المؤلفون: Simon O. Clark, Giovanni Delogu, Emma Rayner, Michela Sali, Ann Williams, Riccardo Manganelli

Relation: url:https://www.openaccessrepository.it/communities/itmirror; https://www.openaccessrepository.it/record/40978

الاتاحة: https://www.openaccessrepository.it/record/40978
https://doi.org/10.1016/j.trivac.2015.03.003

المؤلفون: Graham Hall, Owen Daykin-Pont, Helen McShane, Simon O. Clark, Sally A. Sharpe, Ann Williams, Ashley Jacobs, Lisa M. Stevens, Laura Sibley, Fergus V. Gleeson, Michael Dennis, Philip Marsh, Karen E. Gooch, Rachel Tanner, Geoff Pearson, Anthony McIntyre, Andrew D. White, Randall J. Basaraba, Emma L. Rayner

مصطلحات موضوعية: Mycobacterium tuberculosis, Vaccination, Natural resistance, biology, Vaccine evaluation, business.industry, Chinese origin, Medicine, biology.organism_classification, business, Virology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a57d6051c6d3026e1c3298970c863f2a
https://doi.org/10.21203/rs.3.rs-296520/v1

المؤلفون: Joanna Bacon, Luke J Alderwick, Jon A Allnutt, Evelina Gabasova, Robert Watson, Kim A Hatch, Simon O Clark, Rose E Jeeves, Alice Marriott, Emma Rayner, Howard Tolley, Geoff Pearson, Graham Hall, Gurdyal S Besra, Lorenz Wernisch, Ann Williams, Philip D Marsh

المصدر: PLoS ONE, Vol 9, Iss 2, p e87329 (2014)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3916317?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/c11cea27e6004c5da7415a8a6a12a1b4

المؤلفون: Jérôme Nigou, Claudia Nobrega, Germain Puzo, Sílvia Vale-Costa, Simon O. Clark, Roy Ummels, Ann Williams, A. Afonso-Barroso, Farahnaz Movahedzadeh, Arjen Sloots, P. van der Ley, Jeroen Geurtsen, G.T. Rosa, Rui Appelberg, Sandro Silva-Gomes, B.J. Appelmelk, Neil G. Stoker, Marlène Cot

المصدر: Cellular Microbiology. 15:660-674

مصطلحات موضوعية: 0303 health sciences, Mycobacterium bovis, Lipoarabinomannan, biology, 030306 microbiology, Immunogenicity, Immunology, Virulence, Mannose, biology.organism_classification, Microbiology, Virulence factor, 3. Good health, Mycobacterium tuberculosis, 03 medical and health sciences, chemistry.chemical_compound, Immune system, chemistry, Virology, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f30e03f5c8590ff263502121f1d3ffe4
https://doi.org/10.1111/cmi.12065

المؤلفون: Mark A. Chambers, Julia A. Tree, N. Baker, Ann Williams, S. Smith, Philip Marsh, Frank E. Aldwell, Simon O. Clark

المصدر: Letters in Applied Microbiology. 55:295-300

مصطلحات موضوعية: Mycobacterium bovis, Tuberculosis, Vaccine evaluation, biology, business.industry, medicine.medical_treatment, biology.organism_classification, medicine.disease, Applied Microbiology and Biotechnology, Peripheral blood mononuclear cell, Virology, Guinea pig, Cytokine, Immune system, Antigen, Immunology, medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ac4ca048bf1d616cc8b62496b389199d
https://doi.org/10.1111/j.1472-765x.2012.03292.x

المؤلفون: Yper Hall, Simon O. Clark, Ann Williams, Dominic L.F. Kelly, Graham J. Hatch

المصدر: Journal of Applied Microbiology. 111:350-359

مصطلحات موضوعية: Infectivity, Tuberculosis, Inhalation, General Medicine, Biology, biology.organism_classification, medicine.disease, Applied Microbiology and Biotechnology, Aerosol, Microbiology, Mycobacterium tuberculosis, Immunology, medicine, Aerosolization, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::46fdaadc33a436fe44af85dd3fc91c83
https://doi.org/10.1111/j.1365-2672.2011.05069.x

المؤلفون: Ian M. Orme, Randall J. Basaraba, Ann Williams, Simon O. Clark, Graham Hall, Karen E. Gooch, Susan L. Kraft, George F. Rick Hatch, A. McIntyre, Mike Dennis, E. Eschelbach, Sally Sharpe, Fergus V. Gleeson, Philip Marsh

