المؤلفون: Shangmei Cao, Shaozhe Yang, Bolin Chen, Xixia Chen, Xiuhong Fu, Shuifu Tang

المصدر: Renal Failure, Vol 46, Iss 2 (2024)

مصطلحات موضوعية: Primary membranous nephropathy, machine learning algorithms, differential diagnosis, anti-PLA2R, IgG, Xgboost model, Diseases of the genitourinary system. Urology, RC870-923

وصف الملف: electronic resource

Relation: https://doaj.org/toc/0886-022X; https://doaj.org/toc/1525-6049

URL الوصول: https://doaj.org/article/78b3b26d74fa4d76a57222f224bb84e4

المؤلفون: Shangmei Cao, Xiuhong Fu, Shaozhe Yang, Shuifu Tang

المصدر: Pharmaceutical Biology, Vol 60, Iss 1, Pp 2088-2097 (2022)

مصطلحات موضوعية: Plant-derived agents, anti-inflammatory, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1388-0209; https://doaj.org/toc/1744-5116

URL الوصول: https://doaj.org/article/391d85756f904ea1969b58a3783a051c

المؤلفون: Ping Zhang, Yan Jiang, Chunping Xu, Linghui Zhou, Hongguang Zheng, Deqiong Xie, Minghao Guo, Xiangyang Huang, Guoyuan Lu, Hongli Jiang, Hongyu Qiu, Bicheng Liu, Shaomei Li, Qinkai Chen, Yu'ou Xia, Bengui Sun, Xiao Yang, Shiying Zhang, Shutong Du, Mindan Sun, Menghua Chen, Aimin Zhong, Xiaoling Wang, Zhanzheng Zhao, Hua Zhou, Guisen Li, Yueqin Ren, Qun Luo, Aicheng Yang, Ping Luo, Shuifu Tang, Chengyun Xu, Qin Wang, Xiaoxia Wang, Tiekun Yan, Wei He, Shuguang Qin, Weili Zhang, Lu Lv, Cheng Wang, Hong Liu, Jing Li, Qiong Wu, Chao Pan, Chuan Li, Liangliang He, Jianghua Chen

المصدر: EClinicalMedicine, Vol 65, Iss , Pp 102273- (2023)

مصطلحات موضوعية: Anemia, Chronic kidney disease, Dialysis, Epoetin alfa, Pegmolesatide, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537023004509; https://doaj.org/toc/2589-5370

URL الوصول: https://doaj.org/article/6691532a57474e01b73b507ab1143e8f

المؤلفون: Ting Lin, Li Song, Renwei Huang, Ying Huang, Shuifu Tang, Qizhan Lin, Ying Zhang, Xingbo Wu, Hui Liang, Yuchi Wu, Yuanhan Chen, Huaban Liang, Jianchao Ma, Zhonglin Feng, Zhuo Li, Lixia Xu, Xia Fu, Zhiming Ye, Shuangxin Liu, Xinling Liang

المصدر: BMC Nephrology, Vol 20, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Diseases of the genitourinary system. Urology, RC870-923

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1471-2369

URL الوصول: https://doaj.org/article/9b675cdb53b24719834e9a76b9a89298

المؤلفون: Wei Mao, Nizhi Yang, Lei Zhang, Chuang Li, Yifan Wu, Wenwei Ouyang, Peng Xu, Chuan Zou, Chunpeng Pei, Wei Shi, Jihong Zhan, Hongtao Yang, Hongyu Chen, Xiaoqin Wang, Yun Tian, Fang Yuan, Wei Sun, Guoliang Xiong, Ming Chen, Jianguo Guan, Shuifu Tang, Chunyan Zhang, Yuning Liu, Yueyi Deng, Qizhan Lin, Fuhua Lu, Weihong Hong, Aicheng Yang, Jingai Fang, Jiazhen Rao, Lixin Wang, Kun Bao, Feng Lin, Yuan Xu, Zhaoyu Lu, Guobin Su, La Zhang, David W Johnson, Daixin Zhao, Haijing Hou, Lizhe Fu, Xinfeng Guo, Lihong Yang, Xindong Qin, Zehuai Wen, Xusheng Liu

المصدر: Frontiers in Pharmacology, Vol 11 (2021)

مصطلحات موضوعية: traditional Chinese medicine, losartan, chronic kidney disease, randomized controlled trial, glomerular filtration rate, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2020.627185/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/078bdef1149e4d74ba5b6846d63d0659

المؤلفون: Haitao Tu (8739369), Duanhua Ma (11441389), Yuanyuan Luo (837205), Shuifu Tang (8159547), Ying Li (38224), Gangyi Chen (381813), Liangliang Wang (580395), Zhengkun Hou (8879249), Chuangpeng Shen (11441392), Huan Lu (641668), Xun Zhuang (327636), Liangyou Zhang (11441395)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Marine Biology, Virology, Chemical Sciences not elsewhere classified, CRF, quercetin, pik3r1, pi3k/akt

Relation: https://figshare.com/articles/journal_contribution/Quercetin_alleviates_chronic_renal_failure_by_targeting_the_PI3k_Akt_pathway/16628743

الاتاحة: https://doi.org/10.6084/m9.figshare.16628743.v1

المؤلفون: Haitao Tu, Duanhua Ma, Yuanyuan Luo, Shuifu Tang, Ying Li, Gangyi Chen, Liangliang Wang, Zhengkun Hou, Chuangpeng Shen, Huan Lu, Xun Zhuang, Liangyou Zhang

المصدر: Bioengineered, Vol 12, Iss 1, Pp 6538-6558 (2021)

مصطلحات موضوعية: crf, quercetin, pik3r1, pi3k/akt, Biotechnology, TP248.13-248.65

Relation: http://dx.doi.org/10.1080/21655979.2021.1973877; https://doaj.org/toc/2165-5979; https://doaj.org/toc/2165-5987; https://doaj.org/article/f3957c2a5c3341c2af0852bdd63b7f71

الاتاحة: https://doi.org/10.1080/21655979.2021.1973877
https://doaj.org/article/f3957c2a5c3341c2af0852bdd63b7f71

