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1Academic Journal
المؤلفون: Toshiyuki Nishikido
المصدر: Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-12 (2023)
مصطلحات موضوعية: Inclisiran, Lipid-lowering therapies, Low-density lipoprotein cholesterol, Proprotein convertase subtilisin/kexin type 9, Small interfering ribonucleic acid, Individual variability, Diseases of the circulatory (Cardiovascular) system, RC666-701
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1475-2840
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2Academic Journal
المؤلفون: González-Duarte, Alejandra, Berk, John L., Quan, Dianna, Mauermann, Michelle L., Schmidt, Hartmut H., Polydefkis, Michael, Waddington-Cruz, Márcia, Ueda, Mitsuharu, Conceição, Isabel M., Kristen, Arnt V., Coelho, Teresa, Cauquil, Cécile A., Tard, Céline, Merkel, Madeline, Aldinc, Emre, Chen, Jihong, Sweetser, Marianne T., Wang, Jing Jing, Adams, David
مصطلحات موضوعية: Autonomic nervous system diseases, Hereditary transthyretin-mediated amyloidosis, Patisiran, Polyneuropathy, Small interfering ribonucleic acid (siRNA), Transthyretin
Relation: https://link.springer.com/article/10.1007/s00415-019-09602-8; González-Duarte A, Berk JL, Quan D, et al. Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis. J Neurol. 2020;267(3):703-712. doi:10.1007/s00415-019-09602-8; http://hdl.handle.net/10400.16/2666
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3Academic Journal
المصدر: Journal of Indian Society of Periodontology, Vol 17, Iss 4, Pp 417-422 (2013)
مصطلحات موضوعية: Gene knock down, periodontal regeneration, ribonucleic acid interference, small interfering ribonucleic acid, Dentistry, RK1-715
وصف الملف: electronic resource
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4
المؤلفون: Amy Simon, Jae B. Kim, Yuanxin Xu, Gabriel J. Robbie, Bahru Habtemarium, Sagar Agarwal
المصدر: JIMD Reports
مصطلحات موضوعية: Research Report, givosiran, acute hepatic porphyria (AHP), Endocrinology, Diabetes and Metabolism, Urinary system, Pharmacology, Biochemistry, Genetics and Molecular Biology (miscellaneous), small interfering ribonucleic acid (siRNA), upper limit of normal (ULN), chemistry.chemical_compound, porphobilinogen (PBG), Liquid chromatography–mass spectrometry, Porphobilinogen, Mole, Internal Medicine, In patient, Heme, ALN‐AS1, δ‐aminolevulinic acid (ALA), chemistry.chemical_classification, Research Reports, δ-aminolevulinic acid, Enzyme, chemistry, acute intermittent porphyria (AIP), aminolevulinate synthase 1 (ALAS1)
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5
المؤلفون: Yitao Huang, Shahid M Nimjee, Go Urabe, Debra G Wheeler, David J. Dornbos, Bowen Wang, Allyson Huttinger, Guojun Chen, Mengxue Zhang, Lian-Wang Guo, K. Craig Kent, Shaoqin Gong
المصدر: JACC: Basic to Translational Science
مصطلحات موضوعية: 0301 basic medicine, STAT3, signal transducer and activator of transcription 3, Cell, SMC, smooth muscle cell, DMSO, dimethyl sulfoxide, 030204 cardiovascular system & hematology, ATF, activating transcription factor, PDGF, platelet-derived growth factor, PRECLINICAL RESEARCH, 0302 clinical medicine, siRNA, small interfering ribonucleic acid, Restenosis, PDGF-BB, platelet-derived growth factor with 2 B subunits, I/M, intima to media, GFP, green fluorescent protein, Neointimal hyperplasia, TNF, tumor necrosis factor, Ad, adenovirus, Hyperplasia, Thrombosis, endothelial cells, smooth muscle cells, 3. Good health, Endothelial stem cell, IRE1, inositol-requiring kinase 1, medicine.anatomical_structure, SMA, smooth muscle actin, Cardiology and Cardiovascular Medicine, PERK, endocrine system, Thrombogenicity, IEL, internal elastic lamina, CHOP, CCAAT-enhancer-binding protein homologous protein, eIF2, eukaryotic translation initiation factor 2, ER, endoplasmic reticulum, MRTF-A, myocardin related transcription factor A, restenosis, IH, intimal hyperplasia, 03 medical and health sciences, Tissue factor, FBS, fetal bovine serum, medicine, DES, drug-eluting stents, thrombosis, EC, endothelial cell, business.industry, PERK, protein kinase RNA-like endoplasmic reticulum kinase, medicine.disease, SRF, serum response factor, 030104 developmental biology, Cancer research, business, HA, hemagglutinin
