المؤلفون: James Kinkead, Ryan Ritchie, Paul A.M. Michels, Simon N. Pettit, Adrian J. Highton, Jeremy C. Mottram, Elizabeth A. Blackburn, Carol Austin, Martin Walker, Martin A. Wear, Antonio K. Vong, Malcolm D. Walkinshaw, Andrew John Keats, Scott P. Webster, Divya Malik, Nick Gray, Chris Swain, Li-Hsuan Yen, Iain W. McNae, Peter M Fernandes, Jacqueline Dornan, Elmarie Myburgh

المصدر: McNae, I W, Kinkead, J, Malik, D, Yen, L-H, Walker, M K, Swain, C, Webster, S P, Gray, N, Fernandes, P M, Myburgh, E, Blackburn, E A, Ritchie, R, Austin, C, Wear, M A, Highton, A J, Keats, A J, Vong, A, Dornan, J, Mottram, J C, Michels, P A M, Pettit, S & Walkinshaw, M D 2021, ' Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice ', Nature Communications, vol. 12, no. 1, 1052 . https://doi.org/10.1038/s41467-021-21273-6
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

مصطلحات موضوعية: 0301 basic medicine, Trypanosoma, Science, 030106 microbiology, Allosteric regulation, General Physics and Astronomy, Kaplan-Meier Estimate, Trypanosoma brucei, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Allosteric Regulation, parasitic diseases, medicine, Animals, Humans, African trypanosomiasis, Glycolysis, Parasites, Protein Kinase Inhibitors, Multidisciplinary, biology, Tsetse fly, General Chemistry, Hep G2 Cells, medicine.disease, biology.organism_classification, 030104 developmental biology, Trypanosomiasis, African, Biochemistry, Phosphofructokinases, Acute Disease, Enzyme mechanisms, Phosphorylation, Parasitology, Structure-based drug design, Protein Multimerization, Pathogens, Trypanosomiasis, Phosphofructokinase, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799da05836121fe3900af19fdb8614ee
https://hdl.handle.net/20.500.11820/ba80df50-0eee-4cf5-92f8-bfbfbb7b3473

المؤلفون: Wenzheng Hu, Kangasmetsa Jussi J, Matthew Lawrence, C.S. Spada, Simon N. Pettit, David F. Woodward, Jose L. Martos, Jenny W. Wang, Neil J. Poloso, Robert W. Carling, L David Waterbury

المصدر: ACS Pharmacol Transl Sci

مصطلحات موضوعية: Pharmacology, Chemokine, biology, medicine.drug_class, medicine.medical_treatment, Prostaglandin E2 receptor, Prostaglandin, Prostanoid, Receptor antagonist, chemistry.chemical_compound, Cytokine, chemistry, medicine, biology.protein, Pharmacology (medical), Tumor necrosis factor alpha, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa404d08d89bb58802fc3ffded7c5704
https://pubmed.ncbi.nlm.nih.gov/33344897

المؤلفون: Zhou Wan, David F Woodward, Clive L Cornell, Hans G Fliri, José L Martos, Simon N Pettit, Jenny W Wang, Alexander B Kharlamb, Larry A Wheeler, Michael E Garst, Kari J Landsverk, Craig S Struble, W Daniel Stamer

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://iovs.arvojournals.org/data/Journals/IOVS/932943/z7g00907004107.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1049.1737; http://iovs.arvojournals.org/data/Journals/IOVS/932943/z7g00907004107.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1049.1737
http://iovs.arvojournals.org/data/Journals/IOVS/932943/z7g00907004107.pdf

المؤلفون: Reuben J. Pengelly, Simon N. Pettit, Steve P. Wood, Wenjie Chen, Dallas E. Hughes, Lauren D. Freeman, Jonathan Sanvoisin, Carol Austin, Sharon K. Magnolo

المصدر: SLAS Discovery. 17:868-876

مصطلحات موضوعية: Drug Evaluation, Preclinical, Electrophoretic Mobility Shift Assay, Crystallography, X-Ray, Biochemistry, Analytical Chemistry, Small Molecule Libraries, chemistry.chemical_compound, Adenosine Triphosphate, Capillary electrophoresis, Heat shock protein, Drug Discovery, Humans, Electrophoretic mobility shift assay, HSP90 Heat-Shock Proteins, Binding site, Adenosine Triphosphatases, Binding Sites, Chromatography, biology, Electrophoresis, Capillary, Ligand (biochemistry), Hsp90, Molecular biology, Protein Structure, Tertiary, Radicicol, chemistry, biology.protein, Molecular Medicine, Affinity electrophoresis, Macrolides, Protein Binding, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059f3780d2819207208c4148d1c668f2
https://doi.org/10.1177/1087057112445785

المؤلفون: Victor M. Guzman, D.F. Woodward, C. L. Cornell, Jenny W. Wang, D. F. Scott, K Landsverk, Hans G. Fliri, Simon N. Pettit, Yanbin Liang, A H-P Krauss, Chen Li, Jose L. Martos, M. E. Garst, Larry A. Wheeler, Gary S. Sachs

