المؤلفون: Kaizhen Wang (5139293), Ke Ye (582694), Xiangyu Zhang (630437), Tianyu Wang (397547), Zhihao Qi (12316492), Youjun Wang (4489618), Sheng Jiang (303820), Kuojun Zhang (10339222)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+, robust antitumor efficacy, balanced inhibitory potencies, attractive anticancer strategy, dual nicotinamide phosphoribosyltransferase, de novo <, ido1 could achieve, r cells ), multitarget drug rationales, 10e , ido1 inhibitors according, r cells, vivo <, vitro <, dual nampt, work provides, synthesis pathways, simultaneous blockade, significantly inhibits, significant toxicity

Relation: https://figshare.com/articles/journal_contribution/Dual_Nicotinamide_Phosphoribosyltransferase_NAMPT_and_Indoleamine_2_3-Dioxygenase_1_IDO1_Inhibitors_for_the_Treatment_of_Drug-Resistant_Nonsmall-Cell_Lung_Cancer/21807140

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01954.s004

المؤلفون: Tianyu Wang (397547), Shi Cai (10899090), Mingming Wang (394106), Wanheng Zhang (10899093), Kuojun Zhang (10339222), Dong Chen (448284), Zheng Li (26302), Sheng Jiang (303820)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, CT 26 mouse model, Potent Small-Molecule Inhibitors Ta., Novel Biphenyl Pyridines, small-molecule inhibitors, compound 24 activates, flow cytometry, small-molecule inhibitor, anti-programmed cell death, PD, tumor cells, vivo antitumor activity, compound 24, Compound 24 displays, PD-L, immunohistochemistry data, IC 50 value, cancer therapy

Relation: https://figshare.com/articles/journal_contribution/Novel_Biphenyl_Pyridines_as_Potent_Small-Molecule_Inhibitors_Targeting_the_Programmed_Cell_Death-1_Programmed_Cell_Death-Ligand_1_Interaction/14705805

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00010.s001

المؤلفون: Kuojun Zhang (10339222), Zhiyi Liu (1374696), Yiwu Yao (1514782), Yatao Qiu (2182442), Feng Li (30515), Dong Chen (448284), Dale J. Hamilton (10214737), Zheng Li (26302), Sheng Jiang (303820)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Pharmacology, Cancer, Space Science, Chemical Sciences not elsewhere classified, TNBC detection, HDAC affinity, SAHA, Cy 5.5, Structure-Based Design, Epigenetic Regulation Detection, HDACi-mediated therapy, suberoylanilide hydroxamic acid, TNBC MDA-MB -231 cells, tumor class, TNBC diagnosis, Selective Class, visualizing class, Histone Deacetylase, novel NIR probe, near-infrared imaging probe, Conjugating Cy 5.5, cyclic depsipeptide inhibitor, xenograft tumor models, HDAC expression, Triple-Negative Breast Cancer, TNBC lung metastasis, histone deacetylases

Relation: https://figshare.com/articles/journal_contribution/Structure-Based_Design_of_a_Selective_Class_I_Histone_Deacetylase_HDAC_Near-Infrared_NIR_Probe_for_Epigenetic_Regulation_Detection_in_Triple-Negative_Breast_Cancer_TNBC_/14258233

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02161.s001

المؤلفون: Kaizhen Wang (5139293), Ke Ye (582694), Xiangyu Zhang (630437), Tianyu Wang (397547), Zhihao Qi (12316492), Youjun Wang (4489618), Sheng Jiang (303820), Kuojun Zhang (10339222)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+, robust antitumor efficacy, balanced inhibitory potencies, attractive anticancer strategy, dual nicotinamide phosphoribosyltransferase, de novo <, ido1 could achieve, r cells ), multitarget drug rationales, 10e , ido1 inhibitors according, r cells, vivo <, vitro <, dual nampt, work provides, synthesis pathways, simultaneous blockade, significantly inhibits, significant toxicity

Relation: https://figshare.com/articles/dataset/Dual_Nicotinamide_Phosphoribosyltransferase_NAMPT_and_Indoleamine_2_3-Dioxygenase_1_IDO1_Inhibitors_for_the_Treatment_of_Drug-Resistant_Nonsmall-Cell_Lung_Cancer/21807131

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01954.s001

المؤلفون: Kaizhen Wang (5139293), Ke Ye (582694), Xiangyu Zhang (630437), Tianyu Wang (397547), Zhihao Qi (12316492), Youjun Wang (4489618), Sheng Jiang (303820), Kuojun Zhang (10339222)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+, robust antitumor efficacy, balanced inhibitory potencies, attractive anticancer strategy, dual nicotinamide phosphoribosyltransferase, de novo <, ido1 could achieve, r cells ), multitarget drug rationales, 10e , ido1 inhibitors according, r cells, vivo <, vitro <, dual nampt, work provides, synthesis pathways, simultaneous blockade, significantly inhibits, significant toxicity