المؤلفون: Huan Lu, Yuezhong Luo, Baolin Su, Shuifu Tang, Gangyi Chen, Licai Zhang, Chao Song, Chao Wang, Haitao Tu, Xinbo Wu

المصدر: Evidence-Based Complementary and Alternative Medicine, Vol 2020 (2020)

مصطلحات موضوعية: Other systems of medicine, RZ201-999

Relation: http://dx.doi.org/10.1155/2020/6813760; https://doaj.org/toc/1741-427X; https://doaj.org/toc/1741-4288; https://doaj.org/article/3d583d423af84fcd8a553219ea4d5e01

الاتاحة: https://doi.org/10.1155/2020/6813760
https://doaj.org/article/3d583d423af84fcd8a553219ea4d5e01

المؤلفون: Baolin, Su, Dejin, Cheng, Gangyi, Chen, Shu, Zhang, Liangliang, Wang, Xingbo, Wu, Shuifu, Tang

المصدر: Journal of Biomedical Nanotechnology. 18:488-497

مصطلحات موضوعية: Flavonoids, Male, Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), Estrogens, Bioengineering, Protein Serine-Threonine Kinases, Endoplasmic Reticulum Stress, Rats, Mice, Glucose, Receptors, Estrogen, GTP-Binding Proteins, Diabetes Mellitus, Animals, Humans, Diabetic Nephropathies, Female, General Materials Science

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aae1141a56aa069e7b671e415c1c6ab
https://doi.org/10.1166/jbn.2022.3242

المؤلفون: Gangyi Chen, Liangliang Wang, Yuanyuan Luo, Shuifu Tang, Xun Zhuang, Chuangpeng Shen, Duanhua Ma, Liangyou Zhang, Ying Li, Haitao Tu, Zhengkun Hou, Huan Lu

المصدر: Bioengineered, Vol 12, Iss 1, Pp 6538-6558 (2021)
Bioengineered
article-version (VoR) Version of Record

مصطلحات موضوعية: Male, pik3r1, Renal function, Bioengineering, Pharmacology, Network Pharmacology, crf, Aquaporins, Kidney, Applied Microbiology and Biotechnology, quercetin, Rats, Sprague-Dawley, chemistry.chemical_compound, Phosphatidylinositol 3-Kinases, Western blot, medicine, Animals, heterocyclic compounds, Blood urea nitrogen, PI3K/AKT/mTOR pathway, Creatinine, medicine.diagnostic_test, General Medicine, Rats, Class Ia Phosphatidylinositol 3-Kinase, Disease Models, Animal, pi3k/akt, medicine.anatomical_structure, chemistry, Apoptosis, Kidney Failure, Chronic, Quercetin, Proto-Oncogene Proteins c-akt, TP248.13-248.65, Research Article, Research Paper, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f5d179e5acb2ac96ae77016e29faf5
https://doaj.org/article/f3957c2a5c3341c2af0852bdd63b7f71

المؤلفون: Shangmei Cao, xiaojing liu, xinxin sun, xixia chen, shuifu Tang

مصطلحات موضوعية: Cisplatin, Renal injury, business.industry, Reynoutria japonica, medicine, food and beverages, Pharmacology, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0a893f5f4fcaf9828227dcc22c1d670f
https://doi.org/10.21203/rs.3.rs-611679/v1

المؤلفون: Shuifu Tang, Xianhong Li, Suzhen Hong, Gangyi Chen, Xin Li, Weiying Huang, Baolin Su

المصدر: Clinical Nephrology. 90:419-426

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Urology, Renal function, Blood Pressure, Cochrane Library, law.invention, Diabetic nephropathy, 03 medical and health sciences, chemistry.chemical_compound, Randomized controlled trial, law, medicine, Albuminuria, Humans, Diabetic Nephropathies, Randomized Controlled Trials as Topic, Creatinine, Proteinuria, business.industry, General Medicine, medicine.disease, 030104 developmental biology, Blood pressure, chemistry, Nephrology, Strictly standardized mean difference, Disease Progression, medicine.symptom, business, Platelet Aggregation Inhibitors, Glomerular Filtration Rate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c073453b70884e6e2ffe83155a0e53
https://doi.org/10.5414/cn109588

المؤلفون: Wei Mao (304011), Nizhi Yang (6914279), Lei Zhang (38117), Chuang Li (2010226), Yifan Wu (1702936), Wenwei Ouyang (2504665), Peng Xu (17962), Chuan Zou (723881), Chunpeng Pei (10051751), Wei Shi (68167), Jihong Zhan (10051754), Hongtao Yang (6171521), Hongyu Chen (105612), Xiaoqin Wang (12030), Yun Tian (411157), Fang Yuan (96264), Wei Sun (93580), Guoliang Xiong (757986), Ming Chen (115604), Jianguo Guan (1462282), Shuifu Tang (8159547), Chunyan Zhang (30676), Yuning Liu (4350469), Yueyi Deng (509339), Qizhan Lin (723886), Fuhua Lu (837477), Weihong Hong (10051757), Aicheng Yang (4920943), Jingai Fang (10051760), Jiazhen Rao (10051763), Lixin Wang (343011), Kun Bao (2048122), Feng Lin (23861), Yuan Xu (161775), Zhaoyu Lu (837475), Guobin Su (723883), La Zhang (6641339), David W Johnson (8277471), Daixin Zhao (4920946), Haijing Hou (10051766), Lizhe Fu (10051769), Xinfeng Guo (578077), Lihong Yang (7196), Xindong Qin (10051772), Zehuai Wen (2504662), Xusheng Liu (237726)

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, traditional Chinese medicine, losartan, chronic kidney disease, randomized controlled trial, glomerular filtration rate

Relation: https://figshare.com/articles/dataset/datasheet2_Bupi_Yishen_Formula_Versus_Losartan_for_Non-Diabetic_Stage_4_Chronic_Kidney_Disease_A_Randomized_Controlled_Trial_doc/14095805