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6
المؤلفون: M. Xiong, Yanping Feng, G H Yu, Xiuli Peng, Qing-wu Xin, Y. Gong, Shaomei Li
المصدر: Poultry Science
مصطلحات موضوعية: medicine.medical_specialty, Small interfering RNA, small interfering ribonucleic acid, duck, Abdominal Fat, Peroxisome proliferator-activated receptor, Adipose tissue, Down-Regulation, Biology, Article, chemistry.chemical_compound, Blood serum, Internal medicine, Adipocyte, medicine, Animals, RNA, Small Interfering, Muscle, Skeletal, Triglycerides, chemistry.chemical_classification, Lipoprotein lipase, peroxisome proliferator-activated receptor γ, Adipogenesis, Triglyceride, General Medicine, PPAR gamma, Endocrinology, Ducks, chemistry, Liver, Animal Science and Zoology, RNA Interference
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7
المؤلفون: Mengxue Zhang, Go Urabe, Christopher Little, Lian-Wang Guo, Yitao Huang, Alycia Kent, Bowen Wang, K. Craig Kent
المصدر: JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 782-795 (2018)مصطلحات موضوعية: 0301 basic medicine, Neointima, lcsh:Diseases of the circulatory (Cardiovascular) system, EEL, external elastic lamina, Vascular smooth muscle, Cell, IgG, immunoglobulin G, HDAC, histone deacetylase, IEL, internal elastic lamina, 030204 cardiovascular system & hematology, DMEM, Dulbecco’s modified Eagle’s medium, 03 medical and health sciences, PRECLINICAL RESEARCH, IH, intimal hyperplasia, 0302 clinical medicine, DNA, deoxyribonucleic acid, FBS, fetal bovine serum, siRNA, small interfering ribonucleic acid, Cell Plasticity, medicine, TSA, trichostatin A, Gene silencing, Transcription factor, TNF, tumor necrosis factor, biology, Chemistry, dedifferentiation, PDGF-BB, platelet-derived growth factor-BB, HDAC6, SRF, serum response factor, Cell biology, MMP, matrix metalloproteinase, SMC, vascular smooth muscle cell, 030104 developmental biology, medicine.anatomical_structure, Histone, MRTF-A, lcsh:RC666-701, embryonic structures, MRTF-A, myocardin-related transcription factor A, cardiovascular system, biology.protein, SMA, smooth muscle actin, SRF, vascular smooth muscle cell, SMHC, smooth muscle myosin heavy chain, Cardiology and Cardiovascular Medicine
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8
المؤلفون: Yu Xuewen, Xu Hua, Huang Zhonghua, Li Zhenguo, Min Qinqin, Liang Yingying, Xu Zhouwen, Shi Hongqin, Shao Mumin, Wang Jiachuan
المصدر: Qiguan Yizhi, Vol 9, Iss 6, Pp 417-423 (2018)
مصطلحات موضوعية: induced pluripotent stem cell, small interfering ribonucleic acid (sirna), hypoxia-inducible factor-2α, lcsh:R, sugar metabolism, 18f-fluoro-deoxyglucose (18f-fdg), lcsh:Medicine, stem cell transplantation, cerebral ischemia, micro-positron emission tomography (micro-pet)
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9
المؤلفون: Varun Goel, Xiaoping Zhang, Gabriel J. Robbie
المصدر: Journal of Clinical Pharmacology
مصطلحات موضوعية: patisiran, Pharmacology, 030226 pharmacology & pharmacy, small interfering ribonucleic acid (siRNA), 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, RNA interference, pharmacokinetics (PK), medicine, Distribution (pharmacology), Pharmacology (medical), Dosing, amyloidosis, biology, Chemistry, Amyloidosis, RNA, medicine.disease, lipid nanoparticle, Transthyretin, RNAi therapeutic, 030220 oncology & carcinogenesis, biology.protein, Steady state (chemistry)
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10
المؤلفون: Dong Gil You, Sejin Son, Sun Hwa Kim, Ji Young Yhee, Namho Kim, Kwangmeyung Kim, Ick Chan Kwon, Hong Yeol Yoon
المصدر: Theranostics
