المؤلفون: Paul A. Wilson, Sara Santos Franco, Liu He, Nicholas W. Galwey, Jackie Meakin, Rebecca McIntyre, Simon M. McHugh, Michael A. Nolan, Sarah L. Spain, Thaddeus Carlson, Mercedes Lobera, Justin P. Rubio, Bill Davis, Linda C. McCarthy

المصدر: PLoS ONE, Vol 16, Iss 10 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530322/?tool=EBI; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/379c1f72bac84bec9638d701c7a4dcef

المؤلفون: Paul A. Wilson (8867756), Sara Santos Franco (11592400), Liu He (246513), Nicholas W. Galwey (11592403), Jackie Meakin (11592406), Rebecca McIntyre (688872), Simon M. McHugh (11592409), Michael A. Nolan (11592412), Sarah L. Spain (11592415), Thaddeus Carlson (11592418), Mercedes Lobera (2232325), Justin P. Rubio (11592421), Bill Davis (525333), Linda C. McCarthy (4559770)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, type 3 immunity, sup >+, several autoimmune diseases, profiles reported perturbation, inflammatory bowel disease, differential detoxification response, concept study indicated, cellular detoxification response, attractive therapeutic target, cell maintenance medium, cell differentiation events, wide association studies, metabolic signalling networks, may perturb immune, significant contributory role, div >< p, rorc inverse agonist, four culture conditions, driven transcriptional effects, associated rorc variant, ibd risk associated, cells , transcriptional effects

Relation: https://figshare.com/articles/journal_contribution/Supplementary_experimental_methods_/16848580

الاتاحة: https://doi.org/10.1371/journal.pone.0258316.s001

المؤلفون: Simon M. McHugh, Bill Davis, Liu He, Jackie Meakin, Paul A. Wilson, Sara Santos Franco, Thaddeus J. Carlson, Mercedes Lobera, Linda McCarthy, Justin P. Rubio, Sarah L. Spain, Rebecca E. McIntyre, Michael A. Nolan, Nicholas Galwey

المصدر: PLoS ONE, Vol 16, Iss 10, p e0258316 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Receptors, CXCR3, T cell, Science, Cellular detoxification, Biology, Lymphocyte Activation, Polymorphism, Single Nucleotide, Transcriptome, Immune system, RAR-related orphan receptor gamma, Genotype, medicine, Hypersensitivity, Humans, Genetic Predisposition to Disease, Receptor, Cell Proliferation, Multidisciplinary, Homozygote, Nuclear Receptor Subfamily 1, Group F, Member 3, Inflammatory Bowel Diseases, medicine.anatomical_structure, Gene Expression Regulation, Immunology, Medicine, Ex vivo, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a51219a1299e5099e5290fcffc62fa
https://doaj.org/article/9579a389fd9d4fd68176d966c4cda4dc

المؤلفون: Simon M. McHugh, Paul W. Thompson, Frank A Gray, Onajite Kousin-Ezewu, Jenny L Craigen, Disala Fernando, Alasdair Coles, Donggang Su, Joanne Ellis, Keguan Chen, Sara Santos Franco, Joao-Joaquim Oliveira, Kim Brown, Lea Fortunato, André van Maurik, Ann M. Schwartz, Sophie Gisbert, Jiansong Yang, Sara Brett, Bill Davis, Joseph Cheriyan, Andrew Want, Jeffrey Price

المصدر: British Journal of Clinical Pharmacology

مصطلحات موضوعية: Adult, Male, drug safety, Adolescent, medicine.medical_treatment, T cell, T-Lymphocytes, Pharmacology, Antibodies, Monoclonal, Humanized, 030226 pharmacology & pharmacy, Autoimmune Diseases, immunology, Interleukin-7 Receptor alpha Subunit, Placebos, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pharmacokinetics, Double-Blind Method, medicine, pharmacodynamics, Humans, Pharmacology (medical), 030212 general & internal medicine, Interleukin-7 receptor, Receptor, Infusions, Intravenous, Aged, biology, business.industry, Interleukin, Original Articles, Middle Aged, Healthy Volunteers, Cytokine, medicine.anatomical_structure, Pharmacodynamics, biology.protein, Original Article, Female, monoclonal antibodies, Antibody, business, pharmacokinetics, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af326e175e6773cbef32639a120f87e8
http://europepmc.org/articles/PMC6339973

