المؤلفون: Edith Marcial-Juárez, Marisol Pérez-Toledo, Saba Nayar, Elena Pipi, Areej Alshayea, Ruby Persaud, Sian E. Jossi, Rachel Lamerton, Francesca Barone, Ian R. Henderson, Adam F. Cunningham

المصدر: iScience, Vol 26, Iss 4, Pp 106310- (2023)

مصطلحات موضوعية: Immunology, Immune response, Components of the immune system, Microbiology, Cell biology, Science

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223003875; https://doaj.org/toc/2589-0042

URL الوصول: https://doaj.org/article/66b78e952b064cdaa6f3dbdd10691c6c

المؤلفون: Siân E. Jossi, Melissa Arcuri, Areej Alshayea, Ruby R. Persaud, Edith Marcial-Juárez, Elena Palmieri, Roberta Di Benedetto, Marisol Pérez-Toledo, Jamie Pillaye, Will M. Channell, Anna E. Schager, Rachel E. Lamerton, Charlotte N. Cook, Margaret Goodall, Takeshi Haneda, Andreas J. Bäumler, Lucy H. Jackson-Jones, Kai-Michael Toellner, Calman A. MacLennan, Ian R. Henderson, Francesca Micoli, Adam F. Cunningham

المصدر: Frontiers in Immunology, Vol 14 (2023)

مصطلحات موضوعية: vaccine, antibody, capsular polysaccharide, conjugate, typhoid, Vi antigen, Immunologic diseases. Allergy, RC581-607

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139329/full; https://doaj.org/toc/1664-3224; https://doaj.org/article/8d8d1d6c683c43d999c25609b7e2e59d

الاتاحة: https://doi.org/10.3389/fimmu.2023.1139329
https://doaj.org/article/8d8d1d6c683c43d999c25609b7e2e59d

المؤلفون: Rachel E. Lamerton, Edith Marcial-Juarez, Sian E. Faustini, Marisol Perez-Toledo, Margaret Goodall, Siân E. Jossi, Maddy L. Newby, Iain Chapple, Thomas Dietrich, Tonny Veenith, Adrian M. Shields, Lorraine Harper, Ian R. Henderson, Julie Rayes, David C. Wraith, Steve P. Watson, Max Crispin, Mark T. Drayson, Alex G. Richter, Adam F. Cunningham

المصدر: Frontiers in Immunology, Vol 13 (2022)

مصطلحات موضوعية: complement, COVID-19, SARS-CoV-2, vaccine, antibodies, Immunologic diseases. Allergy, RC581-607

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.838780/full; https://doaj.org/toc/1664-3224; https://doaj.org/article/e96e183f4c0140d195866a01fcba3220

الاتاحة: https://doi.org/10.3389/fimmu.2022.838780
https://doaj.org/article/e96e183f4c0140d195866a01fcba3220

المؤلفون: C. Coral Domínguez-Medina, Marisol Pérez-Toledo, Anna E. Schager, Jennifer L. Marshall, Charlotte N. Cook, Saeeda Bobat, Hyea Hwang, Byeong Jae Chun, Erin Logan, Jack A. Bryant, Will M. Channell, Faye C. Morris, Sian E. Jossi, Areej Alshayea, Amanda E. Rossiter, Paul A. Barrow, William G. Horsnell, Calman A. MacLennan, Ian R. Henderson, Jeremy H. Lakey, James C. Gumbart, Constantino López-Macías, Vassiliy N. Bavro, Adam F. Cunningham

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/5196a15dc94f4468af82d42ac9f3cb2e

المؤلفون: Ross T. Slater, Lucy R. Frost, Sian E. Jossi, Andrew D. Millard, Meera Unnikrishnan

المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/f3b0901153dc407aa7e0aef5a4b78572

المؤلفون: Edith Marcial-Juárez, Marisol Perez-Toledo, Saba Nayar, Elena Pipi, Areej Alshayea, Ruby Persaud, Sian E. Jossi, Rachel Lamerton, Francesca Barone, Ian R. Henderson, Adam F. Cunningham

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::64b5840bdd58556baf13bae52c187a43
https://doi.org/10.1101/2022.12.11.519997

