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1Academic Journal
المؤلفون: Heikki Ruskoaho, Lotta M Pohjolainen, Sini Kinnunen, Virpi Talman
المصدر: Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2018, :PO2-46
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2Academic JournalDiscovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5
المؤلفون: Antti Poso, Heikki J Ruskoaho, Jaana Rysa, Jani Aro, Lotta Pohjolainen, Marja Tolli, Mika Valimaki, Raisa Serpi, Sini Kinnunen, Virpi Talman
المصدر: Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2018, :PO4-24
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3Academic Journal
المؤلفون: Sini Kinnunen, Mika Välimäki, Marja Tölli, Gerd Wohlfahrt, Rami Darwich, Hiba Komati, Mona Nemer, Heikki Ruskoaho
المصدر: PLoS ONE, Vol 10, Iss 12, p e0144145 (2015)
وصف الملف: electronic resource
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4
المؤلفون: Virpi Talman, Marja Tölli, Mika J. Välimäki, S. Tuuli Karhu, Sini Kinnunen, Zoltan Szabo, Heikki Ruskoaho
المساهمون: Division of Pharmacology and Pharmacotherapy, Drug Research Program, Regenerative pharmacology group, Regenerative cardiac pharmacology
المصدر: Archives of Toxicology
مصطلحات موضوعية: Male, 0301 basic medicine, PHARMACOKINETICS, Time Factors, CELL-SURVIVAL, Health, Toxicology and Mutagenesis, Pharmacology, Toxicology, Ventricular Function, Left, Rats, Sprague-Dawley, 0302 clinical medicine, GATA4-targeted compounds, Natriuretic Peptide, Brain, Human induced pluripotent stem cell-derived cardiomyocytes, Myocytes, Cardiac, Chronic toxicity, GENE-EXPRESSION, Antibiotics, Antineoplastic, General Medicine, 3. Good health, BRAIN NATRIURETIC PEPTIDE, 317 Pharmacy, 030220 oncology & carcinogenesis, Toxicity, POSITION PAPER, Signal Transduction, CARDIAC HORMONES, medicine.drug, Heart Diseases, Cell Survival, Induced Pluripotent Stem Cells, Protective Agents, Cell Line, Organ Toxicity and Mechanisms, 03 medical and health sciences, Pharmacokinetics, In vivo, Transcription factors, medicine, Animals, Humans, Doxorubicin, Viability assay, Protein Precursors, Rats, Wistar, INDUCED CARDIOMYOPATHY, Cardiotoxicity, TRANSCRIPTION FACTORS GATA4, business.industry, Caspases, Effector, Stroke Volume, In vitro, GATA4 Transcription Factor, HYPERTROPHY, Disease Models, Animal, 030104 developmental biology, RAT, 1182 Biochemistry, cell and molecular biology, Cardioprotective, business
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5
المؤلفون: Heikki Ruskoaho, Mika J. Välimäki, Samuli Auno, Jari Yli-Kauhaluoma, Ingo B. Aumüller, Virpi Talman, Henri Xhaard, Gustav Boije af Gennäs, Sini Kinnunen, Tanja Bruun, Mikael Jumppanen
المساهمون: Pharmaceutical Design and Discovery group, Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Regenerative pharmacology group, Division of Pharmacology and Pharmacotherapy, Computational Adme, Henri Xhaard / Principal Investigator, Division of Pharmaceutical Biosciences, Jari Yli-Kauhaluoma / Principal Investigator, University Management, Regenerative cardiac pharmacology
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: FIBROBLASTS, endocrine system, medicine.drug_class, Cell Survival, 116 Chemical sciences, REQUIREMENT, Carboxamide, SMALL MOLECULES, 01 natural sciences, Article, Protein–protein interaction, 03 medical and health sciences, Structure-Activity Relationship, Drug Discovery, Chlorocebus aethiops, medicine, Structure–activity relationship, Animals, Viability assay, Rats, Wistar, Transcription factor, Cells, Cultured, 030304 developmental biology, 0303 health sciences, COS cells, Dose-Response Relationship, Drug, Molecular Structure, GATA4, Chemistry, MUTATIONS, DEFECTS, Isoxazoles, respiratory system, Small molecule, 0104 chemical sciences, Cell biology, GATA4 Transcription Factor, Rats, 010404 medicinal & biomolecular chemistry, TRANSCRIPTION FACTORS, 317 Pharmacy, DISCOVERY, embryonic structures, COS Cells, cardiovascular system, Homeobox Protein Nkx-2.5, Molecular Medicine, Protein Binding
