة: https://doi.org/10.1080/17460441.2024.2438226
https://pubmed.ncbi.nlm.nih.gov/39627683

المؤلفون: Kolarski, Dusan, Sugiyama, Akiko, Breton, Ghislain, Rakers, Christin, Ono, Daisuke, Schulte, Albert, Tama, Florence, Itami, Kenichiro, Szymanski, Wiktor, Hirota, Tsuyoshi, Feringa, Ben L.

المصدر: Kolarski , D , Sugiyama , A , Breton , G , Rakers , C , Ono , D , Schulte , A , Tama , F , Itami , K , Szymanski , W , Hirota , T & Feringa , B L 2019 , ' Controlling the Circadian Clock with High Temporal Resolution through Photodosing ' , Journal of the American Chemical Society , vol. 141 , no. 40 , pp. 15784-15791 . https://doi.org/10.1021/jacs.9b05445

مصطلحات موضوعية: PHOTOREMOVABLE PROTECTING GROUPS, SMALL-MOLECULE MODULATORS, PHOTOPROTECTING GROUPS, KINASE INHIBITORS, PHOSPHORYLATION, IDENTIFICATION, CRYPTOCHROME, ARCHITECTURE, MUTATION, BEHAVIOR

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/c8af199f-f0bc-4541-bb65-ea1821cd3e28
https://research.rug.nl/en/publications/c8af199f-f0bc-4541-bb65-ea1821cd3e28
https://doi.org/10.1021/jacs.9b05445
https://pure.rug.nl/ws/files/102025961/jacs.9b05445.pdf

المؤلفون: Jack T. Rogers, Ning Xia, Angela Wong, Rachit Bakshi, Catherine M. Cahill

المصدر: International Journal of Molecular Sciences; Volume 20; Issue 4; Pages: 994

مصطلحات موضوعية: translational control, 5’untranslated regions (5’UTRs), Lead/manganese, neurotoxicity, iron, small molecule modulators, APP, ferritin

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Biology; https://dx.doi.org/10.3390/ijms20040994

الاتاحة: https://doi.org/10.3390/ijms20040994

المؤلفون: Hui-Hsien Lin, Michelle E. Farkas

المصدر: Frontiers in Endocrinology, Vol 9 (2018)

مصطلحات موضوعية: altered circadian rhythms, shift work, breast cancer, molecular mechanism, hormone pathways, small molecule modulators, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fendo.2018.00219/full; https://doaj.org/toc/1664-2392

URL الوصول: https://doaj.org/article/dd8142a0f9be4a528aa7725af5cc61f6

المؤلفون: Hartman, Alwin M., Hirsch, Anna K. H.

المصدر: Hartman , A M & Hirsch , A K H 2017 , ' Molecular insight into specific 14-3-3 modulators : Inhibitors and stabilisers of protein-protein interactions of 14-3-3 ' , European Journal of Medicinal Chemistry , vol. 136 , j.ejmech.2017.04.058 , pp. 573-584 . https://doi.org/10.1016/j.ejmech.2017.04.058

مصطلحات موضوعية: 14-3-3, Protein-protein interactions, Small-molecule modulators, Inhibitors, Stabilisers, Molecular level, STRUCTURAL BASIS, BINDING, IDENTIFICATION, TARGET, FAMILY, RAS, PHOSPHORYLATION, ACTIVATION, INTERFACE, DISCOVERY

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/7c8e05f2-c471-4e2f-9173-eefd11e27f24
https://research.rug.nl/en/publications/7c8e05f2-c471-4e2f-9173-eefd11e27f24
https://doi.org/10.1016/j.ejmech.2017.04.058
https://pure.rug.nl/ws/files/47650694/Molecular_insight_into_specific_14_3_3_modulators.pdf

المؤلفون: Tingting Chen, Ancheng Shen, Ao Zhang, Chunyong Ding, Zilan Song

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2272-2298 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PD-L1, programmed death ligand 1, TBK1, medicine.medical_treatment, ICI, immune checkpoint inhibitor, DC50, concentration for 50% degradation, Review, ACMA, 9-amino-6-chloro-2-methoxyacridine, PD-1, programmed death receptor 1, ULD, ubiquitin-like domain, Anti-tumor, ABZI, amidobenzimidazole, 0302 clinical medicine, GMP, guanosine monophosphate, LBD, ligand-binding domain, GTP, guanosine triphosphate, PRRs, pattern recognition receptors, Interferon, cAIMP, cyclic adenosine-inosine monophosphate, Medicine, CMA, 10-carboxymethyl-9-acridanone, General Pharmacology, Toxicology and Pharmaceutics, IKK, IκB kinase, ISG, interferon stimulated gene, MinEC5×, minimum effective concentration for inducing 5-fold luciferase activity, 0303 health sciences, KD, kinase domain, dsDNA, double-stranded DNA, MG, Mangostin, ITC, isothermal titration calorimetry, Immunogenicity, PBMCs, peripheral-blood mononuclear cells, MDCK, Madin–Darby canine kidney, PROTACs, proteolysis targeting chimeras, FAA, flavone-8-acetic acid, CTD, C-terminal domain, DMXAA, 5,6-dimethylxanthenone-4-acetic acid, DSDP, dispiro diketopiperzine, STAT, signal transducer and activator of transcription, medicine.anatomical_structure, 030220 oncology & carcinogenesis, CDN, cyclic dinucleotide, QC, quinacrine, FP, fluorescence polarization, PDK1, 3-phosphoinositide-dependent protein kinase 1, Immunotherapy, Signal transduction, DCs, dendritic cells, CDA, cyclic diadenosine monophosphate (c-di-AMP), medicine.drug, Ntase, nucleotidyl transferase, ATP, adenosine triphosphate, CDG, cyclic diguanosine monophosphate (c-di-GMP), T cell, SDD, scaffold and dimerization domain, NF-κB, nuclear factor-κB, STING, stimulator of interferon genes, TNFRSF, tumor necrosis factor receptor superfamily, EM, cryo-electron microscopy, ER, endoplasmic reticulum, 03 medical and health sciences, MLK, mixed lineage kinase, Immune system, CBD, cyclic dinucleotide-binding domain, THIQCs, tetrahydroisoquinolone acetic acids, SAR, structure–activity relationship, HCQ, hydrochloroquine, ENPP1, ecto-nucleotide pyrophosphatase/phosphodiesterase, HTS, high throughput screening, 030304 developmental biology, MI, maximum induction, CXCL, chemokine (C-X-C motif) ligand, Innate immune system, PDE, phosphodiesterases, IO, immune-oncology, business.industry, IRF3, interferon regulatory factor 3, i.t., intratumoral, CTT, C-terminal tail, lcsh:RM1-950, BNBC, 6-bromo-N-(naphthalen-1-yl)benzo[d][1,3]dioxole-5-carboxamide, Chimeric antigen receptor, PPi, pyrophosphoric acid, Small molecule modulators, FDA, U.S. Food and Drug Administration, VHL, von Hippel–Lindau, lcsh:Therapeutics. Pharmacology, AMP, adenosine monophosphate, TBK1, TANK-binding kinase 1, Cancer research, cGAMP, cyclic guanosine monophosphate-adenosine monophosphate, business, cGAS, cyclic guanosine monophosphate-adenosine monophosphate synthase, CTLA-4, cytotoxic T lymphocyte associated protein 4, cGAS, STING

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c604607610f05b2d37da5b2cce00382
http://www.sciencedirect.com/science/article/pii/S2211383519316946