الاتاحة: https://doi.org/10.3389/fphar.2020.627185.s002

المؤلفون: Ruilope, Luis M, Agarwal, Rajiv, Anker, Stefan D, Bakris, George L, Filippatos, Gerasimos, Nowack, Christina, Kolkhof, Peter, Joseph, Amer, Mentenich, Nicole, Pitt, Bertram, Diego, Besada, Alfredo, Wassermann, Julio, Bittar, Alicia, Elbert, Augusto, Vallejos, Gloria, Viñes, Hugo, Sanabria, Federico Pérez Manghi, Alberto, Liberman, Inés, Bartolacci, Diego, Aizenberg, Mariano, Chahin, Laura, Maffei, Elizabeth, Gelersztein, Bernhard, Ludvik, Hans-Robert, Schönherr, Heinz, Drexel, Wolfgang, Preiß, Ursula, Hanusch, Peter, Neudorfer, Friedrich, Prischl, Bernhard, Paulweber, Christoph, Ebenbichler, Rudolf, Prager, Harald, Sourij, Gerit-Holger, Schernthaner, Martin, Clodi, Evelyn, Fliesser-Görzer, Elif, Ekinci, Richard, Macisaac, David, Packham, Hugo, Stephenson, Michael, Suranyi, Gary, Wittert, Katie-Jane, Wynne, Alexia, Pape, Duncan, Topliss, Peter, Colman, Craig, Nelson, James, Vandeleur, David, Colquhoun, Simon, Roger, Peak Mann Mah, Walter, Abhayaratna, Luc VAN Gaal, Pieter, Gillard, Jean-Michel, Hougardy, Marijn, Speeckaert, Koen, Stas, Wendy, Engelen, Francis, Duyck, André, Scheen, Hilde, Vanbelleghem, Peter, Doubel, Svetla, Vasileva, Rosen, Rashkov, Boyan, Nonchev, Theodora, Temelkova-Kurktschieva, Mariana, Yoncheva-Mihaylova, Rangel, Rangelov, Neli, Klyuchkova, Pavel, Stanchev, Zhivko, Tagarev, Radostina, Boshnyashka, Petya, Manova, Zhulieta, Prakova, Mariya, Lucheva, Valentina, Gushterova, Ghassan, Farah, Dimitar, Georgiev, Mariyana, Pichmanova, Dotska, Minkova, Bilyana, Stoyanovska-Elencheva, Maria Eugenia Canziani, Miguel, Hissa, Irene, Noronha, Joao Eduardo Salles, Daniela, Antunes, Freddy, Eliaschewitz, Carlos Eduardo Figueiredo, Rogerio de Paula, Luis, Canani, Maurilo Leite Jr, Bruno, Paolino, Rosangela, Rea, Sergio, Vencio, Claudia, Brito, Raphael, Paschoalin, Roberto Pecoits Filho, Eduardo, Vasconcellos, Nathalia, Paschoalin, Adriana, Forti, Roberto, Botelho, Miguel, Riella, Dalton, Precoma, Maria, Cerqueira, Lilia, Maia, Evandro, Portes, Marcio, Pereira, Joanne, Liutkus, Dennis, O Keefe, Richard, Tytus, Brian, Carlson, James, Conway, Michael, Walsh, Igor, Wilderman, Andrew, Steele, Sheldon, Tobe, Louise, Vitou, Karthik, Tennankore, Valdemar, Martinho, Philip, Mcfarlane, Daniel, Shu, Serge, Cournoyer, Richard, Dumas, Giuseppe, Mazza, Guy, Tellier, George, Tsoukas, Stanley, Weisnagel, Jean-Francois, Yale, Sameh, Fikry, Randolph, Hart, Pavel, Hamet, Francois, Madore, Paul, Barre, Daniel, Schwartz, Allan, Kelly, Ivor, Teitelbaum, Sean, Peterson, Sam, Henein, Richard, Goluch, Gregoire, Wuerzner, Markus, Laimer, Stefan, Bilz, Marc, Donath, Gottfried, Rudofsky, Christopher, Strey, Antoinette, Pechère-Bertschi, Paola, Varleta, Fernando, González, Marcelo, Medina, Carmen, Romero, Victor, Saavedra, Juan Carlos Prieto, Eliana, Reyes, Juan Carlos Palma, Jorge, Cobos, Zhihong, Liu, Dalong, Zhu, Nan, Chen, Fang, Liu, Wang, Li, Qing, Su, Bingyin, Shi, Aiping, Yin, Hao, Wang, Yan, Li, Jianying, Niu, Chaoqing, Wu, Xinjun, Wang, Ying, Zhang, Peng, Ai, Jianhua, Ma, Yuxiu, Li, Hongguang, Zheng, Minxiang, Lei, Zhaohui, Mo, Nanwei, Tong, Jinluo, Cheng, Youping, Dong, Xudong, Xu, Qinkai, Chen, Tianjun, Guan, Gang, Long, Changying, Xing, Ling, Li, Yinghong, Liu, Hao, Zhang, Ling, Zhong, Zhonghe, Li, Longyi, Zeng, Jiali, Wei, Hanqing, Cai, Tianfeng, Wu, Weiping, Lu, Ning, Xu, Yibing, Lu, Dejun, Chen, Ruifang, Bu, Jiansong, Shen, Junwu, Dong, Zhiquan, Zhao, Fei, Xiong, Fangfang, Jiang, Jinkui, Yang, Jian, Kuang, Guoyuan, Lu, Lihua, Wang, Yanlin, Zhang, Shuifu, Tang, Weiying, Guo, Jian, Liu, Sheng, Jiang, Fang, Yi, Yuming, Du, Zhuxing, Sun, Yuantao, Liu, Liyong, Zhong, Dongmei, Li, Hongmei, Li, Chuanming, Hao, Feixia, Shen, Jianqin, Wang, Jingmei, Li, Dora, Molina, Carlos, Cure, Jaime, Ibarra, Gustavo, Aroca, Hernán, Yupanqui, Eric, Hernández, Mónica, López, Gregorio, Sánchez, Germán, Barreto, Edgar, Arcos, Miguel, Urina, William, Kattah, Carlos, Durán, Clara, Arango, Julian, Coronel, Guillermo, Blanco, Mónica, Terront, Gustavo, Guzmán, Luis, García, Carlos, Jaramillo, Manuel, Liévano, Diego, Benitez, Tatiana, Cárdenas, Iván, Villegas, Sandra, Barrera, Nicolás, Jaramillo, Rodrigo, Botero, Nelly Beltrán López, Freddy, Trujillo, Martin, Prazny, Jitka Hasalova