THERANOSTICS(7): 1مصطلحات موضوعية: Male, Vascular Endothelial Growth Factor A, photothermal therapy, Cell Survival, Medicine (miscellaneous), Nanotechnology, Antineoplastic Agents, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Self assembled, combination therapy, small interfering ribonucleic acid (siRNA), Mice, Drug Therapy, In vivo, RNA interference, Cell Line, Tumor, Animals, Photothermal ablation, RNA, Small Interfering, gold nanoparticle (AuNP), anti-VEGF therapy, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Neovascularization, Pathologic, Chemistry, RNA, Prostatic Neoplasms, Hyperthermia, Induced, Photothermal therapy, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Nanostructures, Disease Models, Animal, Treatment Outcome, Tumor progression, Heat generation, Heterografts, Gold, 0210 nano-technology, Research Paper
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11
المؤلفون: David G. McLaren, CarolAnn Keohan, Stephanie Williams, Steven R. Bartz, Andy Liaw, Yong Ma, Shirly Pinto, Karen O. Akinsanya, Stephen F. Previs, Yanqing Kan, Marija Tadin-Strapps, Steven J. Stout, Kristian K. Jensen, Ablatt Mahsut, James Hubert, David Coelho, Martin Koser, Gail Forrest, Kithsiri Herath, Satya Yendluri, Shubing Wang, Sheng-Ping Wang
المصدر: Journal of Lipid Research, Vol 57, Iss 12, Pp 2150-2162 (2016)
Journal of Lipid Researchمصطلحات موضوعية: 0301 basic medicine, Male, Small interfering RNA, Simvastatin, small interfering ribonucleic acid, Gene Expression, 030204 cardiovascular system & hematology, Biochemistry, proprotein convertase subtilisin kexin type 9, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, RNA, Small Interfering, Research Articles, Hypolipidemic Agents, Sterol Regulatory Element Binding Proteins, Gene knockdown, cardiometabolic disease, biology, SREBP cleavage-activating protein, Intracellular Signaling Peptides and Proteins, metabolic disease, Lipids, animal models, drug therapy, Liver, Gene Knockdown Techniques, Lipogenesis, lipids/liver, Female, RNA Interference, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, Signal Transduction, medicine.medical_specialty, lipid and lipoprotein metabolism, QD415-436, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, RNA, Messenger, Cholesterol, dyslipidemia, Membrane Proteins, cholesterol, Lipid metabolism, Cell Biology, Macaca mulatta, Sterol regulatory element-binding protein, Mice, Inbred C57BL, 030104 developmental biology, chemistry, Receptors, LDL, LDL receptor, biology.protein, low density lipoprotein
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12
المؤلفون: Kendra S. Carmon, Ling Wu, Liezl E. Francisco, Joan Jacob, Tressie A. Posey, Sheng Zhang, Qingyun Liu, Wangsheng Yu, Treena Chatterjee
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Serum Response Factor, RHOA, ADGRG1, Carcinogenesis, focal adhesion kinase (Fak), Biochemistry, Receptors, G-Protein-Coupled, GPR56, G-protein-coupled receptor 56, RhoA, Ras homolog family member A, siRNA, small interfering ribonucleic acid, SRE, serum response element, Phosphorylation, biology, Chemistry, Antibodies, Monoclonal, Adhesion G-Protein Coupled Receptor G1, G-protein-coupled receptor (GPCR), Cell biology, Gene Expression Regulation, Neoplastic, src-Family Kinases, 7TM, seven-transmembrane, CRC, colorectal cancer, Pax, paxillin, shRNA, short hairpin ribonucleic acid, Colorectal Neoplasms, Signal Transduction, Research Article, Src, CTF, C-terminal fragment, Proto-oncogene tyrosine-protein kinase Src, GPS, GPCR Proteolysis Site, colorectal cancer (CRC), Focal adhesion, 03 medical and health sciences, Cell Line, Tumor, SRF-RE, serum response factor response element, Humans, mAb, monoclonal antibody, Cell adhesion, Molecular Biology, Paxillin, KD, knockdown, paxillin, 030102 biochemistry & molecular biology, STP, Serine–Threonine–Proline-rich, GAIN, GPCR-autoproteolysis inducing, PLL, Pentraxin/Laminin/neurexin/sex-hormone(LNS)-binding-globulin-Like, aGPCR, adhesion G-protein-coupled receptor, cell adhesion, Src, Src proto-oncogene, nonreceptor tyrosine kinase, Cell Biology, ECD, extracellular domain, WT, wild-type, Fak, focal adhesion kinase, NTF, N-terminal fragment, 030104 developmental biology, GPR56, monoclonal antibody, Focal Adhesion Kinase 1, ADGRG1, adhesion G protein-coupled receptor G1, ICC, immunocytochemistry, biology.protein, rhoA GTP-Binding Protein
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13