المؤلفون: Siân E. Jossi, Melissa Arcuri, Areej Alshayea, Ruby R. Persaud, Edith Marcial-Juárez, Elena Palmieri, Roberta Di Benedetto, Marisol Pérez-Toledo, Jamie Pillaye, Will M. Channell, Anna E. Schager, Rachel E. Lamerton, Charlotte N. Cook, Margaret Goodall, Takeshi Haneda, Andreas J. Bäumler, Lucy H. Jackson-Jones, Kai-Michael Toellner, Calman A. MacLennan, Ian R. Henderson, Francesca Micoli, Adam F. Cunningham

مصطلحات موضوعية: Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, vaccine, antibody, capsular polysaccharide, conjugate, typhoid, Vi antigen

Relation: https://figshare.com/articles/dataset/DataSheet_1_Vi_polysaccharide_and_conjugated_vaccines_afford_similar_early_IgM_or_IgG-independent_control_of_infection_but_boosting_with_conjugated_Vi_vaccines_sustains_the_efficacy_of_immune_responses_docx/22322044

الاتاحة: https://doi.org/10.3389/fimmu.2023.1139329.s001
https://figshare.com/articles/dataset/DataSheet_1_Vi_polysaccharide_and_conjugated_vaccines_afford_similar_early_IgM_or_IgG-independent_control_of_infection_but_boosting_with_conjugated_Vi_vaccines_sustains_the_efficacy_of_immune_responses_docx/22322044

المؤلفون: Matthew K. O'Shea, Stephen Taylor, Marisol Perez-Toledo, Gabriella L. Morley, Margaret Goodall, Sian E Jossi, Adam F. Cunningham, Sian E Faustini, Alex G. Richter, Adrian M Shields, Edith Marcial-Juarez, Maddy L. Newby, Yasunori Watanabe, Joel D. Allen, Mark T. Drayson, Max Crispin

المصدر: Emerging Infectious Diseases, Vol 26, Iss 12, Pp 2970-2973 (2020)
Emerging Infectious Diseases

مصطلحات موضوعية: Microbiology (medical), 2019-20 coronavirus outbreak, Epidemiology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 030231 tropical medicine, DBS, lcsh:Medicine, Antibodies, Viral, medicine.disease_cause, COVID-19 Serological Testing, Serology, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, respiratory infections, 0302 clinical medicine, Predictive Value of Tests, antibody, medicine, Humans, viruses, lcsh:RC109-216, 030212 general & internal medicine, Coronavirus, biology, business.industry, SARS-CoV-2, lcsh:R, Dispatch, COVID-19, Serum samples, dried blood spot, Virology, zoonoses, Dried blood spot, nervous system diseases, Sensitive Detection of SARS-CoV-2–Specific Antibodies in Dried Blood Spot Samples, Specific antibody, Infectious Diseases, surgical procedures, operative, nervous system, coronavirus disease, Case-Control Studies, Spike Glycoprotein, Coronavirus, biology.protein, Dried Blood Spot Testing, Antibody, business, therapeutics, severe acute respiratory syndrome coronavirus 2

وصف الملف: text

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e8530524416a366be8e9e607ffd3c1
https://wwwnc.cdc.gov/eid/article/26/12/20-3309_article

المؤلفون: Celina Whalley, Charlotte Poxon, Gabriella L. Morley, Kasun Wanigasooriya, Lyndsey A Dunbar, Mark T. Drayson, Dee E McLoughlin, Saly Al-Taei, Mark I. Garvey, Beena Emmanuel, Golaleh McGinnell, Sian E Jossi, Megan Richter, Andrew D Beggs, Marisol Perez-Toledo, Joel D. Allen, Adam F. Cunningham, Eloise M Walker, Agnieszka E. Zielinska, Joanna Gray, Max Crispin, Joanna O'Neill, Erin L. Aldera, Adrian M Shields, David C. Wraith, Andrew Bosworth, Oliver J Pickles, Sian E Faustini, Claire Backhouse, Alex G. Richter, Daniel Ebanks, I. Michael Kidd, Danai Papakonstantinou, Yasunori Watanabe

المصدر: Thorax

مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Cross-sectional study, Health Personnel, Prevalence, Context (language use), Antibodies, Viral, Asymptomatic, 03 medical and health sciences, 0302 clinical medicine, respiratory infection, Seroepidemiologic Studies, Internal medicine, Humans, Medicine, Seroprevalence, 030212 general & internal medicine, Seroconversion, Pandemics, Asymptomatic Diseases, 0303 health sciences, SARS-CoV-2, 030306 microbiology, business.industry, COVID-19, Respiratory infection, clinical epidemiology, Middle Aged, infection control, Cross-Sectional Studies, RNA, Viral, Female, viral infection, medicine.symptom, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd27dd511f0616b3ed2ed8baf05196f
https://doi.org/10.1136/thoraxjnl-2020-215414