Zapletalova, Libor, Okenka, Dino, Alferi, Tomas, Edelsberger, Pavel, Tomanek, Jiri, Brezina, Olga, Hola, Jana, Houdova, Petr, Bucek, David, Karasek, Sarka, Kopecka, Richard, Kovar, Michal, Brada, Lucie, Hornova, Eva, Krcova, Hana, Lubanda, Vlasta, Kutejova, Jiri, Kuchar, Helena, Hrmova, Jiri, Pumprla, Magdalena, Mokrejsova, Drahomira, Gulakova, Ivo, Matyasek, Thilo, Krüger, Hermann, Haller, Thorsten, Koch, Ludger, Rose, Diethelm, Tschöpe, Lutz, Stemler, Volker, Schettler, Andreas, Pfützner, Karl, Derwahl, Thomas, Horacek, Helena, Sigal, Heidrun, Täschner, Ingolf, Schiefke, Andreas, Hagenow, Andreas, Birkenfeld, Christoph, Axthelm, Christoph, Wanner, Klaus, Busch, Heike, Schlichthaar, Christoph, Hasslacher, Stefan, Degenhardt, Markus van der Giet, Georg, Strack, Norbert, Schöll, Bernhard, R Winkelmann, Lars, Rump, Ruth, Nischik, Bernd, Schröppel, Thomas, Giebel, Achim, Ulmer, Andrea, Rinke, Christel, Contzen, Wolfgang, Jungmair, Nicole, Toursarkissian, Christof, Kloos, Joachim, Müller, Thomas, Schürholz, Hermann, Braun, Frank, Pistrosch, Per, Poulsen, Claus, Juhl, Joan, Nielsen, Jesper, Bech, Ole, Rasmussen, Peter, Rossing, Jens, Faber, Thure, Krarup, Morten, Lindhardt, Ulrik Pedersen-Bjergaard Pedersen-Bjergaard, Karoline, Schousboe, Jørgen, Hangaard, Sten, Madsbad, Gunnar, Gislason, Grzegorz Jaroslaw Pacyk, Olga González Albarrán, Carlos Sánchez Juan, José Julián Segura de la Morena, Secundino Cigarrán Guldris, Francisco Martínez Deben, José María Pascual Izuel, Julio Pascual Santos, Francesca, Calero, Alfonso, Soto, Manuel Polaina Rusillo, Josep, Redón, Josep, Galcerán, Juan, Mediavilla, Mª Dolores Martínez Esteban, Alfredo, Michán, Fernando de Álvaro, Javier Escalada San Martín, Josep Cruzado Garrit, Cristina, Castro, Fernando Cereto Castro, Rafael Santamaría Olmo, Esteban, Poch, Judith, Martins, Julio Hernández Jaras, Meritxell, Ibernón, Daniel, Seron, Hanane, Bouarich, Maribel, Troya, Jorma, Strand, Ilkka, Kantola, Sakari, Nieminen, Arvo, Koistinen, Kristiina, Kananen, Sakari, Sulosaari, Mikko, Honkasalo, Pirkko, Korsoff, Tuomo, Nieminen, Karita, Sadeharju, Kari, Humaloja, Jorma, Lahtela, Philippe, Zaoui, Jean-Pierre, Fauvel, Ronan, Roussel, Didier, Gouet, Pierre, Serusclat, Sylvaine, Clavel, Bruno, Guerci, Bruno, Verges, Olivier, Moranne, Arnaud, Monier, Alexandre, Klein, François, Chantrel, Yannick LE Meur, Rafik, Mesbah, Bertrand, Cariou, Dominique, Guerrot, Karim, Gallouj, Kieran, Mccafferty, Arutchelvam, Vijayaraman, Yuk-Ki, Wong, Dhanya, Kalathil, Sam, Rice, Sui Phi Kon, Hassan, Kahal, Cuong, Dang, Fahmy, Hanna, Christina, Kyriakidou, Imrozia, Arif, Anne, Kilvert, Pauline, Swift, Ioannis, Stefanidis, Ploumis, Passadakis, Aikaterini, Papagianni, Erifili, Hatziagelaki, Dorothea, Papadopoulou, Ioannis, Boletis, Ioanna, Makriniotou, Theodora, Kounadi, Ioannis, Ioannidis, Paul, Lee, Ching Wan Ronald Ma, Vincent, Yeung, Tai Pang Ip, Ebrahim, Noori, Julianna, Kiss, Eleonora, Harcsa, Albert, Szocs, Szilard, Vasas, Krisztina, Wudi, Robert, Kirschner, Dora, Bajcsi, Beata, Lamboy, Botond, Literati-Nagy, Gabor, Nyirati, Gizella, Petro, Karoly, Schneider, Katalin, Keltai, Akos, Kalina, Peter, Danos, Szilvia, Kazup, Zsolt, Zilahi, Judit, Simon, Laszlo, Kovacs, Marianna, Zsom, Margit, Mileder, Laszlo, Nagy, Yoram, Yagil, Julio, Wainstein, Ofri, Mosenzon, Rosane Abramof Ness, Sydney Ben Chetrit, Faiad, Adawi, Idit, Liberty, Ehud, Grossman, Mazen, Elias, Zaher, Armaly, Evgeny, Farber, Assy, Nimer, Amir, Bashkin, Gil, Chernin, Shai, Efrati, Doron, Schwartz, Noa Berar Yanay, Mariela, Glandt, Robert, Zukermann, Majdi, Halabi, Shaul, Atar, Mahmud, Darawsha, Norberto, Perico, Gaetano La Manna, Giovanni Giorgio Battaglia, Domenico, Santoro, Piermarco, Piatti, Bonora, Enzo, Davide Carlo Maggi, Paolo, Calabrò, Roberto, Cimino, Roberto, Trevisan, Paolo, Fiorina, Antonio, Pisani, Antonello, Pani, Gennaro, Santorelli, Carlo Antonio Bossi, Giancarlo, Tonolo, Enrico, Fiaccadori, Anna Maria Veronelli, Michele, Emdin, Paola, Ponzani, Maria Cristina Gregorini, Franco Luigi Cavalot, Carlo Bruno Giorda, Taro, Shibasaki, Akihiro, Hamasaki, Takashi, Nomiyama, Sunao, Matsubayashi, Junji, Shinoda, Kazunari, Matsumoto, Hideo, Kanehara, Yoshihide, Hirohata, Masayo, Yamada, Jun, Nakazawa, Yoshimitsu, Yamasaki, Mikihiro, Nakayama, Ryuichi, Furuya, Osamu, Ebisui, Satsuki, Kawasaki, Daishiro, Yamada, Masayuki, Noritake, Tamayo, Ishiko, Nobuhiro, Sasaki, Daisuke, Suzuki, Asami, Tanaka, Miyuki, Kubota, Hideo, Araki, Hiroshi, Ohashi, Takeshi, Osonoi, Kazuo, Yamagata, Naruhiro, Fujita, Daisuke, Kanda, Seiichi, Tanaka, Junko, Koide, Masao, Ishii, Takayuki, Ogiwara, Masaaki, Suzuki, Taiji, Sekigami, Takayuki, Higashi, Yuko, Yambe, Yoshiro, Kusano, Hidetoshi, Kikuchi, Hiroaki, Miyaoka, Kiyoe, Kato, Masayuki, Kashima, Fumiko, Yamakawa, Shuji, Horinouchi, Hirofumi, Imoto, Hiroshi, Sobajima, Hidetoshi, Kanai, Naoki, Matsuoka, Hirotaka, Shibata, Akemi, Inagaki, Toshiyuki, Sugiura, Toru, Sugiyama, Hidekatsu, Yanai, Yoshiyuki, Hamamoto, Masahiro, Hatazaki, Terumasa, Hayashi, Kunihisa, Kobayashi, Satoshi, Murao, Makoto, Ujihara, Kazuya, Sugitatsu, Katsunori, Kawamitsu, Ken, Yamakawa, Izumi, Tsunematsu, Fumi, Kikuchi, Hideaki, Jinnouchi, Tetsuyuki, Yasuda, Hajime, Maeda, Yasuto, Matsuo, Hideki, Okamoto, Takeshi, Katsuki, Ken, Yajima, Takeshi, Morita, Masayuki, Inagaki, Wooje, Lee, Jungoo, Kang, Cheol