المؤلفون: Paul A. Wilson (8867756), Sara Santos Franco (11592400), Liu He (246513), Nicholas W. Galwey (11592403), Jackie Meakin (11592406), Rebecca McIntyre (688872), Simon M. McHugh (11592409), Michael A. Nolan (11592412), Sarah L. Spain (11592415), Thaddeus Carlson (11592418), Mercedes Lobera (2232325), Justin P. Rubio (11592421), Bill Davis (525333), Linda C. McCarthy (4559770)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, type 3 immunity, sup >+, several autoimmune diseases, profiles reported perturbation, inflammatory bowel disease, differential detoxification response, concept study indicated, cellular detoxification response, attractive therapeutic target, cell maintenance medium, cell differentiation events, wide association studies, metabolic signalling networks, may perturb immune, significant contributory role, div >< p, rorc inverse agonist, four culture conditions, driven transcriptional effects, associated rorc variant, ibd risk associated, cells , transcriptional effects

Relation: https://figshare.com/articles/figure/Characterization_of_the_Th_cell_populations_by_flow_cytometry_at_day_6_of_cell_culture_under_each_of_the_four_growth_medium_formulations_T_cell_maintenance_medium_or_Th17_driving_medium_in_the_presence_of_either_GSK776_GSK2794776A_an_inacti/16848589

الاتاحة: https://doi.org/10.1371/journal.pone.0258316.g002

المؤلفون: Paul A. Wilson (8867756), Sara Santos Franco (11592400), Liu He (246513), Nicholas W. Galwey (11592403), Jackie Meakin (11592406), Rebecca McIntyre (688872), Simon M. McHugh (11592409), Michael A. Nolan (11592412), Sarah L. Spain (11592415), Thaddeus Carlson (11592418), Mercedes Lobera (2232325), Justin P. Rubio (11592421), Bill Davis (525333), Linda C. McCarthy (4559770)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, type 3 immunity, sup >+, several autoimmune diseases, profiles reported perturbation, inflammatory bowel disease, differential detoxification response, concept study indicated, cellular detoxification response, attractive therapeutic target, cell maintenance medium, cell differentiation events, wide association studies, metabolic signalling networks, may perturb immune, significant contributory role, div >< p, rorc inverse agonist, four culture conditions, driven transcriptional effects, associated rorc variant, ibd risk associated, cells , transcriptional effects

Relation: https://figshare.com/articles/dataset/The_complete_statistical_summary_statistics_of_the_differential_expression_analysis_/16848583

الاتاحة: https://doi.org/10.1371/journal.pone.0258316.s002

المؤلفون: Paul A. Wilson (8867756), Sara Santos Franco (11592400), Liu He (246513), Nicholas W. Galwey (11592403), Jackie Meakin (11592406), Rebecca McIntyre (688872), Simon M. McHugh (11592409), Michael A. Nolan (11592412), Sarah L. Spain (11592415), Thaddeus Carlson (11592418), Mercedes Lobera (2232325), Justin P. Rubio (11592421), Bill Davis (525333), Linda C. McCarthy (4559770)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, type 3 immunity, sup >+, several autoimmune diseases, profiles reported perturbation, inflammatory bowel disease, differential detoxification response, concept study indicated, cellular detoxification response, attractive therapeutic target, cell maintenance medium, cell differentiation events, wide association studies, metabolic signalling networks, may perturb immune, significant contributory role, div >< p, rorc inverse agonist, four culture conditions, driven transcriptional effects, associated rorc variant, ibd risk associated, cells , transcriptional effects

Relation: https://figshare.com/articles/figure/Flow_cytometric_analysis_of_CXCR3_versus_CCR6_of_live_CD4_sup_sup_cells_at_day_6_of_culture_was_used_to_characterize_the_Th1-like_and_Th17-like_cell_populations_/16848586

الاتاحة: https://doi.org/10.1371/journal.pone.0258316.g001

المؤلفون: Paul A. Wilson (8867756), Sara Santos Franco (11592400), Liu He (246513), Nicholas W. Galwey (11592403), Jackie Meakin (11592406), Rebecca McIntyre (688872), Simon M. McHugh (11592409), Michael A. Nolan (11592412), Sarah L. Spain (11592415), Thaddeus Carlson (11592418), Mercedes Lobera (2232325), Justin P. Rubio (11592421), Bill Davis (525333), Linda C. McCarthy (4559770)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, type 3 immunity, sup >+, several autoimmune diseases, profiles reported perturbation, inflammatory bowel disease, differential detoxification response, concept study indicated, cellular detoxification response, attractive therapeutic target, cell maintenance medium, cell differentiation events, wide association studies, metabolic signalling networks, may perturb immune, significant contributory role, div >< p, rorc inverse agonist, four culture conditions, driven transcriptional effects, associated rorc variant, ibd risk associated, cells , transcriptional effects