المؤلفون: Ian R. Henderson, David R. Withers, Saeeda Bobat, Nick D. Jones, Adam F. Cunningham, Charlotte N. Cook, Amanda E. Rossiter, Adriana Flores-Langarica, Steve P. Watson, Nonantzin Beristain-Covarrubias, Jessica L. Rooke, Ewan A. Ross, Kyoko Nakamura, Alicia Garcia-Gimenez, Ruby R Persaud, Ruth E. Coughlan, Jessica Hitchcock, Marisol Perez-Toledo, Edith Marcial-Juarez, Sian E Jossi, William M Channell

المساهمون: Perez-Toledo, Marisol [0000-0002-5734-255X], Beristain-Covarrubias, Nonantzin [0000-0002-4828-5282], Bobat, Saeeda [0000-0002-6806-3900], Garcia-Gimenez, Alicia [0000-0003-0604-3215], Jossi, Sian [0000-0003-0447-5030], Persaud, Ruby R [0000-0002-8626-5311], Marcial-Juarez, Edith [0000-0001-9211-2541], Watson, Steve P [0000-0002-7846-7423], Apollo - University of Cambridge Repository

المصدر: The Journal of Immunology Author Choice

مصطلحات موضوعية: Salmonella typhimurium, Salmonella, Infectious Disease and Host Response, Immunology, Cell, Nitric Oxide Synthase Type II, chemical and pharmacologic phenomena, Biology, medicine.disease_cause, Microbiology, 03 medical and health sciences, Interferon-gamma, Mice, 0302 clinical medicine, Inducible no synthase, Immune system, medicine, Immunology and Allergy, Animals, Transcription factor, Mice, Knockout, Granuloma, Interleukin-17, hemic and immune systems, Th1 Cells, biology.organism_classification, Neutrophilia, medicine.anatomical_structure, Salmonella Infections, medicine.symptom, T-Box Domain Proteins, Intracellular, Bacteria, 030215 immunology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f935dc3ac3b79d81de1e6f0bd0639da9
http://europepmc.org/articles/PMC7372318

المؤلفون: Adam F. Cunningham, Yasunori Watanabe, Sian E Faustini, Maddy L. Newby, Firdaus Samsudin, Edith Marcial-Juarez, Jason S. McLellan, Peter J. Bond, Sian E Jossi, Himanshi Chawla, Rachel E Lamerton, Alex G. Richter, Joel D. Allen, Max Crispin

المصدر: Journal of Molecular Biology

مصطلحات موضوعية: glycoprotein, Glycan, Glycosylation, Proline, Mutation, Missense, Oligosaccharides, serology, Antibodies, Viral, law.invention, chemistry.chemical_compound, Protein structure, Antigen, Polysaccharides, Structural Biology, law, antibody, Humans, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, SARS-CoV-2, COVID-19, Protein engineering, Recombinant Proteins, Immunoglobulin A, carbohydrates (lipids), Immunoglobulin M, Biochemistry, chemistry, Immunoglobulin G, Spike Glycoprotein, Coronavirus, Recombinant DNA, biology.protein, Antibody, Glycoprotein, Mannose, Research Article

وصف الملف: text

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28865d83c4336e81c9d352eba937754
https://eprints.soton.ac.uk/453159/

المؤلفون: Rachel E. Lamerton, Edith Marcial-Juarez, Sian E. Faustini, Marisol Perez-Toledo, Margaret Goodall, Siân E. Jossi, Maddy L. Newby, Iain Chapple, Thomas Dietrich, Tonny Veenith, Adrian M. Shields, Lorraine Harper, Ian R. Henderson, Julie Rayes, David C. Wraith, Steve P. Watson, Max Crispin, Mark T. Drayson, Alex G. Richter, Adam F. Cunningham

مصطلحات موضوعية: Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, complement, COVID-19, SARS-CoV-2, vaccine, antibodies

Relation: https://figshare.com/articles/dataset/DataSheet_1_SARS-CoV-2_Spike-_and_Nucleoprotein-Specific_Antibodies_Induced_After_Vaccination_or_Infection_Promote_Classical_Complement_Activation_docx/20220840