Relation: https://figshare.com/articles/dataset/Dual_Nicotinamide_Phosphoribosyltransferase_NAMPT_and_Indoleamine_2_3-Dioxygenase_1_IDO1_Inhibitors_for_the_Treatment_of_Drug-Resistant_Nonsmall-Cell_Lung_Cancer/21807134

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01954.s002

المؤلفون: Kaizhen Wang (5139293), Ke Ye (582694), Xiangyu Zhang (630437), Tianyu Wang (397547), Zhihao Qi (12316492), Youjun Wang (4489618), Sheng Jiang (303820), Kuojun Zhang (10339222)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+, robust antitumor efficacy, balanced inhibitory potencies, attractive anticancer strategy, dual nicotinamide phosphoribosyltransferase, de novo <, ido1 could achieve, r cells ), multitarget drug rationales, 10e , ido1 inhibitors according, r cells, vivo <, vitro <, dual nampt, work provides, synthesis pathways, simultaneous blockade, significantly inhibits, significant toxicity

Relation: https://figshare.com/articles/dataset/Dual_Nicotinamide_Phosphoribosyltransferase_NAMPT_and_Indoleamine_2_3-Dioxygenase_1_IDO1_Inhibitors_for_the_Treatment_of_Drug-Resistant_Nonsmall-Cell_Lung_Cancer/21807137

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01954.s003

المؤلفون: Fan Yu (513775), Xian Zhou (405014), Xiang Jin (402181), Shushu Zhao (11984824), Gan Zhao (4789428), Sheng Jiang (303820), Shuang Geng (176956), Bin Wang (30851)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Neuroscience, Immunology, Marine Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, sup >+, refined temporal analysis, real pathological course, hit second time, cell dominant infiltrates, cell depletion ), mouse data fail, human autoimmune diabetes, obesity diabetes model, div >< p, hit ’ strategy, first hit, cell responses, mouse models, human disease, nod model, improvised model, ‘ double, unleash auto, transient immune

Relation: https://figshare.com/articles/figure/Diabetes_symptoms_covered_by_both_STZ_DT_and_NOD_model_/18859024

الاتاحة: https://doi.org/10.1371/journal.pone.0260100.g002

المؤلفون: Fan Yu (513775), Xian Zhou (405014), Xiang Jin (402181), Shushu Zhao (11984824), Gan Zhao (4789428), Sheng Jiang (303820), Shuang Geng (176956), Bin Wang (30851)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Neuroscience, Immunology, Marine Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, sup >+, refined temporal analysis, real pathological course, hit second time, cell dominant infiltrates, cell depletion ), mouse data fail, human autoimmune diabetes, obesity diabetes model, div >< p, hit ’ strategy, first hit, cell responses, mouse models, human disease, nod model, improvised model, ‘ double, unleash auto, transient immune

Relation: https://figshare.com/articles/figure/Manipulations_of_each_hit_tuned_diabetes_progression_/18859030

الاتاحة: https://doi.org/10.1371/journal.pone.0260100.g004

المؤلفون: Fan Yu (513775), Xian Zhou (405014), Xiang Jin (402181), Shushu Zhao (11984824), Gan Zhao (4789428), Sheng Jiang (303820), Shuang Geng (176956), Bin Wang (30851)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Neuroscience, Immunology, Marine Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, sup >+, refined temporal analysis, real pathological course, hit second time, cell dominant infiltrates, cell depletion ), mouse data fail, human autoimmune diabetes, obesity diabetes model, div >< p, hit ’ strategy, first hit, cell responses, mouse models, human disease, nod model, improvised model, ‘ double, unleash auto, transient immune

Relation: https://figshare.com/articles/dataset/S1_File_-/18859012

الاتاحة: https://doi.org/10.1371/journal.pone.0260100.s001

المؤلفون: Fan Yu (513775), Xian Zhou (405014), Xiang Jin (402181), Shushu Zhao (11984824), Gan Zhao (4789428), Sheng Jiang (303820), Shuang Geng (176956), Bin Wang (30851)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Neuroscience, Immunology, Marine Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, sup >+, refined temporal analysis, real pathological course, hit second time, cell dominant infiltrates, cell depletion ), mouse data fail, human autoimmune diabetes, obesity diabetes model, div >< p, hit ’ strategy, first hit, cell responses, mouse models, human disease, nod model, improvised model, ‘ double, unleash auto, transient immune