Relation: https://figshare.com/articles/figure/Genotype_has_no_significant_effect_on_CD4_T_cell_proliferation_/16848592

الاتاحة: https://doi.org/10.1371/journal.pone.0258316.g003

المؤلفون: Paul A. Wilson (8867756), Sara Santos Franco (11592400), Liu He (246513), Nicholas W. Galwey (11592403), Jackie Meakin (11592406), Rebecca McIntyre (688872), Simon M. McHugh (11592409), Michael A. Nolan (11592412), Sarah L. Spain (11592415), Thaddeus Carlson (11592418), Mercedes Lobera (2232325), Justin P. Rubio (11592421), Bill Davis (525333), Linda C. McCarthy (4559770)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, type 3 immunity, sup >+, several autoimmune diseases, profiles reported perturbation, inflammatory bowel disease, differential detoxification response, concept study indicated, cellular detoxification response, attractive therapeutic target, cell maintenance medium, cell differentiation events, wide association studies, metabolic signalling networks, may perturb immune, significant contributory role, div >< p, rorc inverse agonist, four culture conditions, driven transcriptional effects, associated rorc variant, ibd risk associated, cells , transcriptional effects

Relation: https://figshare.com/articles/figure/Transcriptional_profiles_cluster_according_to_choice_of_differentiation_medium_/16848595

الاتاحة: https://doi.org/10.1371/journal.pone.0258316.g004

المؤلفون: Paul A. Wilson (8867756), Sara Santos Franco (11592400), Liu He (246513), Nicholas W. Galwey (11592403), Jackie Meakin (11592406), Rebecca McIntyre (688872), Simon M. McHugh (11592409), Michael A. Nolan (11592412), Sarah L. Spain (11592415), Thaddeus Carlson (11592418), Mercedes Lobera (2232325), Justin P. Rubio (11592421), Bill Davis (525333), Linda C. McCarthy (4559770)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, type 3 immunity, sup >+, several autoimmune diseases, profiles reported perturbation, inflammatory bowel disease, differential detoxification response, concept study indicated, cellular detoxification response, attractive therapeutic target, cell maintenance medium, cell differentiation events, wide association studies, metabolic signalling networks, may perturb immune, significant contributory role, div >< p, rorc inverse agonist, four culture conditions, driven transcriptional effects, associated rorc variant, ibd risk associated, cells , transcriptional effects

Relation: https://figshare.com/articles/figure/RORC_transcripts_are_differentially_expressed_in_presence_of_differentiating_medium_/16848598

الاتاحة: https://doi.org/10.1371/journal.pone.0258316.g005

المؤلفون: Paul A. Wilson (8867756), Sara Santos Franco (11592400), Liu He (246513), Nicholas W. Galwey (11592403), Jackie Meakin (11592406), Rebecca McIntyre (688872), Simon M. McHugh (11592409), Michael A. Nolan (11592412), Sarah L. Spain (11592415), Thaddeus Carlson (11592418), Mercedes Lobera (2232325), Justin P. Rubio (11592421), Bill Davis (525333), Linda C. McCarthy (4559770)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, type 3 immunity, sup >+, several autoimmune diseases, profiles reported perturbation, inflammatory bowel disease, differential detoxification response, concept study indicated, cellular detoxification response, attractive therapeutic target, cell maintenance medium, cell differentiation events, wide association studies, metabolic signalling networks, may perturb immune, significant contributory role, div >< p, rorc inverse agonist, four culture conditions, driven transcriptional effects, associated rorc variant, ibd risk associated, cells , transcriptional effects

Relation: https://figshare.com/articles/figure/Genotype_is_associated_with_differential_transcriptional_effects_on_effects_on_canonical_immune_and_metabolic_signalling_networks_/16848601