المصدر: Tuberculosis. 89:405-416

مصطلحات موضوعية: Microbiology (medical), Pathology, medicine.medical_specialty, Tuberculosis, Immunology, Stereology, Microbiology, Macaque, Mycobacterium tuberculosis, biology.animal, medicine, Animals, Lung volumes, Pulmonary pathology, Tuberculosis Vaccines, Lung, Tuberculosis, Pulmonary, Aerosols, medicine.diagnostic_test, biology, Reproducibility of Results, Magnetic resonance imaging, medicine.disease, biology.organism_classification, Macaca mulatta, Magnetic Resonance Imaging, Disease Models, Animal, Infectious Diseases, medicine.anatomical_structure

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf41f85f2641e0706763f01d2905819
https://doi.org/10.1016/j.tube.2009.09.002

المؤلفون: Lindsay J. Hall, Philip Marsh, Christine Hale, Derek Pickard, Peter Andersen, Jes Dietrich, Moataz Abd El Ghany, Gordon Dougan, Simon O. Clark, Dominic L.F. Kelly, Simon Clare

المصدر: Vaccine

مصطلحات موضوعية: Salmonella typhimurium, Salmonella, medicine.medical_treatment, Administration, Oral, medicine.disease_cause, Mucosal vaccine, Enterotoxins, Mice, M. tuberculosis, Tuberculosis Vaccines, Lung, 0303 health sciences, biology, Salmonella vector, Escherichia coli Proteins, Salmonella vaccine, Antibodies, Bacterial, 3. Good health, Vaccination, Infectious Diseases, Salmonella enterica, BCG Vaccine, Molecular Medicine, Female, Tuberculosis vaccines, Adjuvant, Recombinant Fusion Proteins, Bacterial Toxins, Guinea Pigs, Immunization, Secondary, Vaccines, Attenuated, Article, Microbiology, Mycobacterium tuberculosis, 03 medical and health sciences, Interferon-gamma, Adjuvants, Immunologic, Bacterial Proteins, Immunology and Microbiology(all), medicine, Animals, Tuberculosis, Immunity, Mucosal, 030304 developmental biology, Antigens, Bacterial, General Veterinary, General Immunology and Microbiology, 030306 microbiology, Public Health, Environmental and Occupational Health, biology.organism_classification, Virology, veterinary(all), Mice, Inbred C57BL, Immunoglobulin G, BCG vaccine, Acyltransferases, Spleen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babafb24eefbc71a14d63b7f8b6138c4

المؤلفون: Edgar Badell, Nathalie Winter, Brigitte Gicquel, Luiz R.R. Castello-Branco, Simon O. Clark, Fabienne Nicolle, Laleh Majlessi, Frédéric Boudou, Philip Marsh, David Lewis, Claude Leclerc, Angelo Martino

المساهمون: Génétique mycobactérienne - Mycobacterial genetics, Institut Pasteur [Paris], Health Protection Agency, Régulation Immunitaire et Vaccinologie, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), St George's Vaccine Institute, Queen Mary University of London (QMUL), Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), This work was supported by the European Commission (Mucosal Vaccines for Poverty Related Diseases) European Union Contract LSHP-CT-2003-503240., European Project: 26823,MUVAPRED, European Project: 9522828(1995), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris]

المصدر: Vaccine
Vaccine, Elsevier, 2009, 27 (1), pp.28-37. ⟨10.1016/j.vaccine.2008.10.034⟩
Vaccine, 2009, 27 (1), pp.28-37. ⟨10.1016/j.vaccine.2008.10.034⟩

مصطلحات موضوعية: MUCOSA, T-Lymphocytes, [SDV]Life Sciences [q-bio], animal diseases, TUBERCULOSIS VACCINES, Mice, 0302 clinical medicine, Medicine, IFN GAMMA, Mice, Inbred BALB C, 0303 health sciences, Mycobacterium bovis, biology, 3. Good health, Vaccination, Infectious Diseases, ESAT-6, BCG Vaccine, Molecular Medicine, Female, Tuberculosis vaccines, Guinea Pigs, Immunization, Secondary, complex mixtures, Mycobacterium tuberculosis, Interferon-gamma, 03 medical and health sciences, Bacterial Proteins, Antigen, Animals, Humans, Tuberculosis, Administration, Intranasal, Antigens, Bacterial, General Veterinary, General Immunology and Microbiology, 030306 microbiology, business.industry, Public Health, Environmental and Occupational Health, biology.organism_classification, Virology, Mice, Inbred C57BL, Immunization, Immunology, bacteria, business, BCG vaccine, Acyltransferases, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076d3bb22fc56b1afb91c91c598c9763
https://doi.org/10.1016/j.vaccine.2008.10.034