الاتاحة: https://doi.org/10.3389/fimmu.2022.838780.s001
https://figshare.com/articles/dataset/DataSheet_1_SARS-CoV-2_Spike-_and_Nucleoprotein-Specific_Antibodies_Induced_After_Vaccination_or_Infection_Promote_Classical_Complement_Activation_docx/20220840

المؤلفون: Adrian M Shields, David C. Wraith, Margaret Goodall, Ian R. Henderson, Julie Rayes, Maddy L. Newby, Lorraine Harper, Sian E Faustini, Sian E Jossi, Iain Chapple, Marisol Perez-Toledo, Tonny Veenith, Adam F. Cunningham, Rachel E Lamerton, Thomas Dietrich, Max Crispin, Steve P. Watson, Edith Marcial Juarez, Mark T. Drayson, Alex G. Richter

مصطلحات موضوعية: chemistry.chemical_classification, chemical and pharmacologic phenomena, Biology, In vitro, Complement (complexity), Complement system, Vaccination, Classical complement pathway, Antigen, chemistry, Immunology, biology.protein, Antibody, Glycoprotein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fd8f94df14f51925dd703f4f234dab7f
https://doi.org/10.1101/2021.11.22.21266681

المؤلفون: Mark J. Ponsford, Stephen Harding, Carrie R. Willcox, Marisol Perez-Toledo, Edith Marcial-Juarez, Margaret Goodall, Maddy L. Newby, Tim Plant, Alex G. Richter, Benjamin E. Willcox, Barbara Torlinska, Sian E Faustini, Yasunori Watanabe, Adrian M Shields, David C. Wraith, Alex R. Cook, Gabriella L. Morley, Jennifer L J Heaney, Adam F. Cunningham, Mark T. Drayson, Matthew K. O'Shea, Mahboob Salim, Stephen Jolles, Aarnoud Huissoon, Sian E Jossi, Tonny Veenith, Max Crispin, Joel D. Allen

المصدر: Immunology
medRxiv
article-version (status) pre
article-version (number) 1

مصطلحات موضوعية: 0301 basic medicine, Immunoglobulin A, Saliva, Immunology, Enzyme-Linked Immunosorbent Assay, Antibodies, Viral, Article, Immunoglobulin G, SARS‐CoV‐2, Serology, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, COVID‐19, Humans, Immunology and Allergy, Medicine, antibodies, Antigens, Viral, biology, SARS-CoV-2, business.industry, COVID-19, Original Articles, 030104 developmental biology, Immunoglobulin M, Spike Glycoprotein, Coronavirus, biology.protein, Original Article, ELISA, Antibody, business, 030215 immunology

وصف الملف: text; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2ae21c4b0fbc69fefbd60f991a6801
https://eprints.soton.ac.uk/449804/

المؤلفون: Aarnoud Huissoon, Sian E Jossi, Leigh J Williams, Mark T. Drayson, Gregg Wallis, Alex M Cook, Adrian M Shields, Dale Kay, Alex G. Richter, Maddy L. Newby, Sian E Faustini, Lorna Taylor, Joel D. Allen, Max Crispin, Stephen Harding, Adam F. Cunningham, Tim Plant, Sarah Beck, Marisol Perez-Toledo

المصدر: Journal of Immunological Methods

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Low prevalence, Coronavirus disease 2019 (COVID-19), Igm antibody, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Serological, Enzyme-Linked Immunosorbent Assay, Dried blood spot, Antibodies, Viral, Gastroenterology, Serology, COVID-19 Serological Testing, Mild disease, Internal medicine, medicine, Immunology and Allergy, Humans, Dried blood, biology, business.industry, SARS-CoV-2, COVID-19, Elisa assay, Middle Aged, Immunoglobulin A, Trimeric spike protein, Immunoglobulin M, Immunoglobulin G, biology.protein, Female, Antibody, business, Research Paper

وصف الملف: text

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1401e675fdbe094703d975983e502b7
https://eprints.soton.ac.uk/448852/

المؤلفون: Eslam Al-Abadi, Deepthi Jyothish, Sian E Faustini, Eleni Syrimi, Joel D. Allen, Mahboob Salim, Marisol Perez-Toledo, Alex G. Richter, Steven B. Welch, Scott Hackett, Benjamin E. Willcox, Ashish Chikermane, Hari Krishnan Kanthimathinathan, Mark T. Drayson, Kavitha Masilamani, Tonny Veenith, Barnaby R. Scholefield, Max Crispinl, Margaret Goodall, Edith Marcial-Juarez, Carrie R. Willcox, Yasunori Watanabe, Adrian M Shields, David C. Wraith, Sian E Jossi, Adam F. Cunningham