الاتاحة: https://doi.org/10.1371/journal.pone.0258316.g006

المؤلفون: Paul A. Wilson (8867756), Sara Santos Franco (11592400), Liu He (246513), Nicholas W. Galwey (11592403), Jackie Meakin (11592406), Rebecca McIntyre (688872), Simon M. McHugh (11592409), Michael A. Nolan (11592412), Sarah L. Spain (11592415), Thaddeus Carlson (11592418), Mercedes Lobera (2232325), Justin P. Rubio (11592421), Bill Davis (525333), Linda C. McCarthy (4559770)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, type 3 immunity, sup >+, several autoimmune diseases, profiles reported perturbation, inflammatory bowel disease, differential detoxification response, concept study indicated, cellular detoxification response, attractive therapeutic target, cell maintenance medium, cell differentiation events, wide association studies, metabolic signalling networks, may perturb immune, significant contributory role, div >< p, rorc inverse agonist, four culture conditions, driven transcriptional effects, associated rorc variant, ibd risk associated, cells , transcriptional effects

Relation: https://figshare.com/articles/figure/The_homozygous_genotype_differentially_effects_transcriptional_response_in_the_presence_of_an_RORC_inverse_agonist_/16848604

الاتاحة: https://doi.org/10.1371/journal.pone.0258316.g007

المؤلفون: Odile Dewit, Chao Chen, Jill C. Richardson, Simon M. McHugh, Paul Scott-Stevens, Bart Laurijssens, Zahid Ali, Anastasia Stylianou, Thor Ostenfeld, Louise Hosking

المصدر: British Journal of Clinical Pharmacology. 75:197-207

مصطلحات موضوعية: Pharmacology, Allosteric modulator, business.industry, Drug development, Pharmacokinetics, Tolerability, In vivo, Blood drug, Pharmacodynamics, Medicine, Pharmacology (medical), Receptor, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0e5128577da8df3d69aa41767ef7b044
https://doi.org/10.1111/j.1365-2125.2012.04320.x

المؤلفون: Chris M. Dodds, Antonella Napolitano, Annelize Koch, Barry V. O'Neill, Simon M. McHugh, Pradeep J. Nathan, Sam R. Miller, Edward T. Bullmore, David Simons

المصدر: Appetite. 59:656-661

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, media_common.quotation_subject, Hyperphagia, Overweight, Body Mass Index, Surveys and Questionnaires, Internal medicine, medicine, Humans, Personality, Obesity, Bulimia, Overeating, Eating behaviour, General Psychology, media_common, Principal Component Analysis, Nutrition and Dietetics, Binge eating, Body Weight, Feeding Behavior, Middle Aged, Anthropometry, medicine.disease, Endocrinology, Adipose Tissue, Female, medicine.symptom, Psychology, Body mass index, Clinical psychology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605947cad3b97bfe6fdf91fe6e80e916
https://doi.org/10.1016/j.appet.2012.07.017

المؤلفون: Darren C. Robertson, Claire Beaumont, Duncan Richards, Simon M. McHugh, William J. Guiney, Steve R. Thomas, Annelize Koch

المصدر: British Journal of Clinical Pharmacology. 72:133-142

مصطلحات موضوعية: Pharmacology, Drug, medicine.medical_specialty, business.industry, Metabolite, media_common.quotation_subject, Disposition, Gastroenterology, chemistry.chemical_compound, medicine.anatomical_structure, Drug development, chemistry, Simvastatin, Biliary tract, Internal medicine, medicine, Duodenum, Pharmacology (medical), business, Enterohepatic circulation, medicine.drug, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::01b34c4c15654bfefed96b3dad8346ba
https://doi.org/10.1111/j.1365-2125.2011.03956.x

المؤلفون: Alexandra Belson, Kelly Hardes, John Stone, Simon M. McHugh, Nicola Scott, Tim S. Schmidt, Sara Brett, Bill Davis, Disala Fernando, Deborah Clark, João Joaquim Oliveira

المصدر: Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 65(5)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Pathology, medicine.medical_specialty, Erythema, medicine.medical_treatment, T cell, T-Lymphocytes, Immunology, Tuberculin, chemical and pharmacologic phenomena, complex mixtures, 03 medical and health sciences, 0302 clinical medicine, Biopsy, Medicine, Cytotoxic T cell, Humans, Hypersensitivity, Delayed, Skin, Pharmacology, integumentary system, biology, medicine.diagnostic_test, business.industry, Vaccination, hemic and immune systems, Middle Aged, Suction blister, 030104 developmental biology, Cytokine, medicine.anatomical_structure, Hemocyanins, biology.protein, Cytokines, Female, medicine.symptom, business, Keyhole limpet hemocyanin, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d344eeb09843b0749d426262a419d8d2
https://pubmed.ncbi.nlm.nih.gov/26969026