المؤلفون: Nigel P. Minton, Ann Williams, Simon O. Clark, Helen Shuttleworth, Graham J. Hatch, Emma Allen-Vercoe, Philip Marsh, Karen Blake, Joanna Bacon, Toby Hampshire, Julia Vipond, Richard Vipond, Karen E. Gooch

المصدر: Vaccine. 24:6340-6350

مصطلحات موضوعية: Tuberculosis, Guinea Pigs, Biology, Microbiology, DNA vaccination, Guinea pig, Mycobacterium tuberculosis, Immune system, Vaccines, DNA, medicine, Animals, Tuberculosis Vaccines, Gene, Aerosols, General Veterinary, General Immunology and Microbiology, Intracellular parasite, Public Health, Environmental and Occupational Health, biology.organism_classification, medicine.disease, Virology, Vaccination, Infectious Diseases, BCG Vaccine, Molecular Medicine, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2f444df30343a1281e9d0fbef0b6b1
https://doi.org/10.1016/j.vaccine.2006.05.025

المؤلفون: Julia Vipond, Richard Vipond, Julia A. Tree, Philip Marsh, Else Marie Agger, Ann Williams, Simon O. Clark, Graham J. Hatch

المصدر: Tuberculosis. 86:218-224

مصطلحات موضوعية: Microbiology (medical), Tuberculosis, medicine.medical_treatment, Genetic Vectors, Guinea Pigs, Immunology, Lymphocyte proliferation, Microbiology, DNA vaccination, Guinea pig, Mycobacterium tuberculosis, Epitopes, Immune system, Adjuvants, Immunologic, Escherichia coli, Vaccines, DNA, medicine, Animals, Tuberculosis Vaccines, Lung, Tuberculosis, Pulmonary, Cells, Cultured, Cell Proliferation, Antigens, Bacterial, Immunity, Cellular, biology, Th1 Cells, biology.organism_classification, medicine.disease, Antibodies, Bacterial, Virology, Vaccination, Disease Models, Animal, Infectious Diseases, Genes, Bacterial, Immunoglobulin G, Vaccines, Subunit, Female, Adjuvant

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ce0d0390a8e6cf29574b871d96ce9c
https://doi.org/10.1016/j.tube.2006.01.014

المؤلفون: Nilu Goonetilleke, Andrzej Pawlowski, Kim A. Hatch, Graham J. Hatch, Peter Andersen, T. Mark Doherty, Ann Williams, Wilfried Dalemans, Helen McShane, Karen E. Gooch, Kris Huygen, Stefan H. E. Kaufmann, Karen Blake, Douglas B. Lowrie, Stewart T. Cole, Philip Marsh, Tanya Parish, Simon O. Clark, Alexander S. Pym, Joe Cohen, Gunilla Källenius, Priscille Brodin, Carlos Martin, Brigitte Gicquel, Kees L. M. C. Franken, Stefan B. Svenson, Yves Lobet, Debbie A. Smith, Peter Seiler, Graham Hall, Neil G. Stoker, Adrian V. S. Hill, Leander Grode, Tom H. M. Ottenhoff

المصدر: Tuberculosis. 85:29-38

مصطلحات موضوعية: Microbiology (medical), Tuberculosis, medicine.medical_treatment, Guinea Pigs, Immunology, Colony Count, Microbial, Drug Evaluation, Preclinical, complex mixtures, Microbiology, Mycobacterium tuberculosis, medicine, Animals, Humans, media_common.cataloged_instance, European Union, European union, Tuberculosis Vaccines, Lung, Tuberculosis, Pulmonary, media_common, Aerosols, biology, business.industry, Vaccination, medicine.disease, Vaccine efficacy, biology.organism_classification, Survival Analysis, Virology, Disease Models, Animal, Infectious Diseases, BCG Vaccine, business, Tuberculosis vaccines, Adjuvant, BCG vaccine, Spleen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b7242e4b1916d57971b66d45c0586d
https://doi.org/10.1016/j.tube.2004.09.009

المؤلفون: Juraj Ivanyi, Graham Hall, Simon O. Clark, Philip Marsh, Alison Williams, Julia A. Tree