Young Park, Hyesoon, Kim, Singon, Kim, Youcheol, Hwang, Injoo, Kim, Jaehyeon, Kim, Young Min Cho, Byungwan, Lee, Choonhee, Chung, Soo, Lim, Jae Myung Yu, Dovile, Kriauciuniene, Antanas, Navickas, Audrone, Velaviciene, Egle, Urbanaviciene, Gediminas, Urbonas, Jurate, Lasiene, Lina, Radzeviciene, Ron, Gansevoort, Adriaan, Kooy, G Lieverse, A, L Penne, E, Ruud J, M van Leendert, M van Buren, H Boonstra, A, C Bakker, R, Marielle, Krekels, B Brouwer, C, T Luik, P, J N, M Barendregt, Bert-Jan van den Born, Trine, Finnes, Thomas, Karlsson, Hilde, Selsås, Emil, Asprusten, Robert, Hagemeier, Erik, Eriksen, Knut, Risberg, Hans, Høivik, Leidulv, Solnør, Frode, Thorup, Jan, Rocke, Rick, Cutfield, Peter, Dunn, Jeremy, Krebs, Russell, Scott, Kingsley, Nirmalaraj, Nine, Smuts, John, Baker, Veronica, Crawford, Albert, Bautista, Roberto, Mirasol, Elizabeth, Catindig, Glenda, Pamugas, Louie, Tirador, Maribel, Tanque, Janusz, Gumprecht, Piotr, Napora, Edward, Franek, Andrzej, Stankiewicz, Katarzyna, Landa, Agnieszka, Tiuryn-Petrulewicz, Kazimierz, Ciechanowski, Bogna, Wierusz-Wysocka, Barbara, Rewerska, Grazyna, Cieslik, Michal, Hoffmann, Michal, Nowicki, Jolanta, Krzykowska, Stanislaw, Mazur, Katarzyna, Wasilewska, Anna, Ocicka-Kozakiewicz, Ewa, Skokowska, Renata, Wnetrzak-Michalska, Jan, Ruxer, Patrycja, Butrymowicz, Katarzyna, Madziarska, Ilona, Kurnatowska, Teresa, Rusicka, Adam, Madrzejewski, Tomasz, Stompor, Jose, Guia, Amalia, Pereira, Pedro, Melo, Cristina, Roque, Francisco, Rosario, Fernando Teixeira, E Costa, Fernando, Nolasco, Edgar, Almeida, Pedro, Matos, Cesar, Esteves, Rui, Carvalho, Ilidio, Brandao, Susana, Heitor, Ana Vila Lobos, Rosa, Ballesteros, Gil, Silva, Carlos, Barreto, Ana, Silva, Natalya, Vorokhobina, Alexander, Sherenkov, Ivan, Gordeev, Olga, Semenova, Sergey, Levashov, Vyacheslav, Marasaev, Ruslan, Sardinov, Vadim, Klimontov, Vitaliy, Baranov, Nadezhda, Verlan, Albert, Galyavich, Arkadiy, Demko, Zhanna, Kobalava, Elena, Zakharova, Lyudmila, Kvitkova, Oleg, Solovev, Elena, Smolyarchuk, Larisa, Zhukova, Elena, Zhdanova, Andrey, Babkin, Galina, Nechaeva, Olga, Barbarash, Elena, Rechkova, Roman, Libis, Elena, Kosmacheva, Tatyana, Rodionova, Irina, Ipatko, Alexander, Dreval, Nina, Petunina, Elena, Chernyavskaya, Alsu, Zalevskaya, Yuriy, Khalimov, Tatyana, Zykova, Anton, Edin, Ashot, Mkrtumyan, Shamil, Palyutin, Vyacheslav, Mareev, Leonid, Strongin, Olga, Ukhanova, Mikhail, Antsiferov, Davyd, Yakhontov, Leonid, Pimenov, Natalya, Koziolova, Konstantin, Nikolaev, Imad, Merai, Olga, Zanozina, Leyla, Gaysina, Mikhail, Arkhipov, Natalia, Malykh, Oksana, Rymar, Vladimir, Martynenko, Sofya, Malyutina, Polina, Ermakova, Marina, Kalashnikova, Bengt-Olov, Tengmark, Carl-Johan, Lindholm, Dan, Curiac, Ken, Eliasson, Erik, Rein-Hedin, Gregor, Guron, Inga, Soveri, Annette, Bruchfeld, Jonas, Spaak, Malin, Frank, Magnus, Löndahl, Hans, Larnefeldt, Margareta, Hellgren, Olof, Hellberg, Yong Mong Bee, Chee Fang Sum, Ru San Tan, Piyamitr, Sritara, Chaicharn, Deerochanawong, Chatlert, Pongchaiyakul, Natapong, Kosachunhanan, Bancha, Satirapoj, Ahmet, Temizhan, Ibrahim, Gul, Ramazan, Sari, Aytekin, Oguz, Mustafa, Tigen, Huseyin, Yilmaz, Ozer, Badak, Oner, Ozdogan, Talat, Tavli, Necmi, Eren, Murat, Cayli, Sedat, Ustundag, Yavuz, Yenicerioglu, Ismail, Kocyigit, Abdulbaki, Kumbasar, Idris, Sahin, Lee-Ming, Chuang, Ju-Ying, Jiang, Chien-Te, Lee, Der-Cherng, Tarng, Shih-Te, Tu, Mai-Szu, Wu, Ming-Ju, Wu, Chiz-Tzung, Chang, Cheng-Chieh, Hung, Liubov, Sokolova, Borys, Mankovsky, Dmytro, Kogut, Viktoriia, Chernikova, Kateryna, Malyar, Nonna, Kravchun, Volodymyr, Botsyurko, Vitaliy, Maslyanko, Liliya, Martynyuk, Oleksandr, Serhiyenko, Vasyl, Stryzhak, Halyna, Myshanych, Oleksandra, Donets, Iryna, Bondarets, Maryna, Vlasenko, Nataliia, Pertseva, Mariia, Grachova, Ivan, Smirnov, Larysa, Pererva, Ivan, Fushtey, Julia, Komisarenko, Anna, Isayeva, Carl, Meisner, Bobby, Khan, Louis, Maletz, Bradley, Dixon, Ahmed, Arif, Timothy, Jackson, Mirela, Ponduchi, Mahfouz El Shahawy, Salil, Nadkarni, Daniel, Urbach, Jorge, Paoli-Bruno, Henry, Lora, Umar, Farooq, Steven, Zeig, Lance, Rudolph, Nabil, Andrawis, William, Kaye, Jill, Meyer, Khalid, Bashir, Glenn, Heigerick, James, Smelser, Javier Ricardo