المؤلفون: Marianne T. Sweetser, Gabriel J. Robbie, Xiaoping Zhang, Varun Goel, Valerie A. Clausen, Husain Attarwala
المصدر: Journal of Clinical Pharmacology
مصطلحات موضوعية: Male, patisiran, Therapeutics, Pharmacology, Placebo, 030226 pharmacology & pharmacy, small interfering ribonucleic acid (siRNA), 03 medical and health sciences, Polyneuropathies, 0302 clinical medicine, Pharmacokinetics, Double-Blind Method, pharmacokinetics (PK), Medicine, Humans, Prealbumin, Pharmacology (medical), Dosing, RNA, Small Interfering, Adverse effect, Aged, Amyloid Neuropathies, Familial, biology, Dose-Response Relationship, Drug, business.industry, Amyloidosis, Middle Aged, pharmacodynamics (PD), medicine.disease, Transthyretin, RNAi Therapeutics, Treatment Outcome, Liver, 030220 oncology & carcinogenesis, Pharmacodynamics, Liposomes, biology.protein, Nanoparticles, Administration, Intravenous, Female, exposure‐response, business, Polyneuropathy, hereditary transthyretin‐mediated amyloidosis (hATTR)
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14Academic Journal
المؤلفون: Feng-Mei Wang, Mo-Jie Gao, Rui-Cheng Xu, Wen-Liang Hu, Xiao-Yi Chen, Zhong-Wei Xu
المصدر: Biological and Pharmaceutical Bulletin. 2010, 33(5):743
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15
المصدر: EBioMedicine
مصطلحات موضوعية: kDa, kilodalton, Notch, EGM-2, endothelial cell growth medium-2, Human umbilical vein endothelial cell, mRNA, messenger ribonucleic acid, NOCTH1, Neurogenic locus notch homolog protein 1, Angiogenesis inhibitors, DLL4, DMSO, dimethyl sulfoxide, In vitro 3D model, PBS, phosphate buffered saline, siRNA, small interfering ribonucleic acid, Sunitinib, HUVEC, human umbilical vein endothelial cells, CLSM, confocal laser scanning microcopy, Microvessel, VE-Cad, vascular-endothelial cadherin, 3D, three-dimensional, VEGFR-2, VEGF receptor-2, Sorafenib, DLL4, Delta-like protein 4, VEGF, vascular endothelial growth factor, UV, ultraviolet, ECM, extracellular matrix, Sprouting angiogenesis, LSFM, light sheet fluorescence microscopy, PDMS, polydimethylsiloxane, BSA, bovine serum albumin, Vascular endothelial growth factor, PFA, paraformaldehyde, Research Paper
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16
المصدر: Neurobiology of Disease, 69, 225-234
Neurobiology of Disease, Vol 69, Iss, Pp 225-234 (2014)
Neurobiology of Diseaseمصطلحات موضوعية: DIV, days in vitro, LJP, liquid junction potential, Migraine with Aura, Cell Culture Techniques, Action Potentials, VIP, vasoactive intestinal peptide, Gating, 5HT3aR, 5-hydroxytryptamine 3a receptor, Synaptic Transmission, AHP, after-hyperpolarization, CGRP, calcitonin gene-related peptide, APhw, action potential half width, Calcium Channels, N-Type, FHM1, familial hemiplegic migraine type 1, siRNA, small interfering ribonucleic acid, Channelopathy, Fast-spiking interneuron, BME, basal Eagle's medium, Gene Knock-In Techniques, PV, parvalbumin, gamma-Aminobutyric Acid, Cerebral Cortex, GAD, glutamic acid decarboxylase, Migraine, calcium channel, inhibitory synaptic transmission, Voltage-dependent calcium channel, Pyramidal Cells, medicine.anatomical_structure, Neurology, KI, knockin, Excitatory postsynaptic potential, Pyramidal cell, Knockin mouse model, Interneuron, Excitatory–inhibitory balance, Presynaptic Terminals, Mice, Transgenic, Neurotransmission, Biology, Inhibitory postsynaptic potential, Article, Cav2.1, lcsh:RC321-571, PBS, phosphate buffered saline, Interneurons, medicine, Animals, Humans, CSD, cortical spreading depression, SNAP25, synaptosomal-associated protein of 25 kDa, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Migraine, Neural Inhibition, Mice, Inbred C57BL, Disease Models, Animal, inhibitory synaptic transmission, Inhibitory Postsynaptic Potentials, GABA, gamma-aminobutyric acid, Mutation, biology.protein, SOM, somatostatin, Excitatory-inhibitory balance, calcium channel, Calcium, BSA, bovine serum albumin, FS, fast-spiking, Calcium Channels, AP, action potential, Neuroscience
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17
المؤلفون: Lena Sibulesky, Raimund Pichler, Scott W. Biggins