Relation: https://figshare.com/articles/figure/Establishment_of_double-hit_model_by_STZ_DT_/18859021

الاتاحة: https://doi.org/10.1371/journal.pone.0260100.g001

المؤلفون: Fan Yu (513775), Xian Zhou (405014), Xiang Jin (402181), Shushu Zhao (11984824), Gan Zhao (4789428), Sheng Jiang (303820), Shuang Geng (176956), Bin Wang (30851)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Neuroscience, Immunology, Marine Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, sup >+, refined temporal analysis, real pathological course, hit second time, cell dominant infiltrates, cell depletion ), mouse data fail, human autoimmune diabetes, obesity diabetes model, div >< p, hit ’ strategy, first hit, cell responses, mouse models, human disease, nod model, improvised model, ‘ double, unleash auto, transient immune

Relation: https://figshare.com/articles/figure/CD8_sup_sup_T_cell_infiltration_and_severe_ketoacidosis_in_STZ_DT_mice_/18859027

الاتاحة: https://doi.org/10.1371/journal.pone.0260100.g003

المؤلفون: Tianyu Wang (397547), Shi Cai (10899090), Mingming Wang (394106), Wanheng Zhang (10899093), Kuojun Zhang (10339222), Dong Chen (448284), Zheng Li (26302), Sheng Jiang (303820)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, CT 26 mouse model, Potent Small-Molecule Inhibitors Ta., Novel Biphenyl Pyridines, small-molecule inhibitors, compound 24 activates, flow cytometry, small-molecule inhibitor, anti-programmed cell death, PD, tumor cells, vivo antitumor activity, compound 24, Compound 24 displays, PD-L, immunohistochemistry data, IC 50 value, cancer therapy

Relation: https://figshare.com/articles/dataset/Novel_Biphenyl_Pyridines_as_Potent_Small-Molecule_Inhibitors_Targeting_the_Programmed_Cell_Death-1_Programmed_Cell_Death-Ligand_1_Interaction/14705808

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00010.s002

المؤلفون: Tianyu Wang (397547), Shi Cai (10899090), Mingming Wang (394106), Wanheng Zhang (10899093), Kuojun Zhang (10339222), Dong Chen (448284), Zheng Li (26302), Sheng Jiang (303820)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, CT 26 mouse model, Potent Small-Molecule Inhibitors Ta., Novel Biphenyl Pyridines, small-molecule inhibitors, compound 24 activates, flow cytometry, small-molecule inhibitor, anti-programmed cell death, PD, tumor cells, vivo antitumor activity, compound 24, Compound 24 displays, PD-L, immunohistochemistry data, IC 50 value, cancer therapy

Relation: https://figshare.com/articles/dataset/Novel_Biphenyl_Pyridines_as_Potent_Small-Molecule_Inhibitors_Targeting_the_Programmed_Cell_Death-1_Programmed_Cell_Death-Ligand_1_Interaction/14705811

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00010.s003

المؤلفون: Kuojun Zhang (10339222), Zhiyi Liu (1374696), Yiwu Yao (1514782), Yatao Qiu (2182442), Feng Li (30515), Dong Chen (448284), Dale J. Hamilton (10214737), Zheng Li (26302), Sheng Jiang (303820)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Pharmacology, Cancer, Space Science, Chemical Sciences not elsewhere classified, TNBC detection, HDAC affinity, SAHA, Cy 5.5, Structure-Based Design, Epigenetic Regulation Detection, HDACi-mediated therapy, suberoylanilide hydroxamic acid, TNBC MDA-MB -231 cells, tumor class, TNBC diagnosis, Selective Class, visualizing class, Histone Deacetylase, novel NIR probe, near-infrared imaging probe, Conjugating Cy 5.5, cyclic depsipeptide inhibitor, xenograft tumor models, HDAC expression, Triple-Negative Breast Cancer, TNBC lung metastasis, histone deacetylases

Relation: https://figshare.com/articles/dataset/Structure-Based_Design_of_a_Selective_Class_I_Histone_Deacetylase_HDAC_Near-Infrared_NIR_Probe_for_Epigenetic_Regulation_Detection_in_Triple-Negative_Breast_Cancer_TNBC_/14258236