المصدر: Clinical and Experimental Immunology. 138:405-409

مصطلحات موضوعية: Lung Diseases, Tuberculosis, Injections, Subcutaneous, Immunology, Colony Count, Microbial, Dose-Response Relationship, Immunologic, complex mixtures, Mice, Immunopathology, medicine, Animals, Immunology and Allergy, Respiratory system, Lung, Administration, Intranasal, Mice, Inbred BALB C, Mice, Inbred C3H, Granuloma, business.industry, Respiratory disease, respiratory system, medicine.disease, Mycobacterium bovis, Mice, Inbred C57BL, Vaccination, BCG Vaccine, Animal Studies, Female, Nasal administration, business, BCG vaccine, Spleen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6ce3d4de63fc77902f3d90d7d864dc
https://doi.org/10.1111/j.1365-2249.2004.02648.x

المؤلفون: Simon O. Clark, N. P. Goonetilleke, Sarah C. Gilbert, Helen McShane, A Hill, Graham J. Hatch, A. Williams

المصدر: Infection and Immunity. 73:3814-3816

مصطلحات موضوعية: Tuberculosis, Guinea Pigs, Immunology, Biology, complex mixtures, Microbiology, Mycobacterium tuberculosis, Antigen, Immunity, medicine, Animals, Poxviridae, Antigens, Bacterial, Vaccines, Synthetic, Mycobacterium bovis, biology.organism_classification, medicine.disease, Virology, Vaccination, Infectious Diseases, Microbial Immunity and Vaccines, BCG Vaccine, Parasitology, BCG vaccine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67560fbe06a7f316394cbcbf14a2ed9
https://doi.org/10.1128/iai.73.6.3814-3816.2005

المؤلفون: António, Afonso-Barroso, Simon O, Clark, Ann, Williams, Gustavo T, Rosa, Cláudia, Nóbrega, Sandro, Silva-Gomes, Sílvia, Vale-Costa, Roy, Ummels, Neil, Stoker, Farahnaz, Movahedzadeh, Peter, van der Ley, Arjen, Sloots, Marlène, Cot, Ben J, Appelmelk, Germain, Puzo, Jérôme, Nigou, Jeroen, Geurtsen, Rui, Appelberg

المصدر: Cellular microbiology. 15(4)

مصطلحات موضوعية: Lipopolysaccharides, Microbial Viability, Virulence Factors, Macrophages, Guinea Pigs, Dendritic Cells, Mycobacterium tuberculosis, Mycobacterium bovis, Disease Models, Animal, Mice, Host-Pathogen Interactions, Animals, Mannose, Tuberculosis, Pulmonary

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::14c0a75c340a97a5a99fb9ffa4391109
https://pubmed.ncbi.nlm.nih.gov/23121245

المؤلفون: Julia A. Tree, Shivani Singh, Simon O. Clark, Robert J. Wilkinson, Jon S. Friedland, Ann Williams, Luisa Saraiva, Nuria Andreu, Graeme Meintjes, Bernadette Pedersen, Dominic L.F. Kelly, Tolu Oni, Paul T. Elkington, Naomi F. Walker, Francesco Mauri, Liku B. Tezera, Jeanine D'Armiento

المصدر: American journal of respiratory and critical care medicine. 185(9)

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Adult, Tuberculosis, Guinea Pigs, HIV Infections, Matrix metalloproteinase, Critical Care and Intensive Care Medicine, Mycobacterium tuberculosis, Young Adult, Immunopathology, medicine, Animals, Humans, Tuberculosis, Pulmonary, Doxycycline, Lung, biology, business.industry, Standard treatment, Macrophages, Sputum, Articles, Middle Aged, medicine.disease, biology.organism_classification, Matrix Metalloproteinases, Anti-Bacterial Agents, CD4 Lymphocyte Count, medicine.anatomical_structure, Matrix Metalloproteinase 8, Immunology, Cytokines, Matrix Metalloproteinase 2, Matrix Metalloproteinase 3, medicine.symptom, Matrix Metalloproteinase 1, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86251b99058a48dac26b01a7d181e0a
https://pubmed.ncbi.nlm.nih.gov/22345579

المؤلفون: Andrew White, Helen McShane, Adrian V. S. Hill, A. McIntyre, Simon O. Clark, Fergus V. Gleeson, Karen E. Gooch, Sally Sharpe, E. Nuth, Alice A. N. Marriott, Graham Hall, Philip Marsh, Ann Williams, Stuart D. Dowall, Natalie E. R. Beveridge, Mike Dennis, Randall J. Basaraba

المصدر: Clinical and vaccine immunology : CVI. 17(8)