المؤلفون: David R. Willé, Philip Lawrence, Chris M. Dodds, Fruzsina Soltesz, Simon M. McHugh, Bai Lu, Edward T. Bullmore, Sam R. Miller, Pradeep J. Nathan, Rodney J. Croft, James T. Teo, Graham D Bentley

المصدر: The international journal of neuropsychopharmacology. 17(5)

مصطلحات موضوعية: Adult, Male, Genotyping Techniques, medicine.medical_treatment, Auditory cortex, Polymorphism, Single Nucleotide, Young Adult, Neuroplasticity, medicine, Humans, Pharmacology (medical), Alleles, Pharmacology, Brain-derived neurotrophic factor, Auditory Cortex, Neuronal Plasticity, Transcranial direct-current stimulation, Brain-Derived Neurotrophic Factor, Motor Cortex, Middle Aged, Evoked Potentials, Motor, Transcranial Magnetic Stimulation, Electric Stimulation, Transcranial magnetic stimulation, Psychiatry and Mental health, Acoustic Stimulation, Synaptic plasticity, Facilitation, Auditory Perception, Evoked Potentials, Auditory, Female, Psychology, Tetanic stimulation, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a03977d86b04f5dc3eaea71c057e57
https://pubmed.ncbi.nlm.nih.gov/24405657

المؤلفون: Richard N. Henson, Kay Maltby, Graham D Bentley, John Suckling, Sam R. Miller, Simon M. McHugh, Andrew L Skeggs, Kamilla W. Miskowiak, Chris M. Dodds, Pradeep J. Nathan, Edward T. Bullmore, Philip Lawrence, Roger Tait, Cinly Ooi, Fruzsina Soltesz

المصدر: PLoS ONE, Vol 8, Iss 11, p e74133 (2013)
PLoS ONE

مصطلحات موضوعية: Adult, Memory, Episodic, Hippocampus, lcsh:Medicine, Biology, Hippocampal formation, Temporal lobe, Double-Blind Method, medicine, Biological neural network, Humans, Allele, lcsh:Science, Episodic memory, Alleles, Brain-derived neurotrophic factor, Multidisciplinary, Polymorphism, Genetic, medicine.diagnostic_test, Brain-Derived Neurotrophic Factor, lcsh:R, Middle Aged, Female, lcsh:Q, Nerve Net, Functional magnetic resonance imaging, Neuroscience, Research Article

وصف الملف: application/octet-stream

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9cfdcee9917f5c82c6c5f2bf8ad2949
http://europepmc.org/articles/PMC3823923?pdf=render

المؤلفون: Sally Wetten, Fredrik Karpe, Simon M. McHugh, Jill C. Richardson, Edward T. Bullmore, Charles J. Cox, Bill Davis, Alison M. Pickett, Annelize Koch, Shilina Roman, Sam R. Miller, John A. Todd

المصدر: British Journal of Clinical Pharmacology; Vol 74

مصطلحات موضوعية: Adult, Lipopolysaccharides, Male, Heterozygote, Pyrrolidines, Genotype, Purinergic P2X Receptor Antagonists, medicine.drug_class, Interleukin-1beta, Short Report, Single-nucleotide polymorphism, Pharmacology, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Adenosine Triphosphate, Genetic variation, medicine, Leukocytes, Humans, Pharmacology (medical), Prospective Studies, Genotyping, Gene, 030304 developmental biology, Genetics, 0303 health sciences, Dose-Response Relationship, Drug, Homozygote, Middle Aged, Receptor antagonist, Phenotype, Pharmacodynamics, Female, Receptors, Purinergic P2X7, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7536978b3e7fe1d3db85574b3285b86f
https://pubmed.ncbi.nlm.nih.gov/22295949

المؤلفون: William J, Guiney, Claire, Beaumont, Steve R, Thomas, Darren C, Robertson, Simon M, McHugh, Annelize, Koch, Duncan, Richards

المصدر: British journal of clinical pharmacology. 72(1)

مصطلحات موضوعية: Adult, Male, Simvastatin, Magnetic Resonance Spectroscopy, Anticholesteremic Agents, Methods in Clinical Pharmacology, Bile Acids and Salts, Pharmaceutical Preparations, Reference Values, Enterohepatic Circulation, Bile, Humans, Female, Reagent Kits, Diagnostic, Biliary Tract, Chromatography, High Pressure Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::aeca5dffff71dddc31c06381d32eaaff
https://pubmed.ncbi.nlm.nih.gov/21366667