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المؤلفون: Sini Kinnunen
المساهمون: Ruskoaho, H. (Heikki), Regenerative pharmacology group, Farmakologian ja lääkehoidon osasto
المصدر: University of Helsinki
مصطلحات موضوعية: transkriptiotekijät, sydäntä suojaava vaikutus, small molecule, heart failure, pienimolekyylinen yhdiste, respiratory system, sydämen vajaatoiminta, protein-protein interaction, 3121 Yleislääketiede, sisätaudit ja muut kliiniset lääketieteet, GATA4, cardioprotection, embryonic structures, proteiini-proteiini vuorovaikutus, cardiovascular system, transcription factor
وصف الملف: application/pdf
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7
المؤلفون: Tuuli Karhu, Heikki Ruskoaho, Sini Kinnunen, Virpi Talman
المصدر: Circulation Research. 125
مصطلحات موضوعية: 0301 basic medicine, Cardiotoxicity, Physiology, business.industry, GATA4, 030204 cardiovascular system & hematology, Pharmacology, Anticancer drug, In vitro, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Toxicity, Medicine, Doxorubicin, Stem cell, Cardiology and Cardiovascular Medicine, business, medicine.drug
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8
المؤلفون: Hongbo Zhang, Heikki Ruskoaho, Alexandra Correia, Jarno Salonen, Jouni Hirvonen, Patrick V. Almeida, Sanjeev Ranjan, Hélder A. Santos, Mohammad-Ali Shahbazi, Anu J. Airaksinen, Sini Kinnunen, Ermei Mäkilä, Mónica P. A. Ferreira
المصدر: Biomaterials. 94:93-104
مصطلحات موضوعية: Male, Silicon, Cell Survival, media_common.quotation_subject, Biophysics, Bioengineering, 02 engineering and technology, Pharmacology, 010402 general chemistry, 01 natural sciences, Biomaterials, Atrial natriuretic peptide, In vivo, Isoprenaline, Undecylenic Acids, Animals, Humans, Medicine, Myocytes, Cardiac, Colloids, Rats, Wistar, Receptor, Internalization, media_common, Tomography, Emission-Computed, Single-Photon, ta114, business.industry, Temperature, technology, industry, and agriculture, Heart, Blood Proteins, 021001 nanoscience & nanotechnology, medicine.disease, In vitro, 0104 chemical sciences, 3. Good health, Mechanics of Materials, Heart failure, Toxicity, Ceramics and Composites, Nanoparticles, Adsorption, Peptides, 0210 nano-technology, business, Porosity, Atrial Natriuretic Factor, Biomedical engineering, medicine.drug
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9
المؤلفون: Gabor Foldes, Gustav Boije af Gennäs, Samuli Auno, Lotta Pohjolainen, Sini Kinnunen, Jari Yli-Kauhaluoma, Virpi Talman, Mikael Jumppanen, S. Tuuli Karhu, Mika J. Välimäki, Heikki Ruskoaho, Robert S. Leigh
المساهمون: Regenerative cardiac pharmacology, Regenerative pharmacology group, Faculty of Pharmacy, Pharmaceutical Design and Discovery group, Division of Pharmacology and Pharmacotherapy, Timo Pyry Juhani Otonkoski / Principal Investigator, Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Jari Yli-Kauhaluoma / Principal Investigator, Medical Research Council (MRC)
المصدر: Archives of Toxicology