مصطلحات موضوعية: Microbiology (medical), Tuberculosis, Vaccine evaluation, Endpoint Determination, Clinical Biochemistry, Immunology, Mycobacterium tuberculosis, Interferon-gamma, medicine, Animals, Humans, Immunology and Allergy, Tuberculosis Vaccines, Lung, Tuberculosis, Pulmonary, Cell Proliferation, Aerosols, biology, business.industry, ELISPOT, Primate Diseases, Vaccine Research, medicine.disease, biology.organism_classification, Vaccine efficacy, Macaca mulatta, Magnetic Resonance Imaging, Survival Analysis, Clinical trial, Vaccination, Disease Models, Animal, Inhalation, Leukocytes, Mononuclear, Radiography, Thoracic, business, Tuberculosis vaccines, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02d68de444da6caffbe6b21256643a7
http://ora.ox.ac.uk/objects/uuid:23f70ce4-9a0f-4086-9b0c-9dbf564cc949

المؤلفون: Nathalie Winter, Edgar Badell, David J. M. Lewis, Frank E. Aldwell, Philip Marsh, Luiz Roberto Ribeiro Castello-Branco, Simon O. Clark, Dominic L.F. Kelly

المساهمون: Centre for Emergency Preparedness and Response, Health Protection Agency, Génétique mycobactérienne - Mycobacterial genetics, Institut Pasteur [Paris], Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centre for Innovation, University of Otago [Dunedin, Nouvelle-Zélande], St George's Vaccine Institute, Queen Mary University of London (QMUL), European Commission, European Union LSHP-CT-2003-503240, Department of Health (UK), Institut Pasteur [Paris] (IP)

المصدر: Vaccine
Vaccine, 2010, 28 (43), pp.7109-7116. ⟨10.1016/j.vaccine.2010.07.087⟩

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Tuberculosis, Injections, Subcutaneous, Guinea Pigs, Administration, Oral, Spleen, 03 medical and health sciences, Lipid formulation, Adjuvants, Immunologic, Immunity, medicine, Animals, Pulmonary pathology, Lung, Tuberculosis, Pulmonary, 030304 developmental biology, 0303 health sciences, General Veterinary, General Immunology and Microbiology, 030306 microbiology, business.industry, Public Health, Environmental and Occupational Health, BCG Moreau, Mycobacterium tuberculosis, Vaccine efficacy, medicine.disease, Virology, Lipids, 3. Good health, Vaccination, Oral delivery, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Infectious Diseases, medicine.anatomical_structure, Immunization, Immunology, BCG Vaccine, Molecular Medicine, business, BCG vaccine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0849d92736230dc3e83f1a56a47791d6
https://pubmed.ncbi.nlm.nih.gov/20708695

المؤلفون: Ann Williams, Simon O. Clark, Martin L. Cross, Frank E. Aldwell, Matthew R. Lambeth, Julia Vipond

المصدر: Microbes and infection. 10(14-15)

مصطلحات موضوعية: Tuberculosis, Immunology, Guinea Pigs, Administration, Oral, Lung pathology, Body weight, complex mixtures, Microbiology, Mycobacterium tuberculosis, Mice, medicine, Animals, Lung, Mice, Inbred BALB C, biology, Immunogenicity, biology.organism_classification, medicine.disease, Alimentary tract, Vaccination, Infectious Diseases, Liposomes, BCG Vaccine, Female, Mycobacterium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331af267fdf7ff351f0d8246c7da2e1d
https://pubmed.ncbi.nlm.nih.gov/18848638

المؤلفون: Yvonne Perrie, Mark A. Chambers, Simon O. Clark, Pinar Court, Frank E. Aldwell, Hannah Batchelor, Ann Williams, Alan M. Smith, Allan K. Nadian, Martin L. Cross, R. Glyn Hewinson, Julia Vipond

المصدر: Vaccine. 26(46)

مصطلحات موضوعية: Tuberculosis, Alginates, Chemistry, Pharmaceutical, Moraxellaceae Infections, Guinea Pigs, Colony Count, Microbial, Administration, Oral, Spleen, Capsules, Lymphocyte proliferation, Microbiology, Mice, Immune system, Adjuvants, Immunologic, Moraxella bovis, medicine, Animals, Lung, Aerosols, Mycobacterium bovis, Drug Carriers, Mice, Inbred BALB C, General Veterinary, General Immunology and Microbiology, biology, business.industry, Immunogenicity, Body Weight, Vaccination, Public Health, Environmental and Occupational Health, Organ Size, medicine.disease, biology.organism_classification, Infectious Diseases, medicine.anatomical_structure, Immunology, Liposomes, BCG Vaccine, Molecular Medicine, Female, Lymph Nodes, business, BCG vaccine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc0000a492bbeb8c163567cccc8f6dd
https://pubmed.ncbi.nlm.nih.gov/18789366