المصدر: World Journal of Hepatology
مصطلحات موضوعية: medicine.medical_specialty, medicine.medical_treatment, 030230 surgery, Liver transplantation, urologic and male genital diseases, Letters To The Editor, 03 medical and health sciences, 0302 clinical medicine, Hepatic ischemia-reperfusion injury, medicine, Intensive care medicine, Hepatology, business.industry, Acute kidney injury, Postoperative complication, Immunosuppression, Perioperative, medicine.disease, Preventive intervention, Etiology, Small interfering ribonucleic acid, 030211 gastroenterology & hepatology, Transplant patient, business, Marginal grafts
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18Academic Journal
المؤلفون: SCHLICH, MICHELE, Longhena, F, Faustini, G, O'Driscoll, C, SINICO, CHIARA, FADDA, ANNA MARIA, Bellucci, A, LAI, FRANCESCO
المساهمون: Schlich, Michele, Longhena, F, Faustini, G, O'Driscoll, C, Sinico, Chiara, Fadda, ANNA MARIA, Bellucci, A, Lai, Francesco
مصطلحات موضوعية: Rabies virus glycoprotein, (RVG) peptide, Liposome, Small interfering ribonucleic acid (siRNA), Alpha-synuclein, Primary neuronal cell, Parkinson’s disease
Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000410304500021; volume:10; issue:10; firstpage:3496; lastpage:3508; numberofpages:13; journal:NANO RESEARCH; http://hdl.handle.net/11584/212917; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85019894388
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19
المصدر: Journal of Indian Society of Periodontology, Vol 17, Iss 4, Pp 417-422 (2013)
Journal of Indian Society of Periodontologyمصطلحات موضوعية: Gene knockdown, small interfering ribonucleic acid, Gene knock down, ribonucleic acid interference, Regeneration (biology), Periodontium, Review Article, Biology, Regenerative medicine, Cell biology, lcsh:RK1-715, Tissue engineering, Biochemistry, RNA interference, lcsh:Dentistry, periodontal regeneration, Periodontics, Periodontal fiber, Stem cell
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20
المؤلفون: Luisa Delsedime, Enrico Lupia, Lorenzo Del Sorbo, Erica L Martin Conte, V. Marco Ranieri, Federica Civiletti, Barbara Vizio, Giacomo Frati, Ornella Bosco, Andrea Costamagna, Giuseppe Muraca, Vito Fanelli, Giuseppe Rotondo
المساهمون: Del Sorbo, L., Costamagna, A., Muraca, G., Rotondo, G., Civiletti, F., Vizio, B., Bosco, O., Martin Conte, E.L., Frati, G., Delsedime, L., Lupia, E., Fanelli, V., Ranieri, V.M.
المصدر: Europe PubMed Central
مصطلحات موضوعية: 0301 basic medicine, Lung Diseases, small interfering ribonucleic acid, Small interfering RNA, Pathology, medicine.medical_treatment, Gene Expression, Apoptosis, nonviral gene delivery system, Pulmonary compliance, Pharmacology, Critical Care and Intensive Care Medicine, Lung Disease, gene targeting, lung lavage, gene silencing, Mice, Random Allocation, isolated lung, caspase 3, protein cleavage, cytokine, Medicine, Edema, animal, reperfusion injury, Animal, Prospective Studies, RNA, Small Interfering, Fa, medicine.diagnostic_test, messenger RNA, C57BL mouse, drug effect, artificial ventilation, cold ischemia, respiratory system, Fas receptor, myeloperoxidase, Antigens, CD95, medicine.anatomical_structure, cytokine release, priority journal, Reperfusion Injury, ischemia and reperfusion, Cytokines, Bronchoalveolar Lavage Fluid, prospective study, medicine.medical_specialty, animal experiment, neutrophil chemotaxi, randomization, Article, animal tissue, histology, biosynthesi, 03 medical and health sciences, small interfering RNA, animal cell, Lung transplantation, Animals, Fas protein, mouse, controlled study, fas Receptor, lung injury, mouse, lung edema, Messenger RNA, nonhuman, Lung, business.industry, animal model, Fas antigen, Apoptosi, acute lung injury, apoptosis, Fas, inflammation, RNA, small interfering RNA, lung hemorrhage, respiratory tract diseases, Mice, Inbred C57BL, Prospective Studie, 030104 developmental biology, Bronchoalveolar lavage, nonviral gene therapy, cytology, business, metabolism
وصف الملف: STAMPA
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