مصطلحات موضوعية: 0301 basic medicine, Health, Toxicology and Mutagenesis, Toxicity screening, Stem cells, Toxicology, 0302 clinical medicine, Chlorocebus aethiops, Myocytes, Cardiac, Cells, Cultured, media_common, Cardiomyocytes, Drug discovery, In vitro toxicology, General Medicine, Isoxazole derivatives, 3. Good health, In Vitro Systems, TRANSCRIPTION FACTORS, Drug development, 317 Pharmacy, 030220 oncology & carcinogenesis, High-content screening, COS Cells, Toxicity, Homeobox Protein Nkx-2.5, HEART, Stem cell, Drug, Cell type, Cell Survival, media_common.quotation_subject, CARDIOGENESIS, Induced Pluripotent Stem Cells, Computational biology, Biology, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, GATA4, ON-WATER, REGENERATION, Toxicity Tests, Structure-toxicity relationship, Animals, ISOXAZOLES, Fibroblasts, GATA4 Transcription Factor, High-Throughput Screening Assays, Rats, 030104 developmental biology, DNA-DAMAGE, CYCLOADDITIONS, High-content analysis, 1115 Pharmacology And Pharmaceutical Sciences, Structure–toxicity relationship
وصف الملف: application/pdf
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10Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5
المؤلفون: Marja Tölli, Virpi Talman, Heikki Ruskoaho, Sini Kinnunen, Lotta Pohjolainen, Raisa Serpi, Mika J. Välimäki, Antti Poso, Jani Aro
المساهمون: Faculty of Pharmacy, Division of Pharmacology and Pharmacotherapy, University of Helsinki, Regenerative pharmacology group, Drug Research Program
مصطلحات موضوعية: Models, Molecular, Transcriptional Activation, 0301 basic medicine, EXPRESSION, CARDIOGENESIS, DISEASE, Cell Line, Small Molecule Libraries, Mice, 03 medical and health sciences, PROTEIN-PROTEIN INTERACTIONS, 0302 clinical medicine, Gene expression, BINDING, Animals, Humans, Protein Interaction Maps, TRANSCRIPTION FACTOR, Transcription factor, REPAIR, Reporter gene, ATF3, General transcription factor, Chemistry, GATA4, Isoxazoles, respiratory system, Molecular biology, Small molecule, ADULT HEART, GATA4 Transcription Factor, 3. Good health, Cell biology, HEAVY-CHAIN GENE, HYPERTROPHY, DRUG DISCOVERY, 030104 developmental biology, BRAIN NATRIURETIC PEPTIDE, 317 Pharmacy, 030220 oncology & carcinogenesis, embryonic structures, Homeobox Protein Nkx-2.5, cardiovascular system, Molecular Medicine, STEM-CELLS, HEART REGENERATION
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11
المؤلفون: Sini Kinnunen, Jarno Salonen, Alexandra Correia, Marianna Kemell, Mónica P. A. Ferreira, Sanjeev Ranjan, Jouni Hirvonen, Brianda Barrios-Lopez, Virpi Talman, Hélder A. Santos, Heikki Ruskoaho, Anu J. Airaksinen, Vimalkumar Balasubramanian, Ermei Mäkilä
المصدر: Small. 13(33)
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Materials science, Chemical Phenomena, Cell Survival, Surface Properties, 02 engineering and technology, Biomaterials, 03 medical and health sciences, Drug Delivery Systems, Atrial natriuretic peptide, In vivo, Internal medicine, medicine, Animals, Myocyte, Tissue Distribution, General Materials Science, Myocardial infarction, Rats, Wistar, ta216, ta116, Endocardium, ta114, Hypertrophy, General Chemistry, Anatomy, 021001 nanoscience & nanotechnology, medicine.disease, 3. Good health, Drug Liberation, 030104 developmental biology, medicine.anatomical_structure, Targeted drug delivery, Ventricle, Drug delivery, Hydrodynamics, cardiovascular system, Cardiology, Nanoparticles, 0210 nano-technology, Signal Transduction, Biotechnology
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12
المؤلفون: Sini Kinnunen, Virpi Talman, Heikki Ruskoaho, Lotta Pohjolainen