مصطلحات موضوعية: business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8aef13b44c0642dfc6bcd9b3cc8c31a
https://doi.org/10.1111/pai.13504/v2/response1

المؤلفون: Lorna Taylor, Max Crispin, Alex G. Richter, Sarah Beck, Maddy L. Newby, Leigh J Williams, Dale Kay, Joel D. Allen, Mark T. Drayson, Sian E Faustini, Gregg Wallis, Marisol Perez-Toledo, Tim Plant, Adrian M Shields, Alex M Cook, Stephen Harding, Adam F. Cunningham, Aarnoud Huissoon, Sian E Jossi

مصطلحات موضوعية: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), biology, business.industry, Igm antibody, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Elisa assay, Serum samples, Gastroenterology, Serology, Internal medicine, medicine, biology.protein, Antibody, business, Dried blood

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d9b339003c72eaecf082b45adfa18403
https://doi.org/10.1101/2020.11.30.20229732

المؤلفون: Claire Backhouse, Alex G. Richter, Daniel Ebanks, Joanne O'Neill, Sian E Faustini, Golaleh McGinnell, Saly Al-Taei, Mark T. Drayson, Mark I. Garvey, Adrian M Shields, David C. Wraith, Sian E Jossi, Lynsey Dunbar, Yasunori Watanabe, Annabel Grinbergs, Adam F. Cunningham, Beena Emmanuel, Marisol Perez-Toledo, Joel D. Allen, Aduragbemi A Faniyi, Max Crispin

المصدر: medRxiv
article-version (status) pre
article-version (number) 1
BMJ Open Respiratory Research, Vol 8, Iss 1 (2021)
BMJ Open Respiratory Research

مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, Immunoglobulin A, Health Personnel, Respiratory Infection, Anosmia, Context (language use), Disease, Antibodies, Viral, Article, Immunoglobulin G, Serology, Diseases of the respiratory system, Seroepidemiologic Studies, Humans, Seroprevalence, Medicine, Retrospective Studies, RC705-779, biology, business.industry, COVID-19, Respiratory infection, Retrospective cohort study, clinical epidemiology, Middle Aged, United Kingdom, Immunoglobulin M, Antibody Formation, Cohort, Immunology, biology.protein, Female, Antibody, medicine.symptom, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369ce2398ffbc976c60a17b3ff997897
https://doi.org/10.1101/2020.11.12.20230763

المؤلفون: Mark T. Drayson, Adrian M Shields, Margaret Goodall, Maddy L. Newby, Gabriella L. Morley, Yasunori Watanabe, Sian E Faustini, Marisol Perez-Toledo, Edith Marcial-Juarez, Adam F. Cunningham, Sian E Jossi, Alex G. Richter, Joel D. Allen, Max Crispin, Stephen Taylor, Matthew K. O'Shea

مصطلحات موضوعية: Venipuncture, biology, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Spike Protein, Serology, Dried blood spot, Specific antibody, Immunology, biology.protein, Medicine, Antibody, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::558fa46a480429a8a28083cb4c52e219
https://doi.org/10.1101/2020.07.01.20144295

المؤلفون: Jennifer L J Heaney, Alex G. Richter, Ponsford J Mark, Joel D. Allen, Maddy L. Newby, Adrian M Shields, David C. Wraith, Stephen Harding, Adam F. Cunningham, Gabriella L. Morley, Matthew K. O'Shea, Mark T. Drayson, Margaret Goodall, Stephen Jolles, Benjamin E. Willcox, Barbara Torlinska, Edith Marcial-Juarez, Carrie R. Willcox, Sian E Faustini, Tim Plant, Aarnoud Huissoon, Tonny Veenith, Max Crispin, Alex R. Cook, Mahboob Salim, Sian E Jossi, Marisol Perez-Toledo, Yasunori Watanabe

مصطلحات موضوعية: Saliva, Allergy, biology, business.industry, medicine.disease, Asymptomatic, Virus, Serology, Immune system, Antigen, Immunology, biology.protein, Medicine, Antibody, medicine.symptom, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eac59e82fddaac5622aa626ad6574d5