Colomar, David, Scott, Brian, First, Stuart, Handelsman, Jose, Bautista, Rajesh, Patel, Stephen, Minton, Juan, Frias, Luis, Ramos-Gonez, John, Bertsch, Ali, Iranmanesh, Vivian, Fonseca, Michael, Yuryev, Larry, Popeil, Jose, Cardona, Sanjeev, Saxena, Santosh, Sharma, Edgar, Gonzalez, Richard, Solomon, Muhammad, Khan, Ahmed, Awad, David, Fitz-Patrick, Douglas, Linfert, David, Grant, Susan, Brian, Leon, Fogelfeld, Rafael, Canadas, Pablo, Pergola, Joseph, Soufer, Rakesh, Patel, Shujauddin, Valika, Jonathan, Winston, Allison, D, Maria, Caramori, Stanley, Koch, Anjay, Rastogi, Jonathan, Bornfreund, Michael, Rocco, Maxine, Hamilton, Luis, Garcia-Mayol, Peter, Weissman, Suzanne, Oparil, Gary, Ruoff, Kyaw, Soe, Gary, Korff, Robert, Busch, Alexander, Lurie, Israel, Hartman, Garfield, Samuels, Derek, Lejeune, Visal, Numrungroad, Stephen, Brietzke, Zeid, Kayali, Harold, Szerlip, Steven, Barag, Gilberto, Seco, Damaris, Vega, Osvaldo, Brusco, Camil, Kreit, Humberto, Cruz, Bharat, Mocherla, Sharma, Prabhakar, George, Fadda, Martin, Valdes, Eugene, Soroka, Ramin, Berenji, Sreedhara, Alla, Shweta, Bansal, Odugbesan, A, Karlton, Pettis, Masoud, Azizad, Idalia, Acosta, Atoya, Adams, William, Sanchez, Rosa, Suarez, Efrain, Reisin, Carlos, Herrera, Keung, Lee, Csaba, Kovesdy, Adam, Whaley-Connell, Aldo, Peixoto, Ronald, Mayfield, Mahendra, Jain, Earl, Martin, Paul, Norwood, Jonathan, Wise, Hugo, Romeu, Stephen, Halpern, Mustafa, Mandviwala, Thomas, Turk, Anna, Burgner, David, Bleich, Ankur, Doshi, Jose, Carpio, Jorge, Posada, Alexander, Magno, Samer, Nakhle, Gary, Goldstein, Caroline, Mbogua, Dierdre, Mcmullen, Dilawar, Ajani, Wayne, Kotzker, Nelson, Kopyt, Richard, Treger, Yusuf, Ruhullah, Sharon, Adler, Harjeet, Brar, Marc, Rendell, Dennis, Ross, Srinivasan, Beddhu, German, Hernandez, Sylvia, Rosas, M Sue Kirkman, Mohammed, El-Shahawy, Jeffrey, Rothman, Ahmad, Barakzoy, Aparna, Tamirisa, Sabrina, Benjamin, Michael, Bahrami, Prabir, Roy-Chaudhury, Ramprasad, Dandillaya, Gretel, Trullenque, Jose, Birriel, John, Flack, Karen, Johnson, Brenda, Lemus, Guillermo, Umpierrez, Geetha, Maddukuri, Kenneth, Jamerson, Christopher, Case, Patrick, Fluck, Saeed, Kronfli, Violet, Habwe, Bala, Subramanian, Tariq, Shafi, Rupesh, Raina, Roland, Fernando, Sourabh, Kharait, Carlos, Hernandez-Cassis, Raymond, Fink, Jamal, Hammoud, Amer, Al-Karadsheh, Manuel, Montero, Philip, Nicol, Jesus, Navarro, Michael, Shanik, Zia, Din, Francisco, Gonzalez-Abreu, Sam, Lerman, Claude, Galphin, John, Evans, Ashwini, Gore, Radica, Alicic, Mandeep, Sahani, Roberto, Pisoni, Tuan-Huy, Tran, Jeffrey, Ryu, Harvey, Serota, Nilda, Neyra, Richard, O Donovan, Sreedhar, Mandayam, Moustafa, Moustafa, Mark, Smith, Arvind, Krishna, Arjun, Sinha, Anuj, Bhargava, Kodangudi, Ramanathan, Soni, Dhanireddy, Stephen, Thomson, Romanita, Nica, Emaad, Abdel-Rahman, Mark, Barney, Mariana, Markell, Nauman, Shahid, David, Oliver, Tran, Khanh, Pham Nguyen Son, Lam VAN Hoang, Boi Ngoc Nguyen, Nguyen Minh Nui, Lan Phuong Tran, Fayzal, Ahmed, Dorothea, Urbach, Dirkie Jansen van Rensburg, Gracjan, Podgorski, Aslam, Amod, Sindeep, Bhana, Shaifali, Joshi, Essack, Mitha, Deepak, Lakha, Louis van Zyl, Trokis, J, Naresh, Ranjith, Mary, Seeber, Mohamed, Sarvan, Mohammed, Tayob, Brian, Rayner, Larry, Distiller, Heidi, Siebert, Mukesh, Joshi, Paul, Rheeder, Magdalena Madero Rovalo, Gustavo Solache Ortiz, Gustavo Méndez Machado, Rafael Valdez Ortiz, Juan Villagordoa Mesa, Saúl Irizar Santana, Sandro Avila Pardo, Jorge Escobedo de la Peña, Guillermo González Gálvez, Leobardo Sauque Reyna, Miriam Bastidas Adrian, Guillermo Fanghänel Salmón, Ramiro Gutiérrez Ochoa, Luis Nevarez Ruiz, Gabriel Ramos López, Alfredo Chew Wong, Arturo Saldaña Mendoza, Pedro García Hernández, José González González, Melchor Alpizar Salazar, José Lazcano Soto, Amaury, Roman-Miranda, Gregorio, Cortes-Maisonet, Liana, Turcu, Adriana, Dumitrescu, Gabriela, Radulian, Hortensia, Barbonta, Cristina, Mistodie, Georgeta, Vacaru, Alexandrina, Popescu, Adrian, Vlad, Silvia, Paveliu, Nicoleta, Mindrescu, Adrian, Albota, Ella, Pintilei, Lavinia, Pop, Gabriela, Negrisanu, Doina, Catrinoiu, Cornelia, Bala, Amorin, Popa, Iosif, Szilagyi, Ciprian, Constantin, Elena, Caceaune, Adriana, Onaca, Li Yuan Lee, Nor Azizah Aziz, Wan Mohd Izani Wan Mohamed, Wan Hasnul Halimi Bin Wan Hasan, Jeyakantha, Ratnasingam, Nik Nur Fatnoon Nik Ahmad, Rizmy Najme Khir, Norhaliza Mohd Ali, Masni, Mohamad, Chek Loong Loh, Joe, Eustace, John, Holian, Donal, Reddan, Yvonne, O Meara, Mensud, Hatunic, Zuzana, Ochodnicka, Dalibor, Sosovec, Andrej, Dzupina, Ingrid, Buganova, Jana, Babikova, Denisa, Spodniakova