المصدر: British Journal of Pharmacology. 154:1079-1093

مصطلحات موضوعية: Pharmacology, Prostaglandin, Biology, Molecular biology, Immediate early protein, chemistry.chemical_compound, Mechanism of action, chemistry, Downregulation and upregulation, Second messenger system, medicine, Enzyme-linked receptor, medicine.symptom, Signal transduction, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9721d2272d73246edcde20bb2c95cb7c
https://doi.org/10.1038/bjp.2008.142

المؤلفون: C. L. Cornell, David F. Woodward, Hans G. Fliri, Jose L. Martos, Robert W. Carling, Thierry Jolas, Simon N. Pettit, David Piwnica, Jenny W. Wang, W. Daniel Stamer

مصطلحات موضوعية: Adult, medicine.medical_specialty, genetic structures, Receptors, Prostaglandin, Glaucoma, Pharmacology, Aqueous Humor, Cornea, chemistry.chemical_compound, Trabecular Meshwork, medicine, Electric Impedance, Humans, Latanoprost, Antihypertensive Agents, Cells, Cultured, Intraocular Pressure, Aged, Bimatoprost, Dose-Response Relationship, Drug, Ciliary Body, Tafluprost, Infant, Cloprostenol, Muscle, Smooth, Articles, Middle Aged, medicine.disease, Amides, eye diseases, Actins, Tissue Donors, Surgery, Ciliary muscle, medicine.anatomical_structure, chemistry, Unoprostone, Travoprost, Trabecular meshwork, sense organs, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67f58ae1a141ec64b6f93b7b64bb6c1
https://europepmc.org/articles/PMC3066606/

المؤلفون: R.W.C. Carling, Hans G. Fliri, C. L. Cornell, Simon N. Pettit, Jenny W. Wang, Yanbin Liang, D.F. Woodward, Jose L. Martos

المصدر: Pharmacologytherapeutics. 120(1)

مصطلحات موضوعية: Prostaglandin Antagonists, Polyunsaturated Alkamides, Arachidonic Acids, Pharmacology, chemistry.chemical_compound, Cannabinoid Receptor Modulators, medicine, Animals, Humans, Pharmacology (medical), Receptor, Bimatoprost, Chemistry, Antagonist, Prostanoid, Glaucoma, Anandamide, Endocannabinoid system, Biochemistry, Cyclooxygenase 2, lipids (amino acids, peptides, and proteins), Arachidonic acid, Cyclo-oxygenase, medicine.drug, Endocannabinoids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d587d8653db05d2b8a42de6613c6147
https://pubmed.ncbi.nlm.nih.gov/18700152

المؤلفون: Craig Struble, C. L. Cornell, Simon N. Pettit, David F. Woodward, Larry A. Wheeler, Jenny W. Wang, Alexander B. Kharlamb, Kari J Landsverk, Hans G. Fliri, W. Daniel Stamer, Jose L. Martos, Michael E. Garst, Z. Wan

المصدر: Investigative ophthalmologyvisual science. 48(9)

مصطلحات موضوعية: Male, Intraocular pressure, medicine.medical_specialty, Receptors, Thromboxane, Cell Culture Techniques, Iris, Organ culture, Dinoprost, Dinoprostone, Article, Aqueous Humor, Organ Culture Techniques, In vivo, Trabecular Meshwork, Internal medicine, medicine, Animals, Humans, Calcium Signaling, Receptor, Oxazoles, Antihypertensive Agents, Intraocular Pressure, Aged, Aged, 80 and over, Bimatoprost, Chemistry, Antagonist, Cloprostenol, Muscle, Smooth, Middle Aged, Amides, Lipids, Recombinant Proteins, Endocrinology, medicine.anatomical_structure, Cats, Calcium, Female, Trabecular meshwork, Perfusion, medicine.drug, Muscle Contraction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346c59c04171383c2fb85ddeeac5feda
https://pubmed.ncbi.nlm.nih.gov/17724194

المؤلفون: W Daniel Stamer, David Piwnica, Thierry Jolas, Robert W Carling, Clive L Cornell, Hans Fliri, Jose Martos, Simon N Pettit, Jenny W Wang, David F Woodward, H Fliri, Selcia, E, J Martos, S N Pettit, J W Wang, Allergan, Allergan (E) D F Woodward

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://iovs.arvojournals.org/data/Journals/IOVS/932962/z7g01010005176.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1081.8241; http://iovs.arvojournals.org/data/Journals/IOVS/932962/z7g01010005176.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1081.8241
http://iovs.arvojournals.org/data/Journals/IOVS/932962/z7g01010005176.pdf

المؤلفون: Zhou Wan, David F. Woodward, Clive L. Cornell, Hans G. Fliri, José L. Martos, Simon N. Pettit, Jenny W. Wang, Er B. Kharlamb, Larry A. Wheeler, Michael E. Garst, Kari J. L, Craig S. Struble, W. Daniel Stamer

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.iovs.org/content/48/9/4107.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.1658; http://www.iovs.org/content/48/9/4107.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.1658
http://www.iovs.org/content/48/9/4107.full.pdf