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02161.s002

المؤلفون: Kuojun Zhang (10339222), Zhiyi Liu (1374696), Yiwu Yao (1514782), Yatao Qiu (2182442), Feng Li (30515), Dong Chen (448284), Dale J. Hamilton (10214737), Zheng Li (26302), Sheng Jiang (303820)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Pharmacology, Cancer, Space Science, Chemical Sciences not elsewhere classified, TNBC detection, HDAC affinity, SAHA, Cy 5.5, Structure-Based Design, Epigenetic Regulation Detection, HDACi-mediated therapy, suberoylanilide hydroxamic acid, TNBC MDA-MB -231 cells, tumor class, TNBC diagnosis, Selective Class, visualizing class, Histone Deacetylase, novel NIR probe, near-infrared imaging probe, Conjugating Cy 5.5, cyclic depsipeptide inhibitor, xenograft tumor models, HDAC expression, Triple-Negative Breast Cancer, TNBC lung metastasis, histone deacetylases

Relation: https://figshare.com/articles/dataset/Structure-Based_Design_of_a_Selective_Class_I_Histone_Deacetylase_HDAC_Near-Infrared_NIR_Probe_for_Epigenetic_Regulation_Detection_in_Triple-Negative_Breast_Cancer_TNBC_/14258242

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02161.s004

المؤلفون: Kuojun Zhang (10339222), Zhiyi Liu (1374696), Yiwu Yao (1514782), Yatao Qiu (2182442), Feng Li (30515), Dong Chen (448284), Dale J. Hamilton (10214737), Zheng Li (26302), Sheng Jiang (303820)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Pharmacology, Cancer, Space Science, Chemical Sciences not elsewhere classified, TNBC detection, HDAC affinity, SAHA, Cy 5.5, Structure-Based Design, Epigenetic Regulation Detection, HDACi-mediated therapy, suberoylanilide hydroxamic acid, TNBC MDA-MB -231 cells, tumor class, TNBC diagnosis, Selective Class, visualizing class, Histone Deacetylase, novel NIR probe, near-infrared imaging probe, Conjugating Cy 5.5, cyclic depsipeptide inhibitor, xenograft tumor models, HDAC expression, Triple-Negative Breast Cancer, TNBC lung metastasis, histone deacetylases

Relation: https://figshare.com/articles/dataset/Structure-Based_Design_of_a_Selective_Class_I_Histone_Deacetylase_HDAC_Near-Infrared_NIR_Probe_for_Epigenetic_Regulation_Detection_in_Triple-Negative_Breast_Cancer_TNBC_/14258239

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02161.s003

المؤلفون: Weiwei Li (364036), Jiajia Feng (5135759), Xiaoliang Zhang (284283), Cong Li (115171), Hongliang Dong (3765625), Wen Deng (123626), Junxiu Liu (644397), Hua Tian (220297), Jian Chen (15340), Sheng Jiang (303820), Hongwei Sheng (4391563), Bin Chen (63682), Hengzhong Zhang (62987)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Neuroscience, Pharmacology, Evolutionary Biology, Ecology, Sociology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, two isostructural changes, enhanced bulk modulus, developing novel applications, ab initio calculations, interlayer atomic bonding, high coordination numbers, critical temperature even, 3 – 5, 2 , vdw layers start, layered vdw compounds, ∼ 20 gpa, simple pressure tuning, 20 gpa, ∼ 10, room temperature, interlayer coupling, high pressure, 40 gpa, 4 gpa

Relation: https://figshare.com/articles/journal_contribution/Metallization_and_Superconductivity_in_the_van_der_Waals_Compound_CuP_sub_2_sub_Se_through_Pressure-Tuning_of_the_Interlayer_Coupling/17072697

الاتاحة: https://doi.org/10.1021/jacs.1c09735.s001

المؤلفون: Weiwei Li (364036), Jiajia Feng (5135759), Xiaoliang Zhang (284283), Cong Li (115171), Hongliang Dong (3765625), Wen Deng (123626), Junxiu Liu (644397), Hua Tian (220297), Jian Chen (15340), Sheng Jiang (303820), Hongwei Sheng (4391563), Bin Chen (63682), Hengzhong Zhang (62987)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Neuroscience, Pharmacology, Evolutionary Biology, Ecology, Sociology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, two isostructural changes, enhanced bulk modulus, developing novel applications, ab initio calculations, interlayer atomic bonding, high coordination numbers, critical temperature even, 3 – 5, 2 , vdw layers start, layered vdw compounds, ∼ 20 gpa, simple pressure tuning, 20 gpa, ∼ 10, room temperature, interlayer coupling, high pressure, 40 gpa, 4 gpa

Relation: https://figshare.com/articles/dataset/Metallization_and_Superconductivity_in_the_van_der_Waals_Compound_CuP_sub_2_sub_Se_through_Pressure-Tuning_of_the_Interlayer_Coupling/17072700

الاتاحة: https://doi.org/10.1021/jacs.1c09735.s002