المساهمون: Ruilope, L, Agarwal, R, Anker, S, Bakris, G, Filippatos, G, Nowack, C, Kolkhof, P, Joseph, A, Mentenich, N, Pitt, B, Trevisan, R, Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy, Diabetes Clinic

المصدر: ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
AMERICAN JOURNAL OF NEPHROLOGY
FIGARO-DKD study investigators & Rossing, P 2019, ' Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial ', American Journal of Nephrology, vol. 50, no. 5, pp. 345-356 . https://doi.org/10.1159/000503712

مصطلحات موضوعية: Male, Endocrinology, Diabetes and Metabolism, Enfermedad cardiovascular, 030232 urology & nephrology, BAY 94-8862, Type 2 diabetes, 030204 cardiovascular system & hematology, Diabete, Kidney, Aparato circulatorio, Azúcar, chemistry.chemical_compound, Mineralocorticoid Receptor Antagonists/therapeutic use, 0302 clinical medicine, Medicine and Health Sciences, Diabetic Nephropathies, Myocardial infarction, Renal Insufficiency, Chronic, Aldosterone, Outcome, Mineralocorticoid Receptor Antagonists, RISK, COMPLICATIONS, Diabetes, Middle Aged, SPIRONOLACTONE, CHRONIC HEART-FAILURE, Treatment Outcome, Mineralocorticoid, Nephrology, Cardiovascular Diseases, Research Design, Disease Progression, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Type 2, Glomerular Filtration Rate, medicine.medical_specialty, Finerenone, Naphthyridines/therapeutic use, Renal function, Outcomes, 03 medical and health sciences, Clinical, Double-Blind Method, Diabetes mellitus, Internal medicine, medicine, Diabetes Mellitus, Humans, Naphthyridines, Renal Insufficiency, Chronic, ANTAGONIST, Sistema cardiovascular, Aged, Patient-Oriented, Translational Research: Research Article, Diabetic Nephropathies/complications, Renal Insufficiency, Chronic/drug therapy, RECEPTOR, Aldosterone, Clinical, Diabetes, Kidney, Mineralocorticoid, Outcomes, business.industry, Cardiovascular Diseases/epidemiology, Diabetes Mellitus, Type 2/complications, MILD, WORSENING RENAL-FUNCTION, EFFICACY, medicine.disease, chemistry, Diabetes Mellitus, Type 2, Spironolactone, Albuminuria, business, Kidney disease, Follow-Up Studies

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db97692f31021cfccbc491658ce0802
https://europepmc.org/articles/PMC6889917/

المؤلفون: Shuangxin Liu, Zhuo Li, Renwei Huang, Huaban Liang, Xingbo Wu, Yuchi Wu, Ying Huang, Li Song, Lixia Xu, Qizhan Lin, Zhonglin Feng, Shuifu Tang, Jianchao Ma, Ting Lin, Ying Zhang, Yuanhan Chen, Xia Fu, Xinling Liang, Zhiming Ye, Hui Liang

المصدر: BMC Nephrology, Vol 20, Iss 1, Pp 1-14 (2019)
BMC Nephrology

مصطلحات موضوعية: Adult, Male, Nephrology, medicine.medical_specialty, medicine.medical_treatment, Hemorrhage, lcsh:RC870-923, Citric Acid, law.invention, Randomized controlled trial, Renal Dialysis, Risk Factors, law, Dialysis Solutions, Internal medicine, medicine, Humans, Prospective Studies, Renal Insufficiency, Chronic, Prospective cohort study, Adverse effect, Blood Coagulation, Saline, Contraindication, Aged, business.industry, Anticoagulants, Heparin, Middle Aged, lcsh:Diseases of the genitourinary system. Urology, Anesthesia, Female, Hemodialysis, business, Research Article, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6e0f932199b32c041b9569ae3ae2b1
https://doi.org/10.21203/rs.2.11875/v1

المؤلفون: Lin, Ting, Song, Li, Renwei Huang, Huang, Ying, Shuifu Tang, Qizhan Lin, Zhang, Ying, Xingbo Wu, Liang, Hui, Yuchi Wu, Yuanhan Chen, Huaban Liang, Jianchao Ma, Zhonglin Feng, Li, Zhuo, Lixia Xu, Fu, Xia, Zhiming Ye, Shuangxin Liu, Xinling Liang

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3dd25304e2bab339c7286b2a6a37c2b

المؤلفون: Liangxiang Xiao, Shuifu Tang, Yanni Zhou

المصدر: Experimental and Therapeutic Medicine

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Pathology, medicine.medical_specialty, Difference gel electrophoresis, Lupus nephritis, 03 medical and health sciences, Immunology and Microbiology (miscellaneous), Medicine, Annexin A2, lupus nephritis, biology, medicine.diagnostic_test, Oncogene, business.industry, General Medicine, Articles, medicine.disease, Molecular medicine, Ferritin, ferritin heavy chain, 030104 developmental biology, biology.protein, Biomarker (medicine), biomarker, Renal biopsy, business, cellar proteomics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6295cc826b26a6f183bb87d0cbc6800a
https://pubmed.ncbi.nlm.nih.gov/30344652

المؤلفون: Xingju Zhang, Yu Meng, Chao Li, Yingying Lin, Gangyi Chen, Shuifu Tang

المصدر: Molecular Medicine Reports. 10:2471-2476

مصطلحات موضوعية: Male, Nucleocytoplasmic Transport Proteins, Cancer Research, Glomerular Mesangial Cell, Cell, Biology, Biochemistry, Cell Line, Diabetes Mellitus, Experimental, Rats, Sprague-Dawley, Transforming Growth Factor beta, Genetics, medicine, Animals, Diabetic Nephropathies, Molecular Biology, Cell Proliferation, Oncogene, Cell cycle, Neoplasm Proteins, Rats, Cell biology, medicine.anatomical_structure, Oncology, Cell culture, Apoptosis, Abietanes, Cancer research, Molecular Medicine, Signal transduction, Signal Transduction, Transforming growth factor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851655729ba708d7545852bf6e08ef22
https://doi.org/10.3892/mmr.2014.2497

المؤلفون: Na Liu, Tianjiang Ma, Lifan Wang, Zhuo Yu, Shangmei Cao, Xin Yang, Wenjing Huang, Shuifu Tang

المصدر: Journal of Ethnopharmacology. 244:112104

مصطلحات موضوعية: Male, medicine.medical_specialty, Urinary system, Urology, Renal function, Benazepril, Kidney, Kidney Function Tests, Protective Agents, Nephropathy, Random Allocation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, medicine, Animals, Medicine, Chinese Traditional, Rats, Wistar, 030304 developmental biology, Pharmacology, 0303 health sciences, Creatinine, Proteinuria, Podocytes, business.industry, Therapeutic effect, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Kidney metabolism, medicine.disease, chemistry, Doxorubicin, 030220 oncology & carcinogenesis, Kidney Diseases, medicine.symptom, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead13a3023a1d46a43287092a26cc9a0
https://doi.org/10.1016/j.jep.2019.112104

المؤلفون: GANGYI CHEN, XINGJU ZHANG, CHAO LI, YINGYING LIN, YU MENG, SHUIFU TANG

المصدر: Molecular Medicine Reports; 2014, Vol. 10 Issue 5, p2471-2476, 6p

مصطلحات موضوعية: TRANSFORMING growth factors-beta, DIABETIC nephropathies, CELL proliferation, GENE expression, GLOMERULAR filtration rate, TREATMENT of chronic kidney failure, THERAPEUTICS