المصدر: Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO2-3
مصطلحات موضوعية: Cardiac regeneration, Applied Mathematics, General Mathematics, Identification (biology), Computational biology, Biology, Coding (social sciences)
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13
المؤلفون: Rami Darwich, Heikki Ruskoaho, Mona Nemer, Sini Kinnunen, Marja Tölli, Gerd Wohlfahrt, Mika J. Välimäki, Hiba Komati
المساهمون: Faculty of Pharmacy, Division of Pharmacology and Pharmacotherapy, Regenerative pharmacology group, Drug Research Program
المصدر: PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0144145 (2015)مصطلحات موضوعية: lcsh:Medicine, Receptors, Cytoplasmic and Nuclear, CARDIAC TRANSCRIPTION, medicine.disease_cause, Conserved sequence, Mice, 0302 clinical medicine, Protein structure, Chlorocebus aethiops, lcsh:Science, GENE-EXPRESSION, Genetics, Zinc finger, 0303 health sciences, Mutation, Multidisciplinary, GATA4, Zinc Fingers, respiratory system, ADULT HEART, OF-FUNCTION MUTATION, 317 Pharmacy, embryonic structures, COS Cells, cardiovascular system, Homeobox Protein Nkx-2.5, Protein Binding, Research Article, Heart Defects, Congenital, Biology, DNA-binding protein, Models, Biological, VENTRAL MORPHOGENESIS, 03 medical and health sciences, MUTUAL COFACTORS, medicine, Animals, Transcription factor, 030304 developmental biology, Homeodomain Proteins, lcsh:R, DNA-binding domain, DNA, GATA4 Transcription Factor, Protein Structure, Tertiary, DNA-BINDING TARGETS, TRANSCRIPTION FACTOR GATA-4, TUBE FORMATION, lcsh:Q, DEFINED FACTORS, 030217 neurology & neurosurgery, Transcription Factors
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14Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5
المؤلفون: Mika J. Välimäki, Marja Tölli, Jani Aro, Antti Poso, Virpi Talman, Heikki Ruskoaho, Lotta Pohjolainen, Jaana Rysä, Raisa Serpi, Sini Kinnunen
المصدر: Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO4-2
مصطلحات موضوعية: Chemistry, GATA4, Applied Mathematics, General Mathematics, Small molecule, Transcription factor, Cell biology
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15
المؤلفون: Jaana Rysä, Ermei Mäkilä, Jarno Salonen, Mónica P. A. Ferreira, Heikki Ruskoaho, Marja Tölli, Pauli Ohukainen, Jouni Hirvonen, Sini Kinnunen, Hélder A. Santos, Raisa Serpi, Alexandra Maria Rebelo Correia, Zoltan Szabo, Mika J. Välimäki
المصدر: Biomaterials. 35(29)
مصطلحات موضوعية: Cardiac function curve, Male, Silicon, Materials science, Biocompatibility, Biophysics, Ischemia, Myocardial Infarction, Bioengineering, Biocompatible Materials, ta3111, Biomaterials, Rats, Sprague-Dawley, Drug Delivery Systems, Fibrosis, medicine, Animals, Myocytes, Cardiac, Myocardial infarction, ta317, Cells, Cultured, Inflammation, Drug Carriers, ta114, Myocardium, medicine.disease, 3. Good health, Rats, Gene Expression Regulation, Mechanics of Materials, Drug delivery, Ceramics and Composites, Myocardial fibrosis, Nanocarriers, Porosity, Biomedical engineering
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16
المؤلفون: Antti Mikael Jumppanen, Sini Kinnunen, Mika Juhani Välimäki, Samuli Auno, Gustav Boije af Gennäs, Henri Xhaard, Virpi Talman, Heikki Juhani Ruskoaho, Jari Tapani Yli-Kauhaluoma
المصدر: University of Helsinki
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17
المؤلفون: Sini Kinnunen, Marja Tölli, Mika Juhani Välimäki, Antti Mikael Jumppanen, Per Gustav Boije af Gennäs, Jari Yli-Kauhaluoma, Heikki Juhani Ruskoaho
المصدر: University of Helsinki
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