يعرض 1 - 1 نتائج من 1 نتيجة بحث عن '"Silvia Portolan"', وقت الاستعلام: 0.29s تنقيح النتائج
  1. 1
    Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis

    المؤلفون: Michael David Rogers, Jeffery N. Carroll, Mark A. Massa, Jeffrey Hitchcock, Peter G. Ruminski, Michelle A. Schmidt, Bruce C. Hamper, Strohbach Joseph Walter, Huey S. Shieh, Laurence O. Whiteley, Katherine E. Palmquist, Joe T. Collins, Grace E. Munie, Hanau Cathleen E, H. Peter Kleine, Mark E. Schnute, T. Sunyer, Nicole Caspers, John E. Baldus, Theresa R. Fletcher, Joseph J. McDonald, Silvia Portolan, Jeffrey A. Scholten, Dean Messing, Margaret L. Grapperhaus, Brandon Collins

    المصدر: Journal of Medicinal Chemistry. 59:313-327

    مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Organic anion transporter 1, biology, Matrix metalloproteinase inhibitor, medicine.drug_class, Stereochemistry, Carboxylic acid, Type II collagen, Kidney metabolism, Carboxamide, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, Hydroxymethyl

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b1bf588f2b187240a5d8f4d5ee2e305b
    https://doi.org/10.1021/acs.jmedchem.5b01434

    View